Pharmacogenomics
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A view on pharmacogenomics and it's industrialization.
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Pharmacogenomics
- 1. UNIVERSITY HOLY SPIRIT KASLIK FACULTY OF SCIENCES Departement « Chemistry and live sciences » Industrialscale, genomics-based drug design and discovery By Imad Nmeir Supervisor: Dr. Walid Harb 1
- 2. Table of content Introduction • Quote • Reasons of these increases Genomics and gene sequencing • Genomics overview • Databases overview Pharmacogenomics • Basis of pharmacogenomics Methodology advancement • Microarrays • Proteomics • Small molecules • In silico Virtual screening The future of drug design 2
- 4. It is estimated that the Number of Therapeutic Molecular target will increase From approximately 1000 used Currently by pharmaceutical Industries to perhaps as many As 10 000 4
- 5. Reason of these increase Understanding how such discovery Tons of research affects drug and funding discovery • Drug design and discovery no longer in academic Fast pace realm discovery • Increase of private • Complete and public funding human • Industrialization of genome drug • 100+bacteria l genome • 4000 gene each • 3 000 000 SNPs 5
- 7. Genomics overview The study of gene sequencing More than 35000 genes discovered in the human genome Inferior to the actual number of proteins discovered Importance of alternative splicing 7
- 8. Databases and their importance Genes stored in databases Databases of simple gene sequences are obsolete Additional information are added to each database for greater value 8
- 10. Basis of pharmacogenomics SNP Individual variation Changes in drug response Important tool for personal medicine 10
- 12. Microarrays Ability to transform mRNA into cDNA technology Transforming the mRNA into electronic output mRNA sequencing Ability to compare large amount of sequences to each other Revolutionize genetics 12
- 13. Proteomics 2D, 3D NMR Protein size and electric nature Amino acid sequences Mass spectrometry X-ray crystallography Protein 3-dimensional shape 13
- 14. Small molecule drugs Basis of modern drug design Difficult to search for 14
- 15. In Silico Virtual screening Virtually screen for molecules to be used as drugs uses molecule shape and properties Uses special algorithm Uses already existing compounds Reshapes these molecules virtualy Combines molecules without synthesis them Relatively new technique Room for improvement 15
- 16. The future of Drug design 16
- 17. Industrial personalized medicine de novo screening The creation of entirely new compound from nonexisting ones • Uses special algorithm to create these compounds • Specific compounds for specific site 17
- 18. Thank you 18