1. Quality Research Today for a Better Tomorrow
Corporate Capabilities
1580 McLaughlin Run Road
Pittsburgh, PA 15241
412-257-4461
www.pprresearch.com

2. Primary Physicians Research is an established clinical research provider
We offer:
10 independent, community-based research sites
2 multi-specialty sites
Over 25 years of experience
Over 700 trials.
Dedicated QA/QC department, assuring quality
conduct as well as patient safety
70+ physician network of investigators
A rapidly growing database of over 300,000
patients
Nearly 33,000 study participants (2005-2011)
A strong history of high-quality performance
Strong Enrollment
Reliability
Clean Data
Quick Turnaround

3. History of strong performance
Phase I-IV and OTC clinical trial capabilities
Ability to accommodate specialist trials
Able to handle large, quick enrollments, due to seasonal issues
Consistent history of achieving and exceeding contracted enrollment
Overenrolled in over 30% of studies from February 2006 – February 2011
Primary Investigators, Sub Investigators, and highly trained staff at each site to
oversee and execute the study protocol
Fully equipped neighborhood offices that offer convenience and familiarity to study
subjects.
A proven track record in pediatric and adult research.

4. PPR’s Facility
PPR’s dedicated research facility is located within the Jefferson Regional Hospital
Comfortable waiting room
On site PI
State of the art on-site
lab capabilities Separate monitor
room with high -speed
Internet, Fax, Phone.

5. 97% of patients completed study protocols
Studies conducted between January 2002 - February 2011
Studies Conducted 300
Total Enrollment Since 2002 30,800
Total Completed 29,974
2.5-Year Average Study Yield
Jan 2008- February 2011
3.3%
Patient completion %
Patient drop-out %
96.6%
Note: The above is all-inclusive of studies taken on by PPR during the period - without regard to size, type, ease/difficulty or
continuance/discontinuance.

6. PPR has a strong history with numerous pharmaceutical companies:
7 Largest Sponsors – 10 Year Snapshot
Novartis Merck
13% 24%
Pfizer/Wyeth
14%
Abbott
Lilly
4%
1%
Sanofi
15%
GSK
29%
Note: The above represents PPR’s mix of business by number of studies across its 7 largest customers over the last 10 years

7. Quality Assurance
Our quality assurance goal is to achieve, sustain, and improve quality in all
aspects of research within the clinical site arena.
PPR’s QA Department has been organized to drive a data quality focus
throughout the organization. This is achieved by:
Training staff on an ongoing basis
Monthly meetings to identify and correct potential adverse trends in
data quality
A Quality Assurance Liaison visits sites monthly to correct identified
problems and trends and works with PIs to ensure adherence to protocol
and GCP’s
In-house audits are performed and quality indicators are reviewed on a
per trial basis
Identifying and implementing best practices for delivering quality data

8. Strong Clinical Trial Management Information System
Clinical Conductor manages the large amounts of data involved with the
operation of a clinical trial.
Some of the benefits of using a CTMS include:
Improves recruitment efficiency
Better management of budgets and financials
Tracks advertising responses
Full oversight of multiple trials at multiple sites

9. Recruitment and marketing: A top priority
PPR has a marketing and site recruitment team who is solely dedicated to patient
enrollment
Marketing techniques play a pivotal role in how targeted patients become aware of
clinical trials
In-house marketing staff creates advertising and marketing tools that are used by
sub-investigators and site personnel to increase enrollment
Staff adheres to ICH guidelines in obtaining IRB approvals for marketing tools

10. Online marketing and social media tools
PPR utilizes online marketing resources and social media tools for patient
recruitment
 PPR maintains an active
online presence through it’s
website, social media
networks, and craigslist
Recent Accomplishments:
 Used Craigslist.com to
recruit nearly 75% of goal
patients in an osteoarthritis
study with a contracted goal
of 20 patients
 Used Craigslist.com to enroll
over 100% of the set 40
patient goal in a Women’s
Health study

