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Management of PATIENTS WITH
end stage tmj diseases
1
PRESENTATION BY
ADITI RAJVANSHI
IIyr PG TRAINEE
2
CONTENTS
INTRODUCTION
END STAGE DISEASE PROCESSES
BASIC ELEMENTS OF CARE
PAIN MANAGEMENT
TMJ RECONSTRUCTION - GOALS OF RECONSTRUCTION
DIFFFERENT TREATMENT MODALITIES
AUTOGENOUS
ALLOPLASTIC
DISTRACTION OSTEOGENESIS
BIOENGINEERING
CONCLUSION
REFERENCES
INTRODUCTION
• Worst disease state of an organ system.
• Negatively affected joint architecture and severe
functional impairment.
Petersons Principles Of Oral And Maxillofacial Surgery 3rd Ed
3
DISEASE PROCESSES LEADING
TO END STAGE TMJ DISEASE
4
1. DEVELOPMENTAL
DISORDERS
 CONDYLAR AGENESIS/HYPOPLASIA
 CONDYLAR HYPERPLASIA
5
2. NEOPLASMS
6
3. ARTHRITIC DISEASES
7
Inflammatory disease
Degenerative disease
8
4. ANKYLOSIS
5. TRAUMA
6. MULTIPLE PRIOR FAILED PROCEDURES
BASIC ELEMENTS OF CARE
 The patients commonly suffers from unrelenting pain and
severe limitation of jaw movement.
 In addition, they may also have facial asymmetry,
dysfunctional malocclusions, sensory and motor
abnormalities.
9
PAIN CONTROL STRATEGIES
 With few exceptions, pain is the primary chief
complaint of these patients and is often the principle
limiting factor in patients willingness to comply with
the recommended physical therapy.
 In addition, these patients often exhibits signs of
depression and are usually socially withdrawn.
10
PERIOPERATIVE
1. PREEMPTIVE ANALGESIA
Regional anesthesia
Opioid based GA
Ketamine
Ketorolac
2.IMMEDIATE POSTSURGICAL PERIOD
Regional anesthesia
Opioids( scheduled regimens)
Ketorolac 11
LONG TERM
1. PHARMACOLOGIC
Tricyclic antidepressants
Opioids(scheduled dose)
GABAergics(gabapentin, baclofen)
Non opioids(pain associated with inflammation)
2.NONPHARMACOLOGIC
Regular exercise
Heat/cold packs
Transcutaneous electrical nerve stimulation 12
TOTAL JOINT
RECONSTRUCTION
13
14
GOALS OF RECONSTRUCTIVE JOINT
SURGERY
•Mandibular form and function
•Reduction of further suffering and disability
•Containment of excessive treatment and cost
•Prevention of further morbidity
15
MANAGEMENT MODALITIES FOR TM JOINT
RECONSTRUCTION
Petersons Principles Of Oral And Maxillofacial Surgery 3rd ED
AUTOGENOUS BONE GRAFTING
Petersons Principles Of
Oral And Maxillofacial
Surgery 3rd Ed
16
ALLOPLASTIC TOTAL JOINT REPLACEMENT
TRANSPORT DISTRACTION OSTEOGENESIS
BIOENGINEERED TISSUES FOR TOTAL JOINT REPLACEMENT
AUTOGENOUS BONE GRAFTING
17
AUTOGENOUS BONE GRAFTING
REPLACEMENT OPTIONS
18
1. Costochondral graft
2. Sternoclavicular joint
3. Calvarium
4. Iliac crest
5. Fibula
6. 2nd, 4th & 5th metatarsophalangeal joint
COSTOCHONDRAL
GRAFT
19
First described by Sir Harold Gillies in the 1920s.
Most frequently recommended autogenous bone for the
reconstruction of the TMJ.
1
2
12
3
5
6
7
8
9
4
10
11
Costal cartilages
Costochondral joints
Atlas of Temporomandibular Joint Surgery, Second
edition
20
21
Costochondral Rib Grafting. Atlas Oral Maxillofacial Surg Clin N Am 13 (2005) 139–149
ADVANTAGES
1. Growth potential
2.Easy accessibility &
adaptation
3.It has a cartilaginous cap
DISADVANTAGES
1. Unpredictable growth
2.Poor bone quality
3.Possible separation of
cartilage from the bone
4.Donor site complications –
pleural tear, pneumothorax
22
STERNOCLAVICULAR
JOINT
SNYDER et al. in 1971 reported the first sternoclavicular (SCJ)
whole joint graft consisting of a portion of the manubrium, the
intact capsule, and a portion of the clavicle.
23
CLAVICLE
ARTICULAR DISC
STERNOCLAVICULAR LIGAMENT
STERNUM
24
In 1986, REID et al. reported a free-flap technique that
included the clavicular head of the pectoralis major muscle
and overlying skin, to provide a vascularized clavicular bone
graft.
For TMJ, they suggested splitting the clavicle
longitudinally and repositioning it with the attached flap as
the entire head of the clavicle was too large to fit into the
glenoid fossa.
25
Later in 1994, WOLFORD
et al. reported splitting
the clavicle head and
applying only the superior
half of the clavicle for
condylar reconstruction.
Sternociavicular Grafts for Temporomanciibular Joint ReconstructionJ Oral Mexillofac Surg 52:119-128. 1994
ADVANTAGES
1. Similar anatomic
characteristics of condyle
2.Contains cartilaginous cap
3.Has growth potential
4.Regeneration of clavicle
DISADVANTAGES
1. Unacceptable scar location
2.Donor site complication –
• damage to greater vessels
• shoulder instability
• clavicle fracture
26
CALVARIAL BONE GRAFT
27
1. Easy accessibility &
adaptation
2.Minimal donor site
morbidity
3.Excellent for glenoid fossa
reconstruction
1. Mostly cortical bone
2.Lack of growth potential
3.Donor site complication –
• Dural tear
• alopecia
ADVANTAGES DISADVANTAGES
ILIAC
CREST
28
INNER LIP
OUTER LIP
TUBERCULUM
ANTERIOR SUPERIOR ILIAC SPINE
ANTERIOR INFERIOR ILIAC SPINE
29
SMITH & ROBINSON used iliac bone grafts in a recurrent case of
bilateral TMJ dislocation, in a patient who had previously undergone
condylectomy.
An iliac graft is a chondro-osseous graft, and the graft consists of a
full-thickness piece of the iliac crest, including the overlying cartilage
layer as a cap.
MATUKAS et al. used a piece of iliac bone with a cartilage cap secured
to the glenoid fossa as a stump to prevent recurrence of TMJ ankylosis
in a child.
ADVANTAGES
1. Has a cartilage cap
2. Has potential for growth
3. More suitable for large
mandibular defects
DISADVANTAGES
1. Donor-site complications:
altered gait, poor scar/bone
contour, herniation of
abdominal contents, ilium
fracture, peritonitis, &
retroperitoneal haematoma
30
FREE FIBULA FLAP
Atlas of Temporomandibular Joint Surgery, Second edition 31
32
• POSNICK et al. first reported a series of cases using the free fibula
flap for immediate reconstruction of paediatric mandibular tumours
in 1993.
• In 2000, WAX et al reported placement of the distal portion of the
flap directly into the glenoid fossa for condylar reconstruction.
• POTTER & DIERKS recommend fibula as the vascularized graft of
choice for defects of the mandibular condyle when the wound beds
are compromised or there are other conditions that preclude the
use of nonvascularized tissues.
1. Longest and strongest
bone
2.Low donor site morbidity
3.Easy positioning
4.Excellent blood supply
5.Supports implants
1. Lacks articular cartilage
2. High incidence of peripheral
vascular disease
3. Decreased ankle strength
4. Technically demanding
5. Longer surgery duration and
anesthesia
6. Numbness of the lateral side of
the leg
33
ADVANTAGES DISADVANTAGES
34
METATARSAL
The metatarsophalangeal (MTP) joint as a graft for
condylar replacement was reported in 1909 by
Bardenheur, as a half-joint transplant of the fourth
metatarsal using the metatarsal head for replacement
of the mandibular condyle.
