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ADDICTION
JATISH SHAH
ADDICTION COUNSELLOR
SHAH BAUG, NO: 1, GROUND FLOOR, GARDEN LEVEL,
BYRAMJI GAMADIA ROAD, OFF: DR. G. DESHMUKH MARG,
BEHIND PRABHU KUNJ (BUILDING), MUMBAI 400 026.
CONTACT NUMBER: +91 98195 33496
E.MAIL I.D.: shah_jatish@hotmail.com
The National Council on Alcohol and
Drug Dependence (U.S.A) defines
alcoholism this way:
"Alcoholism is a primary, chronic disease with
genetic, psychological, and environmental
factors influencing its development and
manifestations. The disease is often
progressive and fatal. It is characterized by
impaired control over drinking, preoccupation
with the drug alcohol, use of alcohol despite
adverse consequences, and distortion in
thinking, most notably denial."
W.H.O. defines that Drug addiction is a stage of periodic
and chronic intoxication detrimental to the individual and to
society, produced by the repeated consumption of a drug
(natural or synthetic). Its characteristics include:
1. An overpowering desire, a need (compulsion) to
continue taking drugs and to obtain it by any means.
2. A tendency to increase the dose.
3. A psychic (psychological) and sometimes a physical
dependence on the effects of the drugs.
From the above definition it is evident that physiological and
psychological need of the drug is inherent in drug addiction.
The need is so overwhelming that the craving for the
addiction forces the individual to acquire it by any means.
DSM-IV-R gives the following seven criteria for addiction
1. Tolerance.
2. Withdrawal.
3. Increased consumption.
4. Persistent desire to control substance use
5. Great deal of time is spent in consuming the substance
6. Important occasions are ignored.
7. Continued consumption despite knowing the
negative consequences.
At least three of the above criteria should have occurred
together in the same period of 12 months.
I.C.D – 10 has similar diagnostic criteria.
Addiction is a Primary Disease and is
recognized as such by the W.H.O.
Alcoholics / Narcotics Anonymous state
that Alcoholism / Addiction is a tri-faceted
disease comprising of a
- Physical Craving
- Mental Obsession
- Spiritual Bankruptcy
The demand that the physical being makes when
deprived of the addictive substance.
This is best seen during “Withdrawals” symptoms
which occur when the chemically dependent
victim is deprived of the substance or behavior.
- Tremors, Abdominal Cramps, Loose motions,
Joint Pains, Cold Sweating, Inability to sleep
fitfully, Loss of Appetite, Restlessness,
Disorientation.
In extreme cases – Delirium Tremens, Rum Fits
and Hallucinations.
When not actually using, the chemically dependent
person is thinking about using the addictive
substance/behavior of his choice.
He thinks about, plans, dreams and looks
forward to using the substance/behavior of
his choice.
All his plans will revolve around the
substance/behavior that he is addicted to.
This is the inability to relate to –
SELF – Self hating, low self-worth.
GOD – a transactional relationship.
OTHERS – Isolation and Loneliness.
The inability to express ones self
openly, honestly and fearlessly.
Poor communication skills.
The disease of addiction, as per AA / NA is:
Progressive – If not treated it can only get
worse with time.
Incurable – There is no cure. However,
it can be arrested.
Predictable – If not arrested, insanity or/&
death is definite.
NEUROBIOLOGICAL FACTORS.
A.Brain reward mechanism – repeated use of
substances triggers off reward area of the brain.
B.Neuro-regulator system – reinforcement of
substance use is mediated by raised dopamine
release.
C.Craving – has been linked to change in
neurotransmitters.
D.Membrane studies – substance induced
Psycho-dynamic factors.
A. Oral fixation and overly punitive super ego.
B. Sense of power and raised self-esteem.
C. Reduce tension, anxiety and psychic pain.
Socio-cultural factors.
A. Social settings – e.g: college dorms, military
barracks.
B. Cultural differences – e.g: Asians tend to
drink less.
Behaviour & learning theories
Re-inforcement of feeling of well-being and
euphoria, reduction of fear, anxiety, tension
through substance use.
Genetic factors.
Genetic predisposition in an individual is
supported by various monozygotic and twin
studies
 + Family history of alcoholism,
addiction or antisocial behavior
 Family modeling of substance use
behaviors
 Poor parenting skills, family
dysfunction
 Permissive attitude toward teen use
 ↑ household conflict, family chaos
 Child abuse or neglect (physical,
sexual)
• ↓ interest in school and achievement,
early academic failure
• ↓ self-esteem
• ↓ religious activity
• Rebelliousness and social alienation
• Early antisocial behavior, delinquency
• Psychopathology, especially depression or
mood disorders.
• Sexual dysfunction or sexual deviance.
• Early ↑ risky behaviors: ATOD*, sex
* Alcohol, Tobacco, Other Drugs
 Perceived peer ATOD use, best
friend’s ATOD use
 Ethnic or cultural influences
 Community/neighborhood
deterioration/ disorganization
 Easy access, early access
 Advertising and media portrayal
 NARCOTICS
 DEPRESSANTS
 STIMULANTS
 HALLUCINOGENS
 CANNABIS
 OTHERS
These are drugs that anaesthetize or
neutralize pain. They contain opium or
substances that are similar to Opium.
 Opium (Afeem).
 Morphine.
 Codeine (Corex, Phensidyl)
 Heroin (Diacetylmorphine, Smack,
Brown Sugar, Gard) (Second most
abused)
 Meperidine (Demerol, Pethidine)
 Methadone
 Others (Lomotil /Lomofen)
These are drugs that slow down the CNS.
 Alcohol (The KING of all addictions)
 Barbiturates (Amytal, Barbital, Seconal,
Phenobarbital)
 Benzodiazepines (Librium, Valium, Alam,
Alprax, Lopez, Calmpose, Ativan, Trika,
Restyl, Etc)
 Methaqualone (Mandrax, Mandy)
 Other depressants (Placidyl)
(Alcohol and tranquilizers/sedatives are
substitutive addictive substances)
These are drugs that stimulate the CNS.
 Cocaine (Crack).
 Amphetamines (Dexerine, Biphetamine)
 Phenmetrazine
 Methylphenidate (Ritalin)
 Dextroamphetamine
These are drugs that alter perception of
reality. Time and space get warped.
