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Canc2

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Flavio Guzmán
Flavio Guzmán
Health & MedicineTechnology
1 of 65
Cancer Chemotherapy-2 Dr. R. Senthil Kumar
Classification
Alkylating agents ,[object Object],[object Object],[object Object],[object Object],[object Object]
MOA ,[object Object]
Alkylating Agents- Used in wide variety of hematologic and solid tumors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cyclophosphamide ,[object Object],[object Object],[object Object],[object Object]
 
 
Mechanism of resistance ,[object Object],[object Object],[object Object],[object Object]
Uses ,[object Object],[object Object],[object Object],[object Object]
ADR ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Cisplatin ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Procarbazine ,[object Object],[object Object],[object Object],[object Object]
Blood in the urine!!! ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Legend Drug Class Sub-class Prototype Drug Trimetrexate Pemetrexed Thioguanine Fludarabine Phosphate Cladribine Cytarabine Gemcitabine Capecitabine Antimetabolites Folic Acid Analogs Purine Analogs Pyrimidine Analogs Methotrexate Mercaptoguanine Fluorouracil
Antimetabolites ,[object Object],[object Object],[object Object],[object Object],[object Object]
Antimetabolits: sites of drug action
Methotrexate
Methotrexate (MTX) ,[object Object],[object Object],[object Object],[object Object]
Mechanism of Resistance 1. Decreased drug transport 2. Altered DHFR 3. Decreased polyglutamate formation 4. Increased levels of DHFR
Contd.. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
ADR ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Leucovorin Rescue ,[object Object],[object Object],[object Object],[object Object],[object Object]
6-Mercaptopurine (6-MP) & Thioguanine ,[object Object],[object Object],[object Object]
6-MP & Allopurinol ,[object Object],[object Object],[object Object],[object Object]
Cytarabine (Ara-C) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
5-FU ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Contd.. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Megaloblastic anemia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Vinblastine Vincristine Vinorelbine Teniposide Irinotecan Docetaxel Plant Alkaloids Vinca Alkaloids Podophyllotoxins Camptothecins Taxanes Vinblastine Etoposide Topotecan Paclitaxel
Vinka alkaloids (Vinblastine, vincristine) ,[object Object],[object Object],[object Object]
Vinka alkaloids (animation and ADR) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
V in B lastine V in C ristine (oncovan) Uses ; (ABVD) Hodgkin’s disease Lymphomas Carcinoma B reast Testicular tumors Toxicity: B one marrow suppression, anorexia, nausea, vomiting & Diarrhea, Alopecia Uses : (MOPP) C hildhood leukemias C hildhood tumors-Wilm’s tumor, Neuroblastoma, Hodgkin’s disease Toxicity: Peripheral neuritis with Paresthesia, Muscle weakness ***Vincristine has marrow sparing effect
Etoposide & Teniposide ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Topoisomerase inhibitors
Paclitaxel & Docetaxel ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Questions ,[object Object],[object Object],[object Object],[object Object]
Anticancer Antibiotics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Doxorubicin & Daunorubicin ,[object Object],[object Object],[object Object],[object Object]
ADR ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Bleomycin ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Questions ,[object Object],[object Object],[object Object],[object Object]
Hormonal agents ,[object Object],[object Object],[object Object],[object Object]
Glucocorticoids (Prednisone) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Sex hormone antagonists
Tamoxifen ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
MOA of drugs
GnRH analogs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Aromatase inhibitors ,[object Object],[object Object],[object Object],[object Object]
Contd..
Contd.. ,[object Object],[object Object],[object Object],[object Object]
Miscellaneous agents Asparaginase, imatinib, interferons, monoclonal antibodies
Asparaginase ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Contd..
Imatinib ,[object Object],[object Object],[object Object],[object Object]
MOA of imatinib ,[object Object]
Interferons ,[object Object],[object Object],[object Object],[object Object],[object Object]
Monoclonal Antibodies ,[object Object],[object Object],[object Object],[object Object],[object Object]
Trastuzumab ,[object Object],[object Object],[object Object]
FDA approved MAb
Questions??? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Treatment of Specific cancers ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Prevention/management of Cancer Chemotherapy induced ADR ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Canc2

  • 1. Cancer Chemotherapy-2 Dr. R. Senthil Kumar
  • 3.
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  • 7.  
  • 8.  
  • 9.
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  • 11.
  • 12.  
  • 13.
  • 14.
  • 15.
  • 16. Legend Drug Class Sub-class Prototype Drug Trimetrexate Pemetrexed Thioguanine Fludarabine Phosphate Cladribine Cytarabine Gemcitabine Capecitabine Antimetabolites Folic Acid Analogs Purine Analogs Pyrimidine Analogs Methotrexate Mercaptoguanine Fluorouracil
  • 17.
  • 20.
  • 21. Mechanism of Resistance 1. Decreased drug transport 2. Altered DHFR 3. Decreased polyglutamate formation 4. Increased levels of DHFR
  • 22.
  • 23.
  • 24.
  • 25.
  • 26.
  • 27.
  • 28.
  • 29.
  • 30.
  • 31.  
  • 32. Vinblastine Vincristine Vinorelbine Teniposide Irinotecan Docetaxel Plant Alkaloids Vinca Alkaloids Podophyllotoxins Camptothecins Taxanes Vinblastine Etoposide Topotecan Paclitaxel
  • 33.
  • 34.
  • 35. V in B lastine V in C ristine (oncovan) Uses ; (ABVD) Hodgkin’s disease Lymphomas Carcinoma B reast Testicular tumors Toxicity: B one marrow suppression, anorexia, nausea, vomiting & Diarrhea, Alopecia Uses : (MOPP) C hildhood leukemias C hildhood tumors-Wilm’s tumor, Neuroblastoma, Hodgkin’s disease Toxicity: Peripheral neuritis with Paresthesia, Muscle weakness ***Vincristine has marrow sparing effect
  • 36.
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  • 53.
  • 54. Miscellaneous agents Asparaginase, imatinib, interferons, monoclonal antibodies
  • 55.
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  • 65.