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peptic ulcer disease
- 1. PUD (Peptic Ulcer Disease) Dr. Alim Al Razy Intern, Medicine Unit 1 Under prof, Dr Gautam Kumar Roy
- 2. The term ‘peptic ulcer’ refers to an ulcer in the lower oesophagus, stomach or duodenum, in the jejunum after surgical anastomosis to the stomach or, rarely, in the ileum adjacent to a Meckel’s diverticulum.
- 3. .
- 4. STOMACH
- 8. Properties Of Gastric Juice • Volume : 1200ml/day • pH : 0.9 – 1.2
- 9. This High acidic environment cant destroy the lining of our Digestive system because there are some NEUTRALIZING FACTORS
- 10. When there is IMBALANE between the erosive effect of GASTRIC JUICE and NEUTRALIZING FACTORS, PEPTIC ULCER occurs
- 11. Causes of Peptic Ulcer - .
- 12. Gastric infection with the bacterium H. pylori (Most common causes)
- 13. Chronic use of NSAID
- 14. Non-H. pylori and Non-NSAID causes Infection • Cytomegalovirus • Herpes simplex virus • H. heilmannii Drug/Toxin • Bisphosphonates • Chemotherapy • Clopidogrel • Crack cocaine • Glucocorticoids (when combined with NSAIDs) • Mycophenolate mofetil • Potassium chloride
- 15. Cont.. Miscellaneous • Basophilia in myeloproliferative disease • Duodenal obstruction (e.g., annular pancreas) • Infiltrating disease • Ischemia • Radiation therapy • Sarcoidosis • Crohn's disease • Idiopathic hypersecretory state
Editor's Notes
- Peptic Ulcer may be defined as single solitery lesion caused by aggravated action of acid