The document discusses various techniques for subcellular chemical imaging, emphasizing methods that do not require labeling or invasive procedures. It highlights continuous infrared intensity monitoring and the use of a benchtop light source for illumination. The authors question the legitimacy and effectiveness of nanosensitizers in this context.

1. FOI 2013, Murten, 16-18 Sept. 2013

2. 6
6

3. Normally…
Mie theory:
Absorbed power:

4. • No prism or evanescent wave
• Continual IR intensity monitoring
• Bottom up illumination from a benchtop source.
• Can be combined in situ with other analysis systems

5. F. Yarrow, E. Kennedy, F. Salaun, J. H. Rice. Biomed Opt Express. 2011, 2(1): 37–43.

6. Rasoul Al-Majmaie et al. Proc. SPIE 8427, 2012

7. Nanosensitizer

8. Is it legitimate?
What can we do?
Is it worth it?
Is it working?
(a)
Label-free, non-invasive
subcellular chemical imaging
E. Kennedy et al. RSC Adv. 2013

9. E. Kennedy et al. RSC Adv. 2013