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THE HEART TEAM
HEALTH BREAKTHROUGH FROM COFFEE
By Dwight Lundell, M.D.
Asantae Java’s HealthyRoast™ process increases antioxidant
strength by up to six times over that of other premium coffees.
Oxidative Stress
Oxidative stress occurs when there is an imbalance between the production of free radicals and
the biological system’s ability to readily neutralize the free radicals and repair the resulting dam-
age. This oxidative damage has been implicated in many diseases including heart disease, hyper-
tension, Alzheimer’s disease, Parkinson’s disease and chronic fatigue syndrome. Oxidative stress
is known to damage DNA, proteins, LDL and other lipids critical to the cell. Oxidative stress is also
connected to the aging process.
The production of free radicals is a normal consequence of metabolism. When we use oxygen in
the process of producing energy, reactive oxygen species (ROS) are created. If not neutralized, they
start a cascade of damage to other molecules which can ultimately result in the death of the cell.
Fortunately our cells have the ability to make and use antioxidants to defend themselves against
oxidative damage.
Things that create an imbalance favoring oxidation and oxidative stress are radiation, cigarette
smoking, air pollution, toxins, inflammation, overeating, and poor nutrition where not enough anti-
oxidants or antioxidant building blocks are consumed in the diet.
Antioxidants and Health
To protect themselves from oxidative stress and damage from the sun, plants contain high con-
centrations of polyphenols which serve as antioxidants. Some of these polyphenols are flavonoids,
flavinols, anthocyanins and phenolic acids.
Populations of humans that regularly consume fruits and vegetables have been documented by
large epidemiological studies to have less disease and oxidative stress than populations that do
not. Oxidative stress reduction in humans by the dietary intake of polyphenols has been shown
in experimental animal studies and cell culture experiments to reduce diseases associated with
oxidative damage. However, supplementing the diet with specific vitamins or compounds derived
from plants has so far been disappointing in dramatically reducing or preventing human disease.
Experts believe that the absorption and metabolism of the complex polyphenols provides the body
the opportunity to produce the amounts and kinds of antioxidants that it needs to avoid oxidative
stress. The key then is not the antioxidant content of the food, but whether it is absorbed and me-
tabolized to compounds that are effective in combating oxidative stress.
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2. Coffee is Rich in Antioxidants
Coffee is rich in polyphenols and is consumed by a large majority of people on a regular basis.
Therefore coffee is the largest single source of antioxidants in the American diet. The major antioxi-
dant compounds in coffee is the polyphenol chlorogenic acid (CGA). It’s absorbed and metabolized
in humans and demonstrates antioxidant activity in plasma.
Chlorogenic acid and its metabolites reduce the oxidation of LDL (so called bad cholesterol).
Oxidized LDL plays a critical role in the formation and growth of atherosclerotic plaques which can
lead to heart attacks and death.
(Journal of Agricultural and Food Chemistry 2002,50,5735-5741, American Society for Nutritional
Sciences 2001,66-71, American Journal of Clinical Nutrition 2007;86:604-9)
Other proven and promising studies have shown the health benefits of coffee in combating
disease, from Parkinson’s to type II diabetes, from Alzheimer’s to heart disease. To list just a few
[Biochemistry 2004; 69:70-74, American Journal of Clinical Nutrition; 2006; 83:1039-46,
Annals Internal Medicine 2004; 140:1-8, FEBS Letters 368 (1995) 188-192, Journal of the
National Cancer Institute, Vol. 97, No. 4, 293-300, February 16, 2005, CANCER RESEARCH 49,
1049-1051, February 15. 1989, Journal of Alzheimer’s Disease, Volume 16, 2009]
Measurement of Antioxidants
ORAC (oxygen radical absorbing capacity) is a popular method to measure antioxidants in food, but
it does not indicate whether the antioxidant is absorbed, metabolized or actually does anything
beneficial in the body.
CGA is the major antioxidant in coffee and we know that it’s absorbed, metabolized, has potent
antioxidant activity, and is incorporated into LDL to prevent its oxidation. Therefore, measuring the
levels of CGA is a valid method of demonstrating the value of coffee to good health.
While coffee is rich in antioxidants, the roasting process which produces most of the taste and
aroma of brewed coffee also destroys the majority of the antioxidant polyphenols. The darker the
roast, the lower the antioxidant content.
The Content of Chlorogenic Acid (CA) in Various Coffee Beans
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7
Percentage concentration of CA
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5
4
3
2
Source: HPLC analysis by
1 Applied Food Sciences 2004
0
Green Beans Light Roasting Medium Roasting Dark Roasting
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3. 100 Mg CGA
96 Milligrams per cup
80
Milligrams
60
40
20 25
Source: Asantae
0 independent study
Green Coffee Beans Major Retail Brand
The Breakthrough
The first advance in coffee in hundreds of years is the invention and patenting of the
HealthyRoast process. This process carefully extracts antioxidants from green (unroasted)
coffee beans and infuses them into the beans at the end stages of the roasting process
thus making it very rich in antioxidant polyphenols. Asantae has the exclusive rights to
these patents for the HealthyRoast process (US patent # 6723368).
Since CGA is the major polyphenol in coffee and is known to be absorbed, metabolized
and is beneficial to the body, Asantae has chosen to measure CGA as a method for quality
control and to compare Asantae Java to other premium coffees. The measurement of CGA
content was done by a technique called high performance liquid chromatography (HPLC)
and was conducted by a third-party independent laboratory.
The Results
Asantae Java is truly the first breakthrough in coffee in hundreds of years. Asantae Java
delivers up to six times more antioxidant than major retail premium coffee. Asantae Java
Healthy Roast multiplies the health benefits of consuming coffee making it unique and
appealing to all those who are concerned about consuming more and more effective
antioxidants from coffee. Because of this breakthrough Asantae Java is poised to become
a significant part of the $34 billion domestic coffee market.
300 Mg Total Polyphenols
Milligrams per cup 246 253
250
200
Milligrams
150
100 77
50
33
0
Major Retail Brand Network Marketing Brand Asantae JavaTM Asantae JavaTM
Decaf Breakfast Blend
Source: Asantae independent study
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4. 192
200 Mg CGA 187
Milligrams per cup
Milligrams 150
100 58
50
25
0
Major Retail Brand Network Marketing Brand Asantae JavaTM Asantae JavaTM
Decaf Breakfast Blend
Source: Asantae independent study
Dr. Lundell is Chief Medical Officer of Asantae. He has performed more that 5,000 coronary bypass
operations and is the author of The Cure for Heart Disease.
These statements have not been evaluated by the Food and Drug TM
Administration. This product is not intended to diagnose, treat, cure,
or prevent any disease. THE HEART TEAM
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