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The Brain Clock :  An Overview of Contemporary Research & Theory Regarding the Neuroscience of Brain-based Interval Timing...
<ul><li>This presentation is based on some VERY broad stroke conclusions and interpretations drawn from reviewing some ver...
There is MUCH more to this research
 
 
Check out “IQ Brain Clock  EWOK ” for specifics
Goal of this presentation To  “connect-the-dots”  across a diverse array of theoretical and empirical fields of study to a...
Status of Mental Timing Research: Historical Note <ul><li>In his chapter  “The Problem of Serial Order in Behavior,”   Kar...
<ul><li>“ We know the  human brain contains some kind of clock , but determining its neural underpinnings and teasing apar...
<ul><li>The holy grail of timing research is to understand the ‘ time-dependent process’: a mechanism equivalent to a piez...
Time  and space are the fundamental dimensions of our life/existence We believe  timing is the foundation for learning and...
Our brains measure time continuously .  We are aware of how long we have been doing a particular thing, how long it has be...
Mental Timing Research:  Importance <ul><li>Many actions (motor) manifest precise timing </li></ul><ul><li>(Zelaznik et al...
Mental Timing Research: Has been implicated as important in human learning and understanding a variety of  clinical disord...
Mental Timing Research:  Modifiability <ul><li>Can the internal clock be “speeded up” </li></ul><ul><li>YES !  - (see revi...
The study of the  neural basis of temporal processing  is in its  infancy   (Mauk & Buonomano, 2004) Our  timing abilities...
Important developments since speaking to you last…… IQ Brain Clock Blog   (www.ticktockbraintalk.blogspot.com ) IQ Brain C...
Timescales of temporal processing (Mauk & Buonomano, 2004) Humans process temporal information over scales of at least  10...
Timing across different timescales (compilation  of data from various human and animal studies – Buhusi & Meck, 2005) <ul>...
Temporal processing  -- the  decoding   of temporal information or the  generation  of timed motor responses. Temporal pro...
Temporal processing:  A definition (Mauk & Buonomano, 2004) (Note  - If  internal temporal  codes are generated by the bra...
<ul><li>Automatic   timing  system  </li></ul><ul><ul><li>Works in the millisecond range </li></ul></ul><ul><ul><li>Discre...
I hypothesize that  SMT interventions  (e.g,  IM)  tap  both the automatic and controlled cognitive timing systems  (and  ...
SMT-based interventions  (e.g., IM) may be operating on the  cognitive and neurological mechanisms that underlie brain-bas...
A domain-general cognitive mechanism? A number of domain (subject)-specific  cognitive mechanisms? OR….
A domain-general cognitive mechanism? <ul><li>There is a long-standing tradition within psychological research to search f...
<ul><li>Searching for the  “essence” of  g  has been the holy grail In intelligence research </li></ul><ul><li>g  is a  do...
<ul><li>Most prominent paradigm for investigating  g  has been the use of  elementary cognitive tasks  (ECTs) (see Jensen)...
g  (general intelligence):  Temporally based? Rammsayer, T. & Brandler, S. (2007).  Performance on  temporal information p...
<ul><li>Analyses suggested a  unitary timing mechanism , referred to as  temporal  g .  </li></ul><ul><li>Performance on t...
<ul><li>The notion of an  internal master clock  represents an  alternative metaphor  to account for the relationship betw...
<ul><li>Temporal information processing models  (Creelman, 1962; Gibbon, 1991; Rammsayer & Ulrich, 2001; Treisman et al., ...
<ul><li>According to the  master internal clock  theory: </li></ul><ul><ul><li>Higher clock speed/rate-  </li></ul></ul><...
<ul><li>Research has suggested that that a  unitary internal master clock  accounts for performance across  four major typ...
Rhythm Perception and Production :  Types of Tasks Studied <ul><li>Rammsayer’s temporal g tasks </li></ul><ul><li>Detectio...
Synchronized (tapping tasks) Theoretical Model (Schulze et al., 2005) <ul><li>Well described by the  Wing- Kristofferson t...
Pacemaker-Accumulator Model based On Scalar Timing/Expectancy Theory (Church, 1984; Gibbon et al., 1984; Meck, 1983) <ul><...
Regularly generates or  emits  neural ticks or pulses “ gaiting” switch from pacemaker to accumulator Accumulates ticks/pu...
“ Raw” representation of stimulus duration transferred to short-term or  working memory Includes “important times” or “sta...