Hallucinogens induce a state of CNS excitation
and central autonomic hyperactivity,
manifested as changes in perception and
mood (usually euphoric, sometimes
depressive).
 LSD (Acid, Blotting paper, Cork).
 Amphetamine Variants ( MDMA, Ecstasy)
 Phencyclidine Phosphate (PCP)
 Others (Magic Mushrooms / Psilocybin)
These drugs create a long term change
in personality and can lead to cannabis
insanity. Delta Tetrahydrocannabinol
(THC) is the active ingredient in
Cannabis.
 Marijuana (Grass, Weed, Ganja, Bhang).
 Hashish (Hash, Charas).
 Hashish Oil (Hash Oil).
 Nicotine
 Inhalents
 Date Rape Drugs
(which may fall under one of the above
categories, but are mentioned seperately
because they are newer and their
function in society has changed)
POPPY POD
OPIUM
HEROIN
OPIUM AND DERIVATIVES
OPIUM USER
 Opioid receptors.
 Endogenous opioids.
 Analgesic.
 Effects on various body systems.
THE WITHDRAWAL SYNDROME IS SELF-LIMITED AND,
ALTHOUGH SEVERELY DISCOMFORTING, IS NOT LIFE
THREATENING.
The withdrawal syndrome from an opioid generally includes
 Symptoms and signs of CNS hyperactivity.
 Severity of the syndrome increases with the size of the
opioid dose and the duration of dependence.
 Symptoms appear as early as 4 to 6 h after withdrawal
and, for heroin, peak within 36 to 72 hrs.
 Anxiety and a craving for the drug.
 Increased resting respiratory rate (>16 breaths/min)
 Yawning, perspiration, lacrimation, and rhinorrhea.
 Other symptoms include mydriasis, piloerection
(gooseflesh), tremors, muscle twitching, hot and cold
flushes, aching muscles and anorexia.
 IV fluids.
 Clonidine.
 Dextropropoxyphene.
 Buprenorphine.
 Benzodiazepines.
 Symtomatic management.
 Pulmonary
 Hepatic
 Musculoskeletal
 Immunologic
 Neurologic
 Others
Opioid analgesics (sometimes termed
narcotic analgesics) are either derived from
the opium poppy or manufactured
synthetically. They include heroin,
morphine, methadone, meperidine and
codeine. They are used medically primarily
for the relief of pain, although they are also
employed to suppress a cough, and
occasionally in the treatment of severe
diarrhea. Their dependence liability is
generally high.
Favoured drugs include the analgesics
meperidine, oxycodone and codeine, and
the cough suppressants hydromorphone
and hydrocodone (in Corex and Phensidyl
cough syrups).
Cough suppressants ( Corex, Phensidyl,
Codiene Linctus, Etc) are very widely used
by the youngster of today and, tragically,
physicians to prescribe these as they
“appear” harmless and offer quick relief.
Codeine can be injected, or taken orally
depending on the form in which it is –
Liquid or Tablet.
It is used for pain relief and euphoria
but it can lead to drowsiness / nausea,
constipation, confusion, sedation,
respiratory depression and arrest,
tolerance, addiction, unconsciousness,
coma and even death.
Oxycodone HCL and Hydrocodone
bitartrate are also used for the feeling of
well being that they generate.
Generally found in the form of cough
syrups, they have the same effect as
codeine
 90% population consumes alcohol at some
point of time in their lives.
 30% - temporary alcohol related problems.
 10% - alcohol dependence.
 25-30% - alcohol abuse.
 45% - co-morbid depression.
 14% - ASPD traits.
 Type I and Type II.
 Jellinek’s classification – alpha, beta, gamma,
delta & epsilon.
 Early onset & Late onset.
Alcohol is a highly lipid soluble and is
largely absorbed in the small intestine.
Pharmacokinetics:
Ethanol Acetaldehyde Acetic Acid
Alcohol Acetaldehyde
dehydrogenase dehydrogenase
Exits through
Urine/Sweat.
The clinical presentation depends upon
the Blood Alcohol Concentration (BAC).
BAC (mg/dl) Clinical presentation
30 Attention difficulties,
Euphoria.
50 Co-ordination problems.
100 Ataxia, Impaired judgment.
200 Confusion, Consciousness.
> 400 Anaesthesia, Coma?, Death?.
 Apart from these symptoms, the
patient may
present with a fall and have head
injury.
 Occasionally, presented are:
Delirium.
Pathological intoxication.
In withdrawal, an alcoholic may present:
 Delirium tremens – abnormal perception,
agitation,
terror,
autonomic instability,
confusion, auditory &
visual
hallucinations.
Other symptoms that may be
presented are:
 Restlessness.
 Tremulousness.
 Withdrawal seizures.
 Lack of sleep.
 Tactile sensations.
 Central Nervous System.
 Peripheral Nervous System.
 Gastro-intestinal Tract.
 Cerebrovascular and Cardiovascular
system.
 Haematological effects.
 Cancer.
 Metabolism.
 Persisting dementia.
 Psychotic disorders.
 Persisting mood disorders.
 Persisting amnestic disorders.
 Persisting anxiety disorders.
 Other behavioural and sexual
disorders.
 Pathological intoxication.
 Alcohol withdrawals
 Delirium tremens
 Routine lab investigations
 Specific investigations
 GGTP / Liver function tests.
 Serum Ammonia.
 MCV.
 Uric acid.
 Triglycerides.
 USG
 Carbohydrate deficient transferrin (CDT).
BARBITURATES
The barbiturates have been used since
the early 1900s for epilepsy. Although
their dangers were universally recognized
- severe respiratory depression, high-
dependence liability and life-threatening
withdrawal reactions, safer alternatives
did not exist until recently.
The short-acting barbiturates such as
Secobarbital are still used illicitly, since
they take effect quickly and produce the
most euphoria. They are often
administered to enhance the effects of
other sedative-hypnotics or to terminate
the unpleasant effects of a long stimulant
binge.
HYPNOTICS
The many prescription drugs that slow the
activity of the central nervous system are
called sedative-hypnotics. They include the
barbiturates, general anesthetics, anti-
anxiety tranquillizers (eg,
benzodiazepines) and a number of non-
barbiturate sedatives. These substances
are prescribed to relieve anxiety, to induce
sleep, to prevent or treat epileptic
seizures, or to produce surgical
anesthesia. All can create dependence in
some individuals.
