2. AREA OF INTEREST
The existing H1N1 (2009) swine flu is pandemic in nature and is
responsible for global economic
losses and fatalities.
. HA( hemagglutinin)protein plays a major role in attachment of virus
to the host cell surface and entry of viral RNA into the host cell leads to
infection.
HA and NA protein are more prominent in H1N1 to cause swine flu.so, i
want to study their stastical analysis with various ligand and their
docking scores on available softwares.
3. Swine flu
Swine influenza virus is common throughout pig
populations worldwide. Transmission of the virus from pigs
to humans is not common and does not always lead to
human flu, often resulting only in the production of
antibodies in the blood. If transmission does cause human
flu, it is called zoonotic swine flu. People with regular
exposure to pigs are at increased risk of swine flu infection
4. Symptoms of swine flu
Symptoms of the swine flu are the same as those of seasonal influenza, and
can include:
cough
fever
sore throat
stuffy or runny nose
body aches
headache
chills
fatigue
nausea and vomiting
5. Proposed plan
Literature review(from ncbi pubmed , pubmed
central)
Gather data
TOOLS REQUIRED
Statistical softwares as R, SAS,or SPSS.
Ligand database as pubchem ,KEGG etc.
DOCKING SOFTWARES AS GOLD,DISCOVERY
STUDIO,FLEX X
6. Goal
My goal is to find the active drug molecule responsible
for inhibition of the activity of HA, or NA protien.