mHealth Israel_A New era for Life Sciences: Reimagining medicine with data and digital

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Jeremy Sohn, VP, Digital BD&L, Novartis, presenting on Nov 5, 2020. Title: "A New era for Life Sciences: Reimagining medicine with data and digital". Presentation begins with using data and digital to diagnose cancer. Overview of the "Map of Life", an initiative to explore, and analyze Novartis' historical clinical trial data, with applications like Qubit, Chord, Chronograph. There is an example of taking the first step toward in-silico development.

A New era for Life Sciences: Reimagining
medicine with data and digital
Jeremy Sohn, VP, Digital BD&L, Novartis
Novartis Digital

Novartis Digital
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Novartis Digital
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Novartis Digital
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Novartis Digital
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Novartis Digital

Novartis Digital
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Novartis Digital

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1st step toward in-silico development

Novartis Digital
Business Use Only10

Novartis Digital
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Novartis Digital
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Novartis Digital
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Novartis Digital
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Novartis Digital
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Presentation by Mark Coticchia, Chief Innovation Officer, Baptist Health, for mHealth Israel community, September, 2023. Baptist Health has internationally renowned centers of excellence in cancer, cardiovascular care, orthopedics and sports medicine, and neurosciences. A not-for-profit organization supported by philanthropy and committed to its faith-based charitable mission of medical excellence, Recognized by Fortune as one of the 100 Best Companies to Work For in America and by Ethisphere as one of the World’s Most Ethical Companies.Innovation is paramount to health system’s performance and reputation. Becker’s 2019 Advisory Board survey revealed innovation and technology ranked as the top priority among healthcare finance professionals - up from eighth in 2018. 90% healthcare/life science leaders agree that the pandemic will fundamentally change the way they do business, requiring new products, services, processes, and business models (McKinsey: Innovation Through Crisis Survey). Innovation has been proven to help health systems in many ways. A capability and culture of innovation accomplish numerous goals: Innovation capability and culture improve the care and work environment. They enhance the reputation through recognition for discoveries made at and through Baptist Health. They aid in the recruitment and retention of top talent. And they help systems harness money that otherwise would be leaving the system – licensing revenues and investment returns and corporate research support and donor revenues. Successful Programs - Common Underpinnings. Innovation as a strategic, institutional priority Program built on institutional assets and centers of excellence Experienced, professional team Technology development and sourcing, Dedicated, long term support. Doing healthcare innovation well at a large enterprise takes a highly specialized team and skill set. Collectively, they need to have deep knowledge of healthcare regulation, medical procedures, patient safety, business development, transactions, business law, innovation markets, entrepreneurship, venture capital, commercialization, tech transfer, organizational change management, and much more. Programs- services, technology management, corporate co-creation, global medical service lines and facilities; Focus on market opportunity vs. technology; Select & concentrate on winners; Operate as a business; Proactive in new company formation; Progress, milestones, preliminary results; Building New Innovation Pathways; Improving Treatment for Cancer Patients; Predicting & Preventing Heart Attacks; Improving Outcomes in Cardiac Care; Enhancing a Culture of Innovation at Baptist Health & South Florida; Cleerly, TriVentures, COTA; Innovation is paramount to health system’s performance and reputation. Baptist Health has established an innovation function predicated on best practices and tailored to its assets and the opportunities extending from Miami’s economic growth

