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Ventricular Assist Devices
Dr. Kewal Krishan
MBBS MS MCh DNB MNAMS FIACS (CTVS)
Advanced Fellow, Mayo Clinic & Mount Sinai, USA
Program Head, Heart Transplant & Ventricular Assist Devices
Senior Consultant Cardiac Surgeon
Max Superspeciality Hospital, Saket, NewDelhi
1
Advanced Heart Failure -
Definition
 Patients have significant cardiac dysfunction and
marked symptoms:
 dyspnea, fatigue
 end-organ hypoperfusion at rest
 or with minimal exertion despite maximal medical
therapy
 AHA Stage D
 Refractory symptoms requiring specialized
interventions to manage symptoms or prolong life
Goodlin et al, Journal of Cardiac Failure Vol. 10 No. 3 2004
Hunt SA et al JACC 2001;38:2101–13.
INTERMACS Profiles 1-3
Interagency Registry for Mechanical Circulatory Support
‘Frequent Flyer’
Stevenson, JHLTX; 09:535
INTERMACS Profiles 4-7
Stevenson, JHLTX; 09:535
‘Housebound’
‘Class IIIb’
DegreeofCirculatorySupport
IABP
PARTIAL SUPPORT
CI* ↑15% CI ↑30-60%
ECMO
+
FULL SUPPORT
CI ↑100%
Levitronix CentriMag
Abiomed BVS 5000
Abiomed AB 5000
Abiomed Impella 5.0 LP
Abiomed Impella 5.0 LD
TandemHeart pVAD
Abiomed Impella 2.5 LP
Short-term MCS Devices
*CI – cardiac index
VAD Components
Inflow cannula
Outflow Graft
Percutaneous drive line
Pump
HEART WARE
• Weigh 145 gms
• Pumps 4-5 liter/min
• No pocket required
• Under clinical trial
Peripherals
Circulite
HeartMate II® Left
Ventricular Assist
System
11
12
CASE 1
 Mr. SDC a 38 yr old man
 Kn case of Dilated CMP with AICD x 2yrs
 Admitted to another hospital, He was put on ventilator due to
pul.edema and was in multiorgan failure.
 He was told he would die in next few hrs.
 I received call if emegernt extracorporeal LVAD can be considered
 Transferred the patient to our hospital
 IV infusions( inotropes/Swan/ IABP was inserted to optimise him as he
had fever(39.5)
13
CASE 1
 Lab at admission were
 TLC 24000, Cr.7.8 Urea 272, SGOT/PT 8700/5660
 Neurological status was unknown.
 CRRT started for high Cr. – Remained for 4 days and Cr. Came
down to 2.2
 After 2 days he woke up
 On esmolol infusion for VT
 Started recovering and 2 options were discussed with family
 Heart Transplant and LVAD
 Becoz of Puacity of organ donation LVAD looked more
appropriate
14
15
CASE 1
 Inotopes weaned to minimal/ Esmolol stopped/
 With the anticipation of putting LVAD IABP was removed to avoid
intravascular lines.
 3 hrs after removal of IABP – Crashed - Reintubated—IABP
reinserted
 LVAD was implanted after few days on Feb 16.
 IABP was removed - All inotropes weaned off – Moved to Room
 Had post op AF –settled with pharmacotherapy
 Discharged home after 3 wks of surgery.
16
17
18
19CT AORTOGRAM
20
CT AORTOGRAM
21
22
Case 2
 36 yrs old young man Kn cae of dilated cardiomayopathy since
Aug 2013.
 CRT was not offerred becoz of narrow QRS complex
 Had 2 episodes of acute heart failure with abnormal labs.
 Airlifted few days ago to another hospital for pulm.edema
 Labs showed raised LFT and RFT and low perfusion state.
23
Case 2
 Advised LVAD – shifted to our hospital
 IV inotropes /Swan /diretics – Medical optimization Cardiac
index at time of insertion was 0.75
 Got better – LVAD implanted on March 12, 2015
 Extubated next morning – Recovered uneventfully.
 Off inotropes/ Swan removed in 4 days
 Discharged home on POD 11
24
25
26
27
28
29
32
Per operative View
Intracorporeal Ventricular assist device ( Heart Ware)
Short-Term Extracorporeal Assist DeviceDevi
 Levitronix CentriMag
 Magnetically-levitated centrifugal pump
 Continuous-flow rotary pump
 Electrical actuation– magnetic coupling of
the motor and impellor
 Capable of 6 ~ 9 L/min at 5500 RPM
 Left, Right, or Biventricular support
 Operative placement requiring sternotomy
 Bridge to recovery
Courtesy of Levitronix, Inc.
Extra Corporeal Membrane
Oxygenation ( ECMO)
www.kewalkrishan.com
Thank you