In 1971, metatarsal as a nonvascularized free bone
graft for bilateral reconstruction of the TMJ was
reported by DINGMAN.
In 1985, TING et al. described the use of a free
vascularized second metatarsal for reconstruction of
the TMJ in four cases of ankylosis.
1. Combination of articular
cartilage and bone upto
7cm
2. Fitting anatomy because
of small size
3. Has potential for growth
4. risk of degeneration and
reankylosis is low
1. Donor-site complications:
aesthetic loss of a toe
2. MTP joint being a simple hinge
joint does not follow the same
movements as the TMJ
3. usually complex and a lengthy
procedure
35
ADVANTAGES DISADVANTAGES
AUTOGENOUS GRAFTS
DERIVED FROM THE
VICINITY
36
CORONOID PROCESS
The use of coronoid process as a free autogenous
graft was introduced by YOUMANS & RUSSELL in 1969
for repairing defects of the mandible.
In 1989, HONG et al. reported the use of coronoid
process for condylar reconstruction.
37
1. avoidance of a secondary
surgical site
2. in long-standing cases of
ankylosis the coronoid
process is usually elongated,
stiffer and sturdy
3. less bony resorption
1. cannot be used as a
substitute for condylar
reconstruction if involved in
ankylosis
38
ADVANTAGES DISADVANTAGES
POST BORDER OF RAMUS
In 1986, LOFTUS et al. reconstructed the
condyle by superior repositioning of the
pedicled stump of the proximal
condylar segment into the condylar
fossa as a local osseous pedicled graft
based on the lateral pterygoid.
39
1. avoids the risk of a free graft
such as resorption, infection
and graft loss and donor-site
complications
2. provides bone of a size and
shape that is adequate for the
new condyle
3. histological characteristics are
similar
4. good and stable function
1. damage to the contour of
the mandibular angle
2. lack of growth
40
ADVANTAGES DISADVANTAGES
ANKYLOTIC MASS
GUNASEELAN reported three cases of ankylosis in which he
reused the ankylotic mass to replace the missing condyle.
ADVANTAGES: Dense bone with a smooth cortical surface
Recycling of bony ankylotic mass
DISADVANTAGES: Bulk resection is a must
Possibility of risking the nearby structures 41
42
ALLOPLASTIC
RECONSTRUCTION OF
THE TM JOINT
COMPARISON OF AUTOGENOUS &
ALLOPLASTIC TMJ REPLACEMENT
AUTOGENOUS
• Biocompatible
• Donor site morbidity
• Ankylosis potential
• Longevity
• Young patient with growth
potential
• Lack of growth or overgrowth
ALLOPLASTIC
• Biocompatible
• No donor site morbidity
• Low ankylosis (heterotopic bone)
• Require revision/replacement
• Adult patient with growth
completion
• Mechanical wear
43
HISTORY
44
• In 1840, JOHN MURRAY CARNOCHAN was credited with the idea of
interposing material(wood) between the surfaces of a diseased joint.
• In 1890, a German surgeon, GLUCK reported total joint arthroplasties using
ivory prosthetic TMJ and hip joints that he stabilized with cement made of
colophony, pumice, and gypsum.
• RISDON in 1933 reported the treatment of an ankylosis of the TMJ by
interposing gold foil between the bony surfaces after a gap was created.
45
• In 1946 EGGERS and in 1947 GOODSELL reported the use
of tantalum foil in cases of TMJ ankylosis.
• In 1951 CASTILIANO & KLEITSCH resurfaced the bone in
TMJ ankylosis with vitallium.
• In 1952 SMITH reported use of stainless steel in
hemiarthroplasty for ankylosis.
• In 1955 UENO reported results in TMJ ankylosis with
zirconia.
46
• In 1960, HENRY described replacement of an ankylosed TMJ
with prosthesis and Robinson reported correction of a TMJ
ankylosis by creating an artificial stainless steel fossa.
• In 1963, 1964 and 1970, CHRISTENSEN reported resurfacing of
the glenoid fossa with a thin vitallium fossa-eminence prosthesis
in cases of TMJ ankylosis. He added a ramus-condyle
component with a PMMA head and a vitallium ramal
component to create a total TMJ prosthesis.
• GARRETT and associates reported the use of a custom
modification of the standard Christensen total alloplastic TMJ
prosthesis.
47
• SMALL et al in 1964 reported that Teflon seem more adaptable to
restoration of large mandibular reconstruction whereas Silastic seem
better suited for condyle.
• In 1970 HAHN & CORGILL first reported use of ramus condyle
hemiarthroplsty prosthesis for the treatment of ankylosis. Condyle
component was fabricated with dental PMMA and ramus
component with stainless steel wire mesh.
• In 1971, 1975, 1977 MORGAN et al reported another type of fossa
resurfacing device. It consisted of a vitallium eminence prosthesis
and silastic fossa components.
• In 1972, TAURUS first published the use of a custom made cast gold
ramus condyle hemiarticulation.
48
• In 1974 HINDS et al reported the use of a Proplast – Teflon coated
vitallium ramus condyle component for hemiarticulation
reconstruction of TMJ.
• In 1974 KIEHN et al applied the principle of hip reconstruction to
TMJ reconstruction using HOWMEDICA vitallium mandibular
fossa plate reinforced on its temporal side with PMMA and a
vitallium modified CORGILL-HAHN ramus condyle prosthesis.
• In 1983 KENT reported the use of a Dacron/Proplast – Teflon and
later reported Dacron/Proplast – Teflon/Ultra high molecular
weight polyethylene(UHMWP) fossa as a prosthetic device for
total joint replacement.
49
• In 1985 & 1990 SONNENBERG reported the use of a
total joint replacement device consisting of a Co-Cr-
Mo ramus condyle component that articulated
against UHMWP fossa.
• In 1995 MERCURI reported on preliminary results
with the use of patient specific CAD/CAM produced
total TMJ reconstruction.
Advantages of Alloplastic
Total Joint Replacement
• Rigid fixation allows immediate postoperative physical
therapy.
• No II donor site.
• Decreased surgical time (vs. autogenous bone).
• Mimics normal anatomy (CAD/CAM or patient-fitted TJR).
• Maintenance of stable occlusion (no remodeling).
50
Disadvantages of Alloplastic
Total Joint Replacement
• Device cost.
• Material wear and/or failure (screw loosening, fracture).
• Possible heterotopic bone formation (ankylosis).
• Possible need for revision and/or replacement.
• Size and design limitations (stock devices).
• No growth potential.
51
Indications of
Alloplastic Total Joint Replacement
1. Ankylosed, degenated or resorbed joints with severe
anatomic discrepancy.
2.Failed autogenous grafting.
3.Recurrent ankylosis.
4.Severe inflammatory joint disease.
52
Relative Contraindications to Alloplastic Total
Joint Replacement
Systemic
• Incomplete facial bone growth (child)
• Advanced medical-surgical risk
• Uncontrolled systemic disease
• Psychological instability
Local, Regional
• Insufficient hard and soft tissues to support the implants
• Active or recent infection (local or systemic)
• Allergy to prosthetic materials (rare)
• Uncontrolled parafunctional oral habit 53
TYPES OF ALLOPLASTIC TMJ
RECONSTRUCTION
STOCK PROSTHESIS
1. immediately available
2. Lower cost
3. Short treatment time
4. Requires bone removal
5. Potential micromovement
6. Placement versatility
CUSTOM PROSTHESIS
1. Made to fit
2. Higher cost
3. Longer treatment time
4. No/minimal removal of bone
5. No micromovement
6. Limited flexibility & versatility
54
CRITERIA FOR SUCCESS
1. Material must be biocompatible.
2.Functionally compatible.
3.Devices must be stable in situ.
55
56
At present, there are three U.S. Food and Drug administration
(FDA)–sanctioned TMJ prosthetic systems available for
implantation.
1. The pre-1976 Amendment
Christensen stock as well as
the Christensen/Garrett
custom devices (TMJ Implant,
Inc., Golden, CO).
