Palestra 6

Partnering on Innovative Health
Research in Brazil

March 7, 2012

Presentation Outline

• Update on Partnership activities in Brazil

• GCE Initiative Overview and FAP Collaboration

• Next Steps

© 2011 Bill & Melinda Gates Foundation | 2
March 7, 2012 © 2011 Bill & Melinda Gates Foundation | 2

Brazil MOH-BMGF Strategic Alliance
Broad Health MoU: Brazilian MoH (SCTIE) and Gates Foundation
Broad Health MoU: Brazilian MoH (SCTIE) and Gates Foundation
October 2011
October 2011

Vaccine Development Discovery Research / Family Health Joint Global Health
and Manufacturing Grand Challenges Research Initiatives

Dengue:
- Field testing of vector
control strategy in
partnership with MOH
and Fiocruz researchers


Grand Challenges Brazil
The foundation is engaged in conversations with the MOH on a possible GC Brazil
focused on:

 Joint funding of projects in Brazil as part of international GC
initiatives
 Focus on global health and development priorities
 Proposed first cooperation around Family Health GC

 GC initiatives pursued and funded by Brazilian sources
 Focus on national health priorities

 Partnership between BMGF and FAPs to provide supplemental
funding to Brazilian GCE Phase I grantees formalized in
December 2011
 Co-funding with CNPq for Phase II grants still under discussion

Next steps:
 Continue dialogue with MOH on Grand Challenges framework and potential Family
Health GC partnership
 Secure partnership with CNPq for Phase II grants
 Continue to engage other research funders in Brazil around potential GC partnerships


In December 2011, the Gates Foundation and the FAPs formed a
partnership around Grand Challenges Explorations to invest in high-
risk health and development research.


Overview:