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Radioactive
Isotopes in
Medicine
Group 2
Radioactive Isotopes in Medicine
The

radioactive isotopes were first
used in medicine for diagnostic
procedures during the early 1930s.
This eventually laid the foundation for
nuclear medicine. This article will
cover all the information regarding
the
procedures
and
uses
of
radioactive isotopes in medicine.
What is Nuclear Medicine


Nuclear medicine is the branch of science
under medicine, that uses radiation to give
information regarding the functioning of a
specific organ in the human body or to treat
a disease. This collected information gives
accurate and immediate diagnosis of the
patient's illness. Radioactive isotopes in
medicine are used to form images of the
thyroid, bones, heart, liver and many other
organs. Radioactive isotopes used in
medicine have also helped in treating
diseased organs and tumors.
What is Nuclear Medicine
 Nuclear

medicine uses radiation to
provide diagnostic information about the
functioning of a person's specific
organs, or to treat them. Diagnostic
procedures are now routine.
Diagnostic techniques in nuclear
medicine




Medical diagnosis refers to the process of
attempting to determine and/or identify a
possible disease or disorder and the opinion
reached by this process.
Diagnostic techniques in nuclear medicine
use radioactive tracers which emit gamma
rays from within the body. These tracers are
generally short-lived isotopes linked to
chemical compounds which permit specific
physiological processes to be scrutinized. They
can be given by injection, inhalation or orally.
Diagnostic techniques in nuclear
medicine




Positron Emission Tomography (PET)- a more
precise and sophisticated technique using
isotopes produced in a cyclotron. A positronemitting radionuclide is introduced, usually by
injection, and accumulates in the target
tissue. As it decays it emits a positron, which
promptly combines with a nearby electron
resulting in the simultaneous emission of two
identifiable gamma rays in opposite directions
These are detected by a PET camera and
give very precise indication of their origin
Diagnostic techniques in nuclear
medicine




The Positron Emission Tomography or the PET scan
was the first diagnostic tool invented by Peter
Alfred Wolf that used radioactive isotopes in
medicine.
New procedures combine PET with Computed Xray tomography (CT) scans to give co-registration
of the two images (PETCT), enabling 30% better
diagnosis than with traditional gamma camera
alone. It is a very powerful and significant tool
which provides unique information on a wide
variety of diseases from dementia to
cardiovascular disease and cancer (oncology).
Radionuclide therapy (RNT)
 Rapidly

dividing cells are particularly sensitive to
damage by radiation. For this reason, some
cancerous growths can be controlled or eliminated
by irradiating the area containing the growth.
 Internal radionuclide therapy is by administering or
planting a small radiation source, usually a gamma
or beta emitter, in the target area. Short-range
radiotherapy is known as brachytherapy, and this is
becoming the main means of treatment.
Radionuclide therapy (RNT)
 External

irradiation (sometimes called
teletherapy) can be carried out using a
gamma beam from a radioactive cobalt60 source, though in developed countries
the much more versatile linear
accelerators are now being utilized as a
high-energy x-ray source (gamma and xrays are much the same)
Biochemical Analysis
 It

is very easy to detect the presence or absence of
some radioactive materials even when they exist in
very low concentrations.
Radioisotopes can
therefore be used to label molecules of biological
samples in vitro (out of the body). Pathologists have
devised hundreds of tests to determine the
constituents of blood, serum, urine, hormones,
antigens and many drugs by means of associated
radioisotopes. These procedures are known as
radioimmuno-assays
and,
although
the
biochemistry is complex, kits manufactured for
laboratory use are very easy to use and give
accurate results.
Diagnostic Radiopharmaceuticals
 Diagnostic

radiopharmaceuticals can be used
to examine blood flow to the brain, functioning
of the liver, lungs, heart or kidneys, to assess
bone growth, and to confirm other diagnostic
procedures. Another important use is to predict
the effects of surgery and assess changes since
treatment.
 A radioisotope used for diagnosis must emit
gamma rays of sufficient energy to escape
from the body and it must have a half-life short
enough for it to decay away soon after
imaging is completed.
Therapeutic Radiopharmaceuticals
 For

some medical conditions, it is useful to destroy
or weaken malfunctioning cells using radiation.
The radioisotope that generates the radiation
can be localized in the required organ in the
same way it is used for diagnosis - through a
radioactive element following its usual biological
path, or through the element being attached to
a suitable biological compound. In most cases, it
is beta radiation which causes the destruction of
the damaged cells. This is radionuclide therapy
(RNT) or radiotherapy.
SOME Isotopes used in Medicine