Baptist Health- Engineering the Future of Healthcare

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Presentation by Yael Klionsky, YEDA, for the mHealth Israel community in September, 2023. Title: Challenges in Academic Technology Transfer. Examples- Transplantation Immunology and Immunometabolism. Efranat Pharma was developing an anticancer immunotherapy treatment based on a natural plasma protein molecule. From target discovery to clinical validation. Clinical-stage drug discovery and development company utilizing a broadly applicable, predictive computational discovery platforms to identify novel drug targets and new biological pathways and develop therapeutics in the field of cancer immunotherapy. To allow SOCIETY to benefit from discoveries made at the academic institution. To enable SCIENTISTS to transfer their new technologies to the market. To create an additional source of INCOME for the INSTITUTE so that more independent research can be conducted. Three important elements that make an idea patentable: 1) The invention must be new: the same idea can’t have been published before in any form; 2) There must be some inventive step of ‘non-obviousness’. This can be hard to define and depends on the context; 3) The disclosure in a patent must be sufficient for a skilled person to reproduce the invention with only routine effort; Technology Transfer Company - modus operandi; OUR PURPOSE- To provoke transformative scientific breakthroughs that will shape the future of humanity; SCIENTIFIC STAFF- 300 Principal investigators, >2,000 Research students and PhDs; 5 FACULTIES – BASIC SCIENCE, Biology, Physics, Biochemistry, Math/CS Chemistry; Generated IP- 57% in Life Science & Biotech; Among the Highest Income per Researcher Worldwide; 1959 (First TTO outside the US); Today- More applications per PI than in most Ivy league universities; Copaxone- >$30B ANNUAL SALES BASED ON Weizmann IP; 20 new licenses per year and 10 new companies per annum; www.yedarnd.com

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Overview of activities in Life Science of Hadasit, the technology transfer arm of Hadassah Hospital in Jerusalem. Includes details about Jerusalem Biodesign program; spinouts like Brainwatch; details about tech transfer (the Secret Engine Behind Israel’s Success); relationship and examples of TTOs enabling Israel's greatest success stories; contrasting of Adademia (Scientific driven research, Creation of new knowledge, Publication, Sharing of Material, Social responsibilities) and Industry (Applied research & specific objectives, Develop new products, Product development, Secrecy and patent protection, Organization responsibilities); Development gap between initial inventions and product development; the Art of translation (from academic research to medical companies); Tech transfer transforms cutting-edge research into marketable healthcare technologies; LICENSING TO EXISTING COMPANIES; SPINNING OFF STARTUPS; CO-DEVELOPMENT OF JOINT IP; Technology Transfer Offices from Academia/Research Hospitals – to Industry; Overview of Hadassah and Hadasit (TECHNOLOGY TRANSFER COMPANY AND INNOVATION ENGINE OF HADASSAH UNIVERSITY HOSPITALS); Examples of “HADASSAH MADE” PRODUCTS IN THE GLOBAL MARKET; RECENT TECH TRANSFER SUCCESS; Example- Lineage Exclusive Worldwide Collaboration with Genentech Opregen® RPE Cell Therapy for the Treatment of Ocular Disorders; HADASIT PILLARS- NURTURING INTERNAL INNOVATION, Tech Transfer, EXTERNAL INNOVATION. External- SERVICES & COLLABORATIONS WITH COMPANIES, BIOHOUSE FOR STARTUPS, DIGITAL HEALTH ACCELERATOR); Internal Innovation- NURTURING INTERNAL INNOVATION, HADASSAH SEED FUND, JERUSALEM BIODESIGN PROGRAM; TYPES OF RELATIONS WITH EXTERNAL COMPANIES- CONSULTING, SAB, CLINICAL TRIALS, R&D SERVICES, DATA LICENCE, ALPHA/BETA SITE, PILOTS, DESIGN PARTNERSHIPS.

