14. H. Pylori
• Turkish study
• Of 138 B12 deficient patients, 77 had HP
• In all 31 who had HP eradicated B12 returned to normal
w/o B12
• FUT2 secretor gene
19. Autoimmune
• HLA A2,A3,A7 and Blood group A
• Antiparietal cell Abs in 90% of PA
• H-K ATPase
• Chief Cells
• 5% of population with Abs
• 50% with Abs have PA
• Associated with other autoimmune disease:
• Thyroid, DM1,Addisons, UC
22. Juvenile PA
• Older children
• + anti IF Abs
• - anti parietal Abs
• 50% with other autoimmune disease
• mucocutaneous candidiasis
• 45 cases documented in literature by 1999Rosenblatt DS, Whitehead VM. Cobalamin and folate deficiency: acquired and hereditary disorders in children.
Semin Hematol. 1999 Jan;36(1):19-34.
23. Clinical Features
• Weight loss
• Anemia: well tolerated
• Tongue
• Neurological
• parasthesias, numbness, tingling, ataxia
• various hypotheses
26. Pica
• Unclear etiology but associated w/ IDA
• Chicken or the Egg?
• Odd cravings for non nutritional items
• “Pagophagia”- Rx Glossitis?
• Border of Turkey and Iran 1960s
37. Summary
• Vit B 12 Deficiency
• Iron Deficiency
• Hemolytic Anemia
• Pica
• IF Ab
38. References• Allen RH, Stabler SP, Savage DG, Lindenbaum J. Metabolic abnormalitiesin
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• Tefferi A, Pruthi RK.The biochemical basis of cobalamin deficiency.Mayo Clin Proc
1994; 69:181.
• Anthony, CA. Megaloblastic anemias. In: Hematology: Basic Principlesand Practice,
2nd ed, Hoffman, R, Benz, EJ, Shattil, SJ, et al (Eds), Churchill Livingston, NewYork
1995. p.552.
• Carmel R. Prevalence of undiagnosed pernicious anemia in the elderly.Arch
Intern Med 1996; 156:1097.
• Toh BH, van Driel IR, Gleeson PA. Pernicious anemia. N Engl J Med1997;
337:1441.
• Carmel R. How I treat cobalamin (vitamin B12) deficiency. Blood 2008; 112:2214.
• Guéant JL, Safi A,Aimone-Gastin I, et al.Autoantibodies in