1. Publications of Full Refereed Papers: 1972-2014
1. Razmovski-Naumovski V, Liew MC, Good AJ, Ren J, Liang H, Chan K (2014). English
translation and content validation of the Chinese quality of life (ChQOL) instrument. Health
Qual Life Outcomes; submitted.
2. Kam A, Li KM, Razmovski-Naumovski V, Nammi S, Chan K, Grau G, Li GQ (2014)
Curcumin reduces microparticle release induced by tumout necrosis factor in human vascular
endothelial cells. Biochemical & Biophysical Research Communications, submitted
3. Wong KH, Razmovski-Naumovski V, Li KM, Li QQ & Chan K (2014) Comparing
morphological, Chemical and abti-diabetic characterisation of Puerariae Lobatae Radix and
Puerariae Thomsonii Radix. Journal of Ethnopharmacology, submitted.
4. Zhou X, Razmovski-Naumovski V, Grace R, Chan K (2014) A comparison study of
Notoginseng Radix et Rhizoma (Sanqi) raw herb and granule by thin layer chromatography
and ultra-performance liquid chromatography using multivariate methods. BMC-Chinese
medicine, accepted.
5. Wong KH, Razmovski-Naumovski V, Li KM, Li GQ, Chan K. (2014) Differentiating
Peurariae Lobatae Radix and Peurariae Thomsonii Radix using HPTLC coupled with
multivariate classification analyses. Journal of Pharmaceutical and Biomedical Analysis, 95
(2014): 11-19.
6. Su Y, Wang Q, Wang C, Chan K, Sun Y, & Kuang H (2014) Anti-alzheimer’s disease
progress on anti-AD effects on AD models, animal and cellular model from Chinese medicinal
plants. Journal of Ethnopharmacology, 152 (3): 403-423.
7. Liu ZL, Li GQ, Bensoussan A, Kiat H, Chan K, Liu JP. (2013) Chinese herbal medicines for
hypertriglyceridaemia. Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.:
CD009560. DOI: 10.1002/14651858.CD009560.pub2.
8. Kam A, Li KM, Razmovski-Naumovski V, Nammi S, Chan K, Li GQ (2013) Gallic acid
protects against endothelial injury by restoring the depletion of DNA methyltransferase 1 and
inhibiting proteasome activities. International Journal of Cardiology, 171: 231-242.
(IF=5.509)
9. Wang Q, Wang C, Shu Z, Chan K, Huang S, Li Y, Yang X, Wu L Kuang H & Sun X (2013).
Valeriana amurensis improves Amyloid-beta 1.42 induced cognitive deficit by enhancing
cerebral cholinergic function and protecting the brain neurones from apoptosis in mice.
Journal of Ethnopharmacology, DOI: 1:1016/j-jep.2013.11.017.
10. Wong KH, Razmovski-Naumovski V, Kong ML, Li GQ, Chan, K (2013) Differentiation of
Pueraria lobata and Pueraria thomsonii using partial square discriminant analysis (PLS-DA).
Journal of Pharmaceutical and Biomedical Analysis, 84: 5-13.
11. Kam A, Kong ML, Razmovski-Naumovski V, Nammi S, Chan K, Li GQ (2013) Variability
of the polyphenolic content and antioxidant capacity of methanolic extracts of pomegranate
peel. Natural Product Communication, 8, 1-4.
12. Chong C-M Zhou Z-Y Razmovski-Naumovski V, Cui G-Z, Zhang L-Q, Sa F, Hoi P-M, Chan
K, Lee SM-Y (2013) Danshensu protects against 6-hydroxydopamine-induced damage of
PC12 cells in vitro and dopaminergic neurons in zebrafish. Neuroscience Letters:
DOI:10.1016/j.neulet.2013.02.069. (IF=2.11).
13. Chua M, Hocking TJ, Chan K and Baldwin TC (2013). Temporal and spatial regulation of
glucomannan deposition and mobilization in corms of Amorphophallus konjac K. Koch.
American Journal of Botany, 100: 337 – 345. (IF = 2.664 in 2011; top 47/190).
14. Kim EJ, Chen Y, Huang JQ, Li KM, Razmovski-Naumovski V, Poon J, Chan K, Roufogalis
BD, McLachlan AJ, Mo SL, Yang D, Yao M, Liu Z, Liu J, Li GQ, (2013). Evidence-based
toxicity evaluation and scheduling of Chinese herbal medicines. Journal of
Ethnopharmacology 146: 40–61. (IF=2.32)

2. 15. Alqahtani A, Hamid K, Kam A, Wong KH, Abdelhak Z, Razmovski-Naumovski V, Chan K,
Li KM, Groundwater PW, Li GQ (2013). The pentacyclic triterpenoids in herbal medicines
and their pharmacological activities in diabetes and diabetic complications. Current Medicinal
Chemistry 20: 908-931.
16. Wang Q, Kuang H, Su Y, Sun Y, Feng J, Guo R, Chan K (2013). Naturally derived anti-inflammatory
compounds from Chinese medicinal plants. Journal of Ethnopharmacology
140: 9-39.
17. Li GQ, Kam A, Wong KH, Zhou X, Omar EA, Alqahtani A, Li KM, Razmovski-Naumovski
V, Chan K, (2012). Herbal medicines for the management of diabetes. Advance in
Experimental Medical Biology 771: 396-413.
18. Li, GQ, Wong KH, Kam A, Zhou X, Omar EA, Alqahtani A, Li KM, Razmovski-Naumovski
V, Chan K, (2012). Anti-Inflammatory Nutraceuticals and Herbal Medicines for the
Management of Metabolic Syndrome, In: Roy, S., Bagchi, D., Raychaudhuri, S.P. (Eds.),
Chronic Inflammation, Molecular Pathophysiology, Nutritional and Therapeutic
Interventions. CRC Press, California, pp. 337-350.
19. Ip PSP, Tsim KWK, Chan K & Bauer R (2012). Application of complementary and
alternative medicine on neurodegenerative disorders: Current status and future prospects.
Evidence-Based Complementary and Alternative Medicine. Vol 2012,
doi:10.1155/2012/930908. (IF = 4.774).
20. Hung MW, Zhang ZJ, Li S, Lei B, Yuan S, Cui GZ, Hoi PM, Chan K & Lee SMY (2012)
From Omics to drug metabolism and high content screen of natural product in Zebrafish: A
new model for discovery of neuroactive compound. Evidence-Based Complementary &
Alternative Medicine, Vol 2012 doi: 101155/2012/605303. (IF= 4.774)
21. Fan Q, Zhou J, Bovey M, Franconi G, Chan K, Smith C, Jiang, D & Robinson N (2012) Does
acupuncture improve the outcome of in vitro fertilization? Guidance for future trials.
European Journal of Integrative Medicine. 4: e234-e244 (IF=0.775)
22. Kam A, Li KM, Razmovski-Naumovski V, Nammi S, Chan K, Li GQ 2012, Combination of
TNF-α, homocysteine and adenosine exacerbated cytotoxicity in human cardiovascular and
cerebrovascular endothelial cells. Cellular Physiology & Biochemistry, 30: 805-814 (Impact
factor=3.585)
23. Kam A, Li KM, Razmovski-Naumovski V, Nammi S, Chan K, Li Y & Li GQ (2012). The
protective effects of natural products on blood-brain barrier breakdown. Current Medicinal
Chemistry. 19: 1830-1845 (Impact factor=4.774).
24. Chan, K., Shaw, D., Simmonds, M.S.J, Leon C.J., Xu, Q., Lu, A., Sutherland, I., Ignatova, S.,
Zhu, Y.-P., Verpoorte, R., Williamson, E.M., Duez, P., (2012). Good practice in reviewing and
publishing studies on herbal medicine, with special emphasis on traditional Chinese medicine
and Chinese materia medica. Journal of Ethnopharmacology, 140: 469-475 (Impact Factor =
3.216).