HADASIT: Tech Transfer and More in Life Science

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Presenting to Investors and the Media, lecture by Drew Levinson, LifeSci Communications to mHealth Israel. Three sections: Making a good presentation, Handling interviews with reporters and Answers that resonate. PRESENTING TO INVESTORS AND THE MEDIA- Compelling delivery, Commanding a room, • Lasting Impact. A good presentation includes Information, Motivation and Excitement. Never put them to sleep. Audience impact includes content, credibility and delivery. Decisions are made leading to potential partnerships, winning business, so much more than a deck, your business, your brand, you. How to captivate begins with storytelling and conversation. More than features- benefits, humanize, positive impact. Don't complicate your message with jargon. Feel the passion- contagious, vision, determination. Know your audience- who are they, what do they know about you, how much do they know, interests, concerns. Articulate your vision- see it, feel it, believe in it. Take them on your journey- compelling narrative, make it personal, why are you doing this, inspiration. Your team- experienced, knowledgeable, aligned, execute. Risks and challenges- recognize, address, plan to mitigate. Test drive your room. What does it look like? Where is the podium? Where will I be standing? Where will you be sitting? Feel comfortable. Three parts to attention. The beginning- attention, interest, what's in it for them, entusiasm, preview. The middle- core, insights, challenges, solutions, relatable. The ending- summary, reinforce, messages, benefits, call to action, keep the momentum going. How to answer questions. The Four R's: repeat, reinforce, refer, remember. Talking to reporters- necessity; Good interview can enhance reputation; Bad interview can tarnish reputation; Preparation is vital. Shapes public opinion: Elevates your brand; Establishes authority; Showcases your business; A bridge; Reputation; Trust; Visibility. Know the reporter. Audience; What have they written; Previous stories; Questions asked. Concise- clear, succinct, engaging. Make it relatable: Stories; Anecdotes; Experiences; Examples; Metaphors; Connect. Honesty and transparency. It is okay not to know every answer. You don’t have to answer every question. Control the narrative. What not to do when talking to reporters. Come up with another way to say no comment. What to wear- solid colors, blues and grays, nothing distracting. Expertise, passion, vision, lasting impression, connections. High stakes, high rewards. Preparation; Know your audience; Deliver with confidence; Enthusiasm; Authenticity. Begin the journey. Engage in dialogue; Build relationships; Inspire trust and confidence; Valued; Enlightened; Motivated and excited.

Presenting to Investors & the Media.pdf

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April, 2023 presentation by Gil Bashe, Global Chair, Health Practice, FINN Partners. Insights and analytics, in collaboration with Galen Growth, tracking Digital Health collaboration, adoption, integration, and best practices across the leading US Health Systems. There is a section about focus areas for digital health in health systems and hospitals. The most active health systems are partnering more in diagnosis and have a higher share of digital tools for research. Comprehensive breakout of digital health activities at the Top 10 players: Mayo, Mount Sinai, Cleveland Clinic, Sloan Kettering, Massachusetts General, Northwell, Cedars Sinai, Brigham & Women's, InterMountain. Global breakout of health systems with digital health partnerships at scale. Geographical breakout of digital health partner headquarters (by region). Strong preference for B2B business model. 1/3 of digital health partnerships with Early Stage venture companies. Emphasis is on strong clinical evidence. Portfolio size allows greater diversity. Cluster distribution depends on therapeutic area. Digital health analytics breakout including alpha score, venture similarity score, venture valuation, team signal, partnership signal, evidence signal.

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Overview of the EU medical technology and digital health regulatory framework by Ulf Grundmann and Elisabeth Kohoutek of King & Spalding LLP. Topics include regulatory scope and definitions, classification and conformity assessment, placing a device on the EU Market, UDI and EUDAMED, Supply Chain Obligations, PMS and Vigilance. MDR covers diagnosis, prevention, monitoring, prediction, prognosis, treatment, or alleviation of a disease. ‘Medical Devices’ means any instrument, apparatus, appliance, software, implant, reagent, material or other article intended by the manufacturer to be used, alone or in combination, for human beings. The Regulation covers all devices for cleaning, sterilizing or disinfecting other medical devices, reprocessed single-use medical devices, and certain devices with no intended medical purpose.

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Global State of Digital Health, Q3 2022, prepared by Finn Partners and Galen Growth. While most analyses suggest digital health investment is declining, that’s a superficial assessment. Last year – when patients were separated from the health professional community – investors from all sectors jumped in with investments to learn and save their business models. That investment surge was from exuberance. Now, the monies being deployed are strategic. More important, 2022 numbers are far higher than the pre-pandemic equity invested in 2019. While more than 60% of the total venture funding value comes from North America, on a regional level, the Middle East (primarily Israel by 92% and the United Arab Emirates) set record highs in venture funding in Q2 2022. Europe maintains momentum throughout 2022 and has not experienced the quarter-on-quarter decrease in venture funding seen in North America. Regions with increased investment correspond to established regulatory, public health and payer systems that prioritize digital health use. Israel – and Israeli-based entrepreneurs – need to keep their profiles high.