11. Trial Experience

12. PPR has conducted numerous vaccine trials including:
Diptherial/Pretussis/Tetanus Haemophilus influenza type B
DTaP Hepatitis A
Tetanus/Diphtheria Hepatitis B
Varicella Human Papillomavirus
eIPV Plague
Rotavirus Respiratory Syncytial Virus (RSV)
Influenza (intranasal Anthrax
Influenza (injection) Diphtherial/Pertussis/Polio/Tetanus
Influenza (cellular) Meningococcal A,C,W,Y
Meningococcal A,C,Y,W-135 MMRV
Meningococcal B Herpes Simplex Virus
Lyme Disease Hepatitis AB
Parainfluenza PIV3RSV
Pneumococcal Dtap/Hib/IPV (Pentacel)
DTaP/IPV/Hep B (Pediarix)

13. PPR has conducted numerous therapeutic and nutritional trials:
Asthma Topical Otologicals
Osteoporosis Topical Ophthalmologics
Osteoarthritis Contraceptives
Obesity Arthritis
Herpes simplex Back pain
Antivirals Pharyngitis
Diabetes Acute bronchitis
Strep throat Chronic bronchitis
Antipyretics Sinusitis
Lipids Pneumonia
Influenza Otitis media
Pharmacokinetics Bacterial vaginosis
Migraine Infant formula
Atrial Fibrillation Hypoactive Sexual Desire
Disorder

14. Our Clients

15. PPR has a strong history with numerous pharmaceutical companies:
Aventis Genentech Osiris Therapeutics
Abbott Gilead Sciences Pfizer
Advancis GlaxoSmithKline Pharmacia
Alcon GlaxoWelcome Protein Sciences
Allergan Inspire Roche
Almirall Iomai RWJ
Prodesfarma
Johnson & Johnson Sanofi
Aviron Sanofi Aventis
KV Pharma
BioCryst Sanofi Pasteur
Eli Lilly
Bristol Myers Sepracor
Mead Johnson &
Squibb
Company Schering-Plough
Cephalon
MedImmune Shire
Chiron
Merck Takeda
Dimethaid
NABI Pharmaceutical VaxGen
Dynavax
Novartis ViroPharma
Dynport
Ortho-McNeil Wyeth
Note: The above is meant to show PPR’s substantial client base developed over time. It should be noted that some of the above listed clients have
since merged, been acquired or otherwise joined with competitors.

16. PPR has strong relationships with CROs and others:
 Advanced Biologics  MDS  PPD
 Covance  OmnicareCR  Quintiles
 I3 research  Parexel  United Biosource Corp
 Icon  Pharmanet
PPR is proud of its working relationships with government agencies
 The National Institutes of Health
Working on protocols that have been initiated by the NIH
 The Department of Defense
Worked on vaccines to protect military men and women over the last 5 years
 The Division of Microbiology and Infectious Diseases (DMID)
Approved by the DMID to work on vaccine trials in collaboration with NIH and VTEU sites
Created QA/QC program that has been approved by the DMID
 Subcontractor for the Vaccine and Treatment Evaluation Units (VTEU) program
Partner with the University of Saint Louis to work with them in numerous vaccine trials

17. PPR provides:
Experienced leadership oversees the key functions supporting trial success
Clinical staff receives extensive training and is dedicated solely to conducting
research
Consistent and strong enrollment
Quality data
A team dedicated to delighting our clients!

18. Our clinical research team:
Primary Physicians Research welcomes the opportunity to speak with you to provide more
information about our experience conducting clinical trials or for the opportunity to conduct a
clinical trial for you. Please contact us:
PRESIDENT & CEO
Paul E. Curley
Phone :412-257-4461 ext 212
Cell: 610-745-9155
curleyp@pprresearch.com
EXECUTIVE DIRECTOR, COMMERCIAL OPERATIONS
Carol L. Miller, LPN, CCRC
Phone :412-257-4461 ext 127
Cell: 724-518-9531
millerc@pprresearch.com
BUSINESS DEVELOPMENT
Corry Knuth
Phone :412-257-4461 ext 126
Cell: 724-570-4798
knuthc@pprresearch.com