The Galveston & Red River Railroad (G&RR) initially chartered in 1848 eventually reached the tiny village of Cypress Top, now called Cypress, Texas, on July 26, 1856 after building northwest from Houston. Cypress Top saw a population growth as railroad workers and others came to work on building the railroad further north. However, the town was hit hard by a yellow fever outbreak in 1859 that killed 33 of the town's 54 residents including the doctor. After the Civil War and Reconstruction, the railroad that was renamed the Houston & Texas Central advanced past Cypress Top, which became just another station along the line, though Cypress would later boom as a town.