57
2. The 1999 FDA-approved
TMJ Concepts patient
fitted device (TMJ
Concepts [previously
Techmedica], Ventura,CA)
58
3. The 2006 FDA-
approved Biomet
Microfixation total
joint stock device.
59
Stock alloplastic reconstruction
of
the TMJ
Atlas of
Temporomandibular
Joint Surgery, Second
edition
60
Kent‐Vitek
total joint
prosthesis
61
SYNTHES SYSTEM
Atlas of Temporomandibular
Joint Surgery, Second edition62
Delrin‐Timesh
Condylar
Prosthesis
Atlas of Temporomandibular Joint Surgery, Second edition
63
Christensen
prostheses
Atlas of Temporomandibular Joint Surgery,
Second edition
64
Type III Christensen prosthesis
Atlas of Temporomandibular Joint Surgery,
Second edition
65
Biomet stock prosthesis
CUSTOM ALLOPLASTIC
RECONSTRUCTION OF
THE TM JOINT
66
67
Prosthetic manufacturing is done using one of the two
methods.
The first method introduced utilizes anatomic models
produced from a CT scan. These models are then used to
fabricate the custom prosthesis via an initial computer‐aided
wax model.
Atlas of Temporomandibular Joint Surgery, Second edition
68
Atlas of
Temporomandibular Joint
Surgery, Second edition
69
Atlas of Temporomandibular Joint Surgery, Second edition
70
The single‐stage approach requires planning and design
replication on the model surgery, with osteotomy sites and
bone contouring marked.
71
A second method for surgical planning and custom device
design utilizes computer modeling entirely.
Mandibular repositioning and osteotomy placement can be
planned on the virtual model and the device is designed and
incorporated into the planning session.
Atlas of Temporomandibular Joint Surgery, Second edition
72
Atlas of Temporomandibular Joint Surgery,
Second edition
73
Atlas of Temporomandibular Joint Surgery,
Second edition
74
Principles for the revision of
total alloplastic TMJ prostheses
Reasons for failures
1. Failure of the concept
2. Failure of embodiment
3. Failure of implantation technique
4. Limitations of the technology
75
PRINCIPLES FOR THE REVISION OF TOTAL ALLOPLASTIC TMJ PROSTHESES. INT. J. ORAL
MAXILLOFAC. SURG. 2003; 32: 353–359
CAUSES OF PAIN
Applying the principles discussed by GHELMAN for total knee revision to
the TMJ, there are two causes for pain in patients with alloplastic joint
prostheses:
 1. Mechanical
1. The most common cause of mechanical pain is a loose prosthetic
component. This is characterized by activity-related pain at the joint.
Imaging helps make this diagnosis.
2. The most common type of prosthetic component failure is wear. This
can lead to breakage, osteolysis, and loosened screws.
76
PRINCIPLES FOR THE REVISION OF TOTAL ALLOPLASTIC TMJ PROSTHESES. INT. J. ORAL MAXILLOFAC. SURG. 2003; 32: 353–359
77
Biological
 Infection—characterized by pain that is constant. Effusion on
physical examination, erythema and drainage later
Neurological problems
1. RSD—reflex sympathetic dystrophy after total joint
replacement leads to excessive pain. Limitation of joint
function is common. Cutaneous hypersensitivity is present.
2. Neuroma formation
3. Frey’s Syndrome
Muscle fatigue and spasm
78
INDICATIONS FOR REVISION
The following should be the indications for revision of an alloplastic TMJ
reconstruction device, based on the work of BOURNE.
1. Failed component/components
2. Breakage of a component or components and/or fixation screws
3. Aseptic loosening
4. Subacute or chronic infection
5. Osteolysis
6. Peri-prosthetic bone fracture
7. Ankylosis
DISTRACTION
OSTEOGENESIS
James McNamara stated that - “distraction osteogenesis means the
slow movement apart (distraction) of two bony segments in a
manner such that new bone is allowed to fill in the gap created by
the separating bony segments.”
In 1997, STUCKI-MCCORMICK was the first to apply transport
distraction osteogenesis (DO) for TMJ reconstruction in two cases of
tumour involving the condyle.
79
Principles of Distraction Osteogenesis (Ilizarov)
80
1. Surgical procedure
a. Corticotomy
b. Device application
2. Latency period (3–7 days)
3. Activation period
a. Rate (1.0 mm/day)
b. Rhythm (daily to four times/day)
4. Consolidation period (8–12 wk)
5. DO device removal
ADVANTAGES OVER AUTOGENOUS
GRAFTING
81
1. Creating a functional joint without using interpositional
material.
2.Avoidance of donor site morbidity.
3.Rigid distraction device allows immediate postoperative
physical therapy.
4.Risk of bone graft necrosis & resorption is greatly reduced.
5.Simultaneous correction of secondary deformities
6.Decreases the risk of surgery, and the possibility of relapse
82
DISADVANTAGES
1. lengthy procedure
2. requires close monitoring of the patient
3. may cause pintract soft-tissue infection, bone infection
and psychological problems
Distraction Osteogenesis for Temporomandibular Joint Reconstruction. J Oral Maxillofac
Surg 66:718-723, 2008
83
TISSUE
ENGINEERING
84
85
• Tissue engineering has demonstrated significant potential for
the skeletal repair that may be applied to the treatment of
craniofacial tissue loss.
• Standard approach to tissue engineering is to seed the cells on
a 3D biomaterial scaffold. This scaffold creates a 3D
environment that promotes tissue development of cells.
• Gene vectors, soluble factors and chemical signals may be
incorporated into the scaffold to promote tissue development
during in vitro incubation or in vivo implantation.
86
Scaffold choices: naturally derived and synthetic scaffold
materials have been used.
Multiple research have described several biomaterials with
osteoconductive properties –
1. Titanium
2. Natural/coralline hydroxyapatite
3. Porous hydroxyapatite
4. Bioglass
5. Calcium phosphate
6. Photopolymerizable polyanhydrides
7. Polyester copolymers
8. Polyglycolic acid
87
Tissue engineering could be applied to regenerate localized
defects or, theoretically, the entire articulating condylar surface.
Implementation could take one of three approaches:
1. ex vivo growth of tissue on the scaffold/ biologic composite in
a bioreactor before implantation on the mandible;
2. implantation of the scaffold/biologic composite at secondary
surgical site before implantation on the mandible; and
3. direct implantation at the mandible site.
1. Nerve injuries
2.Damage to adjacent vessels
3.Damage to adjacent structures
4.Frey’s syndrome
5.Malpositioning of the prosthesis
6.Infection
88
COMPLICATIONS OF TMJ SURGERY
NERVE INJURIES
Nerve injuries can occur to cranial nerves V and VII.
Damage to the CN VII is a known risk in this procedure as it lies
directly over the surgical field of entry.
Damage to cranial nerve V is possible in both the placement of
the joint with the screws leading into the inferior alveolar canal,
or exceeding the medial aspect of the joint and entering into
the base of the skull
89
DAMAGE TO VESSELS
Intraoperative bleeding in total joint replacements can occur
from some of the major vessels located in the surgical field,
including the maxillary artery, temporal artery, masseteric
artery, and facial artery.
Furthermore, as there is muscle stripping and cutting, especially
of the masseter and both pterygoid muscles, there can be a
significant amount of oozing of that musculature. 90
The most clinically important vessel that could be damaged in
TMJ surgery is the maxillary artery, which runs behind the neck
of the condyle and at the level just above the sigmoid notch.
91
DAMAGE TO ADJACENT STRUCTURES
Most relevant structures related to joint replacement TMJ
surgery are the 3 areas –
1. surrounding the condylar component, including the external
and internal structures of the ear,
2. the anatomic areas medial to the joint (specifically the base of
the skull), and
3. damage to the superior aspect of the glenoid fossa into the
intracranial space. 92
MALPOSITION OF THE PROSTHESIS
The dental occlusion must be set appropriately before the
condylar and fossa components are set. Passive stable
occlusion should be obtained.
A second possibility is that the condyle is poorly situated, and
even though the occlusion is stable as soon as the
intermaxillary fixation is released, the condyles returns back to
an unfavorable spot.
