1. The Premier Global Infectious Disease Knowledge Management System www.GIDEONonline.com Copyright © 2005 GIDEON Informatics, Inc. All rights reserved • www.GIDEONonline.com

2. … Country of acquisition and presumed incubation periods … Disease comparisons … Custom notes With over 200 signs & symptoms… Diagnose Continue for step by step demonstration… Copyright © 2005 GIDEON Informatics, Inc. All rights reserved • www.GIDEONonline.com

3. A 55 year old American photographer returned home after a six-week trip to the game parks of Tanzania . Four weeks after return, he developed headache, myalgia, arthralgia, weight loss and intermittent fever. The patient is noticeably confused and distracted, and physical examination reveals hepatosplenomegaly and lymphadenopathy in the supraclavicular and cervical regions. The hemogram is normal, but the cerebrospinal fluid contains 20 lymphocytes per mm3. What is your diagnosis?... Copyright © 2005 GIDEON Informatics, Inc. All rights reserved • www.GIDEONonline.com

4. Main Diagnosis Page: Copyright © 2005 GIDEON Informatics, Inc. All rights reserved • www.GIDEONonline.com

5. First we select the symptoms and signs: Clicking once to select that a symptom is present and twice to specify that a symptom is not present We can then add information such as: Country of Acquisition… … and Incubation Periods Now, lets make a diagnosis! Copyright © 2005 GIDEON Informatics, Inc. All rights reserved • www.GIDEONonline.com

6. The results from GIDEON indicate that our photographer has Trypanosmiasis – African. With these results we can then: Run a disease comparison by selecting the diseases we wish to compare and pressing the “Compare” button Click on a disease name to view more detailed information X Copyright © 2005 GIDEON Informatics, Inc. All rights reserved • www.GIDEONonline.com X

7. Ask GIDEON to explain why a certain disease does not appear in the results by clicking on the “Why Not” button Print the results screen Email the results Next, we explore the case in the Epidemiology module… We can also use the results from GIDEON to: Copyright © 2005 GIDEON Informatics, Inc. All rights reserved • www.GIDEONonline.com

8. Epidemiology This module follows the real-time status of every disease in every country ! With over 13,000 graphs and images available for presentations & lectures… Generates disease lists compatible with any combination of vector, vehicle, reservoir, agent and country. Copyright © 2005 GIDEON Informatics, Inc. All rights reserved • www.GIDEONonline.com

9. In Epidemiology we can find more information on Trypanosomiasis – African: Display general information by selecting it from the disease list below: We can also display distribution information by clicking on the distribution tab Copyright © 2005 GIDEON Informatics, Inc. All rights reserved • www.GIDEONonline.com This module also includes graphs

10. The Epidemiology module also features images: Now lets look at therapy options… The clinical tab, in the Epidemiology module, offers a wealth of information on the signs, symptoms, laboratory abnormalities .. and much more Copyright © 2005 GIDEON Informatics, Inc. All rights reserved • www.GIDEONonline.com

11. Maps in GIDEON New Feature!

12. Maps in GIDEON In the Epidemiology module, under the distribution tab you can now display interactive distribution maps. To start click on the globe icon below Which then displays the following distribution map:

13. Maps in GIDEON The maps are also linked to individual country notes…below we have a map of the worldwide Plague distribution: If we zoom in on Cambodia, and click the red dot, the individual note will appear:

14. Therapy Provides information on over 300 drugs & vaccines worldwide Warnings & Side effects by symptom, drug interactions by drug Spectrum … Copyright © 2005 GIDEON Informatics, Inc. All rights reserved • www.GIDEONonline.com

15. In the previous module we saw that one possible treatment option for Trypanosomiasis – African is the use of Pentamidine. In the Therapy module we can find information on Pentamidine by selecting it from the list of drug choices GIDEON will first display general information for the selection We can then display drug warnings by clicking on the warnings tab The synonym tab displays this information Finally, we can use the spectrum tab to display spectrum information Copyright © 2005 GIDEON Informatics, Inc. All rights reserved • www.GIDEONonline.com

16. Microbiology Identification and Characterization Modules for: Bacteria Yeasts Mycobacteria Ranked Identification Results Pathogen Information Pathogen Comparison Copyright © 2005 GIDEON Informatics, Inc. All rights reserved • www.GIDEONonline.com

17. To explore the Microbiology module we will refer to one of our recent example cases: “Creative DeBugging” A 47 year old man is found to have a large abscess in his left leg. Routine cultures reveal a branched, aerobic, non-sporulating, Gram-positive bacillus. What micro-organisms should be considered ? What procedure should the laboratory perform at this point ? Phenotypic tests were entered into the Microbiology module of GIDEON: Pressing the Identify button gives us these results The organism in question appears to be one of several species of Nocardia. In order to determine the most discriminative laboratory test to perform at this point, we will check all of the organisms, and press ‘Compare’. NEXT Copyright © 2005 GIDEON Informatics, Inc. All rights reserved • www.GIDEONonline.com

18. As we see in this screen, GIDEON recommends that we examine Citrate, myo-Inositol and Mannitol [top three tests]. … Our organism was ‘positive’ for all three of the additional tests. After re-identifying the organism using those results we can see in this screen that the most likely identification in this case is Nocardia brasiliensis. By click on the pathogen name we can display further information on the selection Copyright © 2005 GIDEON Informatics, Inc. All rights reserved • www.GIDEONonline.com Phenotype information can be displayed by clicking on the Phenotype tab in this display

19. NEW FEATURE! GIDEON References To view the reference for this selection from the Epidemiology module, we can click on the reference link [1] Which will then display the reference screen To display the abstract click on the desired reference Coming soon to GIDEON Online Copyright © 2005 GIDEON Informatics, Inc. All rights reserved • www.GIDEONonline.com

20. Why Use GIDEON? Improve Patient Care… Quickly and accurately generate a ranked differential diagnosis Quickly access disease information including current outbreak data Obtain drug & vaccine treatment guidelines for adult and pediatric patients Enable the lab to accurately identify the infectious agent from patient samples Who Can Use GIDEON? Any clinician treating a patient with a possible infection Emergency Room Doctors Pediatricians Infectious Disease Doctors Internists The Clinical Laboratory Medical Educators Among others… Copyright © 2005 GIDEON Informatics, Inc. All rights reserved • www.GIDEONonline.com

21. GIDEON is currently being utilized by hospitals, universities, travel clinics, medical professionals, government health agencies and private corporations worldwide… Including: Copyright © 2005 GIDEON Informatics, Inc. All rights reserved • www.GIDEONonline.com