The document describes several types of blood cells including monoblasts, promonocytes, monocytes, macrophages, histiocytes, lymphoblasts, prolymphocytes, lymphocytes, plasmablasts, proplasmocytes, and plasma cells. It discusses their key characteristics such as size, cytoplasm features, and nuclear features. It also summarizes some cytoplasmic and nuclear abnormalities that can occur in these cells such as toxic granules, Dohle bodies, Pelger-Huet anomaly, and pyknotic cells.

2. Monoblast
Promonocyte
Monocyte

3. Monoblast
Size:
- F F F
10-18
Cytoplasm:
- -
- F F F - F
Nucleus:
- F F F F
(folded over)
-chromatin F
F F
- F
- nucleoli F 1-2

4. Promonocyte
Size:
- F F F
14-18
Cytoplasm:
- , F
- fine azurophilic granules
Nucleus:
- F
-chromatin F F
F
- F
- parachromatin
- nucleoli F F

5. Monocyte
Size:
- F F F
14-18
Cytoplasm:
- - , F F
- fine azurophilic granule
- vacuoles
Nucleus:
- F
-chromatin F F
F F F
- F
- parachromatin

6. Macrophage
Size:
- F F F
25-50
Cytoplasm:
-
- vacuoles
- azurophilic granule
Nucleus:
-
-chromatin
- nucleoli 1-2

7. Histiocyte
Histiocyte
F Reticuloendothelial cell
(RE cell) F
F

8. e

9. Lymphoblast
Size:
- F F F
10-18
Cytoplasm:
- F
- F granules
- perinuclear zone
Nucleus:
- F F F
- F
Nucleus/Cytoplasm = 5-7/1
-chromatin F
- nucleoli 1-2

10. Prolymphocyte
Size:
- F F F
10-18
Cytoplasm:
-
- azurophilic granules
Nucleus:
- ,
-chromatin
F
- nucleoli F

11. Lymphocyte
Size:
- F F F
10-15
( Lymphocyte)
Large lymphocyte
Cytoplasm:
-
- azurophilic granule
Nucleus: Small lymphocyte
- ,
-chromatin F
Medium lymphocyte

12. Spindle-shaped lymphocyte
Large Granular Lymphocyte “N.K cell”

13. Atypical lymphocyte
(Transformed lymphocyte)
lymphocyte F
F F
active stage F 3
Type I
Type 2
Type 3

14. Atypical lymphocyte type I
Size:
- cell F F
F F F
Cytoplasm:
- F F
plasma cell foamy
- fine azurophilic granules
Nucleus:
-
-chromatin
F

15. Atypical lymphocyte type II
Size:
- F F cell type I
Cytoplasm:
-
- F
Nucleus:
- , F
nucleus monocyte
-chromatin F

16. Atypical lymphocyte type III
Size:
- F cell type I
Cytoplasm:
-
- F
Nucleus:
- ,
-chromatin
- nucleoli

17. Plasmoblast
Proplasmocyte
Plasma cell

18. Plasmoblast
Size:
- F F F
18-25
Cytoplasm:
- F
- foamy
- perinuclear zone
Nucleus:
- F,
- nucleoli
-
parachromatin F
(Cartwheel)

19. Proplasmocyte
Size:
- F F F
15-25
Cytoplasm:
- F
- foamy
- perinuclear zone
Nucleus:
-
-
- nucleoli F

20. Plasma cell
Size:
- F F F
8-24
Cytoplasm:
- F
- foamy
- perinuclear zone F
Nucleus:
-
-
- 2 nucleus
- parachromatin

22. F F
:
•Congenital abnormalities
•Acquired abnormalities
F 2
1. Cytoplasmic abnormalities
• F granule
• F F cytoplasm (vacuolization)
2. Nuclear abnormalities

23. Cytoplasmic abnormalities
F granule
Normal
1.Toxic granule
Large azurophilic granules
F F
F :
- Infections
Toxic granule
- Serious burns
- Septicemia
- drug poisoning

24. 2.Chediak- Higashi anomaly
Congenital (autosomal recessive)
granule F F
(Abnormal azurophilic granules) F
Susceptible to infection
F albinism bleeding tendency

25. 3. Döhle bodies
F 1-4 µm
F F F band
form, neutrophil
Aggregates of Rough endoplasmic reticulum
:
- Several toxic status
- Severe burn
- Burns
- Chemotherapy
- Malignant disease
- Pregnancy
F F

26. 4. Alder-Reilly anomaly
Autosomal recessive trait
granule F F F
nucleus neutrophil
lymphocyte monocyte
F Toxic granules
F Cytochemical stains:
Alder-Reilly F F F
Toluidine blue stain Colloidal iron stain
F Toxic granule F F

27. 5. Auer rod
F F -
Abnormal development of
primary granules
Leukemic Blood cells
- Myeloblast
- Promyelocyte
- Monoblast

28. 6. May-Hegglin anomaly
Autosomal dominant trait
F 1-3 m, blue-gray
F Döhle bodies F
Aggregates of mRNA
F
Leukopenia
Thrombocytopenia
Giant platelets

29. Cytoplasmic abnormalities
F F cytoplasm (vacuolization)
F
vacuole F toxic
granule neutrophil F F
septicemia
F F
F F 4

30. Nuclear abnormalities
1. Hypersegmentation
Nucleus F lobe F 5 lobes
hypersegmented neutrophil
Vit.B12 or Folic acid Deficiency
(Megaloblastic anemia or Pernicious anemia)

31. 2. Pelger-Huet anomaly
nucleus F F F neutrophil 2
lobe F F F band form
Congenital (Autosomal dominant)
Acquire
(myeloproliferative disorder)

32. 3. Pyknotic cell
Nucleus F
F
Cytoplasm F F
F

33. 4. Smudge cell or basket cell
F cells F nucleus
F
F F F
Leukemic blood cell
Chronic Lymphocytic Leukemia (CLL)

34. Other
1. L.E cell
WBC PMN hematoxylin body
:Autoimmune disease F Antinuclear
factor (ANF)
Rosettes form
Antigen-antibodies complex complex
F Hematoxylin body (Nucleus:ANF)
Complement F F
Chemotaxis
PMN Rosettes form
PMN Hematoxylin body F F
L.E cell
L.E.Cell

35. 2. Tart cell
monocyte neutrophil phagocytosis
nucleus F F