N O dNaM d5SICs S Solution Answer: The artificial base pairs (dNaM and d5SiCS)were first introduced by Floyd Romesberg into Escherichia coli (Bacteria). Both unnatural base pairs, dNaM and d5SiCS undergo Hydrophobic interactions. These are stable,during replication the retention was 99% in bacteria, they are not remove by error correction mechanisms but they couldn\'t be included into new copy of DNA after replication. As these unnatural bases are retained during replication, so we can tell that helicase can act on DNA containing unnatural bases and unwind strand..