25. Ouedraogo, M., Baudoux, T., Stévigny, C., Nortier, J., Colet, J.-M., Efferth, T., Qu, F., Zhou,
J., Chan, K., Shaw, D., Pelkonen, O., Duez, P., (2012). Review of current and "omics"
methods for assessing the toxicity (genotoxicity, teratogenicity and nephrotoxicity) of herbal
medicines. Journal of Ethnopharmacology, 140: 492-512. (Impact Factor = 3.216)
26. Pelkonen, O., Pasanen, M., Lindon, J.C., Chan, K., Zhao, L., Deal, G.,Xu, Q., Fan, T.-P.,
(2012). Omics and its potential impact on R&D and regulation of complex herbal products.
Journal of Ethnopharmacology, 140: 587-593. (Impact Factor = 3.216)
27. Shaw, D., Ladds, G., Duez, P., Williamson E., Chan, K., (2012). Pharmacovigilance of herbal
medicines. Journal of Ethnopharmacology, 140: 513-518 (Impact Factor = 3.216).
28. Zhang, L., Yan, J., Liu, X., Ye, Z., Yan, X., Meyboom, R.H.B., Chan, K., Shaw, D., Duez, P.,
2012. Pharmacovigilance practice and risk control of traditional Chinese medicine drugs in
China: Current status and future perspective. Journal of Ethnopharmacology, 140: 519-525
(Impact Factor = 3.216).
29. Fan, T.-P., Deal G., Koo H.-L., Rees, D., Svedlund L., Chen, S., Dou, J.-H., Makarov, V.G.,
Pozharitskaya, O.N., Shikov, A.N., Kim, Y.S., Huang Y.-T., Chang Y.S., Jia, W., Dias, A.,
Chan, K., (2012). Future development of global regulations of Chinese herbal products.

3. Journal of Ethnopharmacology, 140: 568-586 (Impact Factor = 3.216).
30. Jiang, M., Lu, C., Zhang, C., Yang, J., Tan, Y., Lu, A., Chan, K., (2012). Syndrome
differentiation in modern research of traditional Chinese medicine. Journal of
Ethnopharmacology, 140: 634-642. (Impact Factor = 3.216)
31. Yeung, JHK Zhou XL, Chan K (2012) Herb-drug interactions with Danshen (Salvia
miltiorrhiza): A review on the role of cytochrome P450 enzymes. Drug Metabolism & Drug
Interactions, 27: 9 -18.
32. Chua M. Chan K, Hocking TR, Williams PA, Perry CJ, & Baldwin TC (2011) Methodologies
for the extraction and analysis of konjac glucomannan from corms of Amorphophallus konjac
K. Koch. Carbohydrate Polymers, 87: 2202-2210. ( IF=3.656)
33. Lu AP, Jiang M, Zhang C & Chan K (2011) An integrative approach of linking traditional
Chinese medicine pattern classification and biomedicine diagnosis. Journal of
Ethnopharmacology, 141: 549-556 (Impact Factor = 3.216)
34. Jiang M, Zhang C, Cao H, Chan K & Lu A (2011) The role of Chinese medicine in the
treatment of chronic diseases in China. Planta Medica, 77: 873-811. (IF=3.098)
35. Chan K, Zhang HW, and Lin ZX (2011) Treatments used in complementary and alternative
medicine. In Jeffrey Aronson, editors: Side Effects of Drugs Annual, 33, SEDA, : Elsevier,
2011, pp. 989-1008
36. Poon,, S.K., Poon, J. McGrane, M., Zhou, X, Kwan, P., Zhang, R, Liu, B., Gao, J., Loy, C.,
Chan K and Sze, D.M (2011), A Novel Approach in Discovering Significant Interactions
from TCM Patient Prescription Data, International Journal of Data Mining and
Bioinformatics 5: 353-368. (IF=0.93)
37. Yeh JC, Cindrova-Davies T, Belleri M, Morbidelli L, Miller, N, Cho CWC, Chan K, Wang
YT, Luo GA, Ziche M, Presta M, Charnock-Jones, DS & Fan TP (2011). The natural
compound n-butylidenphthalide drived from the volatile oil of Radix Angelica sinensis inhibits
angiogenesis in vitro and in vivo. Angiogenesis, 14: 187-197 (IF=6.188).
38. Wong KH, Li G, Li KM, Razmovski-Naumovski V & Chan K (2011) Kudzu root: traditional
uses and potential medicinal benefits in diabetes and cardiovascular diseases. Journal of
Ethnopharmacology, 134: 584-607. (IF=2.466)
39. McGrane, M, Poon S.K., Poon, J., Zhou, Z., Zhang, R., Liu, B., Loy, C., Kwan, P., Chan, K.,
Sze, D. and Gao, J. (2010), Analysis of Synergistic and Antagonistic Effects of TCM: Cases
on Diabetes and Insomnia, In Proceedings of the International Workshop on Information
Technology for Chinese Medicine, In Conjunction with the IEEE International Conference
on Bioinformatics & Biomedicine (BIBM 2010), December 18-21, Hong Kong, pp 620-624.
40. Poon, J., Poon, S.K., Zhou, Z., Zhang, R., Yin, D., Liu, B., Loy, C., Kwan, P., Chan, K., Sze,
D. and Gao, J. (2010), Studying Herb-Herb Interaction in TCM through the theory of
Complementarities, In Proceedings of the International Workshop on Information Technology
for Chinese Medicine, In Conjunction with the IEEE International Conference on
Bioinformatics & Biomedicine (BIBM 2010), December 18-21, Hong Kong, pp 722-726.
41. Omar EA, Kam A, Alqahtani, Li KM, Razmovski-Naumovski, Nammi S, Chan K, Roufogalis
BD & Li G (2010) Herbal medicines and nutraceuticals for diabetic vascular complications:
mechanisms of action and bioactive phytochemicals. Current Pharmaceutical Design, 16:
3776-3807. (IF=4.774)
42. Zhao Z, Liang Z, Chan K, Lu G, Lee E, Chen H & Li L (2010) A unique issue in the
standardization of Chinese materia medica: Processing. Planta Medica, 1975-1986.
(IF=3.098)
43. Sun S, Chen J, Zhou Q, Lu G & Chan K (2010). Application of Mid-infrared spectroscopy in
the quality control of traditional Chinese medicines. Planta Medica, 1987- 1996. (IF=3.098)
44. Liang YZ, Xie PS & Chan K (2010) Perspective of Chemical fingerprinting of Chinese herbs.
Planta Medica, 1997-2003. (IF=3.098)
45. Jiang M, Yang J, Zhang C, Liu B, Chan K, Cao & Lu A (2010) . Clinical studies with
traditional Chinese medicine in the past decade. Planta Medica, 2048-2064. (IF=3.098).
46. Chan K & Lin ZH (2010) Treatments used in complementary and alternative medicine.
Chapter 48. In: Side Effects of Drugs Volume 32, edited by JK Aronson, Elsevier BV.

4. 47. Chua F Y, Baldwin T, Hocking T & Chan K (2010) Traditional uses and potential health
benefits of Amorphophallus konjac K.Koch ex N.E.Br Journal of Ethnopharmacology,
128:268-278. (IF=2.466; 23 citations)
48. Lu G-H, L Cheng S-Q, Chan K, Leung KSY, & Zhao Z-Z. (2010). Determination of free
ferulic acid and total ferulic aid in Chuanxiong by high-performance liquid chromatography
for quality assessment. China Journal of Chinese Materia Medica, 35 (2): 49-53, 2010.
49. Liang Y-Z, Xie P-S, & Chan K (2010). Chromatographic fingerprinting and metabolomics for
quality control of TCM. Combinatorial Chemistry & HTS, 13: 943-953. (IF= 2.46)
50. Chui SH, ChanK, Shek S L, Zhao L Fong MY, Hui I, Shum S (2010). A panel study to assess
the quality of life assessments in patients suffering from allergic rhinitis after treatment with a
Chinese herbal nasal drop. Phytotherapy Research. 24: 609-613. (IF= 1.878)
51. Singh SP, Singh V, Kar N & Chan K (2010) Efficacy of antidepressants in negative
symptoms of chronic schizophrenia: systematic review and meta-analysis. British Journal of
Psychiatry. 197: 174-179. (IF=5.947).
