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Anticancer by David Servan-Schreiber


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David Servan-Schreiber, M.D., Ph.D., is the author of the NY Times best seller "AntiCancer". Here is a review of his findings and some recommendations. David successfully battled brain cancer for 19years but unfortunately passed away last July. His latest book is titled "Not the last goodbye" published by Viking in December 2011.

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Anticancer by David Servan-Schreiber

  1. 1. David Servan-Schreiber, MD, PHD Clinical Professor of Psychiatry, University of Pittsburgh Ajct Professor of General Oncology, M.D. Anderson Cancer Center, Univ. of Texas Lecturer, Faculté de Médecine Lyon I Anticancer A Personal and Scientific Journey
  2. 2. A Story <ul><li>Pittsburgh, late1992 </li></ul>
  3. 3. A Lesson <ul><li>We all carry cancer cells </li></ul><ul><li>We are all exposed to cancer promoting factors </li></ul><ul><li>1/4 will die of cancer </li></ul><ul><li>3/4 will be protected by their natural defenses </li></ul>
  4. 4. Tumor and Terrain <ul><li>Classical Oncology: destroy TUMOR cells </li></ul><ul><li>New Oncology: also strengthen TERRAIN </li></ul>
  5. 5. Epidemic 1 - Evolution SEER, 2003 NCI
  6. 6. Childhood Cancers Steliarova-Foucher et al., 2005 Lancet
  7. 7. Epidemic 2 - Distribution
  8. 8. Key difference = Life style For 100,000 Sasco, 1989 Rev Med Int
  9. 9. Health Busters A Watershed in 1945 <ul><li>Nutrition – sugar and fats </li></ul><ul><li>Chemical exposure </li></ul><ul><li>Sedentarity </li></ul><ul><li>Social support </li></ul><ul><li>Reduced sun exposure </li></ul>
  10. 10. Refined Sugar WW I WW II
  11. 12. Glycemic Load and ER+/PR- Breast Ca Larsson et al., 2009 Int. Jnal. Cancer
  12. 14. Soy Oil (omega-6)
  13. 16. Evolution of Diet Saturated Fat Omega-6 Fatty Acids Omega-3 Fatty Acids % Calories 10 20 - 4M - 10,000 1800 1900 2000 WW II Leaf, A. and P. Weber Am. Jal. Clin. Nut. 1987
  14. 42. Chemical Contamination
  15. 43. Pesticides <ul><li>Atrazine changes sex of frogs in our rivers </li></ul><ul><li>Exposed farm workers have higher cancer risks </li></ul><ul><li>Their children too </li></ul>
  16. 44. Sun Light is a Vitamin 20 min = 20,000 IU of Vitamin D
  17. 45. Colon Cancer and Solar Radiation Garland et al, 2006 Am. J. Pub. Health
  18. 46. Breast Cancer and Sun Exposure Garland et al, 1990 Prev. Med.
  19. 47. Health Boosters
  20. 49. Synergy of Natural Defenses Pierce et al., 2007 Jnal Clin. Onc.
  21. 50. Andersen et al., 2008 Cancer Life Style Changes Post-Treatment Intervention Control 68% reduction in mortality
  22. 51. Anticancer Phytochemicals Surh, 2003 Nature
  23. 52. Specific Activity Boivin et al., 2008 Food Chem.
  24. 53. Anticancer Plate
  25. 54. Helplessness and Tumor Growth
  26. 55. Stress and Support <ul><li>The story of Mish </li></ul>
  27. 57. Friends <ul><li>2,835 US nurses </li></ul><ul><li>Prospective study </li></ul><ul><li>Number of friends </li></ul><ul><li>No benefit of spouse </li></ul>Kroenket al., 2006 Jnal Clin. Onc.
  28. 58. <ul><li>Inhibitors </li></ul><ul><li>Anticancer Phytochemicals </li></ul><ul><li>Omega-3s </li></ul><ul><li>Detox Phytochemicals </li></ul><ul><li>Physical Activity </li></ul><ul><li>Social support / stress mgt </li></ul><ul><li>Vitamin D/Sunshine </li></ul><ul><li>Promoters </li></ul><ul><li>(Tobacco – Alcohol) </li></ul><ul><li>Sugar/White Flour </li></ul><ul><li>Omega-6s </li></ul><ul><li>Chemical pollution </li></ul><ul><li>Sedentary lifestyle </li></ul><ul><li>P owerlessness </li></ul><ul><li>Indoor living </li></ul>Cancer = loss of equilibrium