Comparison  made between contents of  reference memory  (the standard) and  working memory  (are they “close” ?).  Relies ...
Another common representation off this model/theory
Pacemaker-Accumulator Model based On Scalar Timing/Expectancy Theory (Church, 1984; Gibbon et al., 1984; Meck, 1983) Impor...
Pacemaker-Accumulator Model based On Scalar Timing/Expectancy Theory (Church, 1984; Gibbon et al., 1984; Meck, 1983) Anala...
What are the possible underlying neurological functions/structures involved? A very very simplified review
<ul><li>Intelligence  theory </li></ul><ul><ul><ul><li>Cattell-Horn-Carroll (CHC) theory of cognitive abilities  </li></ul...
“ Big five” reciprocal frontal-subcortical circuits (loops/pathways) <ul><li>There are at least five big loops/circuits in...
(Casey & Durston, 2006) Example of a circuit/loop
 
<ul><li>Prefrontal cortex </li></ul><ul><ul><li>“ Cognitively controlled timing  activates the  right  hemispheric  dorsol...
The  executive function  is a theorized cognitive system (cluster of skills) that  controls and manages  other cognitive p...
<ul><li>Increased efficiency of  working memory </li></ul><ul><li>Increased ability to sustain and selectively divide atte...
<ul><ul><li>What mechanism allows the  integration of diverse brain networks  to form coherent perceptions and output, wit...
The internal brain clock as conductor metaphor Brain clock synchronizes neural oscillations across diverse brain structure...
<ul><li>The PFC has been likened to a  switch operator  in a railway system (Miller & Cohen; 2001.)  [Also see  “task swit...
<ul><li>A possible lay-person term for  controlled executive attention  is  focus </li></ul><ul><ul><li>“ the concentratio...
Speed of mental information processing example (CHC info processing model example task)
Cattell-Horn-Carroll (CHC) Model of Human Cognitive Abilities Fluid  Intelligence Crystallized  Intelligence Gen. Memory &...
The CHC Information Processing Model Gsm (MW) Information Processing Loop Cognitive Efficiency Gs Cognitive or Academic Pe...
The CHC Information Processing Model Gsm (MW) Information Processing Loop Cognitive Efficiency Executive Control Gs Gf Glr...
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Brain Clock IM Keynote brief 2007

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These are the primary slides for my "Brain Clock" keynote presentation at the Interactive Metronome conference in October 2007 (Chicago). Joke, video, and some other slides have been deleted to allow for posting at this site.

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Transcript of "Brain Clock IM Keynote brief 2007"

  1. 1. The Brain Clock : An Overview of Contemporary Research & Theory Regarding the Neuroscience of Brain-based Interval Timing & Its Relevance to Learning & Rehabilitation Kevin McGrew, Ph.D. (aka, the “Time Doc”) Institute for Applied Psychometrics LLC ( www.iapsych.com )
  2. 2. <ul><li>This presentation is based on some VERY broad stroke conclusions and interpretations drawn from reviewing some very technical and complex research across a large number of disciplines </li></ul><ul><li>e.g.…………………… </li></ul>
  3. 3. There is MUCH more to this research
  4. 6. Check out “IQ Brain Clock EWOK ” for specifics
  5. 7. Goal of this presentation To “connect-the-dots” across a diverse array of theoretical and empirical fields of study to advance possible explanations/hypotheses of the SMT/IM effect
  6. 8. Status of Mental Timing Research: Historical Note <ul><li>In his chapter “The Problem of Serial Order in Behavior,” Karl Lashley ( 1951 ) was among the first neurophysiologists to broach the issue of temporal processing . </li></ul><ul><ul><li>Temporal integration is not found exclusively in language ; the coordination of leg movements in insects, the song of birds, the control of trotting and pacing in a gaited horse, the rat running the maze, the architect designing a house, and the carpenter sawing a board present a problem of sequences of action which cannot be explained in terms of succession of external stimuli . </li></ul></ul><ul><li>(Mauk & Buonomano, 2004) </li></ul>
  7. 9. <ul><li>“ We know the human brain contains some kind of clock , but determining its neural underpinnings and teasing apart its components have proven difficult.” </li></ul><ul><ul><li>(Lewis & Walsh, 2005) </li></ul></ul>