52. Singh V, Singh S & Chan K (2010). Review and meta-analysis of usage of Ginkgo as an
adjunct therapy in chronic schizophrenia. The International Journal of
Neuropsychopharmacology. 13:257-271. (IF=4.87)
53. Chan, K & Lin TX (2009) Treatments used in complementary and alternative medicine.
Chapter 48. In: Side Effects of Drugs Volume 31, edited by JK Aronson, Elsevier BV.
54. Chan K, Leung KSY & Zhao SS (2009). Harmonization of monographic standards is needed
to ensure the quality of Chinese medicinal materials. Biomed Central: Chinese
Medicine , 4:18 (IF=1.24)
55. Wang JS, Vander Heijden R, Spruit S, Hankermeier, Chan K, Van der Greef J, Xu GW &
Wang M (2009) Quality and safety of Chinese medicine herbal medicines guided by a systems
biology perspective. Journal of Ethnopharmacology, 126: 31-41. (IF=2.466).
56. Yu H, Li WM, Cheung MC, Zuo Z, Carlier PR, Gu ZG, Chan K, Huang M, Wang YT Han
YF (2009). Development and validation of an HPLC-DAD method for bis(12)-hupyridone and
its application to a pharmacokinetic study. Journal of Pharmaceutical and Biomedical
Analysis, 49: 410-414. (IF= 2.723)
57. Chan K (2008). An overview on safety issues of interactions between traditional herbal
medicines and pharmaceutical medicines. Latinoamericano y del Caribe de Plantas
Medicinales y Aromáticas 7 (6), 311 – 330.
58. Zhao L, Leung KF, Liu FB, Chen J, Chan K (2008) Responsiveness of the Chinese quality of
life instrument in patients with congestive heart failure. Chinese Journal of Integrative
Medicine. 14 (3): 173-179.
59. Chui SH, Chow FC, Chan K, Fu S & Seto YT (2008) Slimpid may boost plasma IGF-1 level
and improve the quality of life in patients with risk of developing metabolic syndrome.
Journal of Complementary & Integrative Medicine. 5: (Issue 1), article 17, 1-13.
60. Zhang L, Yu H, Li WM, Cheung MC, Pang YP, Gu ZM, Chan K, Wang YT, Zuo Z , Han YF
(2008) Preclinical characterization of intestinal absorption and metabolism of promising anti-
Alzheimer’s dimer bis(7)-tacrin. International Journal of Pharmaceutics. 357: 85-94.
61. Yu H, Kan KKW, Ho JMK, Li WM, Carlier PR, Pang YP, GU ZM, Chan K, Wang YT &
Han YF (2008) The physicochemical properties and the in vivo AChE inhibition of two
potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine. Journal of
Pharmaceutical and Biomedical Analysis, 46: 75-81.
62. Cui L, Chan W, Wu J-L, Jiang Z-H, Chan K, Cai Z (2008) High Performance liquid
chromatography-mass spectrometry analysis for rat metabolism and pharmacokinetic studies
of lithospermic acid B from danshen, Talanta 75: 1002-1007.
63. Yi T, Leung KSY, Lu GU, Zhang H & Chan K (2007) Identification and determination of the
major constituents in traditional Chinese medicinal plant Polygonum multiflorium tunb by
HPLC coupled to PAD and ES!/MS. Phytochemical Analysis 18: 181-187.
64. Lu G-H, Leung KSY, Chan K, Cheng S-Q, Zhang H & Zhao Z-Z. (2007) Determination of
free and total available ferulic acid in different types of Chinese angelica by high performance
liquid chromatography. Journal of Food and Drug Analysis, 15:438-446.

5. 65. Yu H, Ho JMK, Kan KKW, Cheng BWH, Li WM, Lin G, Pang YP, Gu ZM, Chan K, Wang
YT Li Z & Han YF (2007) Development of a high performance liquid chromatography-tandem
mass method for determination of bis(7)-tacrine, a promising anti-Alzheimer’s dimer,
in rat blood. Journal of Pharmaceutical and Biomedical Analysis. 44: 1133-1188.
66. Tin MMY, Cho CH, Chan K, James AE & Ko JKS. (2007) Astragalus saponins induce
growth inhibition and apoptosis in human colon cancer cells and tumor xenograft.
Carcinogenesis 28 (6): 1347-1355.
67. Yu H, Li WM, Kan KKW, Chan K, Wang YT & Han YF (2007) An overview on the
progress of pharmacokinetics of anti-Alzheimer drugs. Chinese Pharmaceutical Journal. 42:
1121- 1125. (in Chinese).
68. Leung, K.W, Cheng, Y-K., Mak, N.K., Chan K, Fan, T.P.D. and Wong, R.N.S. (2006)
Signalling pathway of ginsenoside-Rg1 leading to nitric oxide production in endothelial cells.
FEBS Letters, 580: 3211-3216.
69. Fang Kai-Tai, Liang Yi-Zhen, Yin Xiao-lin, Chan K, Lu Guang-Hua (2006) Critical value
determination on similarity of fingerprints. Chemometrics and Intelligent Laboratory System.
82: 236-240.
70. Qing Lin-Sen, Zhang Hao, Lu Guang-hua, Chan K, Leung Kelvin Sze-Yin, Chen Chu (.2006)
Determination of oleanolic acid in Caulis Clematidis armandii by HPLC. West China Journal
of Pharmacy Science. 21(3): 273-4.
71. Cheung TP, Xue C, Leung K, Chan K, & Li CG (2006) Aristolochic acids detected in some
raw Chinese medicinal herbs and manufactured herbal products-A consequence of
inappropriate nomenclature and imprecise labelling? Clinical Toxicology 44: 371-378.
72. Liu, H-X, Sun S-Q, Lu G-H & Chan, K, (2006) Study on Angelica and its different extracts
by Fourier transform infrared spectroscopy and two-dimensional correlation IR spectroscopy.
Spcetrochimca acta part A: 64: 321-326.
73. Chan K, Liu ZQ, Jiang ZH, Zhou H, Wong YF, Xu HX, Liu L (2006). The effects of
sinomenine on intestinal absorption of paeoniflorin by the everted rat gut sac model. Journal
of Ethnopharmacology. 103: 425-432.
74. Ha WY, Lay CC, Yue PYK, Hung KKM, Chan K, Chui SH, Yam WC, & Wong RNS (2006)
Simultaneous detection of precore/basal core promoter mutations in hepatitis B virus using
arrayed primer extension. Molecular Diagnosis & Therapy: 10 (2), 125-134.
75. Yi T, Leung, K S-Y, Lu G-H, Chan K & Zhang H (2006) Simultaneous qualitative analysis of
the major constituents in the Rhizome Ligusticum Chuanxioang using HPLC-DAD-MS.
Chemical & Pharmaceutical Bulletin. 54 (2) 255-259.
76. Zhao L & Chan K (2005) Building a bridge for integrating Chinese medicine into
conventional healthcare: Observations drawn from the Chinese Quality of Life Instrument
development. American Journal of Chinese Medicine, 33: 897-902.
77. Yue, P.Y.K., Wong Y.L., Ha, W.Y., Fung, M.C., Mak, N.K., Yeung, H.W., Liu, L., Chan K,
Fan, T.P. and Wong, R.N.S. (2005) Elucidation of mechanisms underlying the angiogenic
effects of ginsenoside Rg1 in vitro and in vivo. Angiogenesis 8(3): 205-216.
78. Liu, ZQ, Chan K, Zhou H, Jiang Z H, Wong YF, Xu HX, & Liu L (2005) The
pharmacokinetics and tissue distribution of sinomenine in rats and its protein binding ability in
vitro. Life Sciences 77: 3197-3209.
79. Zhao L. & Chan K (2005) Patient-reported outcomes (PROs): An approach to evaluate
treatment efficacy of Chinese medicine or integrative medicine. Chinese Journal of
Integrative Medicine, 11(2): 151-153.
80. Zhao L., Chan K, Leung K.F., Liu F.B., Lang J.Y. & Fang J.Q. (2005) The Chinese Quality of
Life Instrument: Development of a new health-related quality of life using factor analysis and
structural equation modelling. Journal of Complementary and Integrative Medicine, 2 (1):
Article 7, 1-22.
