misoprostol pharmacokinetics and different methods of use

1. Misoprostol Theory & Practice In Obstetrics

4. Establish the difference between different routes of drug adminstration.

6. Adverse reactions.

9. Sublingual

10. Vaginal

11. Rectal

13. ORAL RECTAL

15. Abdominal pain

16. Headache

17. Nausea

18. Vomiting

19. Flatulence

20. Chills

21. Shivering

22. fever

23. Less common adverse reactions

27. Termination of pregnancy

28. 1st trimester

29. 2nd trimester

30. 3rd trimester

31. Postpartum hemorrhage

32. Prevention

33. Treatment

34. Gynecological uses

35. Pre-hysteroscopy

36. Intauterine Insemination (IUI)

37. Cervical pregnancy

38. GIT

40. Gestational age more than 56 days (completed 9 weeks) Misoprostol as cervical –priming agent before vaccum-aspiration of the products of conception 400 g vaginal 3 hours before procedure Misoprostol PGE2

42. Misoprostolin 2nd trimester Misoprostol 400 g vaginal every 3 hours Misoprostol = PGE2 = extraamniotic PGs

43. Misoprostol in 3rd trimester Induction of labor Living fetus at term Dead fetus at term Misoprostol25 g every 6 hours Misoprostol50 g every 12 hours why?

45. Uterine hyperstimulation

48. Need for additional uterotonics

49. Shivering

50. PyrexiaThis is in comparison to intramuscular or intravenous oxytocin

51. But Why misoprostol is still evaluated as uterotonic agent despite its side-effects Ease of use Stability in field conditions Longer shelf-life Less expense

57. Thank you for your attention! Any Questions?

58. Mohamed GamalSaleh Ibrahim e-mail:mgs_medicine@hotmail.com mobile:002 012 630 1515