  8. 10. <ul><li>The holy grail of timing research is to understand the ‘ time-dependent process’: a mechanism equivalent to a piezoelectric crystal in a man-made clock or the movement of a shadow on a sundial. This has proven an elusive goal , to the extent that ideas about how this mechanism might work remain near the level of conjecture. Researchers have had great difficulty in pinning timing-related activity in the brain to any specific type of function . This is largely because most time measurement tasks draw upon more than one process, making it difficult to tease the various components apart. </li></ul><ul><ul><li>(Lewis & Walsh, 2005) </li></ul></ul>
  9. 11. Time and space are the fundamental dimensions of our life/existence We believe timing is the foundation for learning and memory , It's hard to find any complex behavioral process that timing isn't involved in To deal with time, organisms have developed multiple systems that are active over more than 10-12 orders of magnitude with various degrees of precision (see figure) Duke Researcher’s Meck & Buhusi (2005) Mental Timing Research: Importance
  10. 12. Our brains measure time continuously . We are aware of how long we have been doing a particular thing, how long it has been since we last slept, and how long it will be until lunch or dinner. We are ready, at any moment, to make complex movements requiring muscle coordination with microsecond accuracy, or to decode temporally complex auditory signals in the form of speech or music. (Lewis, 2005) Time perception is an ability that is taken for granted , yet relatively little understood . Without it, other cognitive functions, especially motor actions and visual awareness, would be severely impaired. Basic tasks such as crossing the road would be near impossible (Livesay et al., 2007) Mental Timing Research: Importance
  11. 13. Mental Timing Research: Importance <ul><li>Many actions (motor) manifest precise timing </li></ul><ul><li>(Zelaznik et al., 2005) </li></ul><ul><ul><li>The musicians in an orchestra time their movements to the gestures of the conductor </li></ul></ul><ul><ul><li>The drag racer uses the countdown lights to anticipate the start of a race </li></ul></ul><ul><ul><li>A pitche r must temporally coordinate muscular activity across different joints to ensure that the ball is delivered to a targeted region of the strike zone </li></ul></ul>
  12. 14. Mental Timing Research: Has been implicated as important in human learning and understanding a variety of clinical disorders . Examples include: <ul><li>Parkinson’s </li></ul><ul><li>Huntington’s </li></ul><ul><li>Schizophrenia </li></ul><ul><li>ADHD </li></ul><ul><li>Reading development and disorders (dyslexia/reading disabilities) </li></ul><ul><li>Speech and language development and related disorders </li></ul><ul><ul><li>Analogy – auditory processing of Morse code </li></ul></ul><ul><li>Musical abilities and performance </li></ul><ul><li>Motor timing disorders </li></ul><ul><li>Aspergers??? </li></ul>(See IQ Brain Clock EWOK for research) Research suggests common dopamine link (e.g., dopaminergic disorders )
  13. 15. Mental Timing Research: Modifiability <ul><li>Can the internal clock be “speeded up” </li></ul><ul><li>YES ! - (see review of Mauk & Buonomano , 2004; Droit-Volet, 2002; Penton-Voak, 1996; Weardon, 2005) </li></ul><ul><ul><li>“ The neural mechanisms underlying timing can be fine-tuned with experience ” </li></ul></ul><ul><li>Select list of approaches </li></ul><ul><ul><li>Physical - drugs, changing body temperature </li></ul></ul><ul><ul><li>Environmental – repetitive streams of stimulation (clicks or flashes - flicker ) prior to stimuli – to increase “arousal” </li></ul></ul><ul><ul><ul><li>SMT/IM ????? </li></ul></ul></ul><ul><li>Research has indicated that it is also possible to “ slow down” the internal clock (Weardon, in press, 2007) </li></ul>
  14. 16. The study of the neural basis of temporal processing is in its infancy (Mauk & Buonomano, 2004) Our timing abilities are impressive , diverse and worthy of investigation. But they are not very well understood . (Lewis, 2005) In comparison with spatial stimuli, there is a significant gap in our understanding of how the brain discriminates simple temporal stimuli (Karmarkar & Buonomano, 2007) Mental Timing Research: Caveats
