Studying B-pharmacy ,

1. PRESENTED BY
GUIDED BY

2. Ulcerative colitis (UC) is an
inflammatory destructive disease of
the large intestine characterized by
motility and secretion disorders.
 Inflammation usually occurs in the
rectum and lower part of the colon,
but it may affect the entire colon.
UC is an inflammatory bowel disease
(IBD) that causes inflammation in the
small intestine and colon.
INTRODUCTION

3.  UC can be difficult to diagnose because its symptoms
are similar to other intestinal disorders and another
type of IBD called Crohn's disease (CD).
 UC may occur in people of any age, but most often it
starts between ages 15 and 30, or less frequently
between ages 50 and 70.

5. There are 4 types of ulcerative colitis (UC):
 Ulcerative proctitis
 Proctosigmoiditis
 Left-sided colitis
 Pan-ulcerative colitis
TYPES OF ULCERATIVE COLITIS

6.  Ulcerative proctitis
IS a mild form of the disease and accounts for
nearly 30% of all cases. Bowel inflammation is
limited to the rectum, and because the affected
area is so small, it is associated with fewer
complications.

7. Proctosigmoiditis
Affects the rectum and the sigmoid colon (the
lower segment of colon located right above the
rectum).
Symptoms include bloody diarrhea, cramps, and
a constant feeling of the need to pass stool.
Moderate pain on the lower left side of the
abdomen may occur in active disease

8. Left-sided colitis
 Begins at the rectum and
extends up to a bend in the colon
near the spleen called the
splenic flexure.
 Symptoms include loss of
appetite, weight loss, diarrhea,
severe pain on the left side of the
abdomen, and bleeding.

9. Pan-ulcerative colitis
 Effects the entire colon. Symptoms include
diarrhea, severe abdominal pain, cramps, and
extensive weight loss.
 Potentially serious complications include
massive bleeding and acute dilation of the
colon (which may lead to an opening in the bowel
wall). Serious complications

10.  The estimated two million Americans suffer from IBD,
CD is far less common than UC, but currently the
Incidences of each are estimated to be about equal.
The incidence may vary depending on gender, age,
and geography.
Men and women have an equal risk for UC.
UC CHARACTERISTICS

12.  Ulcerative colitis symptoms
can vary, depending on the
severity Of inflammation .
 You may have the following
signs and symptoms,
depending on which part of
the colon is inflamed:
SYMPTOMS OF ULCERATIVE COLITIS

13.  Abdominal pain.
 Increased abdominal sounds.
 Bloody stools.
 Diarrhea.
 Fever.
 Rectal pain.
 Weight loss.
SYMPTOMS OF ULCERATIVE COLITIS

15. Different tests can help your doctor diagnose
ulcerative colitis. This disorder mimics other
bowel diseases such as Crohn’s disease.
Tests to diagnose ulcerative colitis include:
Tests for Ulcerative Colitis

16. stool test - a doctor examines your stool for blood,
bacteria, and parasites
endoscopy - a doctor uses a flexible, lighted tube to
examine the stomach, esophagus, and small intestine
colonoscopy - diagnostic test that involves insertion of
a long, flexible tube into the rectum to examine the
inside of the colon
biopsy - surgeon removes a tissue sample from the
colon
barium enema - X-rays are taken of your colon and
rectum, using barium to provide contrast.
A blood test also helps diagnose ulcerative colitis.

18. Ulcerative colitis is a chronic condition. Treatment
usually involves drug therapy or surgery.
Doctor may prescribe an anti-inflammatory
medication. Reducing Inflammation will help with
abdominal cramps and diarrhea.
Treatment of Ulcerative Colitis

19. Drugs used in Treatment of Ulcerative colitis :
Generic Name : MESALAMINE
Brand Names : Asacol ,
Canasa Supposituries tablet 500mg…
• Asacol is a tablet consisting of 5-ASA compound.
• When the tablet reaches the terminal ileum and colon,the
resin coating dissolves, thus releasing 5-ASA into the colon.
SIDE EFFECT :
• Vomiting , Stomach Pain and Fever.

20. Generic Name : OLSAZINE
Brand Names : Dipentum,
Olsalazine Sodium 250mg Caps..
• Olsalazine (Dipentum) consists of two 5-ASA molecules
linked together. It is sulfa free.
• When the drug reaches the terminal ileum and the colon,
normal bacteria in the intestine break the linkage and release
the active drug into the colon and terminal ileum.
SIDE EFFECT :
• side effect unique to olsalazine is secretory diarrhea .
• This condition occurs in 5-10% of patients, and diarrhea
sometimes can be severe.

21. Generic Name : SULFASALAZINE
Brand Names : Azulfidine EN-tabs 500mg,
Salazopyrin EN-tabs..
• Sulfasalazine consists of a 5-ASA molecule linked
chemically to a sulfapyridine molecule.
• When sulfasalazine reaches the colon, bacteria in the colon
will break the linkage between the two molecules.
• After breaking away from 5-ASA, sulfapyridine is absorbed
into the body and then excreted in the urine.
SIDE EFFECT :
Heartburn ,Headache ,Skin rashes…..

22. Any queries

23. DULAM SAVEEN