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Segmenting the fly embryo: by means of non-linear dynamics or Boolean logic? Joseph X. Zhou Konrad Loetzsch  Presentations on lecture "Introduction to Mathematical Biology II", Jan. 2 9 , 2008 Group advisor: Group member: Lutz Brusch
Pattern formation during embryonic development ,[object Object],[object Object],[object Object],[object Object]
Genetic network controlling  segmentation in fly Drosophila ,[object Object],[object Object],[object Object],[object Object],[object Object]
Conventional physics Law ,[object Object],It is to easy to guess the law in a simple system, such as: Newton’s Gravity Law, Coulomb's Law, Schrodinger equation, etc.
When network plays a role ,[object Object],- “Bringing cartoons to life”, John J. Tyson, Nature, 445, 823 A D C ,[object Object],[object Object]
A dynamical model of the segment  polarity gene network ,[object Object],[object Object],[object Object],[object Object],[object Object]
Pathways Database    Network models ,[object Object],[object Object],[object Object],[object Object],[object Object],World-wide Pathways Database 1 Extract a sub-model World-wide Pathways Database n … … Integrate them to Network model Coupled ODEs Stochastic Model Boolean Dynamics SBML CellML
Build a Gene network model for early wing development of Drosophila
Build a Gene network model for early wing development of Drosophila
Build a Gene network model for early wing development of Drosophila ,[object Object],[object Object],[object Object]
Conclusion ,[object Object],[object Object],[object Object]

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Pattern Formation Drosophila

  • 1. Segmenting the fly embryo: by means of non-linear dynamics or Boolean logic? Joseph X. Zhou Konrad Loetzsch Presentations on lecture "Introduction to Mathematical Biology II", Jan. 2 9 , 2008 Group advisor: Group member: Lutz Brusch
  • 2.
  • 3.
  • 4.
  • 5.
  • 6.
  • 7.
  • 8. Build a Gene network model for early wing development of Drosophila
  • 9. Build a Gene network model for early wing development of Drosophila
  • 10.
  • 11.