A short ppt on antidepressants

2.  Depression is a common
clinical condition
associated with feelings of
sadness, loss of interest,
self-neglect, anorexia,
sleep disturbances,
suicidal feelings in severe
cases, etc.

3.  Decrease in levels or functions of
monoamines (5-HT, NE, DA) in cortical and
limbic system
 Decrease in brain-derived neurotrophic
factor (BDNF)
 Abnormalities in thyroid function and sex
steroid levels

4. 1. Tricyclic antidepressants
 Amitriptyline
 Nortriptyline
 Trimipramine
 Imipramine
 Doxepin etc
2. Serotonin and Noradrenaline reuptake inhibitors (SNRIs)
 Duloxetine
 Venlafaxine

5. 3. Selective Serotonin reuptake inhibitors (SSRIs)
 Fluoxetine
 Paroxetine
 Fluvoxamine
 Sertraline etc.
4. MAO-A inhibitors
 Moclobemide
 Clorgyline
5. Atypical antidepressants
 Bupropion
 Mianserin

6.  Inhibit norepinephrine transporter (NET)
enhance the availability of NA at the receptors
in CNS
 Inhibit serotonin transporter (SERT) → block
reuptake
 Muscarinic blockade
 α1- adrenergic blockade
 H1 blockade

7.  Inhibit serotonin transporter (SERT) → block
reuptake → increase availability of 5-HT at
receptors in CNS and enhance serotoninergic
activity
3. Serotonin and Noradrenaline reuptake
inhibitors (SNRIs)
 Inhibit reuptake of serotonin and noradrenaline
into the neuron

8. A. Bupropion
 Inhibits reuptake of DA and NA into the
neuron
B. Mianserin
 Increases NA release by blocking
presynaptic α2 receptors

9.  A selective and reversible inhibitor of MAO-A
(RIMA)
[MAO-A is responsible for mainly metabolism
of NA, 5-HT and tyramine.]

10. 1. Atropine-like side effects [TCA]
2. Insomnia [SSRI]
3. Sexual dysfunction [SSRI,SNRI]
4. Sweating [SNRI]
5. Seizures [Mianserin]

11. 1. Depression
2. Anxiety disorders
3. Obsessive compulsive disorders (OCD)
4. Nocturnal enuresis
5. Prophylaxis of Migraine
6. Chronic pain including Neuralgias
7. Attention deficit hyperactivity disorder