9. ACCORD 7 TRIAL
Eligibility:
- Adenocarcinoma
- Lower third esophagus or GEJ
or stomach.
- Resectable
- PS 0-1
Primary:
- OS
- Secondary:
- DFS, R0 resection rate, Safety
Chemo:
- 2 or 3 cycles pre
- FU 800 mg/m2/d continuous IV
for 5 days (1-5)
- Cisplatin 100 mg/m2 day 1
- Each 28 days
- 3 to 4 cycles post
4 -6 w
4 w
25% stomach
D2??
J Clin Oncol 29: 1715–1721. 2011
10. R0 84 vs 74%
v
v
v
DFS 34 vs 19% HR: 0.65 CI: 0.48-0.89 p=0.003
18. CONCLUSIONS
• Multidisciplinary team approach
• Positive: Perioperative: induces downstaging, increase
R0 resection, improves DFS and OS, better compliance
• Negative: Further research pre vs post, tumor site.