Gestational trophblastic disease (GTD) is a rare tumour of placental origin. There is
a range of malignant potential from the relatively benign (premalignant) Hydatidiform
Mole which occurs about 1 in 1,500 pregnacies to the much rarer malignant form
(Choriocarcinoma, invasive mole, Placenta site trophoblastic disease and the new entity
which called epitheliod trophoblastic tumor. Its incidence is various depend on the
location from 1: 85 in Indonosia to 1; 1500 in Europe and USA . In Saudi Arabia the
incident is 2.6 per 1000 pregnancy. The chance to have chemotherapy after evacuation
oh moler pregnancy depends were you live if you are in UK is 7 % and in Canada is
30% and in Saudi Arabia is 25%.
The Journey of GTD began in 1956 when the sensitivity of gestational trophblastic
neoplasia (GTN )was found to Methotraxate . In 1970 the great Bagashow was used
the folonic acid to decrease the side effect of Methoraxate. and introduce the EMACO
regimen in the management of High risk GTN. Between 1970 and 1980 Actinomycin D
were introduced. different protocol in the management is used which has basically
similar good prognosis.
Since year 2000 we globally thankfully reach to a kind of uniform and
classification system which started to show effect on the way how to report the data
and compare data together. The scoring system validated in 2000 and adapted by
WHO and FIGO and its current classification most of us follow hopefully.
In the UK there is three registration for GTD and 100 % of patient with GTD
registered and death from GTN is now no more accepted especially in a low risk group.
Because the incidence in Saudi Arabia is very low it is very difficult for individuals
to establish and maintain expertise in the management of these rare diseases.
Therefore, the management should be centralized and establishment of Saudi GTD
registry need to in used.
Khalid Hussain Wali Sait
Director of Saudi Gestational Trophoblastic Disease Registry
Email: email@example.com Mobile: +966505693160
Criteria Used to Diagnosed GTN
• Plateauing of HCG level over at least three
• A rise of HCG of 10% or greater for three
values or more over at least two weeks.
• Persistent of HCG beyond six months after
• Ensure adequate follow up of patient with
moler pregnancy and early detection of
• If GTN diagnosed treatment is coordinated
with an expert in the field and help arrange
in the referal.
• To get exact incidence of GTD in Saudi
Theme of GTD Registry
Making death from disease of trophoblast some thing
in the past.
Saudi GTD Registry Team
Prof. Khalid Sait Director of Saudi GTD Registry
Dr. Nisrin Anfinan GTD Registry Coordinator
Dr. Asem Sabghatallah GTD Registry Coordinator
Faten Anfanan GOU Secretary
Rowaida Al Mehy GOU Secretary
Reem Qubaidi Health Educator
Amal Al Montasheri Nurse JCSP
Maribi Marqueses GOU Office Assistant
Prof. Jim Bentley International Advisor
Prof. Abdullah Hussain Basalamah General Advisor
1- While on the website’s home page find the
“Register” link which is illustrated below
How to Register for
2- After clicking the link the registration form
How to Register for
3- The following information are
– Email: this will serve as your User ID.
– Given Name.
– Family Name.
– Password: you must enter the same.
– password twice.
– Password Hint: please make sure the
hint lets you remember your
– Mobile No. – please register a valid
How to Register for
4- After all required fields are
displayed, hit the “Register” button
5- A message will be sent to your email after
a successful registration. Click the link to
continue and activate/confirm your new
1- Locate the Logon form at the top-right corner of the
website page. Supply the User ID and Password then
hit the “Sign In” button.
Now that you have secure access for the website, you may
now logon and access the tools for managing GTD patients.
Your email used for registration will be your User ID. Please
make sure you use the same password during registration to
access the website.
2- Once you are logged on you will be presented with
alerts relating to patients, test results and private
1- Locate the menu link
“Patient Register” from the
2- After hitting Patient Register link, the
patient registration form will display and
the data entry will be available for the
– Patient demographics
– Gestational trophoblastic information
• Gbstetric history events
• Clinical presentation
• Final evaluation
3- Patient Demographics – required fields
– Given Name
– Family Name
– Date of Birth
– Mobile No.
– Document Type
– Document No
– Next of Kin
4- OBSTETRIC HISTORY EVENTS – required fields
– Date of Evacuation
– Gestationa age
– Previous Molar pregnancy
– Initial HCG
• Clinical Presentation
• If Initial Pathology (YES).
• List view will display.
- Complete Mole.
- Partial Mole.
- Invasive Mole.
• After a successful registration Saudi GTD
will be following the patient you registered.
• Saudi GTD will be alerting physicians when
a laboratory exam is due or pending.
• Saudi GTD will follow the patient’s
progress until the disease is cleared.6
1- After the successful registration of the patient
• At the patient registration screen, go down before the FINAL
• Hit Order New HCG link to bring the order HCG screen.
• This is the display of HCG
• HCG Result / Graph
Physician will be alert by the following:
First alert, if the HCG not done in the right time.
Second alert, if the HCG is not going down.
Third alert, Does patient so far had presistent GTD is YES.
At the patient registration screen, go down to the
FINAL EVALUATION section and click link “Scoring
• WHO Scoring is auto calculate once you selected
• The four first will be mandatory.
• Click on save button to proceed.
• Click on reset to reset your entry.
• You can close the screen without saving by clicking
on Close without save.
1- Hit the Referral option to bring out the “Order
Referral” link. Hit this link.
2- Enter all the information asked
• Referral date, Referred to Doctor and
• Save the data
• If chemo therapy is Yes then you should
identify if it is Single or Multiple
• If the “Is Chemo Therapy is Success” is No
then another entry will display once you
click on save button.
• Once you select Other, a free text will
display for entry.
• Act. D
1- Locate the menu link
“Referral List” from
Click on this icon with status “Pending” to accept a referral.
2- The Referral List page should display all
referrals to you from other doctors.
3- The Referral acceptance dialog should display.
Hit the “Accept” button to allow the referral.
4- After a referral is accepted, both the doctor
who registered and the doctor referred to
will be able to manage the patient by:
– Order a new HCG
– Enter HCG results
– Refer the patient
– Read patient progress
Hit the Red
icon to open
• Result entry is accessible at registration screen or patient
• To enter a result go to the Order list and locate the
unreleased order with pending status as seen below:
• Enter the HCG result in the dialog as seen below and hit
the “Save” button.
Hit to save the
Enter HCG Result here
Hit this icon to Create
a patient booking
• Locate the menu link “Planner”
from the Sidebar. To open clinic
• Locate the menu link “Messages”
from the Sidebar.
• Doctors can exchange private
messages in this page.
This website have alert system that
will send you SMS Alerts in this
A HCG result has not been entered or
is delayed (HCG not done in the right
If the HCG is not going down.
If the patient so far had persistent
If there are a new referrals for you.
Scientific Chair of Prof. Abdullah Hussain Basalamah
for Gynecological Cancer
And Gynecology Oncology Unit
Saudi Gestational Trophoblastic Disease Registry
Mobile: (+966540963815) (+966540964759)
Tel: +966(12) 6401000 Ext. 11480 - 11523