Regenerative treatments are gaining popularity because they repair an injury rather than just control pain with steroids or anti-inflammatory drugs. But why repair an injury without addressing the cellular level issues?

1. NUTRITION HELPS PACK A PUNCH IN REGENERATIVEMEDICINE

2. WHAT YOU NEED TO UNDERSTAND ABOUT INFLAMMATION:
Progressive regenerative medical treatments can offer
long term relief where other methods fail. In order for
Prolotherapy and other specialized treatments to have
their full affect, the inflammation in the body must be
irradiated completely by using nutrition in combination
with the procedures.
Time Magazine, Feb. 23, 1004, Vol. 163 No. 8

3. WHAT YOU NEED TO UNDERSTAND ABOUT INFLAMMATION:
Inflammation is simply the body’s normal response to injury. Acute inflammation is a
positive modifying process that the body uses to defend and repair functions. Chronic
inflammation is a negative dysfunctional process that develops over time in the body
and is responsible for a wide variety of diseases.

4. ACUTE VS. CHRONIC – THE INFLAMMATION BREAKDOWN
▪ The body uses acute inflammation to cut off stressors to the body. This type of
inflammation is typically localized and generally beneficial with a few exceptions.
Chronic inflammation is persistent. It is a much more detrimental. Chronic pain
disrupts the body’s natural stability, destroys tissue and changes cell structure.
“C-reactive protein is the classic acute phase reactant, the plasma levels of which can
increase as much as 10,000-fold in response to tissue injury and infection.”
– Danesh, John. JAMA, 12/8/99, Vol. 282: pp. 2165-2171.
▪ In many cases there is a genetic propensity to chronic inflammation. Another
important contributing factor is diet/nutrition. Poor nutrition can cause the body’s
natural “off switch” to malfunction, lead to deficiencies and imbalances.

5. TRADITIONAL MEDICAL MANAGEMENT OF PAIN AND
INFLAMMATION – NSAIDS
▪ NSAIDs (Non-steroidal anti-inflammatory drugs) are too often the “go-to” for
musculoskeletal conditions despite their known risks. Worse still, these drugs
commonly increase joint destruction and compromise gastrointestinal health.
▪ With the constant reliance on NSAIDs, doctors and patients typically ignore the use
of treatments that are more effective and offer long term relief without drug
dependence. Further, NSAIDS do not address the underlying issues commonly
associated with chronic musculoskeletal dysfunction and pain.

6. HOWMUCH ARE NSAIDS REALLY USED?
▪ Annually, more than 70 million prescriptions are written, and more than 30 billion
NSAIDs are sold over-the-counter in the U.S. It is estimated that 13 million people
in the U.S. use NSAIDs regularly. The estimated number of annual hospitalizations
in the U.S. for serious G.I. complications is at least 103,000 with direct costs
exceeding
$2 billion. There are more deaths annually related to NSAID use than AIDS-related
deaths.
– Fnes, JF. NSAID gastropathy, the second most deadly rheumatic disease? Epidemiology and risk appraisal. J Rheumatol 1991: (Suppl 28) 18: 6-
10. / Bland J. Nutritional Management of the Underlying Causes of Chronic Disease. Seminar Series.Washington Institute of Functional
Medicine. 2000.
▪ But just because the pain or swelling is reduced, this does not mean that the
underlying problem has been eradicated. Still worse the temporary relief may
cause other issues.
“…the administration of NSAIDs may lead to loss of intestinal integrity, thus facilitating
antigenic absorption and perhaps contributing to persistence of the disease.”
– Bjamason I, et al. Intestinal permeability and inflammation in rheumatoid arthritis: effects of non-steroidal anti-inflammatory drugs. Lancet.
1984, 2(8413): 1171-1174.

