1. Current Medical Diagnosis and Treatment 2020
33Â09: Infective Endocarditis
Bryn A. Boslett; Brian S. Schwartz
ESSENTIALS OF DIAGNOSIS
Fever.
Preexisting organic heart lesion.
Positive blood cultures.
Evidence of vegetation on echocardiography.
Evidence of systemic emboli.
GENERAL CONSIDERATIONS
Endocarditis is a bacterial or fungal infection of the valvular or endocardial surface of the heart. The clinical presentation depends on the infecting
organism and the valve or valves that are infected. More virulent organismsâS aureus in particularâtend to produce a more rapidly progressive and
destructive infection. Endocarditis caused by more virulent organisms often presents as an acute febrile illnesses and is complicated by early
embolization, acute valvular regurgitation, and myocardial abscess formation. Viridans strains of streptococci, enterococci, other bacteria, yeasts, and
fungi tend to cause a more subacute picture (eFigure 33â8).
eFigure 33â8.
Large vegetations of the mitral valve leaflets from subacute bacterial endocarditis. (Public Health Image Library, CDC).
Underlying valvular disease, less common than in the past, is present in about 50% of cases. Valvular disease alters blood flow and produces jet effects
that disrupt the endothelial surface, providing a nidus for attachment and infection of microorganisms that enter the bloodstream. Predisposing
valvular abnormalities include rheumatic involvement of any valve, bicuspid aortic valves, calcific or sclerotic aortic valves, hypertrophic subaortic
stenosis, mitral valve prolapse, and a variety of congenital disorders such as ventricular septal defect, tetralogy of Fallot, coarctation of the aorta, or
patent ductus arteriosus. Rheumatic disease is no longer the major predisposing factor in developed countries. Regurgitation lesions are more
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2. Underlying valvular disease, less common than in the past, is present in about 50% of cases. Valvular disease alters blood flow and produces jet effects
that disrupt the endothelial surface, providing a nidus for attachment and infection of microorganisms that enter the bloodstream. Predisposing
valvular abnormalities include rheumatic involvement of any valve, bicuspid aortic valves, calcific or sclerotic aortic valves, hypertrophic subaortic
stenosis, mitral valve prolapse, and a variety of congenital disorders such as ventricular septal defect, tetralogy of Fallot, coarctation of the aorta, or
patent ductus arteriosus. Rheumatic disease is no longer the major predisposing factor in developed countries. Regurgitation lesions are more
susceptible than stenotic ones.
The initiating event in native valve endocarditis is colonization of the valve by bacteria or yeast that gain access to the bloodstream. Transient
bacteremia is common during dental, upper respiratory, urologic, and lower gastrointestinal diagnostic and surgical procedures. It is less common
during upper gastrointestinal and gynecologic procedures. Intravascular devices are increasingly implicated as a portal of access of microorganisms
into the bloodstream. A large proportion of cases of S aureus endocarditis are attributable to health careâassociated bacteremia.
Native valve endocarditis is usually caused by S aureus, viridans streptococci, enterococci, or HACEK organisms (an acronym for Haemophilus
aphrophilus [now Aggregatibacter aphrophilus], Actinobacillus actinomycetemcomitans [now Aggregatibacter actinomycetemcomitans],
Cardiobacterium hominis, Eikenella corrodens, and Kingella species). Streptococcal species formerly accounted for the majority of native valve
endocarditis cases; S aureus is now the leading cause. GramÂnegative organisms and fungi account for a small percentage.
In injection drug users, S aureus accounts for over 60% of all endocarditis cases and for 80â90% of cases in which the tricuspid valve is infected.
Enterococci and streptococci comprise the balance in about equal proportions. GramÂnegative aerobic bacilli, fungi, and unusual organisms may
cause endocarditis in injection drug users.
The microbiology of prosthetic valve endocarditis also is distinctive. Early infections (ie, those occurring within 2 months after valve implantation)
are commonly caused by staphylococciâboth coagulaseÂpositive and coagulaseÂnegativeâgramÂnegative organisms, and fungi. In late prosthetic
valve endocarditis, streptococci are commonly identified, although coagulaseÂnegative and coagulaseÂpositive staphylococci still cause many cases.
