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Men’s Health   Prostate Cancer:   A Review and Therapy Updates Joe Crea. D.O. Medco Las Vegas 12/12/10
Disclosure Information ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Goals ,[object Object],[object Object],[object Object]
OBJECTIVES   (for pharmacists)  ,[object Object]
OBJECTIVES   (for pharmacy technicians)  ,[object Object]
Anatomy
Anatomy
Anatomy
Anatomy
Anatomy
Anatomy
Physiology ,[object Object],[object Object],[object Object],[object Object]
Overview of Prostate CA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Epidemiology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Diet ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Genetics ,[object Object],[object Object],[object Object]
Finger length linked to prostate cancer risk  Wed Dec 1, 3:27 AM   PARIS (AFP) - Men whose index fingers are longer than their ring, or fourth, fingers run a significantly lower risk of prostate cancer, according to a study published Wednesday in the British Journal of Cancer. The chances of developing the disease drop by a third, and even more in younger men, the study found. "Our results show that relative finger length could be used as a simple test for prostate cancer risk, particularly in men aged under 60," said Ros Eeles, a professor at the Institute of Cancer Research in Britain and co-author of the study. Finger pattern could help identify which men should undergo regular screening, especially in combination with genetic testing or other risk factors such as a family history of the disease, she said. From 1994 to 2009, Eeles and colleagues questioned more than 1,500 prostate cancer patients in Britain, along with 3,000 healthy control cases. For more than half the men, the index was shorter than the ring finger. Compared to this group, men whose index and ring fingers were the same length -- 19 percent of the cohort -- had a similar prostate cancer risk. But when the index finger was longer, the risk of developing the disease dropped by 33 percent. Men under 60 were 87 percent less likely to be in the cancer group. The relative length of the two fingers in question -- set before birth -- appears to be a marker of different levels of sex hormones to which a baby is exposed in the womb, with less testosterone correlating with a longer index finger. Earlier research has shown that testosterone promotes the growth of prostate cancer. Underlying the unexpected connection between digits and cancer are two genes, HOXA and HOXD, that control both finger length and the development of sex organs. Other studies have found a link between exposure to hormones before birth and the development of other diseases, including breast cancer and osteoarthritis. Copyright © 2010 Agence France Presse. Copyright © 2010 Yahoo! Canada Co. All Rights Reserved.
Screening ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Screening Controversy ,[object Object],[object Object],[object Object],[object Object]
 
Medicolegal  Pitfalls ,[object Object],[object Object]
Discussion
Pathophysiology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Anatomy
Work-up ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Differential Diagnoses ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Work-up ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Anatomy
Work-up ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Prostate-Specific Antigen (PSA) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Prostate-Specific Antigen (PSA) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Work-up ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Work-up ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Bone metastases on bone scan ,[object Object],[object Object],[object Object],[object Object]
Histologic Grading System ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
TNM Staging System ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Whitmore-Jewett   System ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Treatments ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Radiation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Biochemical Failure/Recurrence  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Biochemical Failure/Recurrence  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Androgen Deprivation Therapy (ADT)   ,[object Object],[object Object],[object Object],[object Object]
Hormone feedback loops
Hormone feedback loops
Hormone-refractory Prostate CA   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hormone-refractory Prostate CA   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Drugs
Gonadotropin-releasing  hormone (GnRH) analogs ,[object Object]
Leuprolide  (Lupron, Viadur, Eligard) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Goserelin  (Zoladex) ,[object Object],[object Object],[object Object],[object Object],[object Object]
GnRH antagonist ,[object Object],[object Object]
Abarelix  (Plenaxis) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Bisphosphonates ,[object Object],[object Object]
Zoledronic acid  (Zometa) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Antiandrogens These agents are used as combination agents to treat prostate cancer.
Bicalutamide  (Casodex) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Finasteride  (Proscar) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Flutamide  (Eulexin) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Nilutamide  (Nilandron) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Antifungal agents ,[object Object],[object Object]
Ketoconazole  (Nizoral) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Corticosteroids ,[object Object]
Hydrocortisone  (Hydrocortone, Cortef) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Prednisone  (Deltasone, Meticorten, Orasone) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Chemotherapy agents ,[object Object],[object Object],[object Object],[object Object]
Cabazitaxel  (Jevtana) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cabazitaxel  (Jevtana) ,[object Object],[object Object],[object Object]
Cabazitaxel  (Jevtana) ,[object Object],[object Object]
Cabazitaxel  (Jevtana) ,[object Object],[object Object]
Docetaxel  (Taxotere) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Estramustine  (Emcyt) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Mitoxantrone  (Novantrone) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Paclitaxel  (Taxol) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Immunological Agent Autologous cellular immunotherapy is designed to stimulate a patient’s own immune system to respond against the cancer.
Sipuleucel-T  (Provenge) ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
Sipuleucel-T  (Provenge) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Sipuleucel-T  (Provenge) ,[object Object],[object Object],[object Object],[object Object]
Goals ,[object Object],[object Object],[object Object]
OBJECTIVES   (for pharmacists)  ,[object Object],[object Object]
OBJECTIVES   (for pharmacy technicians)  ,[object Object]

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Medco CE - Prostate Cancer

  • 1. Men’s Health Prostate Cancer: A Review and Therapy Updates Joe Crea. D.O. Medco Las Vegas 12/12/10
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  • 17. Finger length linked to prostate cancer risk Wed Dec 1, 3:27 AM PARIS (AFP) - Men whose index fingers are longer than their ring, or fourth, fingers run a significantly lower risk of prostate cancer, according to a study published Wednesday in the British Journal of Cancer. The chances of developing the disease drop by a third, and even more in younger men, the study found. "Our results show that relative finger length could be used as a simple test for prostate cancer risk, particularly in men aged under 60," said Ros Eeles, a professor at the Institute of Cancer Research in Britain and co-author of the study. Finger pattern could help identify which men should undergo regular screening, especially in combination with genetic testing or other risk factors such as a family history of the disease, she said. From 1994 to 2009, Eeles and colleagues questioned more than 1,500 prostate cancer patients in Britain, along with 3,000 healthy control cases. For more than half the men, the index was shorter than the ring finger. Compared to this group, men whose index and ring fingers were the same length -- 19 percent of the cohort -- had a similar prostate cancer risk. But when the index finger was longer, the risk of developing the disease dropped by 33 percent. Men under 60 were 87 percent less likely to be in the cancer group. The relative length of the two fingers in question -- set before birth -- appears to be a marker of different levels of sex hormones to which a baby is exposed in the womb, with less testosterone correlating with a longer index finger. Earlier research has shown that testosterone promotes the growth of prostate cancer. Underlying the unexpected connection between digits and cancer are two genes, HOXA and HOXD, that control both finger length and the development of sex organs. Other studies have found a link between exposure to hormones before birth and the development of other diseases, including breast cancer and osteoarthritis. Copyright © 2010 Agence France Presse. Copyright © 2010 Yahoo! Canada Co. All Rights Reserved.
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  • 55. Antiandrogens These agents are used as combination agents to treat prostate cancer.
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  • 74. Immunological Agent Autologous cellular immunotherapy is designed to stimulate a patient’s own immune system to respond against the cancer.
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