1. David A. Ruddy
88 Liberty Avenue  Somerville, MA 02144  (617) 949-9539  davidaruddy@gmail.com
RESEARCH SCIENTIST
Delivering Industry-Leading Advancements in Next Generation Technologies
Proven success driving next generation technologies within the Biotechnology and Pharmaceutical sector
through applied scientific research and scalable design. Track record of delivering:
 State-of-the-art NGS facility supporting both Novartis Oncology Research and Development
organizations, including pre and post-PCR rooms, large-scale automation, and computational
software and hardware
 Large-scale positional cloning platform in C. elegans and D. melanogaster
 Sequencing/Informatics leadership in the discovery of the Hemochromatosis gene
Experience
Novartis Institute for BioMedical Research, Oncology Translational Research -- Cambridge, MA
Scientific Technical Leader II, 2004 to Present: Project Highlights:
 Built first NGS lab in NIBR supporting both Novartis Oncology Research and Development Projects
 Developed new NGS applications including, single cell barcoding, large-scale pooled
shRNA/CRISPr screens, CART vector optimizations, RNA-Seq, and targeted resequencing
(SureSelect, RainDance)
 Implemented automation platforms in support of DNA/RNA-Seq applications
 Collaborated extensively across departments to promote NGS technologies and applications
 Managed 1 million dollar annual operating budget with capital equipment expenditures of 750K+
Exelixis Pharmaceuticals -– South San Francisco, CA
Research Scientist, 1998 to 2004
Worked closely with model genetics groups to develop high-throughput positional cloning platform
Mercator Genetics –- Menlo Park, CA
Research Scientist, 1993 to 1998
Managed sequencing and infomatics groups in support of human genetics cloning projects
Genentech –- South San Francisco, CA
Technical Operator, 1990 to 1992
Ran cell culture suite lab in protein production facility and material testing lab in consecutive appointments
Education
Brown University, B.A in Psychopharmacology, 1990 -- Providence, RI
Publications, Patents, Technology Tools, and Interests are available on
LinkedIn (www.linkedin.com) and ResearchGate (www.researchgate.net)