Many radioisotopes are made in nuclear reactors, some
in cyclotrons. Generally neutron-rich ones and those
resulting from nuclear fission need to be made in
reactors, neutron-depleted ones are made in
cyclotrons. There are about 40 activation product
radioisotopes and five fission product ones made in
reactors.
Reactor Radioisotopes (half-life indicated)
Bismuth-213 (46 min): Used for targeted alpha therapy
(TAT), especially cancers, as it has a high energy (8.4
MeV).
Chromium-51 (28 d): Used to label red blood cells and
quantify gastro-intestinal protein loss.
Isotopes used in Medicine
 Cobalt-60

(5.27 yr): Formerly used for external
beam radiotherapy, now used more for sterilizing
 Erbium-169 (9.4 d): Use for relieving arthritis pain in
synovial joints.
 Holmium-166 (26 h): Being developed for
diagnosis and treatment of liver tumours.
 Iodine-125 (60 d): Used in cancer brachytherapy
(prostate and brain), also diagnostically to
evaluate the filtration rate of kidneys and to
diagnose deep vein thrombosis in the leg. It is
also widely used in radioimmuno-assays to show
the presence of hormones in tiny quantities.
Isotopes used in Medicine
 Iodine-131

(8 d)*: Widely used in treating thyroid
cancer and in imaging the thyroid; also in
diagnosis of abnormal liver function, renal
(kidney) blood flow and urinary tract obstruction.
A strong gamma emitter, but used for beta
therapy.
 Iron-59 (46 d): Used in studies of iron metabolism
in the spleen.
 Potassium-42 (12 h): Used for the determination of
exchangeable potassium in coronary blood flow.
Isotopes used in Medicine
 Rhenium-186

(3.8 d): Used for pain relief in bone
cancer. Beta emitter with weak gamma for
imaging.
 Rhenium-188 (17 h): Used to beta irradiate
coronary arteries from an angioplasty balloon.
 Samarium-153 (47 h): Sm-153 is very effective in
relieving the pain of secondary cancers lodged in
the bone, sold as Quadramet. Also very effective
for prostate and breast cancer. Beta emitter.
 Technetium-99m (6 h): Used in to image the
skeleton and heart muscle in particular, but also
for brain, thyroid, lungs (perfusion and ventilation
Isotopes used in Medicine
 Xenon-133

(5 d)*: Used for pulmonary (lung)
ventilation studies.
 Carbon-11, Nitrogen-13, Oxygen-15, Fluorine-18:
These are positron emitters used in PET for
studying brain physiology and pathology, in
particular for localising epileptic focus, and in
dementia, psychiatry and neuropharmacology
studies. They also have a significant role in
cardiology. F-18 in FDG (fluorodeoxyglucose) has
become very important in detection of cancers
and the monitoring of progress in their
treatment, using PET.
Isotopes used in Medicine
 Copper-64

(13 h): Used to study genetic
diseases affecting copper metabolism, such as
Wilson's and Menke's diseases, and for PET
imaging of tumours, and therapy.
 Indium-111 (2.8 d): Used for specialist diagnostic
studies, eg brain studies, infection and colon
transit studies.
 Iodine-123 (13 h): Increasingly used for diagnosis
of thyroid function, it is a gamma emitter
without the beta radiation of I-131.
Isotopes used in Medicine
 Palladium-103

(17 d): Used to make
brachytherapy permanent implant seeds
for early stage prostate cancer.
 Phosphorus-32 (14 d): Used in the
treatment of polycythemia vera (excess
red blood cells). Beta emitter.
 Potassium-42 (12 h): Used for the
determination of exchangeable
potassium in coronary blood flow.