CLINICAL FINDINGS
A. Symptoms and Signs
Virtually all patients have fever at some point in the illness, although it may be very low grade (less than 38°C) in elderly individuals and in patients with
heart failure or kidney failure. Rarely, there may be no fever at all.
The duration of illness typically is a few days to a few weeks. Nonspecific symptoms are common. The initial symptoms and signs of endocarditis may
be caused by direct arterial, valvular, or cardiac damage (eFigure 33â9). Although a changing regurgitant murmur is significant diagnostically, it is the
exception rather than the rule. Symptoms also may occur as a result of embolization, metastatic infection or immunologically mediated phenomena.
These include cough; dyspnea; arthralgias or arthritis; diarrhea; and abdominal, back, or flank pain.
eFigure 33â9.
Subacute bacterial endocarditis. Calcific embolus impacted in arteriole below the disk, producing a distal area of retinal infarction. (Reproduced, with
permission, from Vaughan DG, Asbury T, RiordanÂEva P [editors]. General Ophthalmology, 15th ed. Originally published by Appleton & Lange.
Copyright Š 1999 by The McGrawÂHill Companies, Inc.)
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3. eFigure 33â9.
Subacute bacterial endocarditis. Calcific embolus impacted in arteriole below the disk, producing a distal area of retinal infarction. (Reproduced, with
permission, from Vaughan DG, Asbury T, RiordanÂEva P [editors]. General Ophthalmology, 15th ed. Originally published by Appleton & Lange.
Copyright Š 1999 by The McGrawÂHill Companies, Inc.)
The characteristic peripheral lesionsâpetechiae (on the palate or conjunctiva or beneath the fingernails), subungual (âsplinterâ) hemorrhages (Figure
33â4), Osler nodes (painful, violaceous raised lesions of the fingers, toes, or feet) (Figure 33â5), Janeway lesions (painless erythematous lesions of the
palms or soles), and Roth spots (exudative lesions in the retina)âoccur in about 25% of patients (eFigures 33â10 and 33â11). Strokes and major
systemic embolic events are present in about 25% of patients and tend to occur before or within the first week of antimicrobial therapy. Hematuria and
proteinuria may result from emboli or immunologically mediated glomerulonephritis, which can cause kidney dysfunction.
Figure 33â4.
Splinter hemorrhages appearing as red lineal streaks under the nail plate and within the nail bed, in endocarditis, psoriasis, and
trauma. (Reproduced, with permission, from Richard P. Usatine, MD.)
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4. Figure 33â4.
Splinter hemorrhages appearing as red lineal streaks under the nail plate and within the nail bed, in endocarditis, psoriasis, and
trauma. (Reproduced, with permission, from Richard P. Usatine, MD.)
Figure 33â5.
Osler node causing pain within the pulp of the big toe and multiple painless flat Janeway lesions over the sole of the foot. (Used,
with permission, from David A. Kasper, DO, MBA, in Usatine RP, Smith MA, Mayeaux EJ Jr, Chumley H, Tysinger J. The Color Atlas of Family Medicine.
McGrawÂHill, 2009.)
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5. Figure 33â5.
Osler node causing pain within the pulp of the big toe and multiple painless flat Janeway lesions over the sole of the foot. (Used,
with permission, from David A. Kasper, DO, MBA, in Usatine RP, Smith MA, Mayeaux EJ Jr, Chumley H, Tysinger J. The Color Atlas of Family Medicine.
McGrawÂHill, 2009.)
eFigure 33â10.
Roth spots are retinal hemorrhages with white centers found in infective endocarditis. (From Paul D. Comeau; Reproduced, with permission, from
Usatine RP, Smith MA, Mayeaux EJ Jr, Chumley H, Tysinger J. The Color Atlas of Family Medicine. McGrawÂHill, 2009.)
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6. eFigure 33â10.
Roth spots are retinal hemorrhages with white centers found in infective endocarditis. (From Paul D. Comeau; Reproduced, with permission, from
Usatine RP, Smith MA, Mayeaux EJ Jr, Chumley H, Tysinger J. The Color Atlas of Family Medicine. McGrawÂHill, 2009.)
eFigure 33â11.
