Class 8 TCA cycle
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Dr. Dhiraj J. Trivedi Biochemistry lectures for UG medical students, SDM College of Medical Sciences and Hospital, Dharwad, Karnataka, India
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Class 8 TCA cycle
- 6. Citrate Malate Fumarate Succinate Succinyl CoA Cis Aconitate Oxalosuccinate α -Ketoglutarate Acetyl CoAPyruvate Isocitrate Oxaloacetate NAD+ NADH + H+ NAD+ NADH + H+ FADH2 FAD ADP ATP CoA-SH CoA-SHCO2 CO2 H2O H2O H2O CoA-SH H2O Fatty acids Citrate synthase Aconitase Aconitase ICDH ICDH KGDH Sucinate thiokinase SDH Fumarase MDH
- 7. 1. Isocitrate DH NADH + H 2.5 ATP 2. Ketoglutarate DH NADH + H 2.5 ATP 3. Succinate thiokinase Substrate level 1.0 ATP 4. Succinate DH FADH2 1.5 ATP 5. Malate DH NADH + H 2.5 ATP Total 10 ATP
- 11. Citrate Malate Fumarate Succinate Succinyl CoA Cis Aconitate Oxalosuccinate α -Ketoglutarate Acetyl CoA Pyruvate Isocitrate Oxaloacetate NAD+ NADH + H+ NAD+ NADH + H+ FADH2 FAD ADP ATP CoA-SH CoA-SHCO2 CO2 H2O H2O H2O CoA-SH H2O Fatty acids