The benzodiazepines (13 different kinds are being sold in
India)
 Diazepam
 Chlordiazepoxide
 Oxazepam
 Flurazepam
 Midazolam
 Triazolam
 Alprazolam
 Lorazepam
 Nitrazepam
 Clonazepam
 Estizolam
 Flunitrazepam
Physicians agree that these drugs are safe for short-
term uses (i.e, less than 4 weeks), but there is a high
abuse potential and dependence.
The effects of Benzodiazepines are
sedation, Drowsiness /dizziness
Methaqualone known as Mandrex or
Mandy. This has been withdrawn from
the market. However, it is available as a
street drug and contains a lot of
impurities. The effect seen on consuming
Mandrex are euphoria/depression, poor
reflexes, slurred speech, coma.
Fentanyl is used for pain relief, however
it is abused for the feeling of euphoria
that it creates.
It can cause drowsiness/nausea,
constipation, confusion, sedation,
respiratory depression and arrest,
tolerance, addiction, unconsciousness,
coma, death.
 Psychological dependence leading to
profound psychological addiction,
produced by high doses of cocaine, which
can cause euphoric excitement.
 Tolerance occurs, but physical
dependence has not been confirmed; no
stereotypical withdrawal syndrome occurs
when the drug is discontinued. However,
the tendency to continue taking the drug
is strong.
short acting drug – repeated use leading to:
 Toxic effects, such as tachycardia, hypertension,
mydriasis, muscle twitching, sleeplessness, and
extreme nervousness.
 Hallucinations, paranoid delusions, and aggressive
behavior can develop. Pupils are maximally dilated
 Sympathomimetic effect increases heart and
respiration rates and BP.
 Overdose may produce tremors, convulsions, and
delirium. Death may occur due to arrhythmias and
cardiovascular failure.
“Snorting” Coke
Psychological dependence produced by
amphetamine causes elevated mood;
increased wakefulness, alertness,
concentration and physical performance
and a feeling of well-being.
Known on the streets as chalk, crank,
crystal, fire, glass, go fast, ice, meth,
speed, it can cause aggression, violence,
psychotic behavior/memory loss, cardiac
and neurological damage, impaired
memory and learning, tolerance, addiction.
Crystal Meth is the latest entrant in
this field.
Known on the streets as Adam, Clarity, Ecstasy,
Eve, Lover's speed, Peace, STP, X, XTC, it can
cause mild hallucinogenic effects, increased
tactile sensitivity, empathic feelings/impaired
memory and learning, hyperthermia, cardiac
toxicity, renal failure, liver toxicity, etc, etc.
A new and very dangerous drug. This, too
has found its way into India and instances of
abuses are beninning to be seen
The chemical n-methyl-1-phenyl-propan-2-
amine is called methamphetamine,
methylamphetamine, or desoxyephedrine.
The shortened name is simply 'meth'. When
it is in its crystalline form, the drug is called
crystal meth, ice, Tina, or glass.
What Are the Effects of Methamphetamine Use?
This is a list of effects associated with pure
methamphetamine use. Because of how it's made, crystal
meth is never pure, so the dangers associated with taking
the street drug extend beyond these effects.
Common Immediate Effects
 Euphoria
 Increased energy and alertness
 Diarrhea and nausea
 Excessive sweating
 Loss of appetite, insomnia, tremors, jaw-clenching
 Agitation, irritability, talkativeness, panic, compulsive
fascination with repetitive tasks, violence, confusion
 Increased libido
 Increased blood pressure, body temperature, heart rate,
blood sugar levels, bronchodilation
 Constriction of the walls of the arterties
 In pregnant and nursing women, methampetamine
crosses the placenta and is secreted in breast milk
Effects Associated with Chronic Use
 Tolerance (needing more of the drug to get the
same effect)
 Drug craving
 Temporary weight loss
 Withdrawal symptoms including depression and
anhedonia
 "Meth Mouth" where teeth rapidly decay and fall
out
 Drug-related psychosis (may last for months or
years after drug use is discontinued)
Yaba is a combination of
methamphetamine (a powerful and
addictive stimulant) and caffeine. Yaba,
which means crazy medicine in Thai, is
produced in Southeast and East Asia. The
drug is popular in Asian communities in
the United States and increasingly is
available at raves and techno parties.
It has made its entry into India
through Bangladesh and Burma
 Rapid heart rate, increased blood pressure, and
damage to the small blood vessels in the brain
that can lead to stroke. Chronic use of the drug
can result in inflammation of the heart lining.
Overdoses can cause hyperthermia (elevated
body temperature), convulsions, and death.
Individuals who use Yaba also may have
episodes of violent behavior, paranoia, anxiety,
confusion and insomnia.
 Although most users administer Yaba orally,
those who inject the drug expose themselves to
additional risks, including contracting HIV
(human immunodeficiency virus), hepatitis B and
C, and other blood-borne viruses.
CANNABIS
 Smoked cannabis produces a dreamy
state of consciousness in which ideas
seem disconnected, unanticipated, and
free-flowing. Time, color, and spatial
perceptions may be altered.
 In general, a feeling of well-being and
relaxation (a "high") results.
 Tachycardia, conjunctival injection, and
dry mouth occur regularly.
 Panic reactions have occurred,
particularly in naive users, but have
become unusual as the culture has
become more familiar with the drug.
 Communicative and motor abilities are
decreased, depth perception and tracking
are impaired, and the sense of timing is
altered--all hazardous in certain
situations (eg, driving, operating heavy
equipment).
 Schizophrenic symptoms may be
exacerbated by marijuana, even in
patients being treated with antipsychotic
drugs (eg, chlorpromazine).
 Appetite often increases.
 Cannabis induced psychosis is common
and cannabis induced lunacy can follow in
the case of daily users.
The “high” felt by a marijuana smoker is a very
unique conglomeration of feelings, and there are
only two known sources for the substances which
activate the neuroreceptor for THC. The first source
is our own brains, which produce a neurochemical
very similar to THC called anandamide. The second
source for this substance is the cannabis plant from
which comes marijuana.
