2. Kian Ang, M.D., Ph.D.
• Professor, Radiation
Oncology
• Vice President Global
Academic Programs
2012/3
• expert clinician
• highly accomplished
clinical and translational
scientist
• a respected educator
• trusted friend & valued
colleague
3. Mission and Objectives
• MD Anderson’s
mission:
– … to eliminate
cancer in Texas,
the nation and
the world …
– Global Academic Programs (GAP) supports the work of our faculty
via the Sister Institution Network:
• 33 Sister Institutions in 24 countries incl. 5 consortia
– list at www.mdanderson.org/gap
• the largest global network of cancer centers working collaboratively to accelerate
the mission of Making Cancer History
– Network is a platform to support work in patient care, research,
prevention and education
4. University Cancer Centers
• China - Fudan University Cancer Hospital, Shanghai
• China - Cancer Hospital and Institute, Chinese Academy of
Medical Sciences, Beijing
• China - Sun Yat-Sen University Cancer Center, Guangzhou
• China - Tianjin Medical University Cancer Institute and
Hospital, Tianjin
• China - Chinese University of Hong Kong, Hong Kong
• Japan - Kyoto University, Kyoto
• Korea - Yonsei University Medical Center, Seoul
• Lebanon - The American University in Beirut Faculty of
Medicine and Medical Center, Beirut
• Taiwan - China Medical University Hospital, Taichung
• Thailand – Chulalongkorn University
• Turkey - Hacettepe University Institute of Oncology, Ankara
• United Kingdom - Imperial College of London, London
Consortia
• Italy – Italian Alliance Against Cancer
• Japan - Tokyo Oncology Consortium - Keio University and
St. Luke’s International Hospital, Tokyo
• Norway - Norwegian Cancer Consortium, Oslo including
Oslo University Radium Hospital, Stavanger University
Hospital and the National Cancer Registry
• Poland - Polish Cancer Consortium
• Thailand – Mahidol University, Siriraj Hospital and Bangkok
Hospital
Meet our Sister Institutions
National / Regional Cancer Centers or Equivalent
• Australia - Peter MacCallum Cancer Centre, Melbourne
• China – Hunan Cancer Hospital, Changsha, Hunan Province
• France - Institut Gustave Roussy (IGR), Villejuif
• Germany - German Cancer Research Center, Heidelberg
• India - Tata Memorial Center, Mumbai
• Jordan - King Hussein Cancer Center, Amman
• Mexico - Instituto Nacional de Cancerologia, Mexico City
• Peru - Instituto Nacional de Enfermedades Neoplásicas (INEN),
Lima
• Sweden - Karolinska Institutet, Stockholm
Private Non-Profit Academic Hospitals with
strong Cancer Programs
• Brazil - Hospital Israelita Albert Einstein, Sao Paulo
• Chile - Clinica Alemana, Santiago
• Colombia - Instituto de Cancerología - Clinica Las Américas
(IDC), Medellin
Private Non-Profit Academic Cancer Hospitals
• Brazil - Hospital de Câncer, A.C. Camargo, Sao Paulo
• Brazil - Barretos Cancer Hospital, Barretos
Academic Hospitals with strong Cancer Programs
• Denmark - Rigshospitalet, Copenhagen University Hospital,
Copenhagen
• Israel - Chaim Sheba Medical Center, Tel Hashomer
6. UT MD Anderson
Part of Houston’s Texas Medical
Center
• 53 health and academic
institutions
– UT Health & MD Anderson
– Baylor College of Medicine
– Rice University
• 106,000 employees
• 7,000 beds
• 7.2 million visitors/year
• MD Anderson is the largest single
entity in the TMC
• www.texasmedicalcenter.org
Part of the University of Texas
