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www.totalpregnancycare.com


                             www.totalpregnancycare.com
Multiple Pregnancy
        Dr Shantala Vadeyar
               MD, FRCOG, DM (UK)
   Advanced Obstetric Ultrasound (RCO/RCR)
 Subspecialist in Maternal-Fetal Medicine (RCOG)
Consultant Obstetrics, Fetal & Maternal Medicine
 Kokilaben Dhirubhai Ambani Hospital, Mumbai




                                         www.totalpregnancycare.com
Incidence
•   Increased with Assisted Reproduction
•   Clomiphene citrate / Letrozol/ HMG, hCG
•   Advanced Age
•   Race – Afro-carribeans
•   1:80-100




                                      www.totalpregnancycare.com
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Risks in
Multiple Pregnancy




         www.totalpregnancycare.com
www.totalpregnancycare.com
DC twins - lambda
sign




        www.totalpregnancycare.com
MC twins - T sign




         www.totalpregnancycare.com
Chorionicity v/s Zygosity




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Techniques for invasive
       testing




                www.totalpregnancycare.com
Loss rates: Amniocentesis in Twins




                          www.totalpregnancycare.com
Chorionic Villous Sampling in Twins




                          www.totalpregnancycare.com
Selective Fetocide / ER




                 www.totalpregnancycare.com
Management:
              Antenatal




Maternal and Fetal Surveillance


                    www.totalpregnancycare.com
Ultrasound in Multiples
•   Diagnosis and Chorionicity determinaiton
•   Dating, Chromosomal & Structural Normality
•   Growth, Dopplers
•   Amniotic fluid assessment
•   Twin twin transfusion syndrome
•   Invasive procedures – amniocentesis, CVS
•   Cervical length and funnelling
•   Prediction of preterm labour
•   Timing of delivery – Dopplers, BPS in IUGR, etc


                                                 www.totalpregnancycare.com
Complications in Twins:
                        Based on Chorionicity
              EVENT                    DICHORIONIC   MONOCHORIONIC
     Miscarriage (11-23 weeks)             2%              10%
    Perinatal Death (>23 weeks)            2%               4%
Fetal Growth Restriction (one /both)      20%              30%
   Preterm delivery (<32 weeks)            5%              10%
        Major birth defects                1%               4%




                                                      www.totalpregnancycare.com
Preterm delivery
Early screening for




                                                                                                                           www.totalpregnancycare.com
                                                                                Cervical cerclage
                                                                                 or Progesterone

                                                                                                      25% reduction (4%
                      Prevalence of spontaneous early preterm birth




                                                                                                           of total)
                                                                      Delivery <34 wks
                                                                      Delivery <34 wks                         1.8%
                                                                                                               1.8%
                                                                      Iatrogenic
                                                                      Iatrogenic                    Spontaneous
                                                                                                    Spontaneous
                                                                          1/3rd
                                                                         1/3rd                         2/3rd
                                                                                                       2/3rd
                                                                               Previous affected pregnancy
                                                                             • Previous affected pregnancy                (15%
                                                                                                                          (15%
                                                                               Nulliparous / No previous PTD
                                                                             • Nulliparous / No previous PTD              (85%
                                                                                                                          (85%
Twin Twin Transfusion Syndrome
• Monochorionic twins              Anastomoses in TTTS
• Donor twin is small, growth
  restriction
• Recepient twin is big
• Oligo / polyhydramnios
• Big bladder, heart enlarged in
  recepient
• Oliguria, donor
• Abnormal Dopplers



                                                  www.totalpregnancycare.com
Prognosis - TTTS
•   Staging (Quintero)
     – Stage I
         • Recipient hydramnios
         • Donor bladder visible/present
     – Stage II
         • Recipient hydramnios
         • Donor bladder remains empty (“stuck twin”)
     – Stage III
         • Abnormal Doppler studies:
             – absent or reversed end-diastolic flow in Donor UA OR
             – abnormal venous Doppler pattern in Recipient UA (reverse
               flow in the ductus venosus or pulsatile umbilical venous flow)
     – Stage IV
         • Fetal hydrops means stage IV and the end
     – Stage V
         • Fetal death of one or both twins.                 www.totalpregnancycare.com
Treatment of TTTS by selective
                           laser ablation of A-V
                               Anastamoses
        Laser ablation