 Unfortunately, there are negative side effects
that occur from using marijuana. Some of these
include frequent respiratory infections,
impaired memory, increased heart rate,
impaired learning, panic attacks and
physical dependence on the substance.
Additionally, if used during the first month of
breast feeding, infants can suffer from impaired
motor development. Marijuana may produce
blissful effects in the minds of those who use it,
but its side effects are far from blissful.
Research has shown that THC changes the way in
which sensory information is transmitted to the
brain and the way that the hippocampus acts upon
the information. The hippocampus is a component
of the limbic system that is critical for learning,
memory and the integration of emotions,
motivations and sensory experiences. THC has
been shown to suppress the neurons involved
in information processing by the
hippocampus, and it has also been shown
that learned behaviors (which depend on the
hippocampus to “stick” in the brain) also
deteriorate.
 A person who smokes marijuana on a regular
basis may suffer from many of the same
respiratory problems that tobacco smokers
have. These people may cough daily and have
excess phlegm, may have symptoms of chronic
bronchitis and much more frequent chest colds.
 Continual smoking of marijuana can lead to
abnormal functioning of the lungs due to
tissue damage caused by marijuana smoke.
Additionally, the amount of tar inhaled by
marijuana smokers is three to five times more
than tobacco smokers, which can lead to further
lung damage.
Smoking marijuana while taking other drugs (both
legal and illegal) can lead to a sharp increase in
heart rate and blood pressure, which can
stress the cardiovascular system and risks
overload and potential heart failure.
The Effects on Men
In addition to providing pleasurable effects, marijuana can
also affect parts of the brain responsible for sex and
growth hormones. In men, marijuana can decrease
testosterone, cause enlarged breasts and lead to a
decrease in sperm count and infertility.
The Effects on Women
As in males, marijuana also effects women’s hormones,
which can cause problems such as irregular menstrual
cycles, depression, an increased testosterone level and
the possibility for having children with moderate to
severe physical and mental deficiencies ranging from
learning disabilities to babies born with weak central nervous
systems.
 I.V. Fluids for supportive treatment
 Treatment of any medical complications.
 Treatment for co-morbidity, such as
Psychosis, Anxiety, Mood disorder, etc
 Counselling and psycho-education
TOBACCO
Nicotine is the substance in cigarettes along with
other harmful chemicals (approximately 4400)that
smokers become dependent on. Thus, nicotine
dependence is essentially dependence on tobacco
products – cigarettes, bidis, gutka, cigars, etc.
About 70% of smokers have acknowledged that
they desire to quit smoking but are unable to do
so. Of people who quit, 90% do so on their own,
but only about 3 to 4% successfully quit in any
given year.
 Nicotine is highly addictive. Nicotine
provides an almost immediate “kick”
 Addiction to nicotine results in withdrawal
symptoms when a person tries to stop
smoking - increased anger, hostility, and
aggression, and loss of social
cooperation. Persons suffering from
withdrawal also take longer to regain
emotional equilibrium following stress
 Inhalation of 4000+ noxious chemicals.
 43 of these are proven to be
carcinogens.
 Nicotine, Pyridine, Methyl Alcohol,
Ammonia, Formaldehyde, Carbon
Monoxide, Benzopyrene, Phenols,
Acetone, Arsenic, Formic Acid, Oxalic
Acid, Citric Acid, Acetic Acid, Hydrogen
Cyanide are some of the toxins that are
available in tobacco.
 One cigarette contains approximately 100
Mcg of Nicotine. 500 Mcg directly
injected would cause instant death.
 Nicotine is physically addictive and a
harmful intoxicant.
 Inhaled nicotine takes just 7 seconds to affect
the brain and the C.N.S.
 Tar – directly linked to cancer
 Carbon Monoxide has been used to commit
suicide in enclosed place.
 Hydrogen Cyanide was used to gas criminals
to death in U.S.A. once upon a time.
...And yet we happily consume these
chemicals thinking that the cigarette is
relaxing for us, is good for us, makes us
think better, etc.
 Lung cancer
 Coronary heart disease
 Chronic lung diseases – bronchitis/emphysema
 Gastric and duodenal ulcers
 Cirrhosis of the liver
 Various cancers – pancreas, stomach, kidneys,
prostrate, bladder, liver, gall bladder
 Cancers of the oral cavity – lips, mouth, tongue,
throat
 And many, many more.
CANCER CURES SMOKING
 Pharmacological treatment combined
with behavioral treatment, including
psychological support and skills training
to overcome high-risk situations, results
in some of the highest long-term
abstinence rates
 Nicotine chewing gum
 Transdermal patch
 Bupropion
 Varnecline Tartrate (Champix)
 Anti-depressants
 Mood stabilizers
Among teenagers, inhalants are used more
frequently than cocaine or LSD but less
frequently than marijuana or alcohol.
Inhalant use is particularly a problem
among children aged 12 and younger.
Inhalants are found in many common
household products.
ADHESIVES
•Airplane Glue
•Rubber Cement
•Polyvinyl Chloride Cement
AEROSOLS
•Spray Paint
•Hair Spray
CLEANING AGENTS
•Dry Cleaning Fluid
•Stain Remover
•Degreaser
SOLVENTS AND GASES
•Typing Correction
Fluid Thinner
•Nail Polish Remover
•Paint Thinner
•Acetone
•Cigarette Lighter Fluid
•Petrol Fumes
•Fuels
All inhalants cause stimulation, loss of
inhibition, headache, nausea or vomiting,
slurred speech, loss of motor coordination,
wheezing, unconsciousness, cramps,
weight loss, muscle weakness, depression,
memory impairment, damage to
cardiovascular and nervous systems.
Inhalants can lead to sudden death due to
arrhythmia and asphyxia.
KETAMINE induces a lack of awareness
to pain and to one's general surroundings,
leading to a scattered feeling or to a
feeling of detachment. Ketamine is usually
injected intravenously and may be
snorted as well.
Also known as Vitamin K, Special K, KO,
Horse (because it has veterinary use).
It is also a common “date rape” drug.
GAMMA HYDROXIBUTYRATE (GHB) is taken
by mouth. It is similar to Ketamine in its
effects.
GHB produces feelings of relaxation and
tranquillity. It may also cause fatigue and
feelings of being uninhibited.