  15. 17. Important developments since speaking to you last…… IQ Brain Clock Blog (www.ticktockbraintalk.blogspot.com ) IQ Brain Clock EWOK (access via IQ Brain Clock Blog) “ Time Doc”
  16. 18. Timescales of temporal processing (Mauk & Buonomano, 2004) Humans process temporal information over scales of at least 10-12 orders of magnitude that have been categorized into 3-4 major timescale groups
  17. 19. Timing across different timescales (compilation of data from various human and animal studies – Buhusi & Meck, 2005) <ul><li>Importance of interval timing (Buhusi & Meck, 2005) </li></ul>SMT (IM) would be operating primarily at millisecond/interval timing levels
  18. 20. Temporal processing -- the decoding of temporal information or the generation of timed motor responses. Temporal processing: A definition (Mauk & Buonomano, 2004) This is potentially “the” core construct and theoretical/research domain around which I believe the the “brain clock” and SMT (IM ) research should be examined The Time Doc concludes
  19. 21. Temporal processing: A definition (Mauk & Buonomano, 2004) (Note - If internal temporal codes are generated by the brain, they must be decoded or processed , like the external temporal patterns presented here.) (spike patterns “encode” temporal information) Temporal information/pattern from environment (e.g., music) --- generates action potentials that follow a beat (information is encoded in temporal domain ) Action potential patterns must be decoded in order to decide whether the stimulus was played at a fast or slow tempo—or to generate a timed motor response
  20. 22. <ul><li>Automatic timing system </li></ul><ul><ul><li>Works in the millisecond range </li></ul></ul><ul><ul><li>Discrete-event (discontinuous) timing, </li></ul></ul><ul><ul><li>esp. movement/motor tasks </li></ul></ul><ul><ul><li>Involves the cerebellum </li></ul></ul><ul><li>Cognitively-controlled timing system </li></ul><ul><ul><li>Continuous-event timing </li></ul></ul><ul><ul><li>Requires attention and involvement of </li></ul></ul><ul><ul><li>working memory </li></ul></ul><ul><ul><li>Involves the basal ganglia and related cortical structures </li></ul></ul><ul><li>It is the “ constellation of task characteristics that dictate which timing “circuits” of brain “systems”are invoked in a particular task performance (Lewis & Miall, 2006) </li></ul>Two primary mental timing circuits (Buhusi & Meck, 2005; Lewis & Miall, 2006)
  21. 23. I hypothesize that SMT interventions (e.g, IM) tap both the automatic and controlled cognitive timing systems (and related neurological structures and functions ). SMT-based interventions typically involve a motor component (e.g., clapping hands together to the beat) and requires responding in terms of milliseconds . These characteristics would be associated with the automatic timing system . However, although an individual (during SMT training) is trying to synchronze their tapping in terms of milliseconds, the duration between the continuous tones is more in the range of a second or so . Also, during initial stages of SMT, an individual's working memory is particularly taxed as one monitors the SMT visual and/or auditory feedback provided, makes a decision about whether they are responding &quot;too fast&quot; or &quot;too slow&quot;, and then cognitively implements a correction to their &quot;beat&quot; behavior. These later characteristics are more characteristic of the cognitively controlled timing system. So...it is my hypothesis that both the automatic and cognitively controlled timing systems of mental or interval time-keeping are involved with SMT-based interventions. It is possible that both are significantly active during early stages of SMT training and, with improvement and progress over time, the role of the cognitively controlled system decreases and the automatic system is more responsible. The Time Doc speculates 11-4-06
  22. 24. SMT-based interventions (e.g., IM) may be operating on the cognitive and neurological mechanisms that underlie brain-based temporal processing . That is, SMT interventions may help facilitate the “fine-tuning” of the temporal resolution of the interal brain clock . The Time Doc speculates 9-4-07
  23. 25. A domain-general cognitive mechanism? A number of domain (subject)-specific cognitive mechanisms? OR….
