Antikanker. Een nieuwe levensstijl.

David Servan-Schreiber, MD, PHD Clinical Professor of Psychiatry, University of Pittsburgh Lecturer, Faculté de Médecine Lyon I Anticancer A New Way of Life

Epidemic 1 - Evolution SEER, 2003 NCI

Epidemic 2 - Distribution

Key difference = Life style For 100,000 Sasco, 1989 Rev Med Int

Refined Sugar WW I WW II

Soy Oil (omega-6)

Duckett et al., 1993 J Animal Sci

Transformation of food chain Simopoulos & Salem. NEJM, 1989 - Ailhaud et al., Prog. Lip. Res., 2006 – Omg-6 /Omg-3 x6 x10 x15 x30

Evolution of Diet Saturated Fat Omega-6 Fatty Acids Omega-3 Fatty Acids % Calories 10 20 - 4M - 10,000 1800 1900 2000 WW II Leaf, A. and P. Weber Am. Jal. Clin. Nut. 1987

Omega-6 fatty acids and mammary tumors Carroll et al, 1975 Cancer Res. Days post graft Nb of tumors

Advanced Breast Cancer Gago-Dominguez et al., 2003 Brit J Ca – Singapore Prospective 35 298 women

Breast Cancer Goodstine et al, J Nut 2003

Colon Cancer EPIC Norat et al, 2005 JNCI IARC - Prospective - 478 040 Europeans

Chemical Contamination

Organic vs Conventional Food
42 children 2 to 5 yo - Seatlle, Wash
« organic » children below EPA safety threshold
« conventional » children 4 x above
Curl et al., 2003 Env. Health. Persp.

Heatlh Behaviors Years Survival Khaw et al., 2008 PLoS Med. Relative Risk = 4,04

Cui et al., 2003 Proc Nat Acad Sci - Koebel et al. 2007, Nature

Anticancer Phytochemicals Surh, 2003 Nature

Specific Activity Boivin et al., 2008 Food Chem.

After Breast Cancer Holmes et al., 2005 JAMA Physical Activity

Plain Stress Does Not Feed Cancer
10,519 Finnish Women
Prospective study
Stress of daily activities
Lillberg et al., 2001 Int J Cancer

What kind of stress? Visintainer & Seligman, 1982 Science % Tumor rejection 54% 23% 63% No Shock Shock – no Control Shock + Control

Everson et al., 1996 Psychosomatic Medicine Hopelessness and cancer
2,400 men in Finland
Prospective study
Hopelessness in two questions
Followed for 6 years

Support vs. Hopelessness
514 Australian Women
Prospective study
Stressors in 2 years
intimate support
Price et al., 2001 Cancer 9.5

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Antikanker. Een nieuwe levensstijl.

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