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Stat3 protein & immunocompetent cells cross talks in psoriasis by yousry a mawla
1.
STAT 3
Protein & Immuno Competent Cells Cross Talks in Psoriasis M.YOUSRY ABDEL-MAWLA,MD Zagazig Faculty of Medicine,Egypt .
2.
3.
Cytokines and growth
factors that activate STAT proteins
4.
5.
6.
7.
8.
9.
Regulation of the
STAT3 signal transduction pathway
10.
Regulation of intracellular
Stat3 signalling .
11.
12.
13.
Effects of STAT3
Deficiency on Cellular Function Stuart et al.T he Journal of Immunology, 2009, 182: 21–28
14.
15.
Psoriasis
16.
17.
Psoriasis Clinical Presentation
18.
Clinical Manifestations
of Psoriasis
19.
20.
21.
22.
23.
24.
25.
26.
Immunopathology of Psoriasis
( ( Nickoloff & Nestle : J Clin Invest 2004; 113: 1664–1675.).
27.
28.
29.
30.
31.
32.
33.
34.
35.
36.
Keratinocytes cross
talks among immune cells in psoriasis
37.
38.
39.
40.
41.
42.
43.
Serum IL17
& IL22 in psoriasis Inas Almakhzangy & A. Gaballa Egyptian Dermatology Online Journal 5 (1): 4, 2009
44.
45.
46.
47.
48.
49.
50.
Keratinocytes cross
talks with immune cells in psoriasis
51.
52.
53.
Proinflammatory Effects
of IL17
54.
Roles of
IL-23 on T Helper 17 cells in Chronic Inflammation in Psoriasis Adapted from Iwakura & Ishigame, J Clin Invest 116:1218-1222 (2006) Dendritic cell Macrophage IL-23 IL-12 Th1 Th17 IFN IL-1, IL-6 TNF Inflammatory response Endothelial cells Stromal cells Epithelial cells Fibroblasts Macrophage IL-17, IL-6 IL-1 IL-6 IL-8 TNF IL-12R IL-23R IL-23R
55.
56.
57.
Toll like Receptor
(TLR) in Th17 -mediated Autoimmune Inflammation ( Goriely S, Neurath M, Goldman M, Nature Rev Immunol 2007 ) IL-23 IL-12 IL-27 TLR3 TLR2 Th1 Th1 Th17 IFN- Autoimmune Inflammation polyI : C PGN IFN-
58.
59.
60.
61.
62.
63.
64.
65.
66.
67.
68.
69.
A Tender
Piece of Information
70.
71.
Studies on Stat
3 in Psoriasis
72.
Stat 3 in
Psoriasis
73.
74.
75.
76.
Manipulation of Psorasis
77.
78.
Therapeutic Targets in
Psoriasis As a T Helper 17 Cell-Mediated Disease
79.
Anti TNF approved
for psoriasis treatment JEADV 2010, 24 (Suppl. 5), 2–24
80.
81.
82.
83.
84.
85.
86.
Current Rheumatology Reports
2007 , 9:461–467
87.
88.
89.
Future Psoriasis
Therapy ( Wippel-Slupetzky&Stingl Curr Probl Dermatol., 2009, 38, : 172–189 )
90.
Future Psoriasis
Therapy ( Wippel-Slupetzky&Stingl Curr Probl Dermatol., 2009, 38, : 172–189 )
91.
92.
Message Home
93.
94.
95.
THANK YOU
Editor's Notes
39
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