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Digitally powered participant-directed studies. A Strategy for Decentralized Care. The Evolution of the Digital Patient Experience in Oncology & opportunities for Human Augmented Intelligence and Touch. Outlne: Precedent and example; Opportunities for Artificial Intelligence and/or Machine Learning? The human touch to augment technology; Challenges from a behavioral economics standpoint; Future directions. Digitally powered participant-directed studies are the right direction and may be the new reality. Patient Symptoms During Their Cancer Journey. We must shift our focus to the ‘other’ 99% of time. Patient centricity unrestricted by provider encounters. Patient Generated Health Data. Evolving the Digital Patient Experience in Oncology. AI in Health & Medicine. TREATING THE WHOLE PERSON; Health coaching to address social determinants to: Solve the 4000-hour problem; Keep patients healthy at home; Close care gaps between clinic visits; Motivate healthy behavior changeto drive better outcomes. Digital Health Possibilities for Community-Based Support. Insights from a Pilot of Digital Health Coaching. Pilot Study Data. Outcomes of a Pilot Study Exploring the Role of Digital Health Coaching for Men with Prostate Cancer. Data, Healthcare and Technology...REMEMBER THAT THERE ARE SILOS INSIDE OF EACH OF THESE SILOS – THEY ARE THEMSELVES NOT MONOLITHS. EMPHASIS SHOULD BE THAT WE ARE NOT ONLY CREATING A BRIDGE TO OPEN COMMUNICATION. WE ARE ALSO CREATING A NEW PERSON WHO HAS EXPERTISE IN ALL AREAS BROADLY – NOT ONLY JUST THESE 3.

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AI and the Future of Healthcare, Siemens Healthineers

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A Peek into the Future of Health Systems, by Mark Coticchia, Corporate Vice President, Baptist South Florida, Oct 31, 2022. Context- Skate to where the puck is going. Quote from Sami Inkinen (Founder, Virta Health), "If you want to disrupt an industry like healthcare, you have to do it in a non-disruptive way". Digital Health Care in the context of health system transformation. The direction is towards "Digitally Enhanced Health Care" and personalized medicine. Emphasis on Patient Engagement. Transformation from stand alone facilities to Hospital SuperCenters. Importance of culture, including empathy. Role of staffing. Emphasis on Preventive Medicine.