Also known as “Easy Lay”, “Liquid Ecstasy”.
This is another “date rape” drug”
MAY GOD
HELP ADDICTS
WHERE EVER
THEY BE.
FOR IF THEY
DO NOT GET
HELP, THE END
IS INEVITABLE -
- INSANITY
AND / OR DEATH
THANK YOU!
…… JATISH SHAH.

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ADDICTION COUNSELLOR CONTACT DETAILS

  • 1. ADDICTION JATISH SHAH ADDICTION COUNSELLOR SHAH BAUG, NO: 1, GROUND FLOOR, GARDEN LEVEL, BYRAMJI GAMADIA ROAD, OFF: DR. G. DESHMUKH MARG, BEHIND PRABHU KUNJ (BUILDING), MUMBAI 400 026. CONTACT NUMBER: +91 98195 33496 E.MAIL I.D.: shah_jatish@hotmail.com
  • 2.
  • 3. The National Council on Alcohol and Drug Dependence (U.S.A) defines alcoholism this way: "Alcoholism is a primary, chronic disease with genetic, psychological, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortion in thinking, most notably denial."
  • 4. W.H.O. defines that Drug addiction is a stage of periodic and chronic intoxication detrimental to the individual and to society, produced by the repeated consumption of a drug (natural or synthetic). Its characteristics include: 1. An overpowering desire, a need (compulsion) to continue taking drugs and to obtain it by any means. 2. A tendency to increase the dose. 3. A psychic (psychological) and sometimes a physical dependence on the effects of the drugs. From the above definition it is evident that physiological and psychological need of the drug is inherent in drug addiction. The need is so overwhelming that the craving for the addiction forces the individual to acquire it by any means.
  • 5. DSM-IV-R gives the following seven criteria for addiction 1. Tolerance. 2. Withdrawal. 3. Increased consumption. 4. Persistent desire to control substance use 5. Great deal of time is spent in consuming the substance 6. Important occasions are ignored. 7. Continued consumption despite knowing the negative consequences. At least three of the above criteria should have occurred together in the same period of 12 months. I.C.D – 10 has similar diagnostic criteria.
  • 6. Addiction is a Primary Disease and is recognized as such by the W.H.O. Alcoholics / Narcotics Anonymous state that Alcoholism / Addiction is a tri-faceted disease comprising of a - Physical Craving - Mental Obsession - Spiritual Bankruptcy
  • 7. The demand that the physical being makes when deprived of the addictive substance. This is best seen during “Withdrawals” symptoms which occur when the chemically dependent victim is deprived of the substance or behavior. - Tremors, Abdominal Cramps, Loose motions, Joint Pains, Cold Sweating, Inability to sleep fitfully, Loss of Appetite, Restlessness, Disorientation. In extreme cases – Delirium Tremens, Rum Fits and Hallucinations.
  • 8. When not actually using, the chemically dependent person is thinking about using the addictive substance/behavior of his choice. He thinks about, plans, dreams and looks forward to using the substance/behavior of his choice. All his plans will revolve around the substance/behavior that he is addicted to.
  • 9. This is the inability to relate to – SELF – Self hating, low self-worth. GOD – a transactional relationship. OTHERS – Isolation and Loneliness. The inability to express ones self openly, honestly and fearlessly. Poor communication skills.
  • 10. The disease of addiction, as per AA / NA is: Progressive – If not treated it can only get worse with time. Incurable – There is no cure. However, it can be arrested. Predictable – If not arrested, insanity or/& death is definite.
  • 11. NEUROBIOLOGICAL FACTORS. A.Brain reward mechanism – repeated use of substances triggers off reward area of the brain. B.Neuro-regulator system – reinforcement of substance use is mediated by raised dopamine release. C.Craving – has been linked to change in neurotransmitters. D.Membrane studies – substance induced
  • 12. Psycho-dynamic factors. A. Oral fixation and overly punitive super ego. B. Sense of power and raised self-esteem. C. Reduce tension, anxiety and psychic pain. Socio-cultural factors. A. Social settings – e.g: college dorms, military barracks. B. Cultural differences – e.g: Asians tend to drink less.
  • 13. Behaviour & learning theories Re-inforcement of feeling of well-being and euphoria, reduction of fear, anxiety, tension through substance use. Genetic factors. Genetic predisposition in an individual is supported by various monozygotic and twin studies
  • 14.  + Family history of alcoholism, addiction or antisocial behavior  Family modeling of substance use behaviors  Poor parenting skills, family dysfunction  Permissive attitude toward teen use  ↑ household conflict, family chaos  Child abuse or neglect (physical, sexual)
  • 15. • ↓ interest in school and achievement, early academic failure • ↓ self-esteem • ↓ religious activity • Rebelliousness and social alienation • Early antisocial behavior, delinquency • Psychopathology, especially depression or mood disorders. • Sexual dysfunction or sexual deviance. • Early ↑ risky behaviors: ATOD*, sex * Alcohol, Tobacco, Other Drugs
  • 16.  Perceived peer ATOD use, best friend’s ATOD use  Ethnic or cultural influences  Community/neighborhood deterioration/ disorganization  Easy access, early access  Advertising and media portrayal
  • 17.  NARCOTICS  DEPRESSANTS  STIMULANTS  HALLUCINOGENS  CANNABIS  OTHERS
  • 18. These are drugs that anaesthetize or neutralize pain. They contain opium or substances that are similar to Opium.  Opium (Afeem).  Morphine.  Codeine (Corex, Phensidyl)  Heroin (Diacetylmorphine, Smack, Brown Sugar, Gard) (Second most abused)  Meperidine (Demerol, Pethidine)  Methadone  Others (Lomotil /Lomofen)
  • 19. These are drugs that slow down the CNS.  Alcohol (The KING of all addictions)  Barbiturates (Amytal, Barbital, Seconal, Phenobarbital)  Benzodiazepines (Librium, Valium, Alam, Alprax, Lopez, Calmpose, Ativan, Trika, Restyl, Etc)  Methaqualone (Mandrax, Mandy)  Other depressants (Placidyl) (Alcohol and tranquilizers/sedatives are substitutive addictive substances)
  • 20. These are drugs that stimulate the CNS.  Cocaine (Crack).  Amphetamines (Dexerine, Biphetamine)  Phenmetrazine  Methylphenidate (Ritalin)  Dextroamphetamine
  • 21. These are drugs that alter perception of reality. Time and space get warped. Hallucinogens induce a state of CNS excitation and central autonomic hyperactivity, manifested as changes in perception and mood (usually euphoric, sometimes depressive).  LSD (Acid, Blotting paper, Cork).  Amphetamine Variants ( MDMA, Ecstasy)  Phencyclidine Phosphate (PCP)  Others (Magic Mushrooms / Psilocybin)
  • 22. These drugs create a long term change in personality and can lead to cannabis insanity. Delta Tetrahydrocannabinol (THC) is the active ingredient in Cannabis.  Marijuana (Grass, Weed, Ganja, Bhang).  Hashish (Hash, Charas).  Hashish Oil (Hash Oil).