Additionally, postoperative dislocations can occur. 93
INFECTIONS OF THE
TEMPOROMANDIBULAR JOINT
Infections can be divided into acute, subacute, or chronic.
In the acute phase, it is conceivable to treat the patient with
antibiotics and/or open the joint, wash it out, and reseal it.
The subacute phase is somewhat less clear, and can have a
mixed response.
 In the chronic phase, it is almost imperative that the
components be removed, especially the fossa. 94
95
Reaction to foreign bodies, especially nickel or titanium, can
occur.
Postoperative pain can be considered a potential
complication..
Poor range of motion after surgery can be another
postoperative problem. Most patients have lost their
pterygoid muscular function and therefore cannot translate
or go side to side.
CONCLUSION
The patient with end-stage TMJ disease is typically afflicted by severe
unrelenting pain, restricted jaw function, facial deformity, depression
and financial hardships.
Given the complexities involved, these patients pose a significant
challenge and many give a history of prior surgeries.
In few instances medical management is advised with primary
treatment objectives typically being pain management and
improvement in jaw movements but may require total joint
replacement eventually. 96
97
REFERENCES
 Peterson's Principles of Oral And Maxillofacial Surgery 2nd ed.
 Peterson’s Principles of Oral and Maxillofacial Surgery – 3rd ed
 Atlas of Human Anatomy - Frank H. Netter 6th ed
 Atlas of Temporomandibular Joint Surgery 2nd ed – Quinn
 Management of temporomandibular disorders and occlusion, 6th ed – Okeson
 Fonseca Vol. II
 Custom-Made Total Temporomandibular Joint Prostheses. Atlas Oral Maxillofacial Surg
Clin N Am 13 (2005) 83–89.
 Total Reconstruction of the Temporomandibular Joint with a Stock Prosthesis. Atlas
Oral Maxillofacial Surg Clin N Am 19 (2011) 221–232.
 Patient-Fitted (“Custom”) Alloplastic Temporomandibular Joint Replacement Technique
Atlas Oral Maxillofacial Surg Clin N Am 19 (2011) 233–242.
98
 Complications of TMJ Surgery. Oral Maxillofacial Surg Clin N Am 27 (2015) 109–124.
 sternociavicular grafts for temporomanciibular joint reconstruction j oral mexillofac
surg 52:119-128. 1994.
 temporomandibular joint devices: treatment factors and outcomes. oral surg oral
med oral pathol oral radiol endod 1997;83:143-9.
 alloplastic temporomandibular joint reconstruction. oral surgery oral medicine oral
pathology june 1998 volume 85, number 6
 costochondral rib grafting. atlas oral maxillofacial surg clin n am 13 (2005) 139–149.
 the christensen temporomandibular joint prosthesis system - david a. Gerard.
 Distraction Osteogenesis for Temporomandibular Joint Reconstruction. J Oral
Maxillofac Surg 66:718-723, 2008
99
• The-use-of-autogenous-tissues-for-temporomandibular-joint-reconstruction. J Oral
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• Reconstruction of the temporomandibular joint autogenous compared with
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• Evaluation of Long-Term Stability in Second Metatarsal Reconstruction of the
Temporomandibular Joint. J Oral Maxillofac Surg . 2003;61:65-71.
• Principles for the revision of total alloplastic TMJ prostheses. Int. J. Oral Maxillofac.
Surg. 2003; 32: 353–359.
• Advances in skeletal tissue engineering with hydrogels. Orthod Craniofacial Res 8,
2005; 150–161.
• Free grafting of autogenous coronoid process for condylar reconstruction in patients
with TMJ ankylosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod
2008;106:662-7.
• Autogenous grafts for condylar reconstruction in treatment of TMJ ankylosis: current
concepts and considerations for the future. Int. J. Oral Maxillofac. Surg. 2012; 41: 94–
102
THANK
YOU
100

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management of patients with end stage TMJ diseases

  • 1. Management of PATIENTS WITH end stage tmj diseases 1 PRESENTATION BY ADITI RAJVANSHI IIyr PG TRAINEE
  • 2. 2 CONTENTS INTRODUCTION END STAGE DISEASE PROCESSES BASIC ELEMENTS OF CARE PAIN MANAGEMENT TMJ RECONSTRUCTION - GOALS OF RECONSTRUCTION DIFFFERENT TREATMENT MODALITIES AUTOGENOUS ALLOPLASTIC DISTRACTION OSTEOGENESIS BIOENGINEERING CONCLUSION REFERENCES
  • 3. INTRODUCTION • Worst disease state of an organ system. • Negatively affected joint architecture and severe functional impairment. Petersons Principles Of Oral And Maxillofacial Surgery 3rd Ed 3
  • 4. DISEASE PROCESSES LEADING TO END STAGE TMJ DISEASE 4
  • 5. 1. DEVELOPMENTAL DISORDERS  CONDYLAR AGENESIS/HYPOPLASIA  CONDYLAR HYPERPLASIA 5
  • 7. 3. ARTHRITIC DISEASES 7 Inflammatory disease Degenerative disease
  • 8. 8 4. ANKYLOSIS 5. TRAUMA 6. MULTIPLE PRIOR FAILED PROCEDURES
  • 9. BASIC ELEMENTS OF CARE  The patients commonly suffers from unrelenting pain and severe limitation of jaw movement.  In addition, they may also have facial asymmetry, dysfunctional malocclusions, sensory and motor abnormalities. 9
  • 10. PAIN CONTROL STRATEGIES  With few exceptions, pain is the primary chief complaint of these patients and is often the principle limiting factor in patients willingness to comply with the recommended physical therapy.  In addition, these patients often exhibits signs of depression and are usually socially withdrawn. 10
  • 11. PERIOPERATIVE 1. PREEMPTIVE ANALGESIA Regional anesthesia Opioid based GA Ketamine Ketorolac 2.IMMEDIATE POSTSURGICAL PERIOD Regional anesthesia Opioids( scheduled regimens) Ketorolac 11
  • 12. LONG TERM 1. PHARMACOLOGIC Tricyclic antidepressants Opioids(scheduled dose) GABAergics(gabapentin, baclofen) Non opioids(pain associated with inflammation) 2.NONPHARMACOLOGIC Regular exercise Heat/cold packs Transcutaneous electrical nerve stimulation 12
  • 14. 14 GOALS OF RECONSTRUCTIVE JOINT SURGERY •Mandibular form and function •Reduction of further suffering and disability •Containment of excessive treatment and cost •Prevention of further morbidity
  • 15. 15 MANAGEMENT MODALITIES FOR TM JOINT RECONSTRUCTION Petersons Principles Of Oral And Maxillofacial Surgery 3rd ED
  • 16. AUTOGENOUS BONE GRAFTING Petersons Principles Of Oral And Maxillofacial Surgery 3rd Ed 16 ALLOPLASTIC TOTAL JOINT REPLACEMENT TRANSPORT DISTRACTION OSTEOGENESIS BIOENGINEERED TISSUES FOR TOTAL JOINT REPLACEMENT
  • 18. AUTOGENOUS BONE GRAFTING REPLACEMENT OPTIONS 18 1. Costochondral graft 2. Sternoclavicular joint 3. Calvarium 4. Iliac crest 5. Fibula 6. 2nd, 4th & 5th metatarsophalangeal joint
  • 19. COSTOCHONDRAL GRAFT 19 First described by Sir Harold Gillies in the 1920s. Most frequently recommended autogenous bone for the reconstruction of the TMJ. 1 2 12 3 5 6 7 8 9 4 10 11 Costal cartilages Costochondral joints
  • 20. Atlas of Temporomandibular Joint Surgery, Second edition 20
  • 21. 21 Costochondral Rib Grafting. Atlas Oral Maxillofacial Surg Clin N Am 13 (2005) 139–149
  • 22. ADVANTAGES 1. Growth potential 2.Easy accessibility & adaptation 3.It has a cartilaginous cap DISADVANTAGES 1. Unpredictable growth 2.Poor bone quality 3.Possible separation of cartilage from the bone 4.Donor site complications – pleural tear, pneumothorax 22
  • 23. STERNOCLAVICULAR JOINT SNYDER et al. in 1971 reported the first sternoclavicular (SCJ) whole joint graft consisting of a portion of the manubrium, the intact capsule, and a portion of the clavicle. 23 CLAVICLE ARTICULAR DISC STERNOCLAVICULAR LIGAMENT STERNUM
  • 24. 24 In 1986, REID et al. reported a free-flap technique that included the clavicular head of the pectoralis major muscle and overlying skin, to provide a vascularized clavicular bone graft. For TMJ, they suggested splitting the clavicle longitudinally and repositioning it with the attached flap as the entire head of the clavicle was too large to fit into the glenoid fossa.