  24. 26. A domain-general cognitive mechanism? <ul><li>There is a long-standing tradition within psychological research to search for general principles or cognitive mechanisms that can be used to address all aspects of behavior and cognition. </li></ul><ul><li>Not tied to any specific content or domain. </li></ul><ul><li>An underlying mechanism that can be applied to a wide range of novel problems and domains of performance </li></ul><ul><li>“ Jack-of-all-trades ” mechanisms (Chiappe & McDonald,2005) </li></ul><ul><li>These are the mechanisms that may be captured by the notion of “ g ” (general intelligence ), and include such cognitive mechanisms as executive function and working memory (Chiappe & McDonald, 2005) and a master internal mental clock (Buhusi & Meck, 2005) </li></ul>
  25. 27. <ul><li>Searching for the “essence” of g has been the holy grail In intelligence research </li></ul><ul><li>g is a domain general mechanism as it is not specific to any particular domain of knowledge or mental skill and appears to be independent of cultural context (Gottfrredson, 1998) </li></ul><ul><li>Biological correlates of g include brain size , speed of nerve conduction , energy qualities of brain waves , etc. </li></ul><ul><ul><li>Research has suggested that people differ in g due to some form of differences in speed/efficiency ( resolution ) of neural processing ( neural efficiency/oscillation hypothesis ) </li></ul></ul><ul><ul><ul><li>Speed of information processing </li></ul></ul></ul><ul><ul><ul><li>Efficiency of the CNS </li></ul></ul></ul>g (general intelligence)
  26. 28. <ul><li>Most prominent paradigm for investigating g has been the use of elementary cognitive tasks (ECTs) (see Jensen) </li></ul><ul><ul><li>Reaction time (RT) measures (Hick paradigm; Hicks law ) </li></ul></ul><ul><ul><ul><li>Decision time (DT) </li></ul></ul></ul><ul><ul><ul><li>Movement time (MT) </li></ul></ul></ul><ul><ul><ul><li>Metric is in milliseconds </li></ul></ul></ul><ul><ul><ul><li>No obvious intellectual content </li></ul></ul></ul><ul><li>RT measures are believed to measure the speed with which the brain apprehends, integrates and evaluates information – speed of neural oscillations (Gottfredson, 1998; Hunt, 1999; Jensen, 1998a; Sternberg & Kaufman, 1998). </li></ul><ul><li>Search continues for the underlying biological determinants </li></ul>g (general intelligence)
  27. 29. g (general intelligence): Temporally based? Rammsayer, T. & Brandler, S. (2007). Performance on temporal information processing as an index of general intelligence. Intelligence, 35 , 127-139) Important (seminal?) article that links mental clock, g -based cognitive/IQ, and SMT/IM research ?
  28. 30. <ul><li>Analyses suggested a unitary timing mechanism , referred to as temporal g . </li></ul><ul><li>Performance on temporal information processing provided a more valid predictor of psychometric g than traditional reaction time measures </li></ul><ul><ul><li>r (with psychometric g ) = .56 (temporal g ) vs .34 (reaction time g ) </li></ul></ul><ul><li>Findings suggest that temporal resolution capacity of the brain (as assessed with psychophysical temporal tasks) reflects aspects of neural efficiency associated with general intelligence . </li></ul><ul><li>Rammsayer & Brandler (2007) </li></ul>Temporal g ?
  29. 31. <ul><li>The notion of an internal master clock represents an alternative metaphor to account for the relationship between efficiency and speed of information processing and psychometric g . ( Rammsayer & Brandler, 2006, in press) </li></ul><ul><li>The concept of a hypothetical master clock has been introduced by Surwillo (1968). </li></ul><ul><ul><li>Proposed an internal clock mechanism in the central nervous system for coordination of different neural activities. </li></ul></ul><ul><li>Burle and Bonnet (1997, 1999) provided additional converging experimental evidence for the existence of some kind of master clock in the human information processing </li></ul>Temporal g ?
  30. 32. <ul><li>Temporal information processing models (Creelman, 1962; Gibbon, 1991; Rammsayer & Ulrich, 2001; Treisman et al., 1990; see Grondin, 2001 for review) are based on the central assumption of neural oscilliations (note – same central feature of Jensen’s neural efficiency theory of g) as a major determinant of timing performance. </li></ul><ul><ul><li>The higher the frequency (higher speed) of neural oscillations the finer the temporal resolution of the internal clock = greater timing accuracy (Rammsayer & Brandler; 2007) </li></ul></ul>Temporal g ?
  31. 33. <ul><li>According to the master internal clock theory: </li></ul><ul><ul><li>Higher clock speed/rate-  </li></ul></ul><ul><ul><ul><li>Should enable an individual to perform a specific sequence of mental operations faster </li></ul></ul></ul><ul><ul><ul><li>Decreases the probability of occurrence of interfering incidents (i.e., better inhibition – or conversely – increased disinhibition ) </li></ul></ul></ul><ul><li>Higher clock speed/rate  superior performance in cognitive tasks as well as in basic information processing skills. </li></ul>Temporal g ?
