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Robotic-Assisted Pyeloplasty:
       Technique and Outcomes




                     Rafael F. Coelho
Global Robotics Institute – Florida Hospital Celebration Health
                Faculdade de Medicina USP
Introduction

•UPJ obstruction is the most common
congenital abnormality of the ureter ( 5/100000
births)

•Historically, open dismembered pyeloplasty
has been the “gold-standard” treatment, with
documented success rates greater than 90%

•Laparoscopic Pyeloplasty- First described
1993 by Schuessler and colleagues

• Similar success rates have been reported
with LP with the advantages inherent to a
minimally invasive procedure.

                                                  Schuessler et al, J Urol, 1993
                                                     Lowe et al, Urology, 1984
Laparoscopic Pyeloplasty
• Emerging gold standard
• The problem !!
  Not a part of mainstream urology
  Provided by <1% of urologic surgeons
     Inexperience with laparoscopy
     Difficulty with intracorporeal
       suturing
• A need for a more feasible approach
Surgical Technique
Stent Placement


• Retrograde         prior   to
    positioning for pyeloplasty


                                        UPJO

•   Antegrade            during
    reconstruction of the UPJ
Patient Positioning - Transperitoneal
Trocar Placement - Transperitoneal

Trocar placement for Right   Trocar placement for Left
       Pyeloplasty                  Pyeloplasty
Trocar Placement - Tulane University
Trocar Placement – Vita Salute University




                      Cestari et al, Eur Urol, 2010
OR setup – Transperitoneal RAP




                  Cestari et al, Eur Urol, 2010
Trocar Placement – Retroperitoneal RAP




                      Cestari et al, Eur Urol, 2010
OR setup – Retroperitoneal Pyeloplasty




                         Cestari et al, Eur Urol, 2010
Surgical Technique

•   Reflect the colon and dissect out the ureter
Surgical Technique

•   Preserve crossing vessels (if present) and mobilize the renal pelvis
Surgical Technique

• Locate and excise the UPJO
Surgical Technique

• Spatulate ureter laterally, Transpose anteriorly?
• Anterior Transposition?




When the ureter appeared to be
on          stretch        with
transposition,    the  crossing
vessel was not transposed
• Anterior Transposition?




• Based on renal scan, imaging and symptomatic improvement a
  comparison of RALP outcomes revealed similar success rates in
  patients with crossing vessels with or without transposition of the
  ureteropelvic junction anastomosis.
•

• Transposition of the anterior crossing vessel should be an
  intraoperative decision and only performed when dictated by the
  anatomical relation.




                                          Boylu et al, J Urol, 2010
Surgical Technique

• Anastomosis (4-0 monocryl suture on RB-1 needle)
Surgical Technique

•   JP drain
Outcomes
Critical Analysis of Robotic-Assisted Laparoscopic
 Dismembered Pyeloplasty For Primary and Secondary
Ureteropelvic Junction Obstruction: A Multi-Institutional
                        Experience

 Vipul R. Patel, Ananthakrishnan Sivaraman, Rafael F Coelho, Manoj Patel, Sanket
    Chauhan, Kenneth Palmer, Ravi Munver, Jorge E. Bracho II,Vincent G. Bird,
                               Raymond J. Leveillee
•Retrospective review of prospectively collected data from three
academic institutions
• 168 patients who underwent RALDP for UPJO between June
2002 and October 2008, were analyzed

•161 patients undewent Anderson-Hynes RALDP and 7 pts Foley
Y-V plasty.

•All cases were performed via transperitoneal approach

•Anastomosis -Two five inch 4-0 running monocryl sutures on
RB-1
Etiology: Secondary Pyeloplasty Repairs


Procedure                                  No.
Previous Open Pyeloplasty                        7
Previous Laparoscopic Pyeloplasty                1
Previous Laser Endopyelotomy                     9
Previous Electrosurgical cutting balloon
Endopyelotomy
                                                 3

Previous Open Pyeloplasty and Laser
Endopyelotomy
                                                 1

Total                                            21
Results


                                   Overall              Primary Repair   Secondary Repair
Number of Patients (N)                     168             147 (87.5%)      21 (12.5%)
Mean Age (years)                      37.6 (19-71)             37.8            36.0
Sex (F/M)                                94/74                82/65            12/9
BMI                                 25.57 (17.2-43.5)          25.5            26.7
Side (R/L)                               96/72                88/59            8/13
Intrinsic Etiology                   93/168 (55.4%)       84/147 (57%)     9/21 (43%)
Crossing Vessel Etiology             75/168 (44.6%)       63/147 (43%)     12/21 (57%)
Mean OR Time (Minutes)                   134.87              125.95           190.4
Mean Estimated Blood Loss (EBL)          48.67                42.92            86.2

