Cheminfo Stories APAC 2020 -- Markush technology
•
0 likes•129 views
ChemAxon's Markush Technology for better claims drafting
Recommended
Recommended
More Related Content
More from ChemAxon
More from ChemAxon (20)
Recently uploaded
Recently uploaded (20)
Cheminfo Stories APAC 2020 -- Markush technology
- 2. INTRODUCTION
- 3. SECTION TITLE Drug Discovery & Patents Early-stage idea validation • Are my structures new compared to the prior art? Patent drafting • Does my claim cover my structure series? • Does my claim cover any structures from the prior art? • Does the application that I already filed cover my new structure series or do I need to file a new one?
- 4. Importance of Markush Structures Between 1994 and 2013 3,704,996 US patents 468,262 with Markush claims Every eighth patent contains Markush claims Markush claims often cover >1010 structures Joseph J. Mallon, 2014
- 5. What Are the Limits of the Person Skilled in the Art? USPTO Supplementary Examination Guidelines about Indefiniteness A Markush claim may encompass a large number of alternative species, but is not necessarily indefinite under 35 U.S.C. 112(b) for such breadth. In certain circumstances, however, Markush group may be so expansive that persons skilled in the art cannot determine the metes and bounds of the claimed invention…
- 7. Markush Representation • R-groups • Atom lists • Bond lists • Position variations • Repeating units • Homology groups
- 8. Markush Technology • Search • Hit visualization • Non-hit visualization • Enumeration • Composer • Markush to text
- 9. Search Improvements x100 speed-up New Markush search engine • In Full structure search • Memory requirements reduced by 90% • No impossible structures anymore • Open the way for new representation features
- 10. Representation Improvements • Multiplier • Optionally substituted • Fragment representing a bond • Attachment on pos.var
- 11. PATENT DRAFTING – MARKUSH EDITOR
- 12. Patent Drafting Workflow • Starts with a list of compounds • Find scaffold • Formulate R-groups • Generalize • Formulate subclaims
- 13. Computer-Aided Patent Drafting • Scaffold detection • R-group formualtion • Interactive editor • Search and visualization • Document generation
- 14. Markush Generation Generate Markush structure from a series of compounds
- 16. Markush to Text Generate claim draft from the Markush structure
- 18. Computer-Aided Structure Extraction • Document annotation • Name to structure • Markush representation • Search and visualization
- 19. Naming Technology • IUPAC, Common names, traditional names, brand names • Built-in OCR error correction and flexible recognition • Compounds and R-group fragments • English (2008) • Chinese (2013) • Japanese (2014)
- 22. • Structural representation of Markush claims • High-quality Markush structures extracted from project- related patents or patent drafts • Analysis of the claimed chemical space Patent Curation
- 23. Example Workflow Select Documents Extract Markush Claims Validate Structure Ideas Load to Database MRV files Select project-specific patents and curate or send them for curation Use the MRV representation of the Markush claims for automatic, in-house idea validation
- 24. CASE STUDY
- 27. Example Structures • 11 structures in the claims • 67 structures in the description
- 28. Are These Structures Covered?
- 29. Automatic Validation 6 structures are not covered!
- 30. Hit and Non-Hit Visualization
- 31. Where Is the Mistake?
- 32. Extraction Process (ChemCurator) • Markush curation ChemCurator 30 min • Examples extractions ChemCurator + CLiDE 10 min • Analysis ChemCurator 5 min
- 33. Try to Generate (Markush Editor) • Automatic generation less than 2 sec • All the examples covered • Scaffold and R-groups close to the patent
- 34. CONCLUSION
- 35. Conclusion New solutions exist to Move on the next stage with your inhouse IP process • Write better-quality patents • Understand your competitors’ patents • Integrate IP knowledge into your early- stage discovery process