  32. 34. <ul><li>Research has suggested that that a unitary internal master clock accounts for performance across four major types of elementary timing experiences ( Rammsayer & Brandler, 2006, in press). </li></ul><ul><ul><li>Interval duration or discrimination timing </li></ul></ul><ul><ul><li>Rhythm perception and production </li></ul></ul><ul><ul><li>Temporal-order judgment (TOJ) </li></ul></ul><ul><ul><li>Simultaneity and successiveness </li></ul></ul>Temporal g ?
  33. 35. Rhythm Perception and Production : Types of Tasks Studied <ul><li>Rammsayer’s temporal g tasks </li></ul><ul><li>Detection of rhythmic sequences </li></ul><ul><li>“ Continuation” (non-tapping) tasks </li></ul><ul><li>“ Synchronized” (tapping tasks) </li></ul><ul><ul><li>Synchronization of movements with a sequence of external events has been studied for a long time . The simplest task, synchronization with a metronome that produces auditory sounds equally spaced in time, is well understood (Schulze, 2005) </li></ul></ul>
  34. 36. Synchronized (tapping tasks) Theoretical Model (Schulze et al., 2005) <ul><li>Well described by the Wing- Kristofferson two- level model (Wing & Kristofferson, 1973) augmented by a linear phase-error correction mechanism </li></ul><ul><li>Central notions of model </li></ul><ul><ul><li>The assumption of an internal time keeper that controls the interval between taps and triggers the motor system correspondingly. </li></ul></ul><ul><ul><li>Error correction mechanism is necessary because the timekeeper and the motor system are subject to temporal jitter </li></ul></ul><ul><li>Most prominent and accepted “generic” model is the Pacemaker-Accumulator Model based On Scalar Timing/Expectancy Theory </li></ul>
  35. 37. Pacemaker-Accumulator Model based On Scalar Timing/Expectancy Theory (Church, 1984; Gibbon et al., 1984; Meck, 1983) <ul><li>The most prominent theory/model of time/temporal estimation * </li></ul><ul><li>Time duration judgments are performed by a modular information processing system composed of: </li></ul><ul><ul><li>Clock </li></ul></ul><ul><ul><li>Memory </li></ul></ul><ul><ul><li>Decision processes </li></ul></ul>* [Prominent does not mean exclusive – eg…see alternative MTS (multiple time scales) model that does NOT include internal pacemaker – instead time is based on length of decaying/fading memory traces] (an oscillator) (a counter)
  36. 38. Regularly generates or emits neural ticks or pulses “ gaiting” switch from pacemaker to accumulator Accumulates ticks/pulses that correspond to physical time interval/duration ( neural counting ) (an oscillator) (a counter) The “clock” level “ dopaminergic pacemaker”
  37. 39. “ Raw” representation of stimulus duration transferred to short-term or working memory Includes “important times” or “standards (reference)” appropriate for task (an oscillator) (a counter) The “memory” level
  38. 40. Comparison made between contents of reference memory (the standard) and working memory (are they “close” ?). Relies on a comparator that determines a response on the basis of a decision rule which involves a comparison between a value in the accumulator or working memory corresponding to the current duration with a value from reference memory (an oscillator) (a counter) The “decision” level
  39. 41. Another common representation off this model/theory
  40. 42. Pacemaker-Accumulator Model based On Scalar Timing/Expectancy Theory (Church, 1984; Gibbon et al., 1984; Meck, 1983) Important “cross-walk” links can be made between the PAM model and contemporary cognitive, neuropsychological, and intelligence research (an oscillator) (a counter)
  41. 43. Pacemaker-Accumulator Model based On Scalar Timing/Expectancy Theory (Church, 1984; Gibbon et al., 1984; Meck, 1983) Analagous cognitive & intelligence contsructs (an oscillator) (a counter) Working memory (Gsm-MS; MW) Long-term storage and retrieval (Glr) Executive function Executive controlled attention
  42. 44. What are the possible underlying neurological functions/structures involved? A very very simplified review
  43. 45. <ul><li>Intelligence theory </li></ul><ul><ul><ul><li>Cattell-Horn-Carroll (CHC) theory of cognitive abilities </li></ul></ul></ul><ul><li>Neuropsychological theory </li></ul><ul><ul><ul><li>Executive functioning </li></ul></ul></ul><ul><ul><ul><li>Working memory </li></ul></ul></ul><ul><ul><ul><li>Controlled executive attention </li></ul></ul></ul>What cognitive/neuropsychological mechanisms may be involved/affected?