81. Leung, K. S.Y., Chan K, Chan, C.L. & G-H Lu, (2005) Systematic Evaluation of
Organochlorine Pesticide Residues in Chinese Materia Medica. Phytotheraphy Research,
19:514-518.

6. 82. Chui S.H., Chan K, Chui A.K.K., Shek L.S.L. & Wong R.N.S. (2005). The effects of a
Chinese medicinal suppository (Vitalliver) on insulin-like growth factor-1 and homocysteine
in patients with hepatitis B infection. Phytotherapy Research, 19: 674-678.
83. Leung, K. S.Y., Chan, C. L. & Lau, A. C. Chan K (2005) Measurement Uncertainty for Total
Ash and Acid-Insoluble Ash Determination of Chinese Materia Medica. Accreditation and
Quality Assurance 10:289-294.
84. Liu, Z.Q., Zhou, H., Liu, L., Jiang, Z.H., Wong, Y.F., Xiea, Y., Cai, X., Xu, H.X., & Chan K
(2005) Influence of co-administrated sinomenine on pharmacokinetic fate of paeoniflorin in
unrestrained conscious rats. Journal of Ethnopharmacology, 99:61-67.
85. Leung K.F., Liu F.B., Zhao L., Fang J.Q., Chan K & Lin L.Z. (2005) Development and
validation of the Chinese Quality of Life Instrument. Health and Quality of Life Outcomes,
3:26, 1-19. (IF=2.27).
86. Lu, G.H., Chan K, Liang, Y.Z., Leung, K.S.Y., Chan, C.L., Jiang, Z.H., & Zhao, Z.Z. (2005)
Development of high-performance liquid chromatographic fingerprints for distinguishing
Chinese Angelica from related umbelliferae herbs. Journal of Chromatography A, 1073, 1-2,
383-392.
87. Zhao L., Chan K, Leung K.F., Liu F.B. & Fang J.Q. (2005) The conceptual structure of the
Chinese Quality of Life (ChQOL) Instrument. Annals of Traditional Chinese Medicine,
Chinese Medicine - Modern Practice, Volume 1, Page 187-195. (ISBN 981-256-016-1).
88. Lu, G.H., Chan K, Leung, K.S.Y., Chan, C.L., Zhao, Z.Z., & Jiang, Z.H. (2005) Assay of free
ferulic acid and total ferulic acid for quality assessment of Angelica Sinensis. Journal of
Chromatography A, 1068, 209-219
89. *Chan, K. (2005). Chinese medicinal materials and their interface with Western medical
concepts. Journal of Ethno-pharmacology, 96 (2005) 1-18.
90. Hu SL*, Zhang HQ, Chan K, & Mei QX (2004). Studies on the toxicity of Aristolochia
manshuriensis (Guanmuton). Toxicology, 198:195-201.
91. Liang, Y.Z., Xie, P.S. & Chan K (2004) Quality control of herbal medicines. J.
Chromatography. B, 812, 1-2, 53-70.
92. Liu F.B. & Zhao L., Leung, K.F., Fang, J.Q., Lin, L.Z., & Chan K (2004). Discussing the
probability and steps of setting up the system of instruments used for assessment of clinical
effectiveness of traditional Chinese medicine. Chinese Journal of Clinical Rehabilitation,
8(1): 164-165. (In Chinese).
93. Zhao L., Liu F.B., Leung K.F., Fang J.Q., Lin L.Z. & *Chan K. (2004). Discussion on the
theory and structure model of the Chinese quality of life instrument. Chinese Journal of
Clinical Rehabilitation, 8(16): 3132-3134. (In Chinese).
94. Zhao L., Chan K, Leung K.F., Liu F.B. & Fang J.Q. (2004). Application of factor analysis in
development and validation of a new questionnaire for quality of life. Chinese Journal of
Integrated Traditional and Western Medicine, 24(11): 965-968. (In Chinese).
95. Chui, SH., Chan K, & Wong, RNS. (2004) A panel study on the effects of a Chinese
medicinal suppository, Vigconic VI-28, on insulin-like growth factor-1 and homocysteine in
healthy men. Methods and Findings in Experimental and Clinical Pharmacology, 26(5) 349
– 355.
96. Leung, K.S. Y., & Chan K,. (2004). Regulatory System of Proprietary Chinese Medicine in
Hong Kong. Journal of Complementary and Integrative Medicine, vol. 1, issue 1
97. Lu, G.H., Chan K, Chan, C.L., Leung, K.S.Y., Jiang, Z.H., & Zhao, Z.Z. (2004)
Quantification of ligustilides in the roots of Angelica sinensis and related umbelliferous
medicinal plants by high-performance liquid chromatography and liquid chromatography-mass
spectrometry. Journal of Chromatography A, 1046: 101-107.
98. Chan K, Chui, SH., Wong, DYL, Ha, WY, Chan, CL, & Wong, RNS. (2004) Protective
effects of Danshensu from the aqueous extract of Salvia miltiorrhiza (Danshen) against
homocysteine-induced endothelial dysfunction. Life Sciences, 75: 3157 – 3171.
99. Lu, G.H., Sun, S.Q., Leung, H.W., & Chan K (2004) Study on the identification of
Dangguitou and Dangguiwei by Two-Dimensional infrared correlation spectroscopy.
Spectoscopy and Spectral Analysis. 24(3): 311-314.

7. 100. Zhao L. & Chan K, (2003). The health concept in Chinese medicine. Medicine and
Philosophy, 24(12): 58-59. (In Chinese).
101. Zhao L. & Chan K (2003). Quality of life assessment: An outcome estimation of Chinese
medical treatment. Chinese Journal of Integrative Medicine. 9(4): 299-301.
102. Di X., Chan K, Leung, H. W. and Huie, C.H. (2003) Fingerprint profiling of acid
hydrolyzates of polysaccharide extracted from the fruiting bodies and spores of Lingzhi by
high-performance thin-layer chromatography. J. Chromatography A, 1018, 85-95.
103. Hu S.L., Zhang, H.Q. Chan K, Mei, Q.X. (2003) Preliminary studies on the toxicity of Guang
Fang Ji. Zhong Yao Cai, (Chinese Materia Medica), 26 (4), 274-277. (ISSN 1001-4454, in
Chinese).
104. Choi, M.P.K., Chan K, Leung H.W. and Huie, C.W. (2003) Pressurised liquid extraction of
active ingredients (ginsenosides) from medicinal plants using non-ionic surfactant solutions.
Journal Chromatography A, 983,153-162.
105. Chan K (2003). Some aspects of toxic contaminants in herbal medicines. Chemosphere, 52,
1361-1371.
106. Song, Z.H., Bi, K. S., Xu, L & Chan K (2002). The isolation, identification and
determination of dehydrotumulosic acid in Poria cocos. Analytical. Sciences. 18, 529-531.
107. Chan K (2001). Generating fingerprinting from analytical techniques alone is not enough in
the assurance for quality, efficacy and safety of Chinese medicinal herbs and herbal products.
Analytical. Sciences, 17 (Suppl.), a409-a412.
108. Radhakrishnan, R. Zakaria, M.N.M. Islam, M.W. Chen, H.B. Kamil, M. Chan, K. & Al-
Attas, A. (2001) Neuropharmacological actions of Portulaca oleraceae L v. sativa (Hawk),
Journal of Ethnopharmacology. 76 (2) 171 - 176.
109. Zakaria, M.N.M. Islam, M.W. Radhakrishnan, R. Chen, H.B. Kamil, M. Al-Gifri, A.N. Chan,
K. Al-Attas, A. (2001) Anti-nociceptive and anti-inflammatory properties of Caralluma
arabica, Journal of Ethnopharmacology 76 (2), 155 - 158.
110. Liu, X.M., Zakaria, M.N.M.,. Islam, M.W, Radhakrishnan, R., Ismail, A., Chen, H.B., Chan,
K. &. Al-Attas, A. (2001) Anti-inflammatory and anti-ulcer activity of Calligonum comosum
in rats. Fitoterapia, 72, 487-491.