  • 25. 25 Later in 1994, WOLFORD et al. reported splitting the clavicle head and applying only the superior half of the clavicle for condylar reconstruction. Sternociavicular Grafts for Temporomanciibular Joint ReconstructionJ Oral Mexillofac Surg 52:119-128. 1994
  • 26. ADVANTAGES 1. Similar anatomic characteristics of condyle 2.Contains cartilaginous cap 3.Has growth potential 4.Regeneration of clavicle DISADVANTAGES 1. Unacceptable scar location 2.Donor site complication – • damage to greater vessels • shoulder instability • clavicle fracture 26
  • 27. CALVARIAL BONE GRAFT 27 1. Easy accessibility & adaptation 2.Minimal donor site morbidity 3.Excellent for glenoid fossa reconstruction 1. Mostly cortical bone 2.Lack of growth potential 3.Donor site complication – • Dural tear • alopecia ADVANTAGES DISADVANTAGES
  • 28. ILIAC CREST 28 INNER LIP OUTER LIP TUBERCULUM ANTERIOR SUPERIOR ILIAC SPINE ANTERIOR INFERIOR ILIAC SPINE
  • 29. 29 SMITH & ROBINSON used iliac bone grafts in a recurrent case of bilateral TMJ dislocation, in a patient who had previously undergone condylectomy. An iliac graft is a chondro-osseous graft, and the graft consists of a full-thickness piece of the iliac crest, including the overlying cartilage layer as a cap. MATUKAS et al. used a piece of iliac bone with a cartilage cap secured to the glenoid fossa as a stump to prevent recurrence of TMJ ankylosis in a child.
  • 30. ADVANTAGES 1. Has a cartilage cap 2. Has potential for growth 3. More suitable for large mandibular defects DISADVANTAGES 1. Donor-site complications: altered gait, poor scar/bone contour, herniation of abdominal contents, ilium fracture, peritonitis, & retroperitoneal haematoma 30
  • 31. FREE FIBULA FLAP Atlas of Temporomandibular Joint Surgery, Second edition 31
  • 32. 32 • POSNICK et al. first reported a series of cases using the free fibula flap for immediate reconstruction of paediatric mandibular tumours in 1993. • In 2000, WAX et al reported placement of the distal portion of the flap directly into the glenoid fossa for condylar reconstruction. • POTTER & DIERKS recommend fibula as the vascularized graft of choice for defects of the mandibular condyle when the wound beds are compromised or there are other conditions that preclude the use of nonvascularized tissues.
  • 33. 1. Longest and strongest bone 2.Low donor site morbidity 3.Easy positioning 4.Excellent blood supply 5.Supports implants 1. Lacks articular cartilage 2. High incidence of peripheral vascular disease 3. Decreased ankle strength 4. Technically demanding 5. Longer surgery duration and anesthesia 6. Numbness of the lateral side of the leg 33 ADVANTAGES DISADVANTAGES
  • 34. 34 METATARSAL The metatarsophalangeal (MTP) joint as a graft for condylar replacement was reported in 1909 by Bardenheur, as a half-joint transplant of the fourth metatarsal using the metatarsal head for replacement of the mandibular condyle. In 1971, metatarsal as a nonvascularized free bone graft for bilateral reconstruction of the TMJ was reported by DINGMAN. In 1985, TING et al. described the use of a free vascularized second metatarsal for reconstruction of the TMJ in four cases of ankylosis.
  • 35. 1. Combination of articular cartilage and bone upto 7cm 2. Fitting anatomy because of small size 3. Has potential for growth 4. risk of degeneration and reankylosis is low 1. Donor-site complications: aesthetic loss of a toe 2. MTP joint being a simple hinge joint does not follow the same movements as the TMJ 3. usually complex and a lengthy procedure 35 ADVANTAGES DISADVANTAGES
  • 37. CORONOID PROCESS The use of coronoid process as a free autogenous graft was introduced by YOUMANS & RUSSELL in 1969 for repairing defects of the mandible. In 1989, HONG et al. reported the use of coronoid process for condylar reconstruction. 37
  • 38. 1. avoidance of a secondary surgical site 2. in long-standing cases of ankylosis the coronoid process is usually elongated, stiffer and sturdy 3. less bony resorption 1. cannot be used as a substitute for condylar reconstruction if involved in ankylosis 38 ADVANTAGES DISADVANTAGES
  • 39. POST BORDER OF RAMUS In 1986, LOFTUS et al. reconstructed the condyle by superior repositioning of the pedicled stump of the proximal condylar segment into the condylar fossa as a local osseous pedicled graft based on the lateral pterygoid. 39
  • 40. 1. avoids the risk of a free graft such as resorption, infection and graft loss and donor-site complications 2. provides bone of a size and shape that is adequate for the new condyle 3. histological characteristics are similar 4. good and stable function 1. damage to the contour of the mandibular angle 2. lack of growth 40 ADVANTAGES DISADVANTAGES
  • 41. ANKYLOTIC MASS GUNASEELAN reported three cases of ankylosis in which he reused the ankylotic mass to replace the missing condyle. ADVANTAGES: Dense bone with a smooth cortical surface Recycling of bony ankylotic mass DISADVANTAGES: Bulk resection is a must Possibility of risking the nearby structures 41
  • 43. COMPARISON OF AUTOGENOUS & ALLOPLASTIC TMJ REPLACEMENT AUTOGENOUS • Biocompatible • Donor site morbidity • Ankylosis potential • Longevity • Young patient with growth potential • Lack of growth or overgrowth ALLOPLASTIC • Biocompatible • No donor site morbidity • Low ankylosis (heterotopic bone) • Require revision/replacement • Adult patient with growth completion • Mechanical wear 43
  • 44. HISTORY 44 • In 1840, JOHN MURRAY CARNOCHAN was credited with the idea of interposing material(wood) between the surfaces of a diseased joint. • In 1890, a German surgeon, GLUCK reported total joint arthroplasties using ivory prosthetic TMJ and hip joints that he stabilized with cement made of colophony, pumice, and gypsum. • RISDON in 1933 reported the treatment of an ankylosis of the TMJ by interposing gold foil between the bony surfaces after a gap was created.
  • 45. 45 • In 1946 EGGERS and in 1947 GOODSELL reported the use of tantalum foil in cases of TMJ ankylosis. • In 1951 CASTILIANO & KLEITSCH resurfaced the bone in TMJ ankylosis with vitallium. • In 1952 SMITH reported use of stainless steel in hemiarthroplasty for ankylosis. • In 1955 UENO reported results in TMJ ankylosis with zirconia.
  • 46. 46 • In 1960, HENRY described replacement of an ankylosed TMJ with prosthesis and Robinson reported correction of a TMJ ankylosis by creating an artificial stainless steel fossa. • In 1963, 1964 and 1970, CHRISTENSEN reported resurfacing of the glenoid fossa with a thin vitallium fossa-eminence prosthesis in cases of TMJ ankylosis. He added a ramus-condyle component with a PMMA head and a vitallium ramal component to create a total TMJ prosthesis. • GARRETT and associates reported the use of a custom modification of the standard Christensen total alloplastic TMJ prosthesis.