Stuck ‘donor twin’
wrapped in membrane




Feely floating ‘recipient twin’
In hydramnios


                                           www.totalpregnancycare.com
Electronic
Fetal Heart
    Rate
monitoring
  in labour

              www.totalpregnancycare.com
Epidural Analgesia
  (painless labour)




           www.totalpregnancycare.com
Timing and Mode of
                        Delivery
• Dichorionic twins – 38 weeks
• Monochorionic twins – 36 wks
• Vaginal delivery in uncomplicated DC or MC twins if
  cephalic, cephalic presentations
• Precious pregnancy, abnormal presentations,
  complications like IUGR, preterm, maternal DM/HT
  usually delivered by LSCS
• Increased risk of placenta praevia and APH, PPH


                                           www.totalpregnancycare.com
Complications
• Post-partum haemorrhage

  – Bimanual massage
  – Uterotonics
  – Prophylactic Misoprostol PR
  – Syntocinon infusion
  – B Lynch Suture
  – Uterine Artery Ligation
  – Uterine Artery Embolisation
  – Hysterectomy
                                  www.totalpregnancycare.com
Profile
•   Total Pregnancy Care is an online guide for pregnancy, childbirth and motherhood related
    information. Women wanting to conceive, pregnant women, expecting parents, and new mothers
    can use this pregnancy portal for a healthy pregnancy, fulfilling childbirth and joyful motherhood.
    With pregnancy at its core, this portal covers various important aspects and especially addresses
    those matters that the Indian Woman always wanted to know but did not know whom to ask.

•   This website is compiled by Dr. Shantala, an Indian Obstetrician and Gynaecologist. She has over 20
    years of extensive medical and diagnostics experience in areas commonly related to the Maternity
    and Pregnancy fields. She has studied and practiced in India as well as in the United Kingdom and
    thus brings about the fusion of best practices of the Oriental East and the Progressive West.

•   A mother of three children, she has complete understanding of the emotional, mental and physical
    needs of the New Age Pregnant Woman. Her patients appreciate her empathic approach and
    wholeheartedly express their gratitude for her generosity and care. Dr.Shantala is presently a full
    time Obstetrics and Gynaecology Consultant at the Kokilaben Dhirubhai Ambani Hospital and
    Medical Research Institute, a premier health care initiative of the Reliance ADA Group. Dr.Shantala
    has a clear vision to promote a holistic pregnancy approach and her mission is to provide
    comprehensive maternity care. This website, www.TotalPregnancyCare.com, is her first step
    towards this future.


                                                                                  www.totalpregnancycare.com
Services Offered
•   Pre-pregnancy counseling
•   Genetic counseling
•   Antenatal care, Labour Delivery
•   Specialist Ultrasound scans
     –   Viability scan
     –   The First trimester scan / Nuchal translucency scans
     –   Detailed anatomy / anomaly scans
     –   Fetal Echocardiograph
     –   3D / 4D scans
•   Assessment of the High risk Fetus and Mother
•   Amniocentesis
•   Chorionic Villous sampling
•   Cordocentesis
•   Intra-uterine transfusions
•   Embryo Reduction / Selective fetocide
•   Second opinion scans



                                                                www.totalpregnancycare.com
Topics covered
• Pre-Conception
  – Working on getting pregnant or just starting to think about a family, this is
    the place for you
• Pregnancy
  – From trying to conceive to the first trimester to labor, learn what to
    expect during your pregnancy and more
• Labor Delivery
  – From that first contraction to the final push, here's what to expect
    during labor and delivery
• Post-Pregnancy
  – Learn more about your diet and workouts, shopping, feeding and your
    child's health


                                                               www.totalpregnancycare.com
Interactive Corner
•   Month by Month happenings
•   Articles
•   FAQs
•   Gestation Calendar




                                www.totalpregnancycare.com
Society Memberships
• British Maternal & Fetal Medicine Society
• Fetal Medicine Centre
• Kokilaben Dhirubhai Ambani Hospital &
  Medical Research Institute
• Royal College of Obstetricians and
  Gynaecologists
• International Society of Ultrasound in
  Obstetrics and Gynecology




