36. Concept of "minimal persistent inflammation“ causing chronic disease Threshold level for symptoms Symptoms inflammation Ciprandi et al, J Allergy Clin Immunol 1996 An inflammatory process which is actually present even in asymptomatic subjects who are exposed to allergens 0 , 1 1 1 0 1 0 0 0 2 4 6 8 1 0 1 2 M o n t h s mite allergen (µg/g of dust) Minimal persistent inflammation
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Editor's Notes
When was it built? By whom? Why? Art appreciation like in JAMA. The Taj Mahal is a mausoleum located in Agra , India , that was built under Mughal Emperor Shah Jahan in memory of his favorite wife, Mumtaz Mahal . The Taj Mahal is considered the finest example of Mughal architecture , a style that combines elements from Persian , Turkish , Indian , and Islamic architectural styles. Taj Mahal is an integrated symmetric complex of structures that was completed around 1648.
In people with allergies, the immune system is overly sensitive to substances such as animal dander, molds, pollen, etc. With repeated exposure they build up a sensitivity to these allergens. This sensitivity then causes allergic reactions.
The Eiffel Tower was named after it’s designer, Gustav Eiffel. It is located along the Seine River in Paris. When it was completed in 1889, it was the tallest structure in the world.
The Pietà ( 1498 – 1499 ) by Michelangelo is a marble sculpture in St. Peter's Basilica in Vatican City , the first of a number of works of the same theme by the artist. The statue was commissioned for the French cardinal Jean de Billheres , who was a representative in Rome. The statue was made for the cardinal's funeral monument, but was moved to its current location, the first chapel on the right as one enters the basilica, in the 18th century . This famous work of art depicts the body of Jesus on the lap of his mother Mary after the Crucifixion .
Avoidance of allergens when possible is the most important aspect of allergy treatment. Decreasing exposure to allergens results in improvement in symptoms and less need for medications. Total avoidance of allergens is usually not possible, so medications are usually necessary. Fortunately we have many safe and effective medications for allergies. Allergy injections are usually reserved for those patients whose symptoms are not controlled by avoidance and medications. Allergy injections can be very effective in certain patients with certain allergies, but should be prescribed and administered by physicians with training or experience in this kind of therapy.
For allergy shots to be effective, they have to be used in the proper dose, for the proper allergens, and only when the patients allergies fit the pattern of symptoms. In other words, a patient should not be on allergy shots to grass, when their symptoms only occur in the winter.
Mona Lisa , or (La Joconde) is a 16th-century portrait painted in oil on a poplar panel by Leonardo Da Vinci during the Italian Renaissance . It is arguably the most famous painting in the world, and few other works of art have been subject to as much scrutiny, study, mythologizing and parody. The work is owned by the French government and hangs in the Musée du Louvre in Paris , France with the title Portrait of Lisa Gherardini, wife of Francesco del Giocondo . The painting is a half-length portrait and depicts a woman whose expression is often described as enigmatic. The ambiguity of the sitter's expression, the monumentality of the half-figure composition, and the subtle modeling of forms and atmospheric illusionism were novel qualities that have contributed to the painting's continuing fascination.