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Antikanker. Een nieuwe levensstijl.
 

Antikanker. Een nieuwe levensstijl.

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    Antikanker. Een nieuwe levensstijl. Antikanker. Een nieuwe levensstijl. Presentation Transcript

    • David Servan-Schreiber, MD, PHD Clinical Professor of Psychiatry, University of Pittsburgh Lecturer, Faculté de Médecine Lyon I Anticancer A New Way of Life
    • Epidemic 1 - Evolution SEER, 2003 NCI
    • Epidemic 2 - Distribution
    • Key difference = Life style For 100,000 Sasco, 1989 Rev Med Int
    • Refined Sugar WW I WW II
    •  
    • Soy Oil (omega-6)
    • Duckett et al., 1993 J Animal Sci
    • Transformation of food chain Simopoulos & Salem. NEJM, 1989 - Ailhaud et al., Prog. Lip. Res., 2006 – Omg-6 /Omg-3 x6 x10 x15 x30
    • Evolution of Diet Saturated Fat Omega-6 Fatty Acids Omega-3 Fatty Acids % Calories 10 20 - 4M - 10,000 1800 1900 2000 WW II Leaf, A. and P. Weber Am. Jal. Clin. Nut. 1987
    • Omega-6 fatty acids and mammary tumors Carroll et al, 1975 Cancer Res. Days post graft Nb of tumors
    • Advanced Breast Cancer Gago-Dominguez et al., 2003 Brit J Ca – Singapore Prospective 35 298 women
    • Breast Cancer Goodstine et al, J Nut 2003
    • Colon Cancer EPIC Norat et al, 2005 JNCI IARC - Prospective - 478 040 Europeans
    • Chemical Contamination
    • Organic vs Conventional Food
      • 42 children 2 to 5 yo - Seatlle, Wash
      • « organic » children below EPA safety threshold
      • « conventional » children 4 x above
      Curl et al., 2003 Env. Health. Persp.
    • Heatlh Behaviors Years Survival Khaw et al., 2008 PLoS Med. Relative Risk = 4,04
    • Cui et al., 2003 Proc Nat Acad Sci - Koebel et al. 2007, Nature
    • Anticancer Phytochemicals Surh, 2003 Nature
    • Specific Activity Boivin et al., 2008 Food Chem.
    • After Breast Cancer Holmes et al., 2005 JAMA Physical Activity
    • Plain Stress Does Not Feed Cancer
      • 10,519 Finnish Women
      • Prospective study
      • Stress of daily activities
      Lillberg et al., 2001 Int J Cancer
    • What kind of stress? Visintainer & Seligman, 1982 Science % Tumor rejection 54% 23% 63% No Shock Shock – no Control Shock + Control
    • Everson et al., 1996 Psychosomatic Medicine Hopelessness and cancer
      • 2,400 men in Finland
      • Prospective study
      • Hopelessness in two questions
      • Followed for 6 years
    • Support vs. Hopelessness
      • 514 Australian Women
      • Prospective study
      • Stressors in 2 years
      • intimate support
      Price et al., 2001 Cancer 9.5