Mean Length of Stay (days) (LOS)       1.48 (1-7)              1.45             1.7
Results



                               Overall             Primary Repair     Secondary Repair

Symptom Resolution              157/164 (95.7%)     138/143 (96.5%)     19/21 (90.5%)

T half-life Improvement              96.9%               96.5%             100%

Renal Function Improvement           72.7%               73.3%              67%

Pre-Op GFR (mL/min/1.73 m2)     82.79 (41.4-127)         80.86             99.25

Post-Op GFR (mL/min/1.73 m2)      90 (53-151)            86.45             112.25

GFR Improvement                      51.7%               48%                67%
Results - Complications

                        Overall                 Primary                           Secondary
Complications        11/168 (6.6%)         8/147 (5.4%)                       3/21 (14.2%)
Blood Transfusion          3                    2                                   1
Ileus                      4                    3                                   1
Post-Op
UTI/Pyelonephritis
                          1                          1                                  0
Urine Leak                3                          2                                  1
Need for second
procedure
                          6                          4                                  2
                                     •   Retrograde Laser                •   Retrograde Laser
                                         Endopyelotomy (2 cases)             Endopyelotomy (1 case)
                                     •   Retrograde Balloon              •   Re-Stenting - Clot retention
                                         Endopyelotomy (1 case)              in renal pelvis (1 case)
                                     •   Re-Stenting - Clot retention in
                                         renal pelvis (1 case)
Robotic-Assisted Pyeloplasty: Current Outcomes




                            Singh et al, Can J Urol, 2010
Robotic-Assisted Pyeloplasty: Current Outcomes

 Reference
                   No.    Approach     Operative    Technique         Ports       Stenting   Hospital   Follow up   Success   Complic
                   of                    Time                                                  Stay       (mo)       Rate      ation
                  Cases                 (min)                                                 (days)                  (%)       rate

 Mendez-           32       Trans        300       Dismembered      4 total / 3   RG 100%      1.1        8.6 mo                3%
Torres et al.                                       (31), Fenger     robotic                             (1.5-16)    94%
                                                          (1)

Siddiq et al.      26       Trans         245      Dismembered     4 (46%) and                                                 0%
                                       (165-390)       (23)           3 (54%)     RG 100%       2         6 mo       95%      major/
                                                      Y-V (3)         total / 3                          (2-12)               11.5%
                                                                      robotic                                                 minor
                                         122                        4 total / 3                           11.7
    Patel          50       Trans      (60-330)    Dismembered        robotic     RG 100%      1.1       (1–28)                 0%
                                                                                                                     96%
                                         108.3                      4 total / 3                         39.1 mo
Schwenter et       92       Trans      (72-215)    Dismembered       robotic      AG 94%       4.6       (3-73)      96.7%      3%
    al                                                                            RG 6%

                                                                   4 or 5 total                            29                  7.1%
Muffarij at al.    140      Trans        217       Dismembered     / 3 robotic    AG 71%       2.1       (3-63)      95.7%    major /
                           except 1    (80-510)                                   RG 29%                                       2.9%
                          case retro                                                                                          minor
Robotic vs. Pure Lap Pyeloplasty
Robotic vs. Pure Lap Pyeloplasty
Operative Time
Operative Time
LOS
LOS
Complication Rates
Complication Rates
Success Rates
Success Rates
Conclusion




“RAP and CLP appear to be equivalent with
regard to postoperative urinary leaks,
hospital readmissions, and success rates….”
Robotic Pyeloplasty with Concomitant
                  Stone Removal
Technique
• After the UPJ has been incised, reduction pyeloplasty
   performed, as indicated.

•   The cephalad arm of the robot is undocked

•   This trocar and the bedside surgeon’s trocar site used
    for stone removal

•   One trocar for flexible nephroscope and the other
    trocar for suction irrigator


                          Atug, Thomas et al, BJU, 96:1365-1368, 2005
Suction



   Robotic
                            Flexible
 Pyeloplasty              Nephroscope

     with
 Concomitant
Stone Removal
Concomittant
Stone Removal
RALDP vs. Pure Lap - Costs

•Mathematical cost model:
RLP    2.7    times more
expensive than LP


•If Robot depreciation is
excluded: RALDP 1.7 times
more expensive


•LP time must increase to 6.5
hs     to    become     cost
equivalent to RALDP



                                 Link RE et al. Ann Surg, 2006
Costs


•More than 500 RALDP cases,
with operative times less than 130
minutes per case, would need to
be performed per year to achieve
costs equivalent to laparoscopic
pyeloplasty