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LVAD in India, LVAD Implantation in India, LVAD II Final Output 20/10/2015

  • 1. Ventricular Assist Devices Dr. Kewal Krishan MBBS MS MCh DNB MNAMS FIACS (CTVS) Advanced Fellow, Mayo Clinic & Mount Sinai, USA Program Head, Heart Transplant & Ventricular Assist Devices Senior Consultant Cardiac Surgeon Max Superspeciality Hospital, Saket, NewDelhi 1
  • 2. Advanced Heart Failure - Definition  Patients have significant cardiac dysfunction and marked symptoms:  dyspnea, fatigue  end-organ hypoperfusion at rest  or with minimal exertion despite maximal medical therapy  AHA Stage D  Refractory symptoms requiring specialized interventions to manage symptoms or prolong life Goodlin et al, Journal of Cardiac Failure Vol. 10 No. 3 2004 Hunt SA et al JACC 2001;38:2101–13.
  • 3. INTERMACS Profiles 1-3 Interagency Registry for Mechanical Circulatory Support ‘Frequent Flyer’ Stevenson, JHLTX; 09:535
  • 4. INTERMACS Profiles 4-7 Stevenson, JHLTX; 09:535 ‘Housebound’ ‘Class IIIb’
  • 5. DegreeofCirculatorySupport IABP PARTIAL SUPPORT CI* ↑15% CI ↑30-60% ECMO + FULL SUPPORT CI ↑100% Levitronix CentriMag Abiomed BVS 5000 Abiomed AB 5000 Abiomed Impella 5.0 LP Abiomed Impella 5.0 LD TandemHeart pVAD Abiomed Impella 2.5 LP Short-term MCS Devices *CI – cardiac index
  • 6. VAD Components Inflow cannula Outflow Graft Percutaneous drive line Pump
  • 7. HEART WARE • Weigh 145 gms • Pumps 4-5 liter/min • No pocket required • Under clinical trial
  • 11. 11
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  • 13. CASE 1  Mr. SDC a 38 yr old man  Kn case of Dilated CMP with AICD x 2yrs  Admitted to another hospital, He was put on ventilator due to pul.edema and was in multiorgan failure.  He was told he would die in next few hrs.  I received call if emegernt extracorporeal LVAD can be considered  Transferred the patient to our hospital  IV infusions( inotropes/Swan/ IABP was inserted to optimise him as he had fever(39.5) 13
  • 14. CASE 1  Lab at admission were  TLC 24000, Cr.7.8 Urea 272, SGOT/PT 8700/5660  Neurological status was unknown.  CRRT started for high Cr. – Remained for 4 days and Cr. Came down to 2.2  After 2 days he woke up  On esmolol infusion for VT  Started recovering and 2 options were discussed with family  Heart Transplant and LVAD  Becoz of Puacity of organ donation LVAD looked more appropriate 14
  • 15. 15
  • 16. CASE 1  Inotopes weaned to minimal/ Esmolol stopped/  With the anticipation of putting LVAD IABP was removed to avoid intravascular lines.  3 hrs after removal of IABP – Crashed - Reintubated—IABP reinserted  LVAD was implanted after few days on Feb 16.  IABP was removed - All inotropes weaned off – Moved to Room  Had post op AF –settled with pharmacotherapy  Discharged home after 3 wks of surgery. 16
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  • 23. Case 2  36 yrs old young man Kn cae of dilated cardiomayopathy since Aug 2013.  CRT was not offerred becoz of narrow QRS complex  Had 2 episodes of acute heart failure with abnormal labs.  Airlifted few days ago to another hospital for pulm.edema  Labs showed raised LFT and RFT and low perfusion state. 23
  • 24. Case 2  Advised LVAD – shifted to our hospital  IV inotropes /Swan /diretics – Medical optimization Cardiac index at time of insertion was 0.75  Got better – LVAD implanted on March 12, 2015  Extubated next morning – Recovered uneventfully.  Off inotropes/ Swan removed in 4 days  Discharged home on POD 11 24
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  • 32. 32
  • 33. Per operative View Intracorporeal Ventricular assist device ( Heart Ware)
  • 34.
  • 35.
  • 36.
  • 37.
  • 38.
  • 39.
  • 40. Short-Term Extracorporeal Assist DeviceDevi  Levitronix CentriMag  Magnetically-levitated centrifugal pump  Continuous-flow rotary pump  Electrical actuation– magnetic coupling of the motor and impellor  Capable of 6 ~ 9 L/min at 5500 RPM  Left, Right, or Biventricular support  Operative placement requiring sternotomy  Bridge to recovery Courtesy of Levitronix, Inc.

Editor's Notes

  1. In fact, all major organized religions support an individual’s decision to be an organ donor. I personally consider donation to be a profoundly spiritual act that honors the sanctity of life.