  44. 46. “ Big five” reciprocal frontal-subcortical circuits (loops/pathways) <ul><li>There are at least five big loops/circuits involved in the highest levels of self-management (Lichter & Cummings, 2001) </li></ul><ul><li>These “loops” give rise to the complexity of goal-directed behavior </li></ul><ul><li>All five circuits ( motor , oculomotor, dorsolateral prefrontal , anterior cingulate) are related to the frontal lobe , basal ganglia , and thalamus (Hale & Fiorello, 2004) </li></ul><ul><li>The frontal-striatal loop has been associated with timing related functions (Nobre & O’Reilly, 2004) </li></ul>
  45. 47. (Casey & Durston, 2006) Example of a circuit/loop
  46. 49. <ul><li>Prefrontal cortex </li></ul><ul><ul><li>“ Cognitively controlled timing activates the right hemispheric dorsolateral prefrontal cortex (DLPFC) more frequently than any other brain area” (Lewis & Miall, 2006) </li></ul></ul><ul><li>Right Parietal cortex </li></ul><ul><li>Motor cortex areas </li></ul><ul><li>Cerebellum </li></ul><ul><li>Basal ganglia operating via frontal-striatal loop/network </li></ul>Primary brain mechanisms involved in mental time-keeping/temporal processing
  47. 50. The executive function is a theorized cognitive system (cluster of skills) that controls and manages other cognitive processes (Baddeley & Hitch, 1974). <ul><li>Executive functions include: </li></ul><ul><ul><li>Attention </li></ul></ul><ul><ul><li>Planning </li></ul></ul><ul><ul><li>Strategizing </li></ul></ul><ul><ul><li>Organizing </li></ul></ul><ul><ul><li>Flexibility </li></ul></ul><ul><ul><li>Monitoring </li></ul></ul><ul><ul><li>Evaluation </li></ul></ul><ul><ul><li>Change </li></ul></ul>Processes involved in mental timing are also thought to be components of EF (Welsh, 2001) Has also been called the Supervisory Attention System (SAS; Norman & Shallice, 1986) and Executive Control (Posner and DiGirolamo (2000)
  48. 51. <ul><li>Increased efficiency of working memory </li></ul><ul><li>Increased ability to sustain and selectively divide attention for longer periods of time ( executive/controlled attention )? </li></ul><ul><li>Increased ability to filter or screen out distractions ( increased selective attention )? </li></ul><ul><li>Increased ability to inhibit impulsive responding ( decreased disinhibition )? </li></ul><ul><li>Increased ability to self-regulate/monitor mental operations ( metacognition )? </li></ul><ul><li>Increased efficiency of internal master clock (higher clock rate) </li></ul>Hypothesized changes in specific cognitive efficiency/executive functions due to increased temporal g (higher temporal mental clock resolution ): Increased “ focus ” or “ cognitive efficiency ”
  49. 52. <ul><ul><li>What mechanism allows the integration of diverse brain networks to form coherent perceptions and output, with minimal (or even zero) time lag? </li></ul></ul><ul><ul><li>Evidence from both animal and human studies indicates that the phase synchrony of high frequency Gamma oscillations is a central mechanism in the integration and binding of geographically distinct brain activities (Phillips & Singer, 1997; Stankov et al., 2006). </li></ul></ul><ul><ul><li>At the level of the whole brain (i.e., collective populations of cells), greater phase synchronization of high frequency Gamma oscillations can differ from person to person -- may account for individual differences in measured cognitive ability. </li></ul></ul><ul><ul><li>Synchronous activity - the tuning-in of brain cell populations. </li></ul></ul>Another possible research connection? The “binding problem” (Stankov et al., 2006)
  50. 53. The internal brain clock as conductor metaphor Brain clock synchronizes neural oscillations across diverse brain structures/locations Think of conductor as executive function manager
  51. 54. <ul><li>The PFC has been likened to a switch operator in a railway system (Miller & Cohen; 2001.) [Also see “task switching” attention research summarized by Pashler et al., 2001) </li></ul><ul><ul><li>“ If several trains (different systems of representations or pathways) use the same bit of track to get where they are going (i.e., use the same output pathways when competing for expression in behavior), then a coordinator is needed to guide them safely to their destinations . Some trains must be stopped at the station; others may be stopped mid-route. Some will be allowed to go, and still others asked to speed up. The fastest train will use the track first (the system with the strongest activation pattern is expressed). The resource limitations of controlled attention are thought to reflect the properties of PFC function (Miller & Cohen, 2001) such that the fundamental computational properties of the PFC are likely related to the ability to control the trains.” (Barrett et al., 2004) </li></ul></ul>The internal brain clock as conductor metaphor Brain clock as brain track (pathway) switch coordinator