111. Kamil, M. Chan, K., Habibullah, M. (2000) A review on Portulaca species—with special
reference to Portulaca oleracea. Australian Journal of Medicinal Herbalism, 12 (2), 43-48.
112. Chan K, Islam M.W., Kamil M., Radhakrishnan R., Zakaria M.N.M., Habibullah M., & Attas
A. (2000) The analgesic and anti-inflammatory effects of Portulaca oleracea L. subsp. Sativa
(Haw.) celak. Journal of Ethnopharmacology 73 (3):445-51.
113. Kamil, M., Ahmad F., Jayaraj, A. F., Gunasekhar, C., Thomas, S., Habibullah, M. & Chan, K.
(2000), Isolation and identification of a flavonol glycoside using high speed counter current
chromatographic technique from the leaves of Salvadora persica. Pakistan Journal of Science &
Industrial Research, 43 (4), 255-257.
114. Kamil, M., Ahmad F., Jayaraj, A. F., Gunasekhar, C., Thomas, S., Habibullah, M. & Chan, K.
(1999), Pharmacognostical and studies on Salvadora persica L. Hamdard Medicus, 42 (3), 64-75.
115. Chan, K. (1999) A comparison of practice of Chinese medicine in Europe and the Middle East.
Chinese Traditional & Herbal Drugs (Zhong Cao Yao), 30, 157-159. (in Chinese).
116. Chan, E., Chan, K. & Teoh, R. (1997). Determination of phenobarbitone population clearance
values of physically and mentally handicapped Chinese children with epilepsy. Journal of
Clinical Pharmacy & Therapeutics. 22, 399-403.
117. Lunn J, Chan K, Donoghue J, Riley B & Walley T (1997) A study of the appropriateness of
prescribing in nursing homes. International Journal of Pharmacy Practice, 5: 6-10.
118. Wing, Y.K., Chan, E., Chan, K., Lee, S., & Shek, C.C. (1997). Lithium pharmacokinetics in
Chinese manic-depressive patients. Journal of Clinical Psychopharmacology 17, 179-184.
119. Chen, A.G., Wing, Y.K., Chiu, H., Chen, C.N. & Chan, K. (1997). Simultaneous determination
of imipramine, desipramine, and their 2OH- and 10-OH hydroxylated metabolites in human
plasma and urine by high performance liquid chromatography. Journal of Chromatography
Biomedical Application, 693, 153-158.
120. Woo, J., Cheung, W., Chan, H.S., Chan, C. P., & Chan, K. (1996). In vitro protein binding
characteristics of isoniazid, rifampicin and pyrazinamide to whole plasma, albumin, and alpha-1-

8. acid glycoprotein. Clinical Biochemistry, 29, 1-3.
121. Woo, J., Chan, C., Chan, R., Cheung, W., Or, K., & Chan, K. (1995). Correlation between
steady-state plasma concentrations of anti-tuberculous drugs and age, inclusion of rifampicin in
the treatment regimen, adverse reactions and other clinical parametres. Journal of Medicine, 26,
279-294.
122. Chan, K. (1995) Progress in traditional Chinese medicine. Trends in Pharmacological
Sciences, 16, 182-187. (An Invited Special Feature).
123. Yang, J.M., & Chan, K. (1995). Isolation and characterisation of sulphoxidation metabolites of
moricizine in rat and human biological fluids. Methods & Findings in Experimental & clinical
Pharmacology, 17, 415-421.
124. Chan, K., Lo, A.C.T., Yeung, J.H.K. & Woo, K.S. (1995). The effects of Danshen (Salvia
miltiorrhiza) on warfarin pharmacodynamics and pharmacokinetics of warfarin enantiomers in
rats. Journal of Pharmacy & Pharmacology, 47, 402-406.
125. Lo, A.C.T., Chan, K., Yeung, J.H.K. & Woo, K.S. (1995). Danggui (Angelica sinesis) affects
the pharmacodynamics not the pharmacokinetics of warfarin in rabbits. European Journal of
Drug Metabolism & Pharmacokinetics, 20, 41-46.
126. Yang, J.M. & Chan, K. (1995). The simultaneous determination of moricizine and its
sulphoxidation metabolites in biological fluids by high-performance liquid chromatography.
Journal of Chromatograph: Biomedical Application, 663, 172-176.
127. Wang, Q., Yeung, H.M., & Chan, K. (1994). Studies on the identification and analysis of
borneol. Journal of Chinese Herbal Medicine, 25, 241-244.
128. Houghton, I.T., Aun, C.S.T., Wong, Y.C., Chan, K., Lau, J.T.F. & Oh, T.E. (1994). The
respiratory depressant effect of morphine: A comparative study in three ethnic groups.
Anaesthesia, 49, 197-201.
129. Wang, Q., Yeung, H.W. & Chan, K. (1993). Determination of borneol and isoborneol in 27
species of Liu-Shen-Wan by GC. Journal of China Pharmaceutical University, 24, 318-320.
130. Tang, P.W., Crone, D.L., Chu, C.S., Yeung, J.H.K. & Chan, K. (1993). Measuring the
nandrolone threshold ratio by enzyme-linked immunosorbent assay for 5a-estrane-33,17a-diol.
Analytica Chimica. Acta 275, 139-146.
131. Lee, K. & Chan, K. (1993). Biopharmaceutical studies of a formulated epirubicin emulsion.
Pharmaceutical Science Communications, 4, 39-44.
132. Houghton, I.T., Chan, K., Wong, Y.C., Leung, D.H.Y. & Aun, C.S.T. (1993).
Biotransformation of pethidine: A comparative study of 24 hour urine in three ethnic groups.
European Journal of Drug Metabolism & Pharmacokinetics, 18, 285-288.
133. Chan, K. & Jones, R.D.M. (1993). Simultaneous determination of flumazenil, midazolam and
metabolites in human biological fluids by liquid chromatography. Journal of Chromatograph:
Biomedical Application, 619, 154-160.
134. Houghton, I.T., Aun, C.S.T., & Chan, K. (1993). Pethidine pharmacokinetics in a heroin addict:
A case report. Journal Clinical Pharmacy & Therapeutics, 18, 139-140..
135. Jones, R.D.M., Chan, K., Roulson, C.J., Brown, A.G., Smith, I.D. & Mya, G.H. (1993).
Pharmacokinetics of flumazenil and midazolam in paediatric patients. British Journal of
Anaesthesia, 70, 286-292.
136. Dambisya, Y.M., Chan, K. & Wong, C.L. (1992). Further metabolic studies of codeine and
morphine in mice pretreated with sympathomimetics. Methods & Findings in Experimental &
Clinical Pharmacology 14, 733-780.
137. Lo, A.C.T., Chan, K., Yeung, J.H.K. & Woo, K.S. (1992). The effects of Danshen (Salvia
miltiorrhiza) on pharmacokinetics and pharmacodynamics of warfarin in rats. European Journal
of Drug Metabolism & Pharmacokinetics, 17, 257-262.
138. Lee, K., *Chan, K., Leung, W.T., Leung, N.W.Y., Ho, S., Chan, M., Lau, C.C., Tao, M., Lau,
W.Y., Shiu, W. (1992). Disposition of epirubicin in oily contract medium after intravenous and
intrahepato-arterial administration in liver cancer: A preliminary report. European Journal of
Drug Metabolism & Pharmacokinetics, 17, 221-226.
139. Lee, K. & Chan, K. (1992). Pharmacokinetics of epirubicin emulsion and solution in rabbits
after intra-hepato-arterial and intravenous injection. . Methods & Findings in Experimental &
Clinical Pharmacology, 14, 655-659.

9. 140. Hong, Z., Chan, K., Yeung, H.W. (1992). Simultaneous determination of bufadienolides in the
traditional Chinese medicine preparation. Liu-Shen-Wan, by liquid chromatography. Journal of
Pharmacy & Pharmacology, 44, 1023-1026.
141. Houghton, I.T., Chan, K., Wong, Y.C., Aun, C.S.T., Lau, O.W. & Lowe, D.M. (1992).
Pethidine pharmacokinetics after intramuscular dose: A comparison in Caucasian, Chinese and
Nepalese patients. Methods & Findings in Experimental & Clinical Pharmacology, 14. 451-
458.