  • 23.  Nicotine  Inhalents  Date Rape Drugs (which may fall under one of the above categories, but are mentioned seperately because they are newer and their function in society has changed)
  • 24.
  • 27.
  • 28.
  • 29.
  • 30.  Opioid receptors.  Endogenous opioids.  Analgesic.  Effects on various body systems.
  • 31. THE WITHDRAWAL SYNDROME IS SELF-LIMITED AND, ALTHOUGH SEVERELY DISCOMFORTING, IS NOT LIFE THREATENING. The withdrawal syndrome from an opioid generally includes  Symptoms and signs of CNS hyperactivity.  Severity of the syndrome increases with the size of the opioid dose and the duration of dependence.  Symptoms appear as early as 4 to 6 h after withdrawal and, for heroin, peak within 36 to 72 hrs.  Anxiety and a craving for the drug.  Increased resting respiratory rate (>16 breaths/min)  Yawning, perspiration, lacrimation, and rhinorrhea.  Other symptoms include mydriasis, piloerection (gooseflesh), tremors, muscle twitching, hot and cold flushes, aching muscles and anorexia.
  • 32.  IV fluids.  Clonidine.  Dextropropoxyphene.  Buprenorphine.  Benzodiazepines.  Symtomatic management.
  • 33.  Pulmonary  Hepatic  Musculoskeletal  Immunologic  Neurologic  Others
  • 34. Opioid analgesics (sometimes termed narcotic analgesics) are either derived from the opium poppy or manufactured synthetically. They include heroin, morphine, methadone, meperidine and codeine. They are used medically primarily for the relief of pain, although they are also employed to suppress a cough, and occasionally in the treatment of severe diarrhea. Their dependence liability is generally high.
  • 35. Favoured drugs include the analgesics meperidine, oxycodone and codeine, and the cough suppressants hydromorphone and hydrocodone (in Corex and Phensidyl cough syrups). Cough suppressants ( Corex, Phensidyl, Codiene Linctus, Etc) are very widely used by the youngster of today and, tragically, physicians to prescribe these as they “appear” harmless and offer quick relief.
  • 36. Codeine can be injected, or taken orally depending on the form in which it is – Liquid or Tablet. It is used for pain relief and euphoria but it can lead to drowsiness / nausea, constipation, confusion, sedation, respiratory depression and arrest, tolerance, addiction, unconsciousness, coma and even death.
  • 37. Oxycodone HCL and Hydrocodone bitartrate are also used for the feeling of well being that they generate. Generally found in the form of cough syrups, they have the same effect as codeine
  • 38.
  • 39.  90% population consumes alcohol at some point of time in their lives.  30% - temporary alcohol related problems.  10% - alcohol dependence.  25-30% - alcohol abuse.  45% - co-morbid depression.  14% - ASPD traits.
  • 40.  Type I and Type II.  Jellinek’s classification – alpha, beta, gamma, delta & epsilon.  Early onset & Late onset.
  • 41. Alcohol is a highly lipid soluble and is largely absorbed in the small intestine. Pharmacokinetics: Ethanol Acetaldehyde Acetic Acid Alcohol Acetaldehyde dehydrogenase dehydrogenase Exits through Urine/Sweat.
  • 42. The clinical presentation depends upon the Blood Alcohol Concentration (BAC). BAC (mg/dl) Clinical presentation 30 Attention difficulties, Euphoria. 50 Co-ordination problems. 100 Ataxia, Impaired judgment. 200 Confusion, Consciousness. > 400 Anaesthesia, Coma?, Death?.
  • 43.  Apart from these symptoms, the patient may present with a fall and have head injury.  Occasionally, presented are: Delirium. Pathological intoxication.
  • 44. In withdrawal, an alcoholic may present:  Delirium tremens – abnormal perception, agitation, terror, autonomic instability, confusion, auditory & visual hallucinations.
  • 45. Other symptoms that may be presented are:  Restlessness.  Tremulousness.  Withdrawal seizures.  Lack of sleep.  Tactile sensations.
  • 46.
  • 47.  Central Nervous System.  Peripheral Nervous System.  Gastro-intestinal Tract.  Cerebrovascular and Cardiovascular system.  Haematological effects.  Cancer.  Metabolism.
  • 48.  Persisting dementia.  Psychotic disorders.  Persisting mood disorders.  Persisting amnestic disorders.  Persisting anxiety disorders.  Other behavioural and sexual disorders.  Pathological intoxication.  Alcohol withdrawals  Delirium tremens
  • 49.  Routine lab investigations  Specific investigations  GGTP / Liver function tests.  Serum Ammonia.  MCV.  Uric acid.  Triglycerides.  USG  Carbohydrate deficient transferrin (CDT).
  • 50. BARBITURATES The barbiturates have been used since the early 1900s for epilepsy. Although their dangers were universally recognized - severe respiratory depression, high- dependence liability and life-threatening withdrawal reactions, safer alternatives did not exist until recently.
  • 51. The short-acting barbiturates such as Secobarbital are still used illicitly, since they take effect quickly and produce the most euphoria. They are often administered to enhance the effects of other sedative-hypnotics or to terminate the unpleasant effects of a long stimulant binge.
  • 52. HYPNOTICS The many prescription drugs that slow the activity of the central nervous system are called sedative-hypnotics. They include the barbiturates, general anesthetics, anti- anxiety tranquillizers (eg, benzodiazepines) and a number of non- barbiturate sedatives. These substances are prescribed to relieve anxiety, to induce sleep, to prevent or treat epileptic seizures, or to produce surgical anesthesia. All can create dependence in some individuals.