                                     Bhayani S et al. J Endourol, 2005
Costs


LP is more cost effective than
CP if LP is performed in 338
minutes




                                    Bhayani S et al. J Endourol, 2005
Conclusions

•RALDP is a safe, efficacious and viable option for primary or
secondary repair of UPJO with excellent success rates and low
incidence of complications


•May benefit patients by enabling a greater number of urologists
with limited laparoscopic reconstructive expertise to offer a
minimally invasive approach to correction of UPJO


• Less cost-effective than Laparoscopic Pyeloplasty

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Robotic-Assisted Pyeloplasty

  • 1. Robotic-Assisted Pyeloplasty: Technique and Outcomes Rafael F. Coelho Global Robotics Institute – Florida Hospital Celebration Health Faculdade de Medicina USP
  • 2. Introduction •UPJ obstruction is the most common congenital abnormality of the ureter ( 5/100000 births) •Historically, open dismembered pyeloplasty has been the “gold-standard” treatment, with documented success rates greater than 90% •Laparoscopic Pyeloplasty- First described 1993 by Schuessler and colleagues • Similar success rates have been reported with LP with the advantages inherent to a minimally invasive procedure. Schuessler et al, J Urol, 1993 Lowe et al, Urology, 1984
  • 3. Laparoscopic Pyeloplasty • Emerging gold standard • The problem !! Not a part of mainstream urology Provided by <1% of urologic surgeons  Inexperience with laparoscopy  Difficulty with intracorporeal suturing • A need for a more feasible approach
  • 4.
  • 6. Stent Placement • Retrograde prior to positioning for pyeloplasty UPJO • Antegrade during reconstruction of the UPJ
  • 7. Patient Positioning - Transperitoneal
  • 8. Trocar Placement - Transperitoneal Trocar placement for Right Trocar placement for Left Pyeloplasty Pyeloplasty
  • 9. Trocar Placement - Tulane University
  • 10. Trocar Placement – Vita Salute University Cestari et al, Eur Urol, 2010
  • 11. OR setup – Transperitoneal RAP Cestari et al, Eur Urol, 2010
  • 12. Trocar Placement – Retroperitoneal RAP Cestari et al, Eur Urol, 2010
  • 13. OR setup – Retroperitoneal Pyeloplasty Cestari et al, Eur Urol, 2010
  • 14. Surgical Technique • Reflect the colon and dissect out the ureter
  • 15. Surgical Technique • Preserve crossing vessels (if present) and mobilize the renal pelvis
  • 16. Surgical Technique • Locate and excise the UPJO
  • 17. Surgical Technique • Spatulate ureter laterally, Transpose anteriorly?
  • 18. • Anterior Transposition? When the ureter appeared to be on stretch with transposition, the crossing vessel was not transposed
  • 19. • Anterior Transposition? • Based on renal scan, imaging and symptomatic improvement a comparison of RALP outcomes revealed similar success rates in patients with crossing vessels with or without transposition of the ureteropelvic junction anastomosis. • • Transposition of the anterior crossing vessel should be an intraoperative decision and only performed when dictated by the anatomical relation. Boylu et al, J Urol, 2010
  • 20. Surgical Technique • Anastomosis (4-0 monocryl suture on RB-1 needle)
  • 23. Critical Analysis of Robotic-Assisted Laparoscopic Dismembered Pyeloplasty For Primary and Secondary Ureteropelvic Junction Obstruction: A Multi-Institutional Experience Vipul R. Patel, Ananthakrishnan Sivaraman, Rafael F Coelho, Manoj Patel, Sanket Chauhan, Kenneth Palmer, Ravi Munver, Jorge E. Bracho II,Vincent G. Bird, Raymond J. Leveillee
  • 24. •Retrospective review of prospectively collected data from three academic institutions • 168 patients who underwent RALDP for UPJO between June 2002 and October 2008, were analyzed •161 patients undewent Anderson-Hynes RALDP and 7 pts Foley Y-V plasty. •All cases were performed via transperitoneal approach •Anastomosis -Two five inch 4-0 running monocryl sutures on RB-1
  • 25. Etiology: Secondary Pyeloplasty Repairs Procedure No. Previous Open Pyeloplasty 7 Previous Laparoscopic Pyeloplasty 1 Previous Laser Endopyelotomy 9 Previous Electrosurgical cutting balloon Endopyelotomy 3 Previous Open Pyeloplasty and Laser Endopyelotomy 1 Total 21