142. Lau, O.W., Wong, Y.C. & Chan, K. (1992). The use of a packed column for the determination
of bupivacaine in human plasma by gas chromatography: An application in a pharmacokinetic
study of bupivacaine. Forensic Science International, 53, 125-129.
143. Dambisya, Y.M., Chan, K. & Wong, C.L. (1992). Disposition study of opioids in mice treated
with sympathomimetic agents. Journal of Pharmacy & Pharmacology, 44, 687-690.
144. Woo J., Chan, H.S., Walubo, A. & Chan, K. (1992). Hydrazine - a possible cause of isoniazid
induced hepatic necrosis. Journal of Medicine, 23, 51-59.
145. Jones, R.D.M., Chan, K., Andrew, L.J., Lawson, A.D. & Wong, P.K.S. (1992). Comparative
pharmacokinetics of propofol in Chinese adults and children. Methods & Findings in
Experimental & Clinical Pharmacology, 14, 41-47.
146. Dambisya, Y.M., Chan, K. & Wong, C.L. (1991). The role of adrenoceptors in the potentiation
of opioid antinociception by ephedrine and phenylpropanolamine in mice. Psychopharmacology,
105, 563-567.
147. Dambisya, Y.M., Chan, K., Wong, C.L. (1991). Ephedrine and phenylpropanolamine potentiate
the lethal toxicity of morphine and codeine in naive mice. Asia Pacific Journal of
Pharmacology, 6, 255-258.
148. Walubo, A., Chan, K., Woo, J., Chan, H.S. & Wong, C.L. (1991). The disposition of
antituberculous drugs in the plasma of elderly patients: II. Isoniazid rifampicin and pyrazinamide.
Methods & Findings in Experimental & Clinical Pharmacology, 13, 551-556.
149. Walubo, A., Chan, K., Woo, J., Chan, H.S. & Wong, C.L. (1991). The disposition of
antituberculous drugs in the plasma of elderly patients: I. Isoniazid and hydrazine metabolite.
Methods & Findings in Experimental & Clinical Pharmacology, 13, 545-550.
150. Lau, O.W., Chan, K. & Wong, Y.C. (1991). Gas-liquid chromatographic determinations and
pharmacological studies of six clinically used local anaesthetics. Methods & Findings in
Experimental & Clinical Pharmacology, 13, 475-481.
151. Gin, T., Yau, G., Jong, W., Tan, P., Leung, R.K.W. & Chan, K. (1991). Disposition of propofol
at caesarean section and in the postpartum period. British Journal of Anaesthesia, 67, 49-53.
152. Gin, T., Yau, G., Chan, K., Gregory, M.A. & Oh, T.E. (1991). Disposition of propofol infusions
for caesarean section, Canadian Journal of Anaesthesia, 38, 31-36.
153. Walubo, A., Chan, K. & Wong, C.L. (1991) Simultaneous assay for isoniazid and hydrazine
metabolite in plasma and cerebrospinal fluid in the rabbit. Journal Chromatography Biomedical
Application, 567, 261-266.
154. Wong, Y.C., Chan, K. & Lau, O.W. (1991). Protein binding characterisation of pethidine and
norpethidine and lack of interethnic variability. Methods & Findings in Experimental &
Clinical Pharmacology, 13, 273-279.
155. Dambisya, Y.M., Wong, C.L. & *Chan, K. (1991). Effects of sympathomimetic agents on
opiate analgesia, tolerance and dependence in mice. Methods & Findings in Experimental &
Clinical Pharmacology, 13, 239-248.
156. Walubo, A., Chan, K. & Wong, C.L. (1991). The pharmacokinetics of isoniazid and hydrazine
metabolite in the plasma and CSF of rabbits. Methods & Findings in Experimental & Clinical
Pharmacology, 13, 199-204.
157. Walubo, A., *Chan, K, Wong, C.L. (1991). An overview on the use of anti-tuberculous drugs in
Uganda and Hong Kong. Journal of Clinical Pharmacy & Therapeutics, 16, 63-67.
158. Chan, K., Wong, Y.C. & Lau, O.W. (1991). Determination of pethidine and its major
metabolites in human urine by gas chromatography. Journal Chromatography Biomedical
Application, 565, 247-254.
159. Dambisya, Y.M., Wong, C.L. & Chan, K. (1990). Effects of ephedrine and

10. phenylpropanolamine on the antinociceptive effects of morphine and codeine in mice. Archive of
International Pharmacodynamics &. Therapeutics, 308, 5-12.
160. Jones, R.D.M., Chan, K. & Andrew, L.J. (1990). Pharmacokinetics of propofol in children.
British Journal of Anaesthesia, 65, 661-667.
161. Wong, Y.C., Lau, O.W., *Chan, K., Aun, C., Low, D. & Houghton, I.T. (1990). Improved gas
chromatographic method for the quantitation of plasma pethidine and norpethidine: Application
in determining pharmacokinetic parameters in Chinese patients after intramuscular administration
of pethidine. Journal of Biopharmaceutical Science, 1, 267-276.
162. Wang, H., Xu, X.M., Jiang, W.D., Zu, J.R., Guo, Y., Chan, K., & Arnold, K. (1990). HPLC
assay of debrisoquine and 4-hydroxydebrisoquine. Acta Academiae Medicinae Shanghai, 17,
266-274.
163. Gin, T., Chan, K. Kan, A.F., Gregory, M.A., Wong, Y.C. & Oh, T.E. (1990). Effect of
adrenaline on venous plasma concentrations of bupivacaine after interpleural administration.
British Journal of Anaesthesia, 64, 662-666.
164. Gregory, M.A., Gin, T., Yau, G., Leung, R.K.W., Chan, K. & Oh, T.E. (1990). Propofol
infusion anaesthesia for caesarean section, Canadian Journal of Anaesthesia, 37, 514-520.
165. Gin, T., Gregory, M.A., Chan, K., Buckley, T. & Oh, T.E. (1990). Pharmacokinetics of propofol
in women undergoing elective caesarean section. British Journal of Anaesthesia, 64, 148-153.
166. Gin, T., Gregory, M.A., Chan, K. & Oh, T.E. (1990). Maternal and fetal levels of propofol at
caesarean section. Anaesthesia & Intensive Care, 18, 180-184.
167. Chan, K. & So, A. (1990). The measurement of propofol in human blood samples by liquid
chromatography. Methods & Findings in Experimental & Clinical Pharmacology, 12 135-139.
168. Chan, K. (1990) Drug dependence and drug abuse. Journal of Practising Pharmacy, 8, 20-24.
169. Chan, K., Tse, J., Jennings, F. & Orme, M.L'E (1990). Disposition of pethidine in man under
acidic urinary pH: 4. Oral kinetics among Caucasian, Chinese and Indian subjects. Methods &
Findings in Experimental & Clinical Pharmacology, 12, 61-67.
170. Lui, S.F., Chung, W.M.M., Leung, C.B., Chan, K. & Lai, K.N. (1990). Pharmacokinetics and
pharmacodynamics of subcutaneous and intraperitoneal administration of recombinant human
erythropoietin in patients on continuous ambulatory peritoneal dialysis. Clinical Neuphrology,
33, 47-51.
171. Chan, K., Yang, J.M., Wai, M.K. & Jiang, W.D. (1989). Disposition of ethmozine in
cerebrospinal fluid and plasma of rabbits. European Journal of Drug Metabolism &
Pharmacokinetics, 14, 279-282.
172. Yang, J.M. Chan, K. & Chiang, W.T. (1989). Distribution of moricizine in human blood:
Binding to plasma proteins and erythrocytes. Therapeutic Drug Monitoring, 12, 59-64.
173. Yang, J.M., *Chan, K. & Jiang, W.D. (1989). Physico-chemical properties and buccal
absorption of ethmozine. Asia Pacific Journal of Pharmacology, 4, 281-285.
174. Chan, K. (1989). Predicting plasma concentrations of bupivacaine after epidural administration
in obstetric analgesia. Therapeutic Drug Monitoring, 11, 567-571.