Close up of a Roth spot, actually a cotton wool spot (from ischemic bursting of axons) surrounded by hemorrhage (from ischemic bursting of an
arteriole). (From Paul D. Comeau; Reproduced, with permission, from Usatine RP, Smith MA, Mayeaux EJ Jr, Chumley H, Tysinger J. The Color Atlas of
Family Medicine. McGrawÂHill, 2009.)
B. Imaging
Chest radiograph may show evidence for the underlying cardiac abnormality and, in rightÂsided endocarditis, pulmonary infiltrates. The
electrocardiogram is nondiagnostic, but new conduction abnormalities suggest myocardial abscess formation. Echocardiography is useful in
identifying vegetations and other characteristic features suspicious for endocarditis and may provide adjunctive information about the specific valve
or valves that are infected. The sensitivity of transthoracic echocardiography is between 55% and 65%; it cannot reliably rule out endocarditis but may
confirm a clinical suspicion. Transesophageal echocardiography is 90% sensitive in detecting vegetations and is particularly useful for identifying valve
ring abscesses as well as prosthetic valve endocarditis.
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7. B. Imaging
Chest radiograph may show evidence for the underlying cardiac abnormality and, in rightÂsided endocarditis, pulmonary infiltrates. The
electrocardiogram is nondiagnostic, but new conduction abnormalities suggest myocardial abscess formation. Echocardiography is useful in
identifying vegetations and other characteristic features suspicious for endocarditis and may provide adjunctive information about the specific valve
or valves that are infected. The sensitivity of transthoracic echocardiography is between 55% and 65%; it cannot reliably rule out endocarditis but may
confirm a clinical suspicion. Transesophageal echocardiography is 90% sensitive in detecting vegetations and is particularly useful for identifying valve
ring abscesses as well as prosthetic valve endocarditis.
C. Diagnostic Studies
1. Blood cultures
Three sets of blood cultures are recommended before starting antibiotics to maximize microbiologic diagnosis. To maximize the yield of blood
cultures, adequate volume is important. Each culture bottle should be filled with 10 mL of blood since half of adults have less than 1 colony forming
unit of bacteria per mL blood. The yield of bacteria may be up to 5% higher for every additional milliliter collected. Optimal yield is with two or three
sets of cultures from different sites. There is no difference in yield if blood is collected simultaneously or several hours apart.
Approximately 5% of cases will be cultureÂnegative, usually attributable to administration of antimicrobials prior to cultures. If antimicrobial therapy
has been administered prior to obtaining cultures and the patient is clinically stable, it is reasonable to withhold antimicrobial therapy for 2â3 days so
that appropriate cultures can be obtained. CultureÂnegative endocarditis may also be due to organisms that require special media for growth (eg,
Legionella, Bartonella, Abiotrophia species, formerly referred to as nutritionally deficient streptococci), organisms that do not grow on artificial media
(Tropheryma whipplei, or pathogens of Q fever or psittacosis), or those that may require prolonged incubation (eg, Brucella, anaerobes, HACEK
organisms). Bartonella quintana is an important cause of cultureÂnegative endocarditis.
2. Modified Duke criteria
The Modified Duke criteria are useful for the diagnosis of endocarditis. Major criteria include (1) two positive blood cultures for a microorganism that
typically causes infective endocarditis or persistent bacteremia, or a single positive blood culture for Coxiella burnetii or antiâphase 1 IgG antibody titer
greater than or equal to 1:800; and (2) evidence of endocardial involvement documented by echocardiography showing definite vegetation, myocardial
abscess, new partial dehiscence of a prosthetic valve, or new valvular regurgitation (increase or change in murmur is not sufficient). Minor criteria
include the presence of a predisposing condition; fever of 38°C or higher; vascular phenomena, such as cutaneous hemorrhages, aneurysm, systemic
emboli, or pulmonary infarction; immunologic phenomena, such as glomerulonephritis, Osler nodes, Roth spots, or rheumatoid factor; and positive
blood cultures not meeting the major criteria or serologic evidence of an active infection. A definite diagnosis can be made with 80% accuracy if two
major criteria, one major criterion and three minor criteria, or five minor criteria are fulfilled. A possible diagnosis of endocarditis is made if one major
and one minor criterion or three minor criteria are met. If fewer criteria are found, or a sound alternative explanation for illness is identified, or the
patientâs febrile illness has resolved within 4 days, endocarditis is unlikely.