  • 47. 47 • SMALL et al in 1964 reported that Teflon seem more adaptable to restoration of large mandibular reconstruction whereas Silastic seem better suited for condyle. • In 1970 HAHN & CORGILL first reported use of ramus condyle hemiarthroplsty prosthesis for the treatment of ankylosis. Condyle component was fabricated with dental PMMA and ramus component with stainless steel wire mesh. • In 1971, 1975, 1977 MORGAN et al reported another type of fossa resurfacing device. It consisted of a vitallium eminence prosthesis and silastic fossa components. • In 1972, TAURUS first published the use of a custom made cast gold ramus condyle hemiarticulation.
  • 48. 48 • In 1974 HINDS et al reported the use of a Proplast – Teflon coated vitallium ramus condyle component for hemiarticulation reconstruction of TMJ. • In 1974 KIEHN et al applied the principle of hip reconstruction to TMJ reconstruction using HOWMEDICA vitallium mandibular fossa plate reinforced on its temporal side with PMMA and a vitallium modified CORGILL-HAHN ramus condyle prosthesis. • In 1983 KENT reported the use of a Dacron/Proplast – Teflon and later reported Dacron/Proplast – Teflon/Ultra high molecular weight polyethylene(UHMWP) fossa as a prosthetic device for total joint replacement.
  • 49. 49 • In 1985 & 1990 SONNENBERG reported the use of a total joint replacement device consisting of a Co-Cr- Mo ramus condyle component that articulated against UHMWP fossa. • In 1995 MERCURI reported on preliminary results with the use of patient specific CAD/CAM produced total TMJ reconstruction.
  • 50. Advantages of Alloplastic Total Joint Replacement • Rigid fixation allows immediate postoperative physical therapy. • No II donor site. • Decreased surgical time (vs. autogenous bone). • Mimics normal anatomy (CAD/CAM or patient-fitted TJR). • Maintenance of stable occlusion (no remodeling). 50
  • 51. Disadvantages of Alloplastic Total Joint Replacement • Device cost. • Material wear and/or failure (screw loosening, fracture). • Possible heterotopic bone formation (ankylosis). • Possible need for revision and/or replacement. • Size and design limitations (stock devices). • No growth potential. 51
  • 52. Indications of Alloplastic Total Joint Replacement 1. Ankylosed, degenated or resorbed joints with severe anatomic discrepancy. 2.Failed autogenous grafting. 3.Recurrent ankylosis. 4.Severe inflammatory joint disease. 52
  • 53. Relative Contraindications to Alloplastic Total Joint Replacement Systemic • Incomplete facial bone growth (child) • Advanced medical-surgical risk • Uncontrolled systemic disease • Psychological instability Local, Regional • Insufficient hard and soft tissues to support the implants • Active or recent infection (local or systemic) • Allergy to prosthetic materials (rare) • Uncontrolled parafunctional oral habit 53
  • 54. TYPES OF ALLOPLASTIC TMJ RECONSTRUCTION STOCK PROSTHESIS 1. immediately available 2. Lower cost 3. Short treatment time 4. Requires bone removal 5. Potential micromovement 6. Placement versatility CUSTOM PROSTHESIS 1. Made to fit 2. Higher cost 3. Longer treatment time 4. No/minimal removal of bone 5. No micromovement 6. Limited flexibility & versatility 54
  • 55. CRITERIA FOR SUCCESS 1. Material must be biocompatible. 2.Functionally compatible. 3.Devices must be stable in situ. 55
  • 56. 56 At present, there are three U.S. Food and Drug administration (FDA)–sanctioned TMJ prosthetic systems available for implantation. 1. The pre-1976 Amendment Christensen stock as well as the Christensen/Garrett custom devices (TMJ Implant, Inc., Golden, CO).
  • 57. 57 2. The 1999 FDA-approved TMJ Concepts patient fitted device (TMJ Concepts [previously Techmedica], Ventura,CA)
  • 58. 58 3. The 2006 FDA- approved Biomet Microfixation total joint stock device.
  • 60. Atlas of Temporomandibular Joint Surgery, Second edition 60 Kent‐Vitek total joint prosthesis
  • 62. Atlas of Temporomandibular Joint Surgery, Second edition62 Delrin‐Timesh Condylar Prosthesis
  • 63. Atlas of Temporomandibular Joint Surgery, Second edition 63 Christensen prostheses
  • 64. Atlas of Temporomandibular Joint Surgery, Second edition 64 Type III Christensen prosthesis
  • 65. Atlas of Temporomandibular Joint Surgery, Second edition 65 Biomet stock prosthesis
  • 67. 67 Prosthetic manufacturing is done using one of the two methods. The first method introduced utilizes anatomic models produced from a CT scan. These models are then used to fabricate the custom prosthesis via an initial computer‐aided wax model.
  • 68. Atlas of Temporomandibular Joint Surgery, Second edition 68
  • 70. Atlas of Temporomandibular Joint Surgery, Second edition 70 The single‐stage approach requires planning and design replication on the model surgery, with osteotomy sites and bone contouring marked.
  • 71. 71 A second method for surgical planning and custom device design utilizes computer modeling entirely. Mandibular repositioning and osteotomy placement can be planned on the virtual model and the device is designed and incorporated into the planning session.
  • 72. Atlas of Temporomandibular Joint Surgery, Second edition 72
  • 73. Atlas of Temporomandibular Joint Surgery, Second edition 73
  • 74. Atlas of Temporomandibular Joint Surgery, Second edition 74
  • 75. Principles for the revision of total alloplastic TMJ prostheses Reasons for failures 1. Failure of the concept 2. Failure of embodiment 3. Failure of implantation technique 4. Limitations of the technology 75 PRINCIPLES FOR THE REVISION OF TOTAL ALLOPLASTIC TMJ PROSTHESES. INT. J. ORAL MAXILLOFAC. SURG. 2003; 32: 353–359
  • 76. CAUSES OF PAIN Applying the principles discussed by GHELMAN for total knee revision to the TMJ, there are two causes for pain in patients with alloplastic joint prostheses:  1. Mechanical 1. The most common cause of mechanical pain is a loose prosthetic component. This is characterized by activity-related pain at the joint. Imaging helps make this diagnosis. 2. The most common type of prosthetic component failure is wear. This can lead to breakage, osteolysis, and loosened screws. 76 PRINCIPLES FOR THE REVISION OF TOTAL ALLOPLASTIC TMJ PROSTHESES. INT. J. ORAL MAXILLOFAC. SURG. 2003; 32: 353–359
  • 77. 77 Biological  Infection—characterized by pain that is constant. Effusion on physical examination, erythema and drainage later Neurological problems 1. RSD—reflex sympathetic dystrophy after total joint replacement leads to excessive pain. Limitation of joint function is common. Cutaneous hypersensitivity is present. 2. Neuroma formation 3. Frey’s Syndrome Muscle fatigue and spasm
  • 78. 78 INDICATIONS FOR REVISION The following should be the indications for revision of an alloplastic TMJ reconstruction device, based on the work of BOURNE. 1. Failed component/components 2. Breakage of a component or components and/or fixation screws 3. Aseptic loosening 4. Subacute or chronic infection 5. Osteolysis 6. Peri-prosthetic bone fracture 7. Ankylosis
  • 79. DISTRACTION OSTEOGENESIS James McNamara stated that - “distraction osteogenesis means the slow movement apart (distraction) of two bony segments in a manner such that new bone is allowed to fill in the gap created by the separating bony segments.” In 1997, STUCKI-MCCORMICK was the first to apply transport distraction osteogenesis (DO) for TMJ reconstruction in two cases of tumour involving the condyle. 79
  • 80. Principles of Distraction Osteogenesis (Ilizarov) 80 1. Surgical procedure a. Corticotomy b. Device application 2. Latency period (3–7 days) 3. Activation period a. Rate (1.0 mm/day) b. Rhythm (daily to four times/day) 4. Consolidation period (8–12 wk) 5. DO device removal
  • 81. ADVANTAGES OVER AUTOGENOUS GRAFTING 81 1. Creating a functional joint without using interpositional material. 2.Avoidance of donor site morbidity. 3.Rigid distraction device allows immediate postoperative physical therapy. 4.Risk of bone graft necrosis & resorption is greatly reduced. 5.Simultaneous correction of secondary deformities 6.Decreases the risk of surgery, and the possibility of relapse
  • 82. 82 DISADVANTAGES 1. lengthy procedure 2. requires close monitoring of the patient 3. may cause pintract soft-tissue infection, bone infection and psychological problems
  • 83. Distraction Osteogenesis for Temporomandibular Joint Reconstruction. J Oral Maxillofac Surg 66:718-723, 2008 83
  • 85. 85 • Tissue engineering has demonstrated significant potential for the skeletal repair that may be applied to the treatment of craniofacial tissue loss. • Standard approach to tissue engineering is to seed the cells on a 3D biomaterial scaffold. This scaffold creates a 3D environment that promotes tissue development of cells. • Gene vectors, soluble factors and chemical signals may be incorporated into the scaffold to promote tissue development during in vitro incubation or in vivo implantation.
