ARNI in hypertension

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2. ARNI IN HYPERTENSION
MANAGEMENT
ONE SENTENCE SUMMARIZINGTHE EVENT, OR A FAMOUSQUOTEABOUTTHE EVENT.

3. • Introduction 1.1 Welcome and Introduction 1.2 Brief Overview of ARNI
• Overview of Hypertension and HFPEF 2.1 Understanding Hypertension and
Its Impact 2.2 Introduction to Heart Failure with Preserved Ejection
Fraction (HFPEF) 2.3 Key Challenges in Managing Hypertension and HFPEF
• ARNI in Hypertension: Recent Evidence 3.1 Overview of ARNI and Its
Mechanism of Action 3.2 Recent Studies and ClinicalTrials on ARNI in
Hypertension 3.3 Efficacy and Safety Profile of ARNI inTreating
Hypertension 3.4Comparison of ARNI with Other Antihypertensive
Medications 3.5 Implications of ARNI Use in Hypertensive Patients
• Real-World Practice:ARNI in HFPEF 4.1 Understanding HFPEF and Its
Clinical Characteristics 4.2 Real-World Evidence on the Use of ARNI in
HFPEF 4.3 Benefits and Challenges of ARNI in Real-World Practice 4.4 Case
Studies or Experiences from Healthcare Professionals 4.5 Patient Selection
Criteria for ARNI in HFPEF Management
• Addressing Unmet Needs and Future Directions 5.1 Unmet Needs in the
Management of Hypertension and HFPEF 5.2 Role of ARNI in Addressing
Unmet Needs 5.3 Ongoing Research and Future Directions in ARNITherapy
5.4 Personalized Medicine andTailoring ARNITreatment

4. INTRODUCTION
• Making it one of the significant contributors of premature death and morbidity
Hypertension is an important modifiable risk factor for cardiovascular diseases (CVD)
• Only 21% of hypertensive patients had their blood pressure under control in 2021.1
Globally,
• National Family Health Survey (NFHS-5) (2019–2020) reported a hypertension prevalence
• 24% in men and 21% among women, an increase from 19% and 17% respectively from the
previous round (2015–16).
Hypertension is the most important risk factor for death and disability in India.
The Lancet Regional Health - Southeast Asia 2023;9: 100113

5. IMPORTANCE OF HYPERTENSION IN DEVELOPMENT OF
CARDIOVASCULAR RISK
Nocturnal hypertension is a significant risk factor for cardiovascular disease (CVD) development and events
Changes in the circadian variation of blood pressure (BP) also increase cardiovascular risk.
Attention to both nighttime BP and the circadian BP pattern is essential for mitigating cardiovascular
risk in hypertensive patients.
Management of nocturnal hypertension is an unmet medical need due to the once-daily morning dosing
of most current antihypertensive medication.
Therapeutic blind spots exist in the early morning hours, where drug levels and BP-lowering effects are at
their lowest before morning dosing.
Bedtime dosing of antihypertensive therapy can potentially overcome these issues.
J Am Heart Assoc. 2023;12:e027612.

6. • Novel agents may have favorable effects on circadian BP control in hypertensiontreatment
• Sacubitril/valsartan, an angiotensin receptor neprilysin inhibitor, is a newer agent approved in Japan for
treating hypertension.
• Studies have shown that sacubitril/valsartan significantly decreases office BP in hypertensive patients (14-26).
• Reductions in 24-hour, daytime, and nighttime BP have been observed during sacubitril/valsartan treatment
(14,15,17,18,20,22-25).
• The impact of sacubitril/valsartan on ambulatory BP in patients with different circadian profiles of nighttime
BP dipping, including the abnormal nondipper phenotype, has not been determined yet.
J Am Heart Assoc. 2023;12:e027612.

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