COMPLICATIONS
The course of infective endocarditis is determined by the degree of damage to the heart, by the site of infection (rightÂsided versus leftÂsided, aortic
versus mitral valve), by the presence of metastatic foci of infection, by the occurrence of embolization, and by immunologically mediated processes.
Destruction of infected heart valves is especially common and precipitous with S aureus, but can occur with any organism and can progress even after
bacteriologic cure. The infection can also extend into the myocardium, resulting in abscesses leading to conduction disturbances, and involving the
wall of the aorta, creating sinus of Valsalva aneurysms.
Peripheral embolization to the brain and myocardium may result in infarctions. Embolization to the spleen and kidneys is also common. Peripheral
emboli may initiate metastatic infections or may become established in vessel walls, leading to mycotic aneurysms. RightÂsided endocarditis, which
usually involves the tricuspid valve, causes septic pulmonary emboli, occasionally with infarction and lung abscesses.
PREVENTION
The American Heart Association recommends antibiotic prophylaxis for infective endocarditis in a relatively small group of patients with predisposing
congenital or valvular anomalies (Table 33â3) undergoing select dental procedures, operations involving the respiratory tract, or operations of
infected skin, skin structure, or musculoskeletal tissue (Table 33â4). Current antimicrobial recommendations are given in Table 33â5.
Table 33â3.
Cardiac conditions with high risk of adverse outcomes from endocarditis for which prophylaxis with dental procedures is recommended.1,2
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8. 1Reproduced, with permission, from Wilson W et al. Prevention of infective endocarditis. Circulation. 2007 Oct 9;116(15):1736â54. Copyright Š 2007 American Heart
Association, Inc.
2See Table 33â5 for prophylactic regimens.
3Except for the conditions listed above, antibiotic prophylaxis is no longer recommended for other forms of CHD.
4Prophylaxis is recommended because endothelialization of prosthetic material occurs within 6 months after procedure.
1Reproduced, with permission, from Wilson W et al. Prevention of infective endocarditis. Circulation. 2007 Oct 9;116(15):1736â54. Copyright Š 2007 American Heart
Association, Inc.
PREVENTION
The American Heart Association recommends antibiotic prophylaxis for infective endocarditis in a relatively small group of patients with predisposing
congenital or valvular anomalies (Table 33â3) undergoing select dental procedures, operations involving the respiratory tract, or operations of
infected skin, skin structure, or musculoskeletal tissue (Table 33â4). Current antimicrobial recommendations are given in Table 33â5.
Table 33â3.
Cardiac conditions with high risk of adverse outcomes from endocarditis for which prophylaxis with dental procedures is recommended.1,2
Prosthetic cardiac valve
Previous infective endocarditis
Congenital heart disease (CHD)3
Unrepaired cyanotic CHD, including palliative shunts and conduits
Completely repaired congenital heart defect with prosthetic material or device, whether placed by surgery or by catheter intervention, during the first 6
months after the procedure4
Repaired CHD with residual defects at the site or adjacent to the site of a prosthetic patch or prosthetic device
Cardiac transplantation recipients in whom cardiac valvulopathy develops
Table 33â4.
Recommendations for administration of bacterial endocarditis prophylaxis for patients according to type of procedure.1
Prophylaxis Recommended Prophylaxis Not Recommended
Dental procedures
All dental procedures that involve
manipulation of gingival tissue or the
periapical region of the teeth or perforation
of the oral mucosa
Respiratory tract procedures
Only respiratory tract procedures that
involve incision of the respiratory mucosa
Procedures on infected skin, skin
structure, or musculoskeletal tissue
Dental procedures
Routine anesthetic injections through noninfected tissue, taking dental radiographs, placement of
removable prosthodontic or orthodontic appliances, adjustment of orthodontic appliances, placement of
orthodontic brackets, shedding of deciduous teeth, and bleeding from trauma to the lips or oral mucosa
Gastrointestinal tract procedures
Genitourinary tract procedures
Table 33â5.