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Radioactive isotopes in medicine

  • 2. Radioactive Isotopes in Medicine The radioactive isotopes were first used in medicine for diagnostic procedures during the early 1930s. This eventually laid the foundation for nuclear medicine. This article will cover all the information regarding the procedures and uses of radioactive isotopes in medicine.
  • 3. What is Nuclear Medicine  Nuclear medicine is the branch of science under medicine, that uses radiation to give information regarding the functioning of a specific organ in the human body or to treat a disease. This collected information gives accurate and immediate diagnosis of the patient's illness. Radioactive isotopes in medicine are used to form images of the thyroid, bones, heart, liver and many other organs. Radioactive isotopes used in medicine have also helped in treating diseased organs and tumors.
  • 4. What is Nuclear Medicine  Nuclear medicine uses radiation to provide diagnostic information about the functioning of a person's specific organs, or to treat them. Diagnostic procedures are now routine.
  • 5. Diagnostic techniques in nuclear medicine   Medical diagnosis refers to the process of attempting to determine and/or identify a possible disease or disorder and the opinion reached by this process. Diagnostic techniques in nuclear medicine use radioactive tracers which emit gamma rays from within the body. These tracers are generally short-lived isotopes linked to chemical compounds which permit specific physiological processes to be scrutinized. They can be given by injection, inhalation or orally.
  • 6. Diagnostic techniques in nuclear medicine   Positron Emission Tomography (PET)- a more precise and sophisticated technique using isotopes produced in a cyclotron. A positronemitting radionuclide is introduced, usually by injection, and accumulates in the target tissue. As it decays it emits a positron, which promptly combines with a nearby electron resulting in the simultaneous emission of two identifiable gamma rays in opposite directions These are detected by a PET camera and give very precise indication of their origin
  • 7. Diagnostic techniques in nuclear medicine   The Positron Emission Tomography or the PET scan was the first diagnostic tool invented by Peter Alfred Wolf that used radioactive isotopes in medicine. New procedures combine PET with Computed Xray tomography (CT) scans to give co-registration of the two images (PETCT), enabling 30% better diagnosis than with traditional gamma camera alone. It is a very powerful and significant tool which provides unique information on a wide variety of diseases from dementia to cardiovascular disease and cancer (oncology).
  • 8. Radionuclide therapy (RNT)  Rapidly dividing cells are particularly sensitive to damage by radiation. For this reason, some cancerous growths can be controlled or eliminated by irradiating the area containing the growth.  Internal radionuclide therapy is by administering or planting a small radiation source, usually a gamma or beta emitter, in the target area. Short-range radiotherapy is known as brachytherapy, and this is becoming the main means of treatment.
  • 9. Radionuclide therapy (RNT)  External irradiation (sometimes called teletherapy) can be carried out using a gamma beam from a radioactive cobalt60 source, though in developed countries the much more versatile linear accelerators are now being utilized as a high-energy x-ray source (gamma and xrays are much the same)
  • 10. Biochemical Analysis  It is very easy to detect the presence or absence of some radioactive materials even when they exist in very low concentrations. Radioisotopes can therefore be used to label molecules of biological samples in vitro (out of the body). Pathologists have devised hundreds of tests to determine the constituents of blood, serum, urine, hormones, antigens and many drugs by means of associated radioisotopes. These procedures are known as radioimmuno-assays and, although the biochemistry is complex, kits manufactured for laboratory use are very easy to use and give accurate results.