• 9 academic institutions
• 6 health institutions
– UT Southwestern Medical Center
– UT Medical Branch at Galveston
– UT Health Science Center at Houston
– UT Health Science Center at San
Antonio
– UT MD Anderson Cancer Center
– UT Health Science Center at Tyler
10. Research & Game Changing Initiatives
• Moon Shots:
• Ambitious and comprehensive plan to
dramatically accelerate the pace of scientific
discoveries into clinical advances, focused
on six key areas:
– breast & ovarian
– lung
– prostate
– melanoma
– leukemia (CLL)
– leukemia (AML/MDS)
12. Departmental Structure
Clinical Divisions
• Anesthesiology & Critical Care
• Cancer Medicine
• Cancer Prevention & Population
Science
• Diagnostic Imaging
• Internal Medicine
• Nursing
• Pathology/Laboratory Medicine
• Pediatrics
• Quantitative Sciences
• Radiation Oncology
• Surgery
research driven, multidisciplinary patient care
Basic Science Departments
• Biochemistry & Molecular Biology
• Biomedical Engineering
• Cancer Biology
• Cancer Genetics
• Epigenetics & Molecular
Carcinogenesis
• Immunology
• Molecular & Cellular Oncology
• Molecular Genetics
• Veterinary Medicine & Surgery
• Veterinary Sciences
13. Multi-Disciplinary Care Centers
• Bone Marrow/Stem
Cell
• Brain and Spine
• Breast
• Gastrointestinal
• Genitourinary
• Gynecology
• Head and Neck
• Leukemia
• Lymphoma and
Myeloma
• Melanoma/Skin
• Sarcoma
• Thoracic
research driven, multidisciplinary patient care
14. Sister Institution Membership
• Sister Institutions are academic partners with broad engagement
across multiple areas/departments/disciplines
• Relationships built around faculty champions – “GAP follows the
faculty”
• Relationships take 1-2 years to build
• Thorough assessment of partner with reciprocal visits, seminars
• Assess/score
various criteria
• Presented to advisory
committee, which
makes a
recommendation to the
President
• 5-year renewable
agreement
Status in country/region
Impact & Significance of relationship
Strategic Plan for collaborations
Basis/activities already ongoing
Infrastructure and capabilities of
partner
Feasibility & institutional support
15. GAP Activities – Patient Care
Sister Institution Referral Assistance Center
• SIRAC Supports the collaborative management of patients from abroad, between our
physicians and those at the home institution.
• SIRAC provides language and “concierge-light” services & community to those
patients to ease their entry to MD Anderson’s International Center.
www.mdanderson.org/sirac
• ~110 patients / 3 years
• Focus on China & Latin America
• Recently added 2nd opinion pathology service
“Fudan University […] Tumor hospital and American MD
Anderson Cancer Center [are] sisters hospital, [and] we have the
treatment determination, [and] help to recommend the US to treat!!”
16. GAP Activities – Research
Sister Institution Network Fund
• 82 projects
• 4 RFAs (FY11/12/13/14)
• 47 collaborating institutions
• 27 countries
Clinical
Basic
Total ~ $16M (MD Anderson: $8.2; Network ~ $8M)
Papers (71):
• Nature (3), Nature Cell Biol. (4),
Nature Imm., NEJM, Cell, Mol. Cell,
Dev. Cell, JNCI, PNAS
Grants (19):
• NIH/NCI (11), CPRIT (6), ASCO,
Foundations
• 20+ cancer types
• broad range of research
• http://bit.ly/SINF_2014
“collaborate
globally & fund
locally”
17. GAP Activities – Research
Sister Institution Network Fund
What are the projects focused on?