                                              www.totalpregnancycare.com
Contact Us
• Email: shantala@totalpregnancycare.com
• Mobile: +91 9324304212
• KDAH Board line: +91 22 30999999




                                  www.totalpregnancycare.com
THANK YOU
www.totalpregnancycare.com
                             www.totalpregnancycare.com

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Pregnancy Portal Provides Comprehensive Maternity Care Information

  • 1. www.totalpregnancycare.com www.totalpregnancycare.com
  • 2. Multiple Pregnancy Dr Shantala Vadeyar MD, FRCOG, DM (UK) Advanced Obstetric Ultrasound (RCO/RCR) Subspecialist in Maternal-Fetal Medicine (RCOG) Consultant Obstetrics, Fetal & Maternal Medicine Kokilaben Dhirubhai Ambani Hospital, Mumbai www.totalpregnancycare.com
  • 3. Incidence • Increased with Assisted Reproduction • Clomiphene citrate / Letrozol/ HMG, hCG • Advanced Age • Race – Afro-carribeans • 1:80-100 www.totalpregnancycare.com
  • 7. Risks in Multiple Pregnancy www.totalpregnancycare.com
  • 9. DC twins - lambda sign www.totalpregnancycare.com
  • 10. MC twins - T sign www.totalpregnancycare.com
  • 11. Chorionicity v/s Zygosity www.totalpregnancycare.com
  • 16. Techniques for invasive testing www.totalpregnancycare.com
  • 17. Loss rates: Amniocentesis in Twins www.totalpregnancycare.com
  • 18. Chorionic Villous Sampling in Twins www.totalpregnancycare.com
  • 19. Selective Fetocide / ER www.totalpregnancycare.com
  • 20. Management: Antenatal Maternal and Fetal Surveillance www.totalpregnancycare.com
  • 21. Ultrasound in Multiples • Diagnosis and Chorionicity determinaiton • Dating, Chromosomal & Structural Normality • Growth, Dopplers • Amniotic fluid assessment • Twin twin transfusion syndrome • Invasive procedures – amniocentesis, CVS • Cervical length and funnelling • Prediction of preterm labour • Timing of delivery – Dopplers, BPS in IUGR, etc www.totalpregnancycare.com
  • 22. Complications in Twins: Based on Chorionicity EVENT DICHORIONIC MONOCHORIONIC Miscarriage (11-23 weeks) 2% 10% Perinatal Death (>23 weeks) 2% 4% Fetal Growth Restriction (one /both) 20% 30% Preterm delivery (<32 weeks) 5% 10% Major birth defects 1% 4% www.totalpregnancycare.com
  • 23. Preterm delivery Early screening for www.totalpregnancycare.com Cervical cerclage or Progesterone 25% reduction (4% Prevalence of spontaneous early preterm birth of total) Delivery <34 wks Delivery <34 wks 1.8% 1.8% Iatrogenic Iatrogenic Spontaneous Spontaneous 1/3rd 1/3rd 2/3rd 2/3rd Previous affected pregnancy • Previous affected pregnancy (15% (15% Nulliparous / No previous PTD • Nulliparous / No previous PTD (85% (85%
  • 24. Twin Twin Transfusion Syndrome • Monochorionic twins Anastomoses in TTTS • Donor twin is small, growth restriction • Recepient twin is big • Oligo / polyhydramnios • Big bladder, heart enlarged in recepient • Oliguria, donor • Abnormal Dopplers www.totalpregnancycare.com
  • 25. Prognosis - TTTS • Staging (Quintero) – Stage I • Recipient hydramnios • Donor bladder visible/present – Stage II • Recipient hydramnios • Donor bladder remains empty (“stuck twin”) – Stage III • Abnormal Doppler studies: – absent or reversed end-diastolic flow in Donor UA OR – abnormal venous Doppler pattern in Recipient UA (reverse flow in the ductus venosus or pulsatile umbilical venous flow) – Stage IV • Fetal hydrops means stage IV and the end – Stage V • Fetal death of one or both twins. www.totalpregnancycare.com
  • 26. Treatment of TTTS by selective laser ablation of A-V Anastamoses Laser ablation Stuck ‘donor twin’ wrapped in membrane Feely floating ‘recipient twin’ In hydramnios www.totalpregnancycare.com
  • 27. Electronic Fetal Heart Rate monitoring in labour www.totalpregnancycare.com
  • 28. Epidural Analgesia (painless labour) www.totalpregnancycare.com