  • 53. The benzodiazepines (13 different kinds are being sold in India)  Diazepam  Chlordiazepoxide  Oxazepam  Flurazepam  Midazolam  Triazolam  Alprazolam  Lorazepam  Nitrazepam  Clonazepam  Estizolam  Flunitrazepam Physicians agree that these drugs are safe for short- term uses (i.e, less than 4 weeks), but there is a high abuse potential and dependence.
  • 54. The effects of Benzodiazepines are sedation, Drowsiness /dizziness
  • 55. Methaqualone known as Mandrex or Mandy. This has been withdrawn from the market. However, it is available as a street drug and contains a lot of impurities. The effect seen on consuming Mandrex are euphoria/depression, poor reflexes, slurred speech, coma.
  • 56. Fentanyl is used for pain relief, however it is abused for the feeling of euphoria that it creates. It can cause drowsiness/nausea, constipation, confusion, sedation, respiratory depression and arrest, tolerance, addiction, unconsciousness, coma, death.
  • 57.
  • 58.  Psychological dependence leading to profound psychological addiction, produced by high doses of cocaine, which can cause euphoric excitement.  Tolerance occurs, but physical dependence has not been confirmed; no stereotypical withdrawal syndrome occurs when the drug is discontinued. However, the tendency to continue taking the drug is strong.
  • 59. short acting drug – repeated use leading to:  Toxic effects, such as tachycardia, hypertension, mydriasis, muscle twitching, sleeplessness, and extreme nervousness.  Hallucinations, paranoid delusions, and aggressive behavior can develop. Pupils are maximally dilated  Sympathomimetic effect increases heart and respiration rates and BP.  Overdose may produce tremors, convulsions, and delirium. Death may occur due to arrhythmias and cardiovascular failure.
  • 60.
  • 62. Psychological dependence produced by amphetamine causes elevated mood; increased wakefulness, alertness, concentration and physical performance and a feeling of well-being.
  • 63.
  • 64.
  • 65. Known on the streets as chalk, crank, crystal, fire, glass, go fast, ice, meth, speed, it can cause aggression, violence, psychotic behavior/memory loss, cardiac and neurological damage, impaired memory and learning, tolerance, addiction. Crystal Meth is the latest entrant in this field.
  • 66.
  • 67. Known on the streets as Adam, Clarity, Ecstasy, Eve, Lover's speed, Peace, STP, X, XTC, it can cause mild hallucinogenic effects, increased tactile sensitivity, empathic feelings/impaired memory and learning, hyperthermia, cardiac toxicity, renal failure, liver toxicity, etc, etc.
  • 68.
  • 69. A new and very dangerous drug. This, too has found its way into India and instances of abuses are beninning to be seen The chemical n-methyl-1-phenyl-propan-2- amine is called methamphetamine, methylamphetamine, or desoxyephedrine. The shortened name is simply 'meth'. When it is in its crystalline form, the drug is called crystal meth, ice, Tina, or glass.
  • 70. What Are the Effects of Methamphetamine Use? This is a list of effects associated with pure methamphetamine use. Because of how it's made, crystal meth is never pure, so the dangers associated with taking the street drug extend beyond these effects. Common Immediate Effects  Euphoria  Increased energy and alertness  Diarrhea and nausea  Excessive sweating  Loss of appetite, insomnia, tremors, jaw-clenching  Agitation, irritability, talkativeness, panic, compulsive fascination with repetitive tasks, violence, confusion  Increased libido  Increased blood pressure, body temperature, heart rate, blood sugar levels, bronchodilation  Constriction of the walls of the arterties  In pregnant and nursing women, methampetamine crosses the placenta and is secreted in breast milk
  • 71. Effects Associated with Chronic Use  Tolerance (needing more of the drug to get the same effect)  Drug craving  Temporary weight loss  Withdrawal symptoms including depression and anhedonia  "Meth Mouth" where teeth rapidly decay and fall out  Drug-related psychosis (may last for months or years after drug use is discontinued)
  • 72.
  • 73. Yaba is a combination of methamphetamine (a powerful and addictive stimulant) and caffeine. Yaba, which means crazy medicine in Thai, is produced in Southeast and East Asia. The drug is popular in Asian communities in the United States and increasingly is available at raves and techno parties. It has made its entry into India through Bangladesh and Burma
  • 74.
  • 75.  Rapid heart rate, increased blood pressure, and damage to the small blood vessels in the brain that can lead to stroke. Chronic use of the drug can result in inflammation of the heart lining. Overdoses can cause hyperthermia (elevated body temperature), convulsions, and death. Individuals who use Yaba also may have episodes of violent behavior, paranoia, anxiety, confusion and insomnia.  Although most users administer Yaba orally, those who inject the drug expose themselves to additional risks, including contracting HIV (human immunodeficiency virus), hepatitis B and C, and other blood-borne viruses.
  • 77.  Smoked cannabis produces a dreamy state of consciousness in which ideas seem disconnected, unanticipated, and free-flowing. Time, color, and spatial perceptions may be altered.  In general, a feeling of well-being and relaxation (a "high") results.  Tachycardia, conjunctival injection, and dry mouth occur regularly.  Panic reactions have occurred, particularly in naive users, but have become unusual as the culture has become more familiar with the drug.
  • 78.  Communicative and motor abilities are decreased, depth perception and tracking are impaired, and the sense of timing is altered--all hazardous in certain situations (eg, driving, operating heavy equipment).  Schizophrenic symptoms may be exacerbated by marijuana, even in patients being treated with antipsychotic drugs (eg, chlorpromazine).  Appetite often increases.  Cannabis induced psychosis is common and cannabis induced lunacy can follow in the case of daily users.
  • 79. The “high” felt by a marijuana smoker is a very unique conglomeration of feelings, and there are only two known sources for the substances which activate the neuroreceptor for THC. The first source is our own brains, which produce a neurochemical very similar to THC called anandamide. The second source for this substance is the cannabis plant from which comes marijuana.