  • 86. 86 Scaffold choices: naturally derived and synthetic scaffold materials have been used. Multiple research have described several biomaterials with osteoconductive properties – 1. Titanium 2. Natural/coralline hydroxyapatite 3. Porous hydroxyapatite 4. Bioglass 5. Calcium phosphate 6. Photopolymerizable polyanhydrides 7. Polyester copolymers 8. Polyglycolic acid
  • 87. 87 Tissue engineering could be applied to regenerate localized defects or, theoretically, the entire articulating condylar surface. Implementation could take one of three approaches: 1. ex vivo growth of tissue on the scaffold/ biologic composite in a bioreactor before implantation on the mandible; 2. implantation of the scaffold/biologic composite at secondary surgical site before implantation on the mandible; and 3. direct implantation at the mandible site.
  • 88. 1. Nerve injuries 2.Damage to adjacent vessels 3.Damage to adjacent structures 4.Frey’s syndrome 5.Malpositioning of the prosthesis 6.Infection 88 COMPLICATIONS OF TMJ SURGERY
  • 89. NERVE INJURIES Nerve injuries can occur to cranial nerves V and VII. Damage to the CN VII is a known risk in this procedure as it lies directly over the surgical field of entry. Damage to cranial nerve V is possible in both the placement of the joint with the screws leading into the inferior alveolar canal, or exceeding the medial aspect of the joint and entering into the base of the skull 89
  • 90. DAMAGE TO VESSELS Intraoperative bleeding in total joint replacements can occur from some of the major vessels located in the surgical field, including the maxillary artery, temporal artery, masseteric artery, and facial artery. Furthermore, as there is muscle stripping and cutting, especially of the masseter and both pterygoid muscles, there can be a significant amount of oozing of that musculature. 90
  • 91. The most clinically important vessel that could be damaged in TMJ surgery is the maxillary artery, which runs behind the neck of the condyle and at the level just above the sigmoid notch. 91
  • 92. DAMAGE TO ADJACENT STRUCTURES Most relevant structures related to joint replacement TMJ surgery are the 3 areas – 1. surrounding the condylar component, including the external and internal structures of the ear, 2. the anatomic areas medial to the joint (specifically the base of the skull), and 3. damage to the superior aspect of the glenoid fossa into the intracranial space. 92
  • 93. MALPOSITION OF THE PROSTHESIS The dental occlusion must be set appropriately before the condylar and fossa components are set. Passive stable occlusion should be obtained. A second possibility is that the condyle is poorly situated, and even though the occlusion is stable as soon as the intermaxillary fixation is released, the condyles returns back to an unfavorable spot. Additionally, postoperative dislocations can occur. 93
  • 94. INFECTIONS OF THE TEMPOROMANDIBULAR JOINT Infections can be divided into acute, subacute, or chronic. In the acute phase, it is conceivable to treat the patient with antibiotics and/or open the joint, wash it out, and reseal it. The subacute phase is somewhat less clear, and can have a mixed response.  In the chronic phase, it is almost imperative that the components be removed, especially the fossa. 94
  • 95. 95 Reaction to foreign bodies, especially nickel or titanium, can occur. Postoperative pain can be considered a potential complication.. Poor range of motion after surgery can be another postoperative problem. Most patients have lost their pterygoid muscular function and therefore cannot translate or go side to side.
  • 96. CONCLUSION The patient with end-stage TMJ disease is typically afflicted by severe unrelenting pain, restricted jaw function, facial deformity, depression and financial hardships. Given the complexities involved, these patients pose a significant challenge and many give a history of prior surgeries. In few instances medical management is advised with primary treatment objectives typically being pain management and improvement in jaw movements but may require total joint replacement eventually. 96
  • 97. 97 REFERENCES  Peterson's Principles of Oral And Maxillofacial Surgery 2nd ed.  Peterson’s Principles of Oral and Maxillofacial Surgery – 3rd ed  Atlas of Human Anatomy - Frank H. Netter 6th ed  Atlas of Temporomandibular Joint Surgery 2nd ed – Quinn  Management of temporomandibular disorders and occlusion, 6th ed – Okeson  Fonseca Vol. II  Custom-Made Total Temporomandibular Joint Prostheses. Atlas Oral Maxillofacial Surg Clin N Am 13 (2005) 83–89.  Total Reconstruction of the Temporomandibular Joint with a Stock Prosthesis. Atlas Oral Maxillofacial Surg Clin N Am 19 (2011) 221–232.  Patient-Fitted (“Custom”) Alloplastic Temporomandibular Joint Replacement Technique Atlas Oral Maxillofacial Surg Clin N Am 19 (2011) 233–242.
  • 98. 98  Complications of TMJ Surgery. Oral Maxillofacial Surg Clin N Am 27 (2015) 109–124.  sternociavicular grafts for temporomanciibular joint reconstruction j oral mexillofac surg 52:119-128. 1994.  temporomandibular joint devices: treatment factors and outcomes. oral surg oral med oral pathol oral radiol endod 1997;83:143-9.  alloplastic temporomandibular joint reconstruction. oral surgery oral medicine oral pathology june 1998 volume 85, number 6  costochondral rib grafting. atlas oral maxillofacial surg clin n am 13 (2005) 139–149.  the christensen temporomandibular joint prosthesis system - david a. Gerard.  Distraction Osteogenesis for Temporomandibular Joint Reconstruction. J Oral Maxillofac Surg 66:718-723, 2008
  • 99. 99 • The-use-of-autogenous-tissues-for-temporomandibular-joint-reconstruction. J Oral Maxillofac Surg 58:63-69,2000. • Reconstruction of the temporomandibular joint autogenous compared with alloplastic. British Journal of Oral and Maxillofacial Surgery (2002) 40, 296–299 • Evaluation of Long-Term Stability in Second Metatarsal Reconstruction of the Temporomandibular Joint. J Oral Maxillofac Surg . 2003;61:65-71. • Principles for the revision of total alloplastic TMJ prostheses. Int. J. Oral Maxillofac. Surg. 2003; 32: 353–359. • Advances in skeletal tissue engineering with hydrogels. Orthod Craniofacial Res 8, 2005; 150–161. • Free grafting of autogenous coronoid process for condylar reconstruction in patients with TMJ ankylosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;106:662-7. • Autogenous grafts for condylar reconstruction in treatment of TMJ ankylosis: current concepts and considerations for the future. Int. J. Oral Maxillofac. Surg. 2012; 41: 94– 102

Editor's Notes

  1. End stage disease represents the worst condition or disease state of an organ system when the organ is functioning minimally or not at all. When used for functional joints the term end stage indicates that the joint is so negatively affected archietecturally by disease or injury that functional impairment is the final result for the patient.
  2. The patients with end stage tmj disease are typically characterized by a history of multiple therapeutic interventions. Therefore the effective management of these disorders is primarily aimed at reducing pain and disability.