  29. 59. To be continued…
  30. 60. <ul><ul><ul><li>My husband gave me a card early in my illness, which I pinned up in front of me on my bulletin board at work. I read it frequently. Here is what the card said: </li></ul></ul></ul><ul><ul><ul><li>The cover read: ‘Open this card and hold it close to you. Now squeeze.’ Inside my husband wrote: </li></ul></ul></ul><ul><ul><ul><li>‘ You are my everything--my joy in the morning, (even on the days we don’t make love!), my sexy and warm and laughing midmorning daydream, my phantom lunchmate, my building excitement at mid-afternoon, my soothing joy at seeing you when I get home, my workout decompressor, my sous-chef, my playmate, my lover, my all.’ </li></ul></ul></ul><ul><ul><ul><li>The card continued, ‘It’s going to be just fine.’ He wrote under that, ‘And I’ll be there at your side, always.’ </li></ul></ul></ul><ul><ul><ul><li>‘ Love, </li></ul></ul></ul><ul><ul><ul><li>PJ’ </li></ul></ul></ul><ul><ul><ul><li>He was by my side every step of the way. His card meant so much to me and buoyed me throughout my journey. </li></ul></ul></ul><ul><ul><ul><li>Since you asked, </li></ul></ul></ul><ul><ul><ul><li>Mish </li></ul></ul></ul>
  31. 62. Mobile Phone Electromagnetic Penetration Gandhi et al, 1996 IEEE Transac.
  32. 63. Mobile Phones and Blood-Brain Barrier Salford et al, 2003 Env. Health. Persp.
  33. 64. Gliomas Hardell et al, 2008 Int Jal Onc. Relative Risk
  34. 65. Organic vs Conventional Food <ul><li>42 children 2 to 5 yo - Seattle, Wash </li></ul><ul><li>« organic » children below EPA safety threshold </li></ul><ul><li>« conventional » children 4 x above </li></ul>Curl et al., 2003 Env. Health. Persp.
  35. 66. Ailhaud et al., Prog. Lip. Res., 2006 – Simopoulos & Salem. NEJM, 1989 Omg-6 /Omg-3 x6 x10 x15 x20 Transformation of food chain
  36. 67. Food Synergies Zhang, et al. 2009 Int. J. Cancer -89%
  37. 68. Cancer Genes ?
  38. 69. BRCA 1- 2 and Variety of Vegetables Ghadirian et al. 2009, Breast Ca. Res. Treat. Vegetables and Fruits in Diet -73% -73%
  39. 70. Prostate Cancer and Fish Fradet al. 2009 Clin Ca Res
  40. 71. Stress Does Not Cause Cancer <ul><li>10,519 Finnish Women </li></ul><ul><li>Prospective study </li></ul><ul><li>Stress of daily activities </li></ul>Lillberg et al., 2001 Int J Cancer
  41. 72. What kind of stress? Visintainer & Seligman, 1982 Science % Tumor rejection 54% 23% 63% No Shock Shock – no Control Shock + Control
  42. 73. Support vs. Helplessness <ul><li>514 Australian Women </li></ul><ul><li>Prospective study </li></ul><ul><li>Stressors in 2 years </li></ul><ul><li>intimate support </li></ul>Price et al., 2001 Cancer 9.5
  43. 74. Change in Gene Expression Ornish et al., 2008 Proc Nat Acad Sci , USA
  44. 75. Synergy Pulmonary Adenocarcinoma - Lamy et al. In sub Cancer Res Reguar Diet +Vegetable cocktail
  45. 76. Organic or Conventional?
  46. 77. Synergy in vitro Liu et al., 2004, J Nut
  47. 78. Household Products <ul><li>Air out dry cleaned clothing </li></ul><ul><li>Avoid pesticides and insecticides </li></ul><ul><li>Avoid chemical cleaning products </li></ul><ul><li>Avoid parabens and phthalates in cosmetics and perfumes </li></ul><ul><li>Avoid BPA of heated plastics </li></ul><ul><li>Avoid inorganic phosphate additives </li></ul><ul><li>Avoid skin contact with aluminum </li></ul>
  48. 79. Anti-perspirant and Shaving McGrath et al., 2003 Eur Jnal Ca Prev ,