7. SOME OF THE ADVERSE EFFECTS OF NSAIDS:
▪ Gastrointestinal bleeding and gastric ulceration
▪ Increased intestinal permeability
▪ Promotion of bone necrosis and cartilage destruction
▪ Promotion of hepatic and renal injury and failure
▪ Unacceptable cost-benefit and risk-benefit ratios
▪ Death

8. COMMON SIDE EFFECTS OF CORTICOSTEROIDS:
▪ Muscle weakness; myopathy
▪ Impaired wound healing
▪ Increased gut permeability
▪ Peptic ulcer; gut perforation
▪ Osteoporosis
▪ Calcium malabsorption
– Physicians’ Desk Reference. 53rd ed., 1999.

9. CONGRESS PROBES AGENCY ON ARTHRITIS DRUG
SAFETYWARNINGS
WASHINGTON — The American public is “virtually defenseless” if another medication
such as Vioxx proves to be unsafe after it is approved for sale, a government drug
safety reviewer told a congressional committee Thursday.
▪ The U.S. Food and Drug Administration failed the public in its oversight ofMerck
& Co Inc.’s withdrawn painkiller Vioxx and is “incapable of protecting America”
from another dangerous drug, agency researcher David Graham told Congress.
“I would argue that the FDA as currently configured is incapable of protecting America
against another Vioxx,” said Graham, who had warned that the arthritis drug had
been linked to an increased risk of heart attack and stroke.
▪ He called the FDA’s actions “a profound regulatory failure.”
▪ Concerns about a possible link between Vioxx and heart problems were building
during the drug’s more than four years on the market. The FDA required a
warning about heart risks but felt the drug’s benefits made it worth keeping on
the market.
▪ Merck Chief Executive Raymond Gilmartin said the company had believed
wholeheartedly in Vioxx and had followed a rigorous scientific procedure every
step of the way.
“In fact, my wife was taking Vioxx, using Vioxx, up until the day we withdrew it from
the market,” Gilmartin told the Senate Finance Committee.
– Physicians’ Desk Reference. 53rd ed., 1999.
Kevin Lamarque / Reuters

10. SOWHAT IS A PATIENTWITH CHRONIC PAIN TO DO?
In order for the body to heal, balance and stability need to be restored to the body
and all of its functions. The underlying causes of the pain and inflammation need to
be addressed.
▪ Remove ongoing triggers – known and potential
▪ Decrease the total toxic load
▪ Optimize gastrointestinal health
▪ Remove pathogens
▪ Control microbial imbalance and repair the inflamed gastrointestinal wall
▪ Identify potential antecedents
▪ Genetic markers and family history

11. SOWHAT IS A PATIENTWITH CHRONIC PAIN TO DO?
▪ Modify mediators
▪ Correct nutritional deficiencies and oxidative stress
▪ Introduce anti-inflammatory diet
▪ Optimize fatty acids and eicosanoids synthesis
▪ Vitamin D – pro-inflammatory epidemic
▪ Phytonutritional modulation of NF-kappaB
▪ Restore structural integrity and remove subluxation
▪ Chondro-support
▪ Botanical analgesies:White Willow bark, Boswellia and Devil’s Claw
▪ Proteolytic enzymes for acute/chronic pain and inflammation

12. REMOVE THE TOP ALLERGENS – “THE SENSITIVE SEVEN”
1. Dairy
2. Wheat
3. Sugar
4. Corn
5. Soy
6. Eggs
7. Peanuts

13. OPTIMIZE FATTY ACIDS
▪ Omega-3 fatty acids: from flax oil and fish oil; generally these have health-promoting
benefits; these fats are generally deficient in American diets.
▪ Omega-6 fatty acids: from vegetable, corn and nut oils, beef, liver, pork, lamb,
turkey, and chicken; increases cancer and inflammation; American intake is high.
▪ Omega-9: Oleic acid is found in olive oil; reduces inflammation, CAD and cancer risk;
American intake is low.
”Fish oil supplementation allows patients with inflammatory diseases such as
rheumatoid arthritis to reduce their need for anti-inflammatory drugs.”
– BR J Rheumatol. 1993 Nov; 32(11): 982-9.
”This is important because NSAIDs, like aspirin, hospitalize 107,000 people and kill
more than 16,500 people each year. “
– Am J Med. 1998 Jul 27; 105(1B): 31S-38S.