American Heart Association recommendations for endocarditis prophylaxis for dental procedures for patients with cardiac conditions.1â3
Oral Amoxicillin 2 g 1 hour before procedure
Penicillin
allergy
Clindamycin 600 mg 1 hour before procedure
or
Cephalexin 2 g 1 hour before procedure (contraindicated if there is history of a betaÂlactam immediate hypersensitivity
reaction)
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9. 1Reproduced, with permission, from Wilson W et al. Prevention of infective endocarditis. Circulation. 2007 Oct 9;116(15):1736â54. Copyright Š 2007 American Heart
Association, Inc.
1Data from the American Heart Association. Circulation. 2007 Oct 9;116(15):1736â54.
2For patients undergoing respiratory tract procedures involving incision of respiratory tract mucosa to treat an established infection or a procedure on infected skin,
skin structure, or musculoskeletal tissue known or suspected to be caused by S aureus, the regimen should contain an antiÂstaphylococcal penicillin or
cephalosporin. Vancomycin can be used to treat patients unable to tolerate a betaÂlactam or if the infection is known or suspected to be caused by a methicillinÂ
resistant strain of S aureus.
3See Table 33â3 for list of cardiac conditions.
structure, or musculoskeletal tissue
Table 33â5.
American Heart Association recommendations for endocarditis prophylaxis for dental procedures for patients with cardiac conditions.1â3
Oral Amoxicillin 2 g 1 hour before procedure
Penicillin
allergy
Clindamycin 600 mg 1 hour before procedure
or
Cephalexin 2 g 1 hour before procedure (contraindicated if there is history of a betaÂlactam immediate hypersensitivity
reaction)
or
Azithromycin or
clarithromycin
500 mg 1 hour before procedure
Parenteral Ampicillin 2 g intramuscularly or intravenously 30 minutes before procedure
Penicillin
allergy
Clindamycin 600 mg intravenously 1 hour before procedure
or
Cefazolin 1 g intramuscularly or intravenously 30 minutes before procedure (contraindicated if there is history of a betaÂ
lactam immediate hypersensitivity reaction)
TREATMENT
Empiric regimens for endocarditis while culture results are pending should include agents active against staphylococci, streptococci, and enterococci.
Vancomycin 1 g every 12 hours intravenously plus ceftriaxone 2 g every 24 hours provides appropriate coverage pending definitive diagnosis;
consultation with an infectious disease expert is strongly recommended when initiating treatment.
A. Viridans Streptococci
For penicillinÂsusceptible viridans streptococcal endocarditis (ie, MIC 0.1 mcg/mL or less), penicillin G, 18 million units intravenously either
continuously or in four to six equally divided doses, or ceftriaxone, 2 g intravenously once daily for 4 weeks, is recommended. The duration of therapy
can be shortened to 2 weeks if gentamicin, 3 mg/kg intravenously every 24 hours, is used with penicillin or ceftriaxone. The 2Âweek regimen is
reasonable and can be considered in patients with uncomplicated endocarditis, rapid response to therapy, and no underlying kidney disease. For the
patient unable to tolerate penicillin or ceftriaxone, vancomycin, 15 mg/kg intravenously every 12 hours for 4 weeks, is given with a desired trough level
of 10â15 mcg/mL. Prosthetic valve endocarditis is treated with a 6Âweek course of penicillin or ceftriaxone and the clinician can consider adding 2
weeks of gentamicin at the start of therapy.
Viridans streptococci relatively resistant to penicillin (ie, MIC greater than 0.12 mcg/mL but less than or equal to 0.5 mcg/mL) should be treated for 4
weeks. Penicillin G, 24 million units intravenously either continuously or in four to six equally divided doses, is combined with gentamicin, 3 mg/kg
intravenously every 24 hours for the first 2 weeks. Ceftriaxone may be a reasonable alternative treatment option for isolates that are susceptible to
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10. continuously or in four to six equally divided doses, or ceftriaxone, 2 g intravenously once daily for 4 weeks, is recommended. The duration of therapy
can be shortened to 2 weeks if gentamicin, 3 mg/kg intravenously every 24 hours, is used with penicillin or ceftriaxone. The 2Âweek regimen is
reasonable and can be considered in patients with uncomplicated endocarditis, rapid response to therapy, and no underlying kidney disease. For the
patient unable to tolerate penicillin or ceftriaxone, vancomycin, 15 mg/kg intravenously every 12 hours for 4 weeks, is given with a desired trough level
of 10â15 mcg/mL. Prosthetic valve endocarditis is treated with a 6Âweek course of penicillin or ceftriaxone and the clinician can consider adding 2
weeks of gentamicin at the start of therapy.