A Peek into the Future of Health Systems, Mark Coticchia, Baptist Health

A Peek into the Future of Health Systems, Mark Coticchia, Baptist Health

A Peek into the Future of Health Systems, Mark Coticchia, Baptist Health

The Speed of Change is Faster Than Our Response, presentation by Howard Yana Shapiro, Chief Agiculture Officer, Mars, Inc., for the mHealth Israel community, September 29, 2022. Howard-Yana Shapiro, PhD is Senior Fellow College of Agricultural & Environmental Sciences, University of California, Davis; Distinguished Senior Fellow Resilient Landscapes CIFOR-ICRAF; Venture Partner, TO VC. 'Wicked' is the term used to describe some of the most challenging and complex issues of our time, many of which threaten human health. A convergence of technologies enables us to work with biology in entirely new ways. A chip that rivals the human brain. In 2019, Cerebras Systems unveiled a record 1.2-trillion-transistor chip. This is about 10 times more transistors than neurons in a human brain. Analyzing biological systems at the molecular level. Advances in mass spectrometry allow us to readily see almost every molecule in a biological system. Genetic technologies are now more accessible than ever. Advances in genetic technologies now allow everyone to read and write in the languageof biology. Heroines, Heroes andHumankind. Barbara McClintock, Cytogeneticist. Jumping genes and transposons. First evidence for wandering DNA segments came from McClintock’s experiments with Native American maize. She identified changes in the color of kernels that made sense only by postulating that some genetic elements move from other genome locations into the genes for kernel color. These transposable elements movefrom one site to another in a cell’s DNA; they are present in both prokaryotesand eukaryotes. Nitrogen fixation in a landrace of maize is supported by a mucilage-associated diazotrophic microbiota. Analysis of the mucilage microbiota indicated that it was enriched in taxa for which many known species are diazotrophic, was enriched for homologs of genes encoding nitrogenase subunits, and harbored active nitrogenase activity as assessed by acetylene reduction and 15N2 incorporation assays. Field experiments in Sierra Mixe using 15N natural abundance or 15N-enrichment assessments over 5 years indicated that atmospheric nitrogen fixation contributed 29%–82% of the nitrogen nutrition of Sierra Mixe maize. Gurdev Khush, Agronomist and geneticist. Agriculture scientists and geneticists need to work overtime to meet the ever-growing human need for foodand to alleviate hunger and poverty. 1985: IR-64 a high-quality,high-yielding mega variety. Gene editing and CRISPR. Editing a gene using CRISPR/Cas9. Genetic modification of flavone biosynthesis in rice enhances biofilm formation of soil diazotrophic bacteria and biological nitrogen fixation. Improving Biological Nitrogen Fixation (BNF) in cereal crops is a long-sought objective. Hunger + malnutrition = stunting. Stunting prevalence worldwide. Stunting caused by chronic hunger and malnutrition =physical, neurological,economic loss. Key figures in the 2019 FAO report on Africa. We need to produce plants that are bred

mHealth Israel: The Speed of Change is Faster Than Our Response_Howard Yana S...

mHealth Israel: The Speed of Change is Faster Than Our Response_Howard Yana S...

mHealth Israel: The Speed of Change is Faster Than Our Response_Howard Yana S...

Presentation by Avner Finger, Head, R&D, Phibro, Unmet R&D Needs and Opportunities – Farm animals. Phibro business includes Medicated Feed Additives includes Antibiotics, Anticoccidials, Antimicrobials, Bloat Control, Anthelmintics. Vaccines. Fully Licensed includes Autogenous, Poultry, Swine, Bovine, Aqua. Nutritional Specialties include Immune Modulators, DCAD Solutions, Yeast Solutions, Mycotoxin Solutions, Phytogenic Feed Additives, DFM Solutions. MVP Adjuvants. Mineral Nutrition. Ethanol Performance. Plant Science. World meat production. Disease Pressure on the Rise. Intensive livestock production. Antimicrobial resistance. Global warming. Disease vectors prevalence. Global trade and travel. Major Challenges. Animal Protein Supply. Food Safety. Zoonotic diseases. Sustainable production. Vaccines - Our Most Effective Tool. All farmed animals are vaccinated against at least several diseases. Animal vaccines are based on some of the most advanced technologies. However…We Continue to Require Real Innovation. Rapid and accurate diagnostic tools. Vaccine platforms. Mass application.