175. Lau, O.W., *Chan, K., Lau, Y.K. & Wong, W.C. (1989). The simultaneous determination of
active ingredients in cough-cold mixtures by isocratic reversed-phase ion-pair high performance
liquid chromatography. Journal of Pharmaceutical & Biomedical Analysis, 7, 725-736.
176. Yang, J.M., *Chan, K. & Jiang, W.D., (1989). Improved column liquid chromatographic
method for the determination of moricizine in plasma or serum. Journal of Chromatography
Biomedical Applications, 490, 458-463.
177. Chan, K. (1988). Peptides as targets for drug research. Drugs of Today, 24, 891-894.
178. Chan, K. & Woo, K.S. (1988). Determination of warfarin in human plasma by high
performance liquid chromatography, Methods & Findings in Experimental & Clinical
Pharmacology, 10, 699-703.
179. Chan, K. (1988). Modern anti-malarial therapy drug in South East Asia and China. Drugs of
Today, 24, 693-695.
180. Aun, C., Houghton, I.T., Chan, K., Lam, Y.M. & Thornton, J.A. (1988). A comparison of
alfentanil requirements in European and Asian patients during general anaesthesia. Anaesthesia &
Intensive Care, 16, 396-404.
181. Chan, K. (1988). Determination of alfentanil in human plasma using gas liquid chromatography

11. with capillary column and nitrogen selective detection. Asia Pacific Journal of Pharmacology, 3,
63-68.
182. Woo J., Leung, A., Chan, K., Lai, K.N. & Teoh, R. (1988). Pyrazinamide and rifampicin
regimens for patients on maintenance dialysis. International Journal of Artificial Organs, 11,
181-185.
183. Chan, K. (1988). A systematic approach for the simultaneous assay of some anti-tuberculous
drugs in CSF and plasma by liquid chromatography. Journal of Liquid Chromatography, 11,
1051-1073.
184. Chan, K. & Wong, C.L. (1988). Pharmacokinetics of pyrazinamide in plasma and CSF of
rabbits following intravenous and oral administration European Journal of Drug Metabolism &
Pharmacokinetics, 13, 57-61.
185. Chan, K., Miners, J.O. & Birkett, D.J. (1988). Direct and simultaneous high performance liquid
chromatographic assay for the determination of p-aminobenzoic acid and its conjugates in human
urine, Journal of Chromatography Biomedical Applications, 426, 103-109.
186. Chan, K. (1988). Comparison of a GLC and a HPLC assay for the determination of
debrisoquine and its 4-hydroxy metabolite in human biological fluids. Journal of
Chromatography Biomedical Applications, 425, 311-321.
187. Woo, J., Wong, C.L., Teoh, R. & *Chan, K. (1987). A liquid chromatographic assay for the
simultaneous determination of pyrazinamide and rifampicin in serum samples from patients with
tuberculous meningitis. Journal of Chromatography Biomedical Applications, 420, 73-80.
188. Wong, C.L., *Chan, K., Woo, J. & Teoh, R. (1987). Pharmacokinetics of pyrazinamide in CSF
and plasma of rabbits: Influence of anaesthesia Asia Pacific Journal of Pharmacology, 2, 53-56.
189. Woo, J. Humphries, M., Chan, K., O'Mahony, G. & Teoh, R.. (1987). Cerebrospinal fluid and
serum levels of pyrazinamide and rifampicin in patients with tuberculous meningitis. Current
Therapeutic Research, 42, 235-242.
190. Chan, K. (1987). A simultaneous determination of rifampicin and 25-desacetylrifampicin in
cerebrospinal fluids and plasma of the rabbit by liquid chromatography. Acta Pharmacologica
Sinica, 8, 552-556.
191. Chan, K., Tse, J., Jennings, F. & Orme, M.L'E (1987). Disposition of pethidine in man under
acidic urinary pH: 3. A comparison of pharmacokinetics among Caucasian, Chinese and Indian
subjects. Methods & Findings in Experimental & Clinical Pharmacology, 9, 243-250.
192. Chan, K., Tse, J., Jennings, F. & Orme, M.L'E (1987). Pharmacokinetics of low-dose
intravenous pethidine in patients with renal dysfunction. Journal of Clinical Pharmacology, 27,
516-522.
193. Chan, K. & Chan, G. (1987). A study of prescribed H1-antihistamine preparations over a period
of 12-month in community pharmacy. Journal of Clinical Pharmacy & Therapeutics, 12, 1-9.
194. Chan, K., Tse, J., Jennings, F. & Orme, M.L'E (1987). Influence of urinary pH on pethidine
kinetics in healthy volunteer subjects: 2. A study of 10 Chinese people. Methods & Findings in
Experimental & Clinical Pharmacology, 9, 49-54.
195. Chan, K. (1986). Rifampicin concentrations in cerebrospinal fluid and plasma of the rabbit by
high performance liquid chromatography Methods & Findings in Experimental & Clinical
Pharmacology, 8, 721-726.
196. Chan, C.Y., Chan, K. & French, G.L. (1986). Rapid high performance liquid chromatographic
assay of cephalosporins in biological fluids. Journal of Antimicrobial & Chemotherapy, 18,
537-545.
197. Chan, K. (1986). High performance liquid chromatographic characterisation and quantitation of
p-aminobenzoic acid N-acetylation in Chinese subjects. European Journal of Drug Metabolism
& Pharmacokinetics, 11, 129-134.
198. Chan, K., Wong, C.L. & Wai, M.K. (1986). Anti-tuberculous drug penetration into
cerebrospinal fluid in a rabbit-model. Asian Pacific Journal of Pharmacology, 1, 41-45.
199. Chan K., Wong, C.L. & Lok, S. (1986). High performance liquid chromatographic
determination of pyrazinamide in cerebrospinal fluid and plasma in the rabbit. Journal of
Chromatography Biomedical Applications, 380, 367-373.
200. Chan, K., Lok, S. & Teoh, R. (1985). An improved gas liquid chromatographic assay for
plasma valproic acid concentrations in mentally handicapped epileptic children. Meth. Find. exp.

12. clin. Pharmac., 7, 589-593.
201. Chan, K. (1985). Pharmacokinetic contributions to drug use. Journal of Clinical & Hospital
Pharmacy, 10, 257-268.
202. Chan, K. (1985). The simultaneous determination of carbamazepine and its epoxide metabolite
in plasma and urine by high performance liquid chromatography. Journal of Chromatography
Biomedical Applications, 342, 341-347.
203. Chan, K., Tse, J., Jennings, F. & Orme, M.L'E (1985). Influence of urinary pH on pethidine
kinetics in health volunteer subjects. Methods & Findings in Experimental & Clinical
Pharmacology, 7, 245-253.
204. Elliott, P.N.C., Ford, J.L. & Chan, K. (1984). The effect of incorporation of indomethacin with
polyethylene glycol 6000 in a solid dispersion on its in vivo properties in the rat. Agents &
Actions, 15, 367-370.
205. Chan, K., Lok, S. & Teoh, R. (1984). The simultaneous determination of five antiepileptic
drugs in plasma by high performance liquid chromatography. Methods & Findings in
Experimental & Clinical Pharmacology, 6., 701-704.
206. Murray, G.R., Calvey, T.N., Williams, N.E. & *Chan, K. (1984). Quantitative capillary column
gas chromatographic method for the determination of glycopyrronium in human plasma. Journal
of Chromatography Biomedical Application, 308, 143-151.
207. Isherwood, C.N., Calvey, T.N., Williams, N.E., Chan, K. & Murray, G.R. (1984). Elimination
of phenoperidine in liver disease. British Journal of Anaesthesia, 56, 843-847.
208. Calvey, T.N., Milne, L.A., Williams, N.E., Chan, K. & Murray, G.R. (1983). Effect of antacids
on the plasma concentration of phenoperidine. British Journal of Anaesthesia, 55, 535-539.
209. Chan, K., Tse, J., Deeks, P.A. & Pilling, M. (1983). The dissolution and oral bioavailability of
mexiletine capsules modified for clinical trial. A preliminary report. Methods & Findings in
Experimental & Clinical Pharmacology, 5, 471-478.