Viridans streptococci relatively resistant to penicillin (ie, MIC greater than 0.12 mcg/mL but less than or equal to 0.5 mcg/mL) should be treated for 4
weeks. Penicillin G, 24 million units intravenously either continuously or in four to six equally divided doses, is combined with gentamicin, 3 mg/kg
intravenously every 24 hours for the first 2 weeks. Ceftriaxone may be a reasonable alternative treatment option for isolates that are susceptible to
ceftriaxone. In the patient with IgEÂmediated allergy to penicillin, vancomycin alone, 15 mg/kg intravenously every 12 hours for 4 weeks, should be
administered. Prosthetic valve endocarditis is treated with a 6Âweek course of penicillin or ceftriaxone plus gentamicin as above.
Endocarditis caused by viridans streptococci with an MIC greater than 0.5 mcg/mL or by nutritionally deficient streptococci should be treated the same
as enterococcal endocarditis.
B. Other Streptococci
Endocarditis caused by S pneumoniae, S pyogenes (group A streptococcus), or groups B, C, and G streptococci is unusual. S pneumoniae sensitive to
penicillin (MIC less than 0.1 mcg/mL) can be treated with penicillin 18 million units intravenously either continuously or in four to six equally divided
doses or cefazolin 6 g intravenously either continuously or in three equally divided doses, or ceftriaxone 2 g daily intravenously for 4 weeks. HighÂdose
penicillin (24 million units) or a thirdÂgeneration cephalosporin may be required for the treatment of endocarditis (without meningitis) caused by
strains resistant to penicillin (MIC greater than 0.1 mcg/mL). The addition of vancomycin and rifampin to ceftriaxone may be considered in patients
with S pneumoniae strains with cefotaxime MIC greater than 2 mcg/mL. Group A streptococcal infection can be treated with penicillin or ceftriaxone for
4â6 weeks. Groups B, C, and G streptococci tend to be more resistant to penicillin than group A streptococci, and some experts have recommended
adding gentamicin, 3 mg/kg intravenously every 24 hours, to penicillin for the first 2 weeks of a 4Â to 6Âweek course. Endocarditis caused by S
gallolyticus (bovis) is associated with liver disease, especially cirrhosis, and gastrointestinal abnormalities, especially colon cancer. Colonoscopy
should be performed to exclude the latter.
C. Enterococci
For enterococcal endocarditis, penicillin or ampicillin alone is inadequate. The combination of penicillin or ampicillin with gentamicin had been the
treatment of choice but several clinical studies of the combination of ampicillin plus ceftriaxone have demonstrated clinical outcomes equivalent to the
combination of ampicillin plus gentamicin. One recommended regimen is ampicillin, 2 g intravenously every 4 hours, or penicillin G, 18â30 million
units intravenously continuously or in six equally divided doses plus gentamicin, 1 mg/kg intravenously every 8 hours. The second recommended
regimen is ampicillin (2 g intravenously every 4 hours) plus ceftriaxone 2 g intravenously every 12 hours. The recommended duration of therapy is 4â6
weeks (the longer duration for patients with symptoms for more than 3 months, relapse, or prosthetic valve endocarditis). The combination of
ampicillin plus ceftriaxone is recommended for patients with creatinine clearance less than 50 mL/min or whose enterococcal isolates are resistant to
gentamicin. In patients intolerant of penicillin and ampicillin or who have enterococcal isolate resistant to these agents, vancomycin plus gentamicin
can be used.
Endocarditis caused by strains resistant to penicillin and vancomycin are difficult to treat and should always be managed in consultation with an
infectious diseases specialist.