  • 26. Results Overall Primary Repair Secondary Repair Number of Patients (N) 168 147 (87.5%) 21 (12.5%) Mean Age (years) 37.6 (19-71) 37.8 36.0 Sex (F/M) 94/74 82/65 12/9 BMI 25.57 (17.2-43.5) 25.5 26.7 Side (R/L) 96/72 88/59 8/13 Intrinsic Etiology 93/168 (55.4%) 84/147 (57%) 9/21 (43%) Crossing Vessel Etiology 75/168 (44.6%) 63/147 (43%) 12/21 (57%) Mean OR Time (Minutes) 134.87 125.95 190.4 Mean Estimated Blood Loss (EBL) 48.67 42.92 86.2 Mean Length of Stay (days) (LOS) 1.48 (1-7) 1.45 1.7
  • 27. Results Overall Primary Repair Secondary Repair Symptom Resolution 157/164 (95.7%) 138/143 (96.5%) 19/21 (90.5%) T half-life Improvement 96.9% 96.5% 100% Renal Function Improvement 72.7% 73.3% 67% Pre-Op GFR (mL/min/1.73 m2) 82.79 (41.4-127) 80.86 99.25 Post-Op GFR (mL/min/1.73 m2) 90 (53-151) 86.45 112.25 GFR Improvement 51.7% 48% 67%
  • 28. Results - Complications Overall Primary Secondary Complications 11/168 (6.6%) 8/147 (5.4%) 3/21 (14.2%) Blood Transfusion 3 2 1 Ileus 4 3 1 Post-Op UTI/Pyelonephritis 1 1 0 Urine Leak 3 2 1 Need for second procedure 6 4 2 • Retrograde Laser • Retrograde Laser Endopyelotomy (2 cases) Endopyelotomy (1 case) • Retrograde Balloon • Re-Stenting - Clot retention Endopyelotomy (1 case) in renal pelvis (1 case) • Re-Stenting - Clot retention in renal pelvis (1 case)
  • 29. Robotic-Assisted Pyeloplasty: Current Outcomes Singh et al, Can J Urol, 2010
  • 30. Robotic-Assisted Pyeloplasty: Current Outcomes Reference No. Approach Operative Technique Ports Stenting Hospital Follow up Success Complic of Time Stay (mo) Rate ation Cases (min) (days) (%) rate Mendez- 32 Trans 300 Dismembered 4 total / 3 RG 100% 1.1 8.6 mo 3% Torres et al. (31), Fenger robotic (1.5-16) 94% (1) Siddiq et al. 26 Trans 245 Dismembered 4 (46%) and 0% (165-390) (23) 3 (54%) RG 100% 2 6 mo 95% major/ Y-V (3) total / 3 (2-12) 11.5% robotic minor 122 4 total / 3 11.7 Patel 50 Trans (60-330) Dismembered robotic RG 100% 1.1 (1–28) 0% 96% 108.3 4 total / 3 39.1 mo Schwenter et 92 Trans (72-215) Dismembered robotic AG 94% 4.6 (3-73) 96.7% 3% al RG 6% 4 or 5 total 29 7.1% Muffarij at al. 140 Trans 217 Dismembered / 3 robotic AG 71% 2.1 (3-63) 95.7% major / except 1 (80-510) RG 29% 2.9% case retro minor
  • 31. Robotic vs. Pure Lap Pyeloplasty
  • 32. Robotic vs. Pure Lap Pyeloplasty
  • 35. LOS
  • 36. LOS
  • 41. Conclusion “RAP and CLP appear to be equivalent with regard to postoperative urinary leaks, hospital readmissions, and success rates….”
  • 42. Robotic Pyeloplasty with Concomitant Stone Removal Technique • After the UPJ has been incised, reduction pyeloplasty performed, as indicated. • The cephalad arm of the robot is undocked • This trocar and the bedside surgeon’s trocar site used for stone removal • One trocar for flexible nephroscope and the other trocar for suction irrigator Atug, Thomas et al, BJU, 96:1365-1368, 2005
  • 43. Suction Robotic Flexible Pyeloplasty Nephroscope with Concomitant Stone Removal
  • 45.
  • 46. RALDP vs. Pure Lap - Costs •Mathematical cost model: RLP 2.7 times more expensive than LP •If Robot depreciation is excluded: RALDP 1.7 times more expensive •LP time must increase to 6.5 hs to become cost equivalent to RALDP Link RE et al. Ann Surg, 2006
  • 47. Costs •More than 500 RALDP cases, with operative times less than 130 minutes per case, would need to be performed per year to achieve costs equivalent to laparoscopic pyeloplasty Bhayani S et al. J Endourol, 2005
  • 48. Costs LP is more cost effective than CP if LP is performed in 338 minutes Bhayani S et al. J Endourol, 2005
  • 49. Conclusions •RALDP is a safe, efficacious and viable option for primary or secondary repair of UPJO with excellent success rates and low incidence of complications •May benefit patients by enabling a greater number of urologists with limited laparoscopic reconstructive expertise to offer a minimally invasive approach to correction of UPJO • Less cost-effective than Laparoscopic Pyeloplasty