18. 6 7 9 14
23
36
49
61 64
112 116
137
204
221
231
204
0
50
100
150
200
250
1999
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
2013
2014
NumberofPublicatsionsinSCOPUS
Co-Publications between MD Anderson and Sister Institutions
GAP Activities – Research
Publications
Data obtained from SCOPUS - www.mdanderson.org/scival
GAP started
SINF started
20. GAP Activities – Research
Clinical Trials
• In 2011 gathered an “inventory” of the capabilities of 17 of our Sister Institutions regarding
clinical trials – shared this internally with clinical investigators
• With Institute De Cancerologia, Clinica Las Americas, Medellin, Colombia:
• *Conservative surgery for women with low-risk, early cervical cancer
• *Laparoscopic approach to cervical carcinoma: a phase III randomized clinical trial of
laparoscopic or robotic radical hysterectomy versus abdominal radical hysterectomy in patients
with early stage cervical cancer
• With Fudan University Cancer Center, Shanghai, China:
• External qigong therapy for women with breast cancer prior to surgery
• Pilot study of Huachansu in patients with hepatocellular carcinoma, small cell lung cancer or
pancreatic cancer (Phase I)
• *Huachansu and gemcitabine in pancreatic cancer (Phase II)
• With Sheba Medical Center, Tel Hashomer, Israel & University of Heidelberg, Germany:
• A phase I, open-label, dose escalation study to evaluate the safety, tolerability and
pharmacokinetics of INNO-406 in adult patients with Imatinib-resistant or intolerant Ph+
leukemias
• With Institute Gustave Roussy, Paris, France:
• A phase II trial of the multitargeted kinase inhibitor E7080 in advanced radioiodine (RAI)
refractory differentiated thyroid cancer (DTC)
Total: 7 trials (*3 are ongoing)
21. GAP Activities – Prevention
Tobacco Control with Moon Shots Platform
Nov. 2012 – LOI signed by the Commission of
National Institutes and High Specialty Hospitals of
Mexico, the National Cancer Institute of Mexico
and MD Anderson Cancer Center (picture)
Oct. 2013 – LOI signed by the Government of the
City of Medellin, the Instituto de Cancerologia
Clinica las Americas and MD Anderson Cancer
Center
The implementation, evaluation, refinement and dissemination of prevention
and control programs:
• community-based tobacco use prevention and control pilot programs for
children and adolescents
• formalized prevention and control programs, including programs related to
public health policy, education for the public and professionals, clinical and
community services, comprehensive initiatives, research endeavors, and
other public health and academic programs
22. GAP Activities – Education
Annual GAP Conference
Conference held at MD Anderson in odd years and hosted by a
Sister Institution in even years. 2012 - Norwegian Cancer
Consortium and 2014 - Yonsei Cancer in Seoul, South Korea.
• Global Participation
• Program built to
foster collaboration
• Brings entire
network together
www.MDAnderson.org/GapConference
Norway
Korea
http://gapbrazil2016.org/
23. GAP Activities – Education
Visitors, Video-Conferences, Conferences
multidisciplinary patient video conference
24. Institutional Investment
• Organization and governance
– Part of Division of Academic Affairs, reports through Provost
– 10 team members in GAP office
• GAP is a significant institutional investment
– SINF & GAP Conference supported by the MD Anderson Cancer Foundation
(unrestricted donor funds); SINF some support from the National Breast
Cancer Foundation.
• Return on investment
– SINF:
• leverages from network at 1:1
• $14M in new grants from NCI/NIH, CPRIT, foundations etc have been obtained in
connection with SINF grants (updated 4/15)
– SIRAC supported >120 patients who gained access to expertise, technology
and drugs not available in their home country
– GAP activity has resulted in Cancer Network projects e.g. at Hospital Israelita
Albert Einstein, Sao Paulo; GAP provides academic component for Cancer
Network activities
25. Program Stewardship
and Integration
GAP
MD Anderson Faculty
– “GAP follows the
faculty”
International
Advisory Board
MD Anderson
Committee
Sister Institution
Directors
Presidents/CEOs/Rep
resentatives of the
Sister Institutions
Sister Institution
Network Fund
•Study Section
•Sister Institution
Program Board
International
Advisory
Board
GAP
Business
Development
International
Fund Raising
Development
Office
Other
programs
GAP Directors Meeting, April 2015
26. MD Anderson
+
Sister Institutions
+
Partners
Onsite Workshops
Observerships / Fellowships
Online Teaching / Telementoring
Train 1000 healthcare providers over the next 5
years
Africa Initiative
5 African PG Trainees,
New Oncology Masters Program,
2 SINF grants,
1 NCI grant, Multi-disciplinary Onc Seminars
Telementoring for Women’s
Cancer with Project Echo
(MDACC, Barretos & HIAE)
March 2015: 1st In-Country Workshop
w/MOH- Zambia with all the partners
shown above
3yr Training & Education Plan developed
focused on breast and cervical cancer,
including telementoring, rotations,
fellowships etc
Ultimately also aim to develop research
infrastructure
27. Recognition
MD Anderson Cancer Center was presented the
People’s Republic of China International Science
and Technology Cooperation Award at a
ceremony held January 9, 2015 at Beijing’s Great
Hall of the People.
“It is increasingly important to share information and
create ties that help all nations in our collective fight
against cancer. Receiving this coveted award from China
is an honor for our institution and one that speaks to our
commitment to collaboration, here at home and across
the globe.”
- Ron DePinho, M.D., President of MD Anderson