D. Staphylococci
For methicillinÂsusceptible S aureus isolates, nafcillin or oxacillin, 12 g intravenously daily given continuously or in four to six divided doses or
cefazolin, 6 g intravenously daily given continuously or in three divided doses for 6 weeks, is the preferred therapy. In cases of brain abscess resulting
from methicillinÂsusceptible S aureus endocarditis, nafcillin should be used instead of cefazolin. For patients with history of immediate type
hypersensitivity to betaÂlactams, a desensitization protocol should be undertaken. For patients with a history of nonanaphylactoid reactions to
penicillins, cefazolin should be used. Patients who are infected with methicillinÂresistant S aureus or who are unable to tolerate betaÂlactam therapy
should receive vancomycin, 30 mg/kg/day intravenously divided in two or three doses, to achieve a goal trough level of 15â20 mcg/kg, or daptomycin
intravenously at greater than or equal to 8 mg/kg/day. Aminoglycoside combination regimens are not recommended. The effect of rifampin with
antistaphylococcal drugs is variable, and its routine use is not recommended.
Because coagulaseÂnegative staphylococciâa common cause of prosthetic valve endocarditisâare routinely resistant to methicillin, betaÂlactam
antibiotics should not be used for this infection unless the isolate is demonstrated to be susceptible. A combination of vancomycin, 30 mg/kg/day
intravenously divided in two or three doses for 6 weeks; rifampin, 300 mg every 8 hours for 6 weeks; and gentamicin, 3 mg/kg intravenously every 8
hours for the first 2 weeks, is recommended for prosthetic valve infection. If the organism is sensitive to methicillin, either nafcillin or oxacillin or
cefazolin can be used in combination with rifampin and gentamicin. Combination therapy with nafcillin or oxacillin (vancomycin or daptomycin for
methicillinÂresistant strains), rifampin, and gentamicin is also recommended for treatment of S aureus prosthetic valve infection.
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11. intravenously at greater than or equal to 8 mg/kg/day. Aminoglycoside combination regimens are not recommended. The effect of rifampin with
antistaphylococcal drugs is variable, and its routine use is not recommended.
Because coagulaseÂnegative staphylococciâa common cause of prosthetic valve endocarditisâare routinely resistant to methicillin, betaÂlactam
antibiotics should not be used for this infection unless the isolate is demonstrated to be susceptible. A combination of vancomycin, 30 mg/kg/day
intravenously divided in two or three doses for 6 weeks; rifampin, 300 mg every 8 hours for 6 weeks; and gentamicin, 3 mg/kg intravenously every 8
hours for the first 2 weeks, is recommended for prosthetic valve infection. If the organism is sensitive to methicillin, either nafcillin or oxacillin or
cefazolin can be used in combination with rifampin and gentamicin. Combination therapy with nafcillin or oxacillin (vancomycin or daptomycin for
methicillinÂresistant strains), rifampin, and gentamicin is also recommended for treatment of S aureus prosthetic valve infection.
E. HACEK Organisms
HACEK organisms are slowÂgrowing, fastidious gramÂnegative coccobacilli or bacilli (H aphrophilus [now A aphrophilus], A actinomycetemcomitans, C
hominis, E corrodens, and Kingella species) that are normal oral flora and cause less than 5% of all cases of endocarditis. They may produce betaÂ
lactamase, and thus the treatment of choice is ceftriaxone (or another thirdÂgeneration cephalosporin), 2 g intravenously once daily for 4 weeks.
Prosthetic valve endocarditis should be treated for 6 weeks. In the penicillinÂallergic patient, experience is limited, but fluoroquinolones have in vitro
activity and should be considered.
F. CultureÂNegative Endocarditis
Failure to culture microorganisms from patients with suspected infective endocarditis may be due to infection from organisms not recovered in
routine microbiology testing or previous administration of antimicrobial agents before blood cultures were obtained. These cases must be managed
with the assistance of an infectious disease specialist. Pathogens that are not able to be cultured by commonly used techniques include Bartonella
species, Chlamydia species, Brucella species, and Tropheryma whipplei. Serologic testing should be performed in patients who have epidemiologic
risk factors for these infections. Treatment should be directed at likely pathogens while awaiting serologic results; treatment of patients given prior
antimicrobials before cultures were obtained must also consider likely pathogens.