210. Milne, L.A., Williams, N.E., Calvey, T.N., Murray, G.R. & Chan, K. (1983). Effect of urine pH
on the elimination of phenoperidine. British Journal of Clinical Pharmacology., 16, 101-103.
211. Williams, N.E., Calvey, T.N. & Chan, K. (1982). Plasma concentration of pyridostigmine
during the antagonism of neuromuscular block. British Journal of Anaesthesia, 55, 27-31.
212. Chan, K. (1982). Disposition of pethidine in man under acidic urinary pH: 2. A
pharmacokinetic analysis. Methods & Findings in Experimental & Clinical Pharmacology, 4,
591-599.
213. Chan, K., Tse, J., Orme, M.L'E & Sibeon, R.G. (1982). The influence of urinary pH on the
disposition of indomethacin in health volunteers. Journal of Clinical & Hospital Pharmacy, 7,
155-160.
214. Pilling, M., Tse, J. & Chan, K. (1982). A modified gas-liquid chromatographic assay to monitor
plasma mexiletine in a tinnitus study. Methods & Findings in Experimental & Clinical
Pharmacology, 4., 243-247.
215. Calvey, T.N., Williams, N.E., Chan, K., Dehghan, A. & Somani, S.M. (1981). Plasma
concentration and urinary elimination of neostigmine after intramuscular administration to
myasthenic patients. Annuals of New York Academy of Science, 377, 816-817.
216. Davison, S.C., Hyman, N., Dehghan, A. & Chan, K. (1981). The relationship of plasma levels
of pyridostigmine to clinical effects in patients with myasthenia gravis. Journal of Neurology &
Neurosurgery & Psychiatry. 44, 1141-1145.
217. Chan, K., Dehghan, A., Davison, S.C. & Hyman, N. (1981). The effect of neostigmine on
pyridostigmine bioavailability in myasthenic patients after oral administration. Methods &
Findings in Experimental & Clinical Pharmacology, 3, 291-296.
218. Chan, K. (1981). Disposition of pethidine in man under acidic urinary pH: 1. Plasma levels and
urinary excretion of pethidine and norpethidine. Journal of Clinical & Hospital Pharmacy, 6,
107-116.
219. Calvey, T.N., Chan, K., Dehghan, A. & Williams, N.E. (1981). Kinetics of intravenous
pyridostigmine in man. British Journal of Clinical Pharmacology, 11, 406-408.
220. Tse, J. & Chan, K., (1981). The simultaneous determination of pethidine and norpethidine in
biofluids by nitrogen selective gas chromatography. Methods & Findings in Experimental &
Clinical Pharmacology, 3., 99-104.

13. 221. Chan, K., Murray, G.R., Rostron, C., Calvey, T.N. & Williams, N.E. (1981) Quantitative gas
liquid chromatographic method for the determination of phenoperidine in human plasma.
Journal of Chromatography Biomedical Applications, 223, 213-218.
222. Davison, S.C., Hyman, N., Prentis, R.A., Dehghan, A. & *Chan, K. (1980). The simultaneous
monitoring of plasma levels of neostigmine and pyridostigmine in man. Methods & Findings in
Experimental & Clinical Pharmacology, 2, 77-82.
223. Somani, S.M., Chan, K., Dehghan, A. & Calvey, T.N. (1980). Kinetics and metabolism of
intramuscular neostigmine in myasthenia gravis. Clinical Pharmacology & Therapeutics, 28,
64-68.
224. Baber, N., Halliday, L. Littler, T., Orme, M.L'E, Sibeon, R.C. & Chan, K. (1980). The effect of
indomethacin on renal function in man. Scandinavian Journal of Rheumatology, 9, 52-54.
225. Milne, L., Williams, N.E., Calvey, T.N., Murray, G.R. & Chan, K. (1980). Kinetics and
metabolism of phenoperidine in man. British Journal of Anaesthesia, 52, 537-540.
226. Chan, K. (1980). Determination of clinically used anticholinesterase drugs and metabolites in
biofluids: A review Methods & Findings in Experimental & Clinical Pharmacology, 2, 33-44.
227. Chan, K. & McCann, J.F. (1979). An improved ECD-GLC method for the determination of
paracetamol in plasma and urine. Journal of Chromatography Biomedical Applications, 164,
394-398.
228. Chan, K. (1979). The effects of physico-chemical properties of pethidine and its basic
metabolites of their buccal absorption and renal elimination. Journal of Pharmacy &
Pharmacology, 31 672-675.
229. Chan, K. & Groves, R.L. (1979). The use of "Controlled Drugs" in general practice. Journal of
Clinical & Hospital Pharmacy, 4, 101-112.
230. Calvey, T.N., Williams, N.E., Wareing, M. & Chan, K. (1979). Pharmacokinetics and
pharmacological effects of neostigmine in man. Journal of Clinical & Hospital Pharmacy, 7,
149-155.
231. Chan, K. & Edwards, J.A. (1978). The use of narcotic analgesics in hospital practice II. A
survey on the use in the Mersey Region. Journal of Clinical & Hospital Pharmacy, 3, 253-266.
232. Sibeon, R.G., Baty, J.D., Baber, N., Chan, K. & Orme, M.L'E (1978). Quantitative gas-liquid
chromatographic method for the determination of indomethacin in biological fluids. Journal of
Chromatography Biomedical Applications, 153, 189-194.
233. Chan, K. & Dehghan, A. (1978). The isolation and determination of neostigmine
pyridostigmine and their metabolites in human biological fluids. J. Pharmacological Methods, 1,
311-320.
234. Williams, N.E., Calvey, T.N. & Chan, K. (1978). Clearance of neostigmine from the
circulation during the reversal of neuromuscular block. British Journal of Anaesthesia, 50 1055-
1057.
235. Baker, P.R., Calvey, T.N., Chan, K., MacNee, C.M., & Taylor, K. (1978). Plasma clearance of
neostigmine and pyridostigmine in the dog. British Journal of Pharmacology, 63, 509-512.
236. Chan, K. & Calvey, T.N. (1978). Plasma concentration of pyridostigmine and effects in
myasthenia gravis. Clinical Pharmacology & Therapeutics, 22, 596-601.
237. Chan, K. & Calvey, T.N. (1977). Renal clearance of pyridostigmine in patients with myasthenia
gravis. European Neurololgy, 16, 69-72.
238. Calvey, T.N. & Chan, K. (1977). Plasma concentration of pyridostigmine in patients with
myasthenia gravis. Clinical Pharmacology & Therapeutics, 21, 187-193.
239. Chan, K., Williams, N.E., Baty, J.D. & Calvey, T.N. (1976). A quantitative gas-liquid
chromatographic procedure for the determination of neostigmine and pyridostigmine in human
plasma. Journal of Chromatography Biomedical Applications, 120, 349-358.
240. Chan, K., Mitchard, M. & Trueman, G. (1976). The use of narcotic analgesics in hospital
practice. Journal of Clinical & Hospital Pharmacy,1, 153-162.
241. Chan, K., Kendall, M.J., Mitchard, M., Wells, W.D.E. & Vickers, M.D. (1975). The effect of
ageing on plasma concentrations of pethidine. British Journal Clinical Pharmacology, 2, 297-
302.
242. Chan, K., Kendall, M.J., Mitchard, M. & Wills, W.D.E. (1975). Factors influencing the
excretion and relative physiological availability of pethidine in man. Journal of Pharmacy &

14. Pharmacology, 27, 235-241.
243. Chan, K., Kendall, M.J. & Mitchard, M. (1974). A quantitative gas-liquid chromatographic
method for the determination of pethidine and its metabolites, norpethidine and pethidine N-oxide
in human biological fluids. Journal of Chromatography, 89 169-176.
244. Kendall, M.J. & Chan, K. (1973). Drug induced malabsorption. Xenobiotica, 3, 727-744.
245.Mitchard, M., Kendall, M.J. & Chan, K. (1972). Pethidine N-oxide: a metabolite in human
urine. Journal of Pharmacy & Pharmacology, 24, 915.