  • 80.  Unfortunately, there are negative side effects that occur from using marijuana. Some of these include frequent respiratory infections, impaired memory, increased heart rate, impaired learning, panic attacks and physical dependence on the substance. Additionally, if used during the first month of breast feeding, infants can suffer from impaired motor development. Marijuana may produce blissful effects in the minds of those who use it, but its side effects are far from blissful.
  • 81. Research has shown that THC changes the way in which sensory information is transmitted to the brain and the way that the hippocampus acts upon the information. The hippocampus is a component of the limbic system that is critical for learning, memory and the integration of emotions, motivations and sensory experiences. THC has been shown to suppress the neurons involved in information processing by the hippocampus, and it has also been shown that learned behaviors (which depend on the hippocampus to “stick” in the brain) also deteriorate.
  • 82.  A person who smokes marijuana on a regular basis may suffer from many of the same respiratory problems that tobacco smokers have. These people may cough daily and have excess phlegm, may have symptoms of chronic bronchitis and much more frequent chest colds.  Continual smoking of marijuana can lead to abnormal functioning of the lungs due to tissue damage caused by marijuana smoke. Additionally, the amount of tar inhaled by marijuana smokers is three to five times more than tobacco smokers, which can lead to further lung damage.
  • 83. Smoking marijuana while taking other drugs (both legal and illegal) can lead to a sharp increase in heart rate and blood pressure, which can stress the cardiovascular system and risks overload and potential heart failure.
  • 84. The Effects on Men In addition to providing pleasurable effects, marijuana can also affect parts of the brain responsible for sex and growth hormones. In men, marijuana can decrease testosterone, cause enlarged breasts and lead to a decrease in sperm count and infertility. The Effects on Women As in males, marijuana also effects women’s hormones, which can cause problems such as irregular menstrual cycles, depression, an increased testosterone level and the possibility for having children with moderate to severe physical and mental deficiencies ranging from learning disabilities to babies born with weak central nervous systems.
  • 85.  I.V. Fluids for supportive treatment  Treatment of any medical complications.  Treatment for co-morbidity, such as Psychosis, Anxiety, Mood disorder, etc  Counselling and psycho-education
  • 86.
  • 87.
  • 88. TOBACCO Nicotine is the substance in cigarettes along with other harmful chemicals (approximately 4400)that smokers become dependent on. Thus, nicotine dependence is essentially dependence on tobacco products – cigarettes, bidis, gutka, cigars, etc. About 70% of smokers have acknowledged that they desire to quit smoking but are unable to do so. Of people who quit, 90% do so on their own, but only about 3 to 4% successfully quit in any given year.
  • 89.  Nicotine is highly addictive. Nicotine provides an almost immediate “kick”  Addiction to nicotine results in withdrawal symptoms when a person tries to stop smoking - increased anger, hostility, and aggression, and loss of social cooperation. Persons suffering from withdrawal also take longer to regain emotional equilibrium following stress
  • 90.  Inhalation of 4000+ noxious chemicals.  43 of these are proven to be carcinogens.  Nicotine, Pyridine, Methyl Alcohol, Ammonia, Formaldehyde, Carbon Monoxide, Benzopyrene, Phenols, Acetone, Arsenic, Formic Acid, Oxalic Acid, Citric Acid, Acetic Acid, Hydrogen Cyanide are some of the toxins that are available in tobacco.  One cigarette contains approximately 100 Mcg of Nicotine. 500 Mcg directly injected would cause instant death.
  • 91.  Nicotine is physically addictive and a harmful intoxicant.  Inhaled nicotine takes just 7 seconds to affect the brain and the C.N.S.  Tar – directly linked to cancer  Carbon Monoxide has been used to commit suicide in enclosed place.  Hydrogen Cyanide was used to gas criminals to death in U.S.A. once upon a time. ...And yet we happily consume these chemicals thinking that the cigarette is relaxing for us, is good for us, makes us think better, etc.
  • 92.  Lung cancer  Coronary heart disease  Chronic lung diseases – bronchitis/emphysema  Gastric and duodenal ulcers  Cirrhosis of the liver  Various cancers – pancreas, stomach, kidneys, prostrate, bladder, liver, gall bladder  Cancers of the oral cavity – lips, mouth, tongue, throat  And many, many more.
  • 94.  Pharmacological treatment combined with behavioral treatment, including psychological support and skills training to overcome high-risk situations, results in some of the highest long-term abstinence rates  Nicotine chewing gum  Transdermal patch  Bupropion  Varnecline Tartrate (Champix)  Anti-depressants  Mood stabilizers
  • 95. Among teenagers, inhalants are used more frequently than cocaine or LSD but less frequently than marijuana or alcohol. Inhalant use is particularly a problem among children aged 12 and younger. Inhalants are found in many common household products.
  • 96. ADHESIVES •Airplane Glue •Rubber Cement •Polyvinyl Chloride Cement AEROSOLS •Spray Paint •Hair Spray CLEANING AGENTS •Dry Cleaning Fluid •Stain Remover •Degreaser SOLVENTS AND GASES •Typing Correction Fluid Thinner •Nail Polish Remover •Paint Thinner •Acetone •Cigarette Lighter Fluid •Petrol Fumes •Fuels
  • 97. All inhalants cause stimulation, loss of inhibition, headache, nausea or vomiting, slurred speech, loss of motor coordination, wheezing, unconsciousness, cramps, weight loss, muscle weakness, depression, memory impairment, damage to cardiovascular and nervous systems. Inhalants can lead to sudden death due to arrhythmia and asphyxia.
  • 98. KETAMINE induces a lack of awareness to pain and to one's general surroundings, leading to a scattered feeling or to a feeling of detachment. Ketamine is usually injected intravenously and may be snorted as well. Also known as Vitamin K, Special K, KO, Horse (because it has veterinary use). It is also a common “date rape” drug.
  • 99.
  • 100. GAMMA HYDROXIBUTYRATE (GHB) is taken by mouth. It is similar to Ketamine in its effects. GHB produces feelings of relaxation and tranquillity. It may also cause fatigue and feelings of being uninhibited. Also known as “Easy Lay”, “Liquid Ecstasy”. This is another “date rape” drug”
  • 101. MAY GOD HELP ADDICTS WHERE EVER THEY BE. FOR IF THEY DO NOT GET HELP, THE END IS INEVITABLE - - INSANITY AND / OR DEATH