G. Role of Surgery
While many cases can be successfully treated medically, operative management is frequently required. Acute heart failure unresponsive to medical
therapy is an indication for valve replacement even if active infection is present. Infections unresponsive to appropriate antimicrobial therapy after 7â
10 days (ie, persistent fevers, positive blood cultures despite therapy) are more likely to be eradicated if the valve is replaced. Surgery is nearly always
required for cure of fungal endocarditis and is more often necessary with highly resistant bacteria. It is also indicated when the infection involves the
sinus of Valsalva or produces septal abscesses. Recurrent infection with the same organism prompts an operative approach, especially with infected
prosthetic valves. Continuing embolization presents a difficult problem when the infection is otherwise responding; surgery may be the proper
approach. Particularly challenging is a large and fragile vegetation demonstrated by echocardiography in the absence of embolization. Most clinicians
favor an operative approach with vegetectomy and valve repair if the patient is a good candidate. Operation without delay may be considered in
patients with endocarditis and an ischemic stroke who have an indication for surgery. If not urgent or if intracranial hemorrhage is present, a delay of
at least 4 weeks should be considered. Embolization after bacteriologic cure does not necessarily imply recurrence of endocarditis.
H. Role of Anticoagulation
Anticoagulation is contraindicated in native valve endocarditis because of an increased risk of intracerebral hemorrhage from mycotic aneurysms or
embolic phenomena. The role of anticoagulant therapy during prosthetic valve endocarditis is more controversial. Reversal of anticoagulation may
result in thrombosis of the mechanical prosthesis, particularly in the mitral position. Conversely, anticoagulation during active prosthetic valve
endocarditis caused by S aureus has been associated with fatal intracerebral hemorrhage. One approach is to discontinue anticoagulation during the
septic phase of S aureus prosthetic valve endocarditis. In patients with S aureus prosthetic valve endocarditis complicated by a CNS embolic event,
anticoagulation should be discontinued for the first 2 weeks of therapy. Indications for anticoagulation following prosthetic valve implantation for
endocarditis are the same as for patients with prosthetic valves without endocarditis (eg, nonporcine mechanical valves and valves in the mitral
position).
RESPONSE TO THERAPY
If infection is caused by viridans streptococci, enterococci, or coagulaseÂnegative staphylococci, defervescence occurs in 3â4 days on average; with S
aureus or Pseudomonas aeruginosa, fever may persist for longer. Blood cultures should be obtained every 1â2 days to document sterilization. Other
causes of persistent fever are myocardial or metastatic abscess, sterile embolization, superimposed hospitalÂacquired infection, and drug reaction.
Most relapses occur within 1â2 months after completion of therapy. Obtaining one or two blood cultures during this period is prudent.
WHEN TO REFER
Consider consulting an infectious diseases specialist in all cases of suspected infective endocarditis.
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12. RESPONSE TO THERAPY
If infection is caused by viridans streptococci, enterococci, or coagulaseÂnegative staphylococci, defervescence occurs in 3â4 days on average; with S
aureus or Pseudomonas aeruginosa, fever may persist for longer. Blood cultures should be obtained every 1â2 days to document sterilization. Other
causes of persistent fever are myocardial or metastatic abscess, sterile embolization, superimposed hospitalÂacquired infection, and drug reaction.
Most relapses occur within 1â2 months after completion of therapy. Obtaining one or two blood cultures during this period is prudent.
WHEN TO REFER
Consider consulting an infectious diseases specialist in all cases of suspected infective endocarditis.
Consult a cardiac surgeon in the situations mentioned in the Role of Surgery section above to prevent further embolic disease, heart failure, and
other complications including death.
WHEN TO ADMIT
Patients with infective endocarditis should be hospitalized for expedited evaluation and treatment.
Baddour LM et al. Infective endocarditis in adults: diagnosis, antimicrobial therapy, and management of complications: a scientific statement for
healthcare professionals from the American Heart Association. Circulation. 2015 Oct 13; 132(15):1435â86. Erratum in: Circulation. 2015 Oct 27;
132(17):e215.
[PubMed: 26373316]
Vincent LL et al. Infective endocarditis: update on epidemiology, outcomes and management. Curr Cardiol Rep. 2018 Aug 16;20(10):86.
[PubMed: 30117004]
Wilson W et al. Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association
Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical
Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group.
Circulation. 2007 Oct 9; 116(15):1736â54.
[PubMed: 17446442]
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