This document outlines a strategic plan for Native American and Indigenous Affairs at the University of Wyoming. It begins with background on Indigenous peoples in Wyoming and the university's commitment to promoting Indigenous self-determination through education. The vision, mission, and values focus on meeting Indigenous needs through education, research, outreach, and promoting self-determination. A multi-phase process gathered input from over 200 community members to inform the plan's goals of driving excellence in teaching, research, and innovation related to Indigenous communities and ensuring excellent education for Indigenous students. Performance indicators and targets are established to measure progress.