  3. preemptive analgesia is used to describe methods that apparently reduce postsurgical pain by protecting the CNS from surgical stimulation. The control of pain in the immediate postsurgical period permits immediate postsurgical physical therapy by improving patients compliance
  4. Classically, end stage TMJ disorders have been managed with the use of autogenous bone or soft tissue grafting
  5. The current technique for TMJ replacement with the CCG was popularized by POSWILLO The ribs most commonly used for joint reconstruction are the fifth, sixth, and seventh ribs. The sixth or seventh rib is resected along with 1 cm of intact costal cartilage for CCG
  6. The rib is harvested through a horizontal incision in the inframammary fold. If two ribs are needed, they should be harvested on the same side (e.g., the fourth and sixth ribs or fifth and seventh ribs) to prevent bilateral pneumothorax
  7. After dissecting through skin and subcutaneous tissue, an incision is given over the periosteum circumferentially. periosteum on the undersurface of the rib is carefully excised to prevent a pneumothorax. a strip of periosteum and perichondrium is left overlying the junction of the rib and the costal cartilage helps prevent separation of the cartilage from the rib during function. After reflecting the periosteum an elevator is kept underneath the rib and osteotomy cut is made. Approximately 1 cm of cartilage and 3–4 cm of bone is normally sufficient. After the rib is removed, the wound can be filled with saline and is checked for pleural injury. Harvested rib is then contoured to the shape of condyle Once the rib is harvested, a scalpel blade is used to contour the hyaline cartilage so that it simulates the shape of the condylar head and fits in the fossa
  8. Recently authors have recommended using thinner sections of cartilage (2–3 mm) due to the potential for overgrowth
  9. If the clavicular graft was to be placed on the lateral aspect of the mandible, usually the ipsilateral clavicle was harvested. If the graft was to be placed on the medial side or posterior border of the mandible, usually a better fit could be achieved by using the contralateral clavicular donor site.
  10. An incision was made 1 to 2 cm above the level of the clavicle extending 8-10cm laterally Once into the subcutaneous tissues, the incision was pulled down directly over the clavicle extending medially toward the capsule of the sternoclavicular joint. The periosteum and muscle attachments were then dissected from the superior and medial aspects of the clavicle. The superior half of the clavicle was used as a graft, maintaining the integrity of the lower half for arm and shoulder support. bur was used to mark the site to be cut. A reciprocating saw with a thin blade was used to cut through both the anterior and posterior cortical plates of the clavicle The articular disc was sectioned overlying the harvested head remained attached to the graft
  11. WOLFORD et al. suggested the use of a figure-of-eight bandage for up to 3 months to support the shoulders, as for clavicular fractures, as well as the use of arm slings to immobilize the arm
  12. The intact epiphysis in the transplanted MTP joint, which contains an epiphyseal growth plate, ensures the normal growth of the transplant in young patients
  13. In order to avoid the donor site morbidity of autogenous bone grafting, alloplastic TJR has become an acceptable alternative to autogenous grafting. All implanted alloplastic devices (dental implants, orthopedic, and TMJ prostheses) depend on the principle of osseointegration
  14. Various others reported on the development and use of alloplastic partial and total TMJ reconstruction prostheses. The indications for their use ranged from ankylosis to reconstruction after ablative surgery for disease and/or trauma to the multiply operated failed TMJ patient
  15. 2. Devices must withstand forces delivered over full range of joint function
  16. Has 2 components 1 fossa component comprising of custom fitted alloy glenoid fossa with articulating surface made of UHMWP 2. Mandibular component with shaft made up of wrought titanium alloy and articulating head made up of co-mo
  17. Proplast was used for the lining of the glenoid fossa prosthesis on the fossa side and also on the surface of the condylar prosthesis
  18. the most commonly used one was the AO–ASIF prosthesis marketed by Synthes. This type of prosthesis was essentially an extended reconstruction plate with a rounded condylar head. It was used without a matching glenoid fossa implant, as a temporary replacement. Surgeons did use the prosthesis in combination with a Vitek‐Kent (VK) fossa
  19. In the late 1980s, Boyne reported a series of joint replacements using a Delrin (polyoxymethylene) head secured to a titanium mesh plate. Although this method did not require a glenoid fossa prosthesis, some experts were concerned about Delrin‐induced excessive heterotopic bone formation, leading to ankylosis.
  20. The Christensen system now consists of a fossa and a condyle prosthesis both made from cobalt–chrome alloy. There are 44 preformed fossa templates from which the most suitable is chosen. This is secured with alloy screws to the lateral aspect of the eminence. The condyle prosthesis is sized using a metal template and is available in 45, 50, and 55mm lengths. This is then secured with alloy screws to the ramus of the mandible. In the original Christensen system, the condyle cap was made of polymethylmethacralyte, but since March 1997 an all metal condyle has been available that allows a metal on metal articulation and decreased generation of wear particles
  21. Christensen all‐metal condylar prosthesis articulating with a Christensen fossa. Both components are made with Vitallium
  22. The Biomet stock prosthesis is a metal‐on‐polyethylene design, composed of a high‐molecular‐weight polyethylene fossa and a cobalt–chromium alloy condylar component. The fossa should parallel Frankfort horizontal or optimize function and reduce the chance of dislocation The fossa is secured to the zygomatic arch by four self‐tapping 2.0‐mm screws. Once the fossa is fitted, the patient is placed in intermaxillary fixation and the chrome– cobalt condylar prosthesis is fitted.
  23. The use of a custom implant system is usually necessitated in patients with compromised bone stock where there is a severe craniofacial deformity present with an anatomical discrepancy
  24. Utilizing this method, the reconstruction can be accomplished with a single‐ or two‐staged approach
  25. The two‐staged reconstruction requires initial joint preparation, including tumor resection, device removal, or bony resection to occur. Once this is completed, the patient is placed in intermaxillary fixation and a CT scan is obtained. The device is then fabricated from this scan .
  26. The advantage to this approach. is that the defect and new mandibular position is set The obvious disadvantages include a second procedure and the need for prolonged mandibular immobilization during device manufacturing
  27. The single‐stage approach requires initial site preparation and device placement in a single surgery. Advantage - single operation. Disadvantages - included the need to recapitulate osteotomy and mandibular repositioning precisely as they were placed on the model
  28. Example of total alloplastic joint surgical planning and design via computer aid modeling. Nerve position and bone thickness are easily visualized, allowing for ideal screw fixation placement Final custom prosthesis design with predetermined screw lengths indicated.
  29. Advantages Utilizing computer design has the added advantage of rapidly producing and comparing alternative designs and treatment plans prior to implementation
  30. As well as simultaneous Disadvantages include additional cost of the planning session or software views in multiple dimensions.
  31. If the device cannot satisfy the principles of anatomy and joint mechanics It includes variables of design amd material, and manufacturing tolerances
  32. As compared with nonvascularized free bone grafts as the transported bone here retains its internal muscle and periosteal blood supply. DO is
  33. The use of transport distraction induces the formation of new bone along the vector of movement without use of a bone graft. This form of reconstruction takes advantage of the fibrocartilaginous cap that forms on the advancing front of the neocondyle towards the fossa allowing formation of pseudoarthrosis and prevent ankylosis
  34. Mandibular condyle tissue engineering has been proposed recently to address the current limitations of both autogenous and alloplastic reconstruction options tissue engineering strategy would incorporate a biodegradable scaffold delivering biologic substances such as cells, genes, and/or proteins to regenerate the bone/cartilage tissues of the mandibular condyle
  35. These scaffold comes in variety of forms – solids, mesh, fibres and gels.
  36. Cranial nerve V can be damaged, because its foramen lies medial to the medial draping of the glenoid fossa Damage can either be permanent or temporary.
  37. Bleeding and nerve damage often run hand in hand. In the attempt to stop bleeding with a cautery, the burn can propagate to a nearby nerve Inadvertent damage to the masseteric artery can occur when the area underlying the sigmoid notch is not protected while remove sufficient bone to place the joint, during ankylosis, or in attempts to remove the coronoid process
  38. It poses a significant intraoperative threat because of the lack of accessibility to tie it off, especially in ankylosis
  39. Intraoperative damage to adjacent structures is always a concern as an intraoperative complication.
  40. Many times, attempts are made to reposition the mandible during surgery, and there is a significant amount of pulling and an inability to release some of the scarring from previous surgical endeavors.