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CELL MEMBRANE 
FACTORS AFFECTING THE RATE OF 
DIFFUSION
Summary of Membrane Transport
Diffusion of Nonelectrolytes 
 Simple diffusion
Concentration Gradient (CA − CB)
Partition Coefficient (K) 
 Solubility of a solute in oil relative to its solubility in 
water 

Diffusion Coefficient (D) 
 Size of the solute molecule 
 Viscosity of the medium
Thickness of the Membrane (ΔX) 
 The thicker the cell membrane, the lower the rate of 
diffusion.
Surface Area (A) 
 The greater the surface area of membrane available, 
the higher the rate of diffusion
Diffusion of Electrolytes 
 Facilitated Diffusion 
 Primary Active Transport 
 Secondary Active Transport 
 Cotransport 
 Countertransport
Saturation 
 Carrier proteins have a limited number of binding 
sites for the solute
Stereospecifity 
 The binding sites for solute on the transport proteins 
are stereospecific
Competition 
 Chemically related solutes can be recognized, bound, 
and get transport, thereby occupying some of the 
binding sites of other solutes
Reference: 
 Costanzo Physiology 5th edition

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Factors affecting rate of diffusion