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1. 1 Studying host-pathogen interactions with a clinical perspective Marc LECUIT, MD PhD Institut Pasteur, Inserm Hôpital Necker-Enfantsmalades, Université Paris-Descartes
2. Studying host-pathogen interactionsis critically needed on a clinical standpoint Ongoing outbreak of Hemolytic-Uremic Syndrome in Germany Shiga toxin-producing E. coli O104:H4 STX recognizes Gb3Cer/CD77 receptor Species- and tissue-specific Expressed on human endothelial cells STX blocks protein synthesis Endothelial cell damages, cell death Activation of complement cascade Coagulopathy, leading to HUS Therapeutic options Antimicrobial therapy: the outbreak strain is multi-resistant (ESBL-producing strain) Targeted therapy: blockade of complement cascade with an anti-C5 monoclonal antibody 2 Lapeyraqueet al. N Engl J Med, May 2011
7. Species specificity of Listeria monocytogenes,and its molecular basisL.monocytogenes Guinea pig Rabbit Mouse Rat Human Lecuit et al, EMBO J 1999 Khelef et al, Cell Microbiol 2006 4