14. EPA: EICOSAPENTAENOIC ACID
▪ EPA is only available from fish oil. It has powerful anti-inflammatory benefits.
Clinical studies have shown benefits in the treatment of many conditions:
rheumatoid arthritis, ulcerative colitis, and cancer, just to name a few.
“Conclusion: fish-oil ingestion results in subjective alleviation of active rheumatoid
arthritis and reduction in neutrophil leukotriene B4 production.”
– AM Intern Med. 1987 Apr; 106(4): 497-503.

15. GLA: GAMMA-LINOLENIC ACID
▪ GLA appears to be the exception to the rule when it comes to the Omega-6 fatty
acids. GLA has been shown to have powerful beneficial effects.
“GLA treatment is associated with clinical improvement in patients with RA, as
evaluated by duration of morning stiffness, joint pain and swelling, and ability to
reduce other medications.”
– Semin Arthritis Rheum. 1995 Oct; 25(2): 87-96.
▪ While beneficial on their own, fatty acids work even better when used together.
Doctors need to use health-promoting fatty acids in combination to optimize the
benefits and increase the effectiveness of these powerhouse supplements for
patients.

16. VITAMIN D DEFICIENCY
▪ Vitamin D deficiency is a common problem with serious consequences. Diagnosis is
easy and treatment with oral supplementation is easy, safe, affordable, and
beneficial.
Vasquez A, Manso G, Cannell J. The Clinical Importance of Vitamin D (Cholecalciferol): A Paradigm Shift with Implications for All Healthcare
Providers. Alternative Therapies in Health and Medicine 2004; 10: 28-37 http://www.bioticsresearch.com/vitD.htm

17. MAYO CLINIC PROCEEDINGS – VITAMIN D DEFICIENCY
▪ Supplementation of Vitamin D is a safe, simple and beneficial intervention method
for restoring health to patients. Clinical studies have shown reduction in pain,
inflammation and numerous other maladies.

18. THE 10 GREEN-GENE FOOD GUIDELINES
By changing eating habits, you can help your body heal.
1. Eat fresh whole food in its natural state as often as possible.
2. Eat a wide variety of foods.
3. Select organic, grass-fed, free-range, local and sustainable foods whenever possible.
4. Consume high-quality food with the proportion of protein, carbohydrates, and fats our genes adapted to over the
millennia.
5. Choose ONLYminimally processed oils and fats that have retained their naturally occurring proportion of nutrients.
6. Choose plant and animal foods that have been grown or raised on sustainable and nutrient-rich soil.
7. Choose wild-caught fish from the least-polluted waters.
8. Select store, and prepare food in ways that preserve its nutrients.
9. Drink clean water.
10. Give regard to every aspect of the meal.
– Graham, Gray L. Pottenger’s Prophecy

19. THE ANTI-INFLAMMATORY DIET
By changing eating habits, you can help your body heal.

20. NUTRIENTS TO SUPPORT HEALTHY JOINTS
▪ Water and the electrolytes to hold it
▪ Chondroitin sulfates
▪ Glucosamine
▪ Sulfur
▪ Silicon
For Collagen
▪ Amino Acids
▪ Vitamin C
▪ Iron
▪ Copper
▪ Manganese

21. THE FINAL PIECE – REGENERATIVEMEDICINE
Regenerative treatments are gaining popularity because they repair an injury rather
than just control pain with steroids or anti-inflammatory drugs. But why repair an
injury without addressing the cellular level issues? When regenerative medicine is
combined with nutrition, your body can begin to function at its full potential,
uninhibited by chronic pain and inflammation.