  • 29. Timing and Mode of Delivery • Dichorionic twins – 38 weeks • Monochorionic twins – 36 wks • Vaginal delivery in uncomplicated DC or MC twins if cephalic, cephalic presentations • Precious pregnancy, abnormal presentations, complications like IUGR, preterm, maternal DM/HT usually delivered by LSCS • Increased risk of placenta praevia and APH, PPH www.totalpregnancycare.com
  • 30. Complications • Post-partum haemorrhage – Bimanual massage – Uterotonics – Prophylactic Misoprostol PR – Syntocinon infusion – B Lynch Suture – Uterine Artery Ligation – Uterine Artery Embolisation – Hysterectomy www.totalpregnancycare.com
  • 31. Profile • Total Pregnancy Care is an online guide for pregnancy, childbirth and motherhood related information. Women wanting to conceive, pregnant women, expecting parents, and new mothers can use this pregnancy portal for a healthy pregnancy, fulfilling childbirth and joyful motherhood. With pregnancy at its core, this portal covers various important aspects and especially addresses those matters that the Indian Woman always wanted to know but did not know whom to ask. • This website is compiled by Dr. Shantala, an Indian Obstetrician and Gynaecologist. She has over 20 years of extensive medical and diagnostics experience in areas commonly related to the Maternity and Pregnancy fields. She has studied and practiced in India as well as in the United Kingdom and thus brings about the fusion of best practices of the Oriental East and the Progressive West. • A mother of three children, she has complete understanding of the emotional, mental and physical needs of the New Age Pregnant Woman. Her patients appreciate her empathic approach and wholeheartedly express their gratitude for her generosity and care. Dr.Shantala is presently a full time Obstetrics and Gynaecology Consultant at the Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute, a premier health care initiative of the Reliance ADA Group. Dr.Shantala has a clear vision to promote a holistic pregnancy approach and her mission is to provide comprehensive maternity care. This website, www.TotalPregnancyCare.com, is her first step towards this future. www.totalpregnancycare.com
  • 32. Services Offered • Pre-pregnancy counseling • Genetic counseling • Antenatal care, Labour Delivery • Specialist Ultrasound scans – Viability scan – The First trimester scan / Nuchal translucency scans – Detailed anatomy / anomaly scans – Fetal Echocardiograph – 3D / 4D scans • Assessment of the High risk Fetus and Mother • Amniocentesis • Chorionic Villous sampling • Cordocentesis • Intra-uterine transfusions • Embryo Reduction / Selective fetocide • Second opinion scans www.totalpregnancycare.com
  • 33. Topics covered • Pre-Conception – Working on getting pregnant or just starting to think about a family, this is the place for you • Pregnancy – From trying to conceive to the first trimester to labor, learn what to expect during your pregnancy and more • Labor Delivery – From that first contraction to the final push, here's what to expect during labor and delivery • Post-Pregnancy – Learn more about your diet and workouts, shopping, feeding and your child's health www.totalpregnancycare.com
  • 34. Interactive Corner • Month by Month happenings • Articles • FAQs • Gestation Calendar www.totalpregnancycare.com
  • 35. Society Memberships • British Maternal & Fetal Medicine Society • Fetal Medicine Centre • Kokilaben Dhirubhai Ambani Hospital & Medical Research Institute • Royal College of Obstetricians and Gynaecologists • International Society of Ultrasound in Obstetrics and Gynecology www.totalpregnancycare.com
  • 36. Contact Us • Email: shantala@totalpregnancycare.com • Mobile: +91 9324304212 • KDAH Board line: +91 22 30999999 www.totalpregnancycare.com
  • 37. THANK YOU www.totalpregnancycare.com www.totalpregnancycare.com