  52. 55. <ul><li>A possible lay-person term for controlled executive attention is focus </li></ul><ul><ul><li>“ the concentration of attention or energy on something” </li></ul></ul><ul><ul><li>“ concentrate: direct one's attention on something” </li></ul></ul>Controlled Executive Attention Model of Working Memory
  53. 56. Speed of mental information processing example (CHC info processing model example task)
  54. 57. Cattell-Horn-Carroll (CHC) Model of Human Cognitive Abilities Fluid Intelligence Crystallized Intelligence Gen. Memory & Learning Broad Visual Perception Broad Auditory Perception Broad Retrieval Ability Broad Cognitive Speediness Dec/Reaction Time/Speed Gf Gq Gsm Gv Ga Gs CDS Grw Gc Glr Fluid Intelligence Crystallized Intelligence Quantitative Knowledge Short-Term Memory Visual Processing Auditory Processing Long-Term Retrieval Processing Speed Correct Decision Speed Reading/ Writing g Cattell-Horn Carroll Gf Gy Gv Gs Gt Gc Gr Gu
  55. 58. The CHC Information Processing Model Gsm (MW) Information Processing Loop Cognitive Efficiency Gs Cognitive or Academic Performance Executive Control Bas. Rdg Skills (Grw) Rdg Comp (Grw) Math Calc (Gq) Math Reas (Gq) Basic Writ. Skills (Grw) Written Exp (Grw) List. Comp (Gc ) Oral Exp (Gc) Comp-Know (Gc) Stores of Acquired Knowledge Facilitators-Inhibitors -Health/medications -Motivation/interest -Cog. style/temperament -Environmental/cultural -Emotional -etc Input Gf Glr Ga Gv Thinking Abilities
  56. 59. The CHC Information Processing Model Gsm (MW) Information Processing Loop Cognitive Efficiency Executive Control Gs Gf Glr Ga Gv Thinking Abilities Stores of Acquired Knowledge SMT (e.g. IM) is hypothesized to increase the efficiency of the “information processing loop” – increased “cognitive efficiency” due to increased efficiency/resolution of the internal mental clock- --which results in greater “synchronization” or “path/track switch coordination” Cognitive or Academic Performance
  57. 60. Summary Comments
  58. 61. <ul><li>Mental timing is a domain-general mechanism important for human learning and memory and governs the temporal processing efficiency of the human information processing system </li></ul><ul><li>Key concepts relevant to understanding mental time-keeping and temporal processing , which may lie at the heart of SMT (IM)-based interventions , include  </li></ul>Summary Comments
  59. 62. <ul><li>Internal master clock </li></ul><ul><ul><li>Faster clock speed/rate </li></ul></ul><ul><ul><li>More coordinated/integrated/synchronized master clock (the “conductor”) </li></ul></ul><ul><ul><ul><li>Increased “ tuning in ” or synchronization across brain activities/brain cell populations </li></ul></ul></ul><ul><ul><ul><li>Finer temporal resolution of internal clock (via higher frequency of neural oscillations ) </li></ul></ul></ul><ul><ul><ul><li>Increased temporal g ? </li></ul></ul></ul><ul><li>Working memory –research suggests that time measurement and working tasks draw upon many of the same cognitive/brain resources </li></ul><ul><ul><li>e.g.- both are modulated by dopamine </li></ul></ul><ul><li>Executive functions , esp. </li></ul><ul><ul><li>Controlled executive attention (“focus”) </li></ul></ul><ul><ul><li>Self-regulation/monitoring or metacognition (e.g., railroad switching efficiency) </li></ul></ul>Summary Comments
  60. 63. Other SMT (IM)-Specific Speculations <ul><li>Anecdotal reports from treatment subjects suggests possible improvements in non-cognitive variables that have been demonstrated to positively impact school learning </li></ul><ul><li>Conative variables (work of Richard Snow et al.) </li></ul><ul><ul><li>Increased self-efficacy </li></ul></ul><ul><ul><ul><li>Confidence in ability to organize, execute, and regulate performance in order to solve problem or perform a task at a designated level of skill and ability </li></ul></ul></ul>
  61. 64. For consideration: Internal brain clock metaphors Mental synchronization is all about timing
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