mHealth Israel_Unmet Needs and Opportunities – Farm animals

mHealth Israel_Unmet Needs and Opportunities – Farm animals

mHealth Israel_Unmet Needs and Opportunities – Farm animals

September 19, 2022 presentation about Animal Health Landscape- by Andras Bolcskei, Executive Vice President & Global Commercial Lead, CEVA Sante Animal Health. Three part agenda covers Global macroeconomic outlook, Animal Health industry trends, Implication on the Animal Health industry. Inflation Growth and Unemployment Costs. China’s consumer Inflation. CASH- Cost and availability of cash is changing which means that there is again a cost associated to taking risk = investors start being more selective. ATTRACTIVITY- In this context, attractivity of the AH sector is increased, especially in Pets, given the track record of resilience of the sector vs. other investment opportunities. We will continue to see M&A activity and R&D investment in the sector. CORPORATIZATION- Despite the increased cost of money, the predictability and history of AH and veterinary business in the last financial crises and the early stage of vet clinics consolidations in many markets are strong drivers for continued, fast-paced corporatization to continue. PET PARENT AND CONSUMER POWER- It will continue to increase in the AH, with megatrends like online 24/7 availability omnichannel, pet as family member, steady increase of pet plans / pet insurance / data driven personalization. This creates value in the market for agile companies. Transactional Customers- Know what they want, Treat you as commodity, Digital interaction, Cost focus, Buy on price, Short term. Consultative Customers- Share problems, Value your value add, Digital & analogue interaction, Advice focus, Buy on expertise and trust, Long term. Vet Landscape Evolution 2022-2025. Market consolidation. Independent Vet clinics. Companion Animals. Corporates. GPOs. Corporate landscape in Europe (data Q2 2022)- A number of large, well capitalized veterinary strategic accounts are expanding. Global trends in pet population. There are currently billions of pets worldwide. Pet ownership is rising globally, particularly in millennial households. Expanding middle class is driving pet population growth in emerging markets. Pet ownership leads to improved human health outcomes for people including better heart health, lower levels of depression and anxiety, etc. Brands & blockbusters. Increasing brand value. Zoetis, Elanco (and BI indirectly through their sales reporting) qualify blocbkusters as products > $100m – 25 brands. One Heath Concept. Sustainability. Technology innovation. Veterinary / Nurse shortage. Farms, trades, on-line shop, independent. More customers are moving to the extremes. More want deeper consultative relationships. More buy transactionally

mHealth Israel- Animal Health Landscape

mHealth Israel- Animal Health Landscape

mHealth Israel- Animal Health Landscape

Human and Animal Healthcare- Where do they meet? Sept 29, 2022 animal health presentation by Cindy Cole, Partner, Digitalis Ventures. Overview of Digitalis Ventures and their $100 million Companion Fund, Mars-backed VC Fund dedicated to the companion animal space. Context about solving a problem vs creating a want. For example, dogs are not small humans. Specific Opportunities include supplements. This is a huge market, very fragmented, Very little science to support the activies. How do you differentiate your products? Example of Telemedicine- a cautionary tale for startups and investors. Summary- if your coming from human healthcare…Understand dogs and cats, Don’t over index on the “humanization” of pets, Solving a problem or creating a want. YouTube video recording available, along with other presenters, Ila Shukla Roof, Executive Commercial Director, Covetrus; Andras Bolcksei, Executive Vice President and Global Commercial Lead, CENA Sante; Avner Finger, VP Global R&D- Vaccines, Phibro; Moderated by Gil Bashe, Head of Global Health and PURPOSE, Finn Partners.

mHealth Israel: Human and Animal Healthcare- Where do they meet? Presentation...

mHealth Israel: Human and Animal Healthcare- Where do they meet? Presentation...

mHealth Israel: Human and Animal Healthcare- Where do they meet? Presentation...

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Editor's Notes

UC goals: Learn from the past: leverage experience from stability data generated from 1000s past formulations Connect heterogeneous data: integrate data in the same context coming from diverse source systems “Bring your data and models”: make your data and models available to a wider user community User journey: problem statement #1 I am testing two variants of my drug product, which is currently formulated as a liquid in vial. I am exploring two possible strengths of this drug: 5mg and 10mg. I have one batch of each strength available for testing and I am putting these on stability testing. My goal is to validate if this drug product is stable chemically and physically both at 5mg potency and in 10 mg potency. Performing the experiment, my drug product resulted not stable at certain conditions (e.g. 6 months at 40°C/75% RH) Opportunities for Data Science and AI:: Is the failure at 6 months a true failure, or a data outlier? Should I try to continue or should I stop here and change formulation? The failure is at 40°C/75%RH, but how critical it is for 25°C/60% RH? Could we have predicted the failure basing on historical data? If yes, what is the common element to the failing experiments? Could we have started mitigation work earlier? Can we help finding a root cause? Were there similar failures in the past? Were there anomalies in the production?