  • 11. Diagnostic Radiopharmaceuticals  Diagnostic radiopharmaceuticals can be used to examine blood flow to the brain, functioning of the liver, lungs, heart or kidneys, to assess bone growth, and to confirm other diagnostic procedures. Another important use is to predict the effects of surgery and assess changes since treatment.  A radioisotope used for diagnosis must emit gamma rays of sufficient energy to escape from the body and it must have a half-life short enough for it to decay away soon after imaging is completed.
  • 12. Therapeutic Radiopharmaceuticals  For some medical conditions, it is useful to destroy or weaken malfunctioning cells using radiation. The radioisotope that generates the radiation can be localized in the required organ in the same way it is used for diagnosis - through a radioactive element following its usual biological path, or through the element being attached to a suitable biological compound. In most cases, it is beta radiation which causes the destruction of the damaged cells. This is radionuclide therapy (RNT) or radiotherapy.
  • 13. SOME Isotopes used in Medicine     Many radioisotopes are made in nuclear reactors, some in cyclotrons. Generally neutron-rich ones and those resulting from nuclear fission need to be made in reactors, neutron-depleted ones are made in cyclotrons. There are about 40 activation product radioisotopes and five fission product ones made in reactors. Reactor Radioisotopes (half-life indicated) Bismuth-213 (46 min): Used for targeted alpha therapy (TAT), especially cancers, as it has a high energy (8.4 MeV). Chromium-51 (28 d): Used to label red blood cells and quantify gastro-intestinal protein loss.
  • 14. Isotopes used in Medicine  Cobalt-60 (5.27 yr): Formerly used for external beam radiotherapy, now used more for sterilizing  Erbium-169 (9.4 d): Use for relieving arthritis pain in synovial joints.  Holmium-166 (26 h): Being developed for diagnosis and treatment of liver tumours.  Iodine-125 (60 d): Used in cancer brachytherapy (prostate and brain), also diagnostically to evaluate the filtration rate of kidneys and to diagnose deep vein thrombosis in the leg. It is also widely used in radioimmuno-assays to show the presence of hormones in tiny quantities.
  • 15. Isotopes used in Medicine  Iodine-131 (8 d)*: Widely used in treating thyroid cancer and in imaging the thyroid; also in diagnosis of abnormal liver function, renal (kidney) blood flow and urinary tract obstruction. A strong gamma emitter, but used for beta therapy.  Iron-59 (46 d): Used in studies of iron metabolism in the spleen.  Potassium-42 (12 h): Used for the determination of exchangeable potassium in coronary blood flow.
  • 16. Isotopes used in Medicine  Rhenium-186 (3.8 d): Used for pain relief in bone cancer. Beta emitter with weak gamma for imaging.  Rhenium-188 (17 h): Used to beta irradiate coronary arteries from an angioplasty balloon.  Samarium-153 (47 h): Sm-153 is very effective in relieving the pain of secondary cancers lodged in the bone, sold as Quadramet. Also very effective for prostate and breast cancer. Beta emitter.  Technetium-99m (6 h): Used in to image the skeleton and heart muscle in particular, but also for brain, thyroid, lungs (perfusion and ventilation
  • 17. Isotopes used in Medicine  Xenon-133 (5 d)*: Used for pulmonary (lung) ventilation studies.  Carbon-11, Nitrogen-13, Oxygen-15, Fluorine-18: These are positron emitters used in PET for studying brain physiology and pathology, in particular for localising epileptic focus, and in dementia, psychiatry and neuropharmacology studies. They also have a significant role in cardiology. F-18 in FDG (fluorodeoxyglucose) has become very important in detection of cancers and the monitoring of progress in their treatment, using PET.
  • 18. Isotopes used in Medicine  Copper-64 (13 h): Used to study genetic diseases affecting copper metabolism, such as Wilson's and Menke's diseases, and for PET imaging of tumours, and therapy.  Indium-111 (2.8 d): Used for specialist diagnostic studies, eg brain studies, infection and colon transit studies.  Iodine-123 (13 h): Increasingly used for diagnosis of thyroid function, it is a gamma emitter without the beta radiation of I-131.
  • 19. Isotopes used in Medicine  Palladium-103 (17 d): Used to make brachytherapy permanent implant seeds for early stage prostate cancer.  Phosphorus-32 (14 d): Used in the treatment of polycythemia vera (excess red blood cells). Beta emitter.  Potassium-42 (12 h): Used for the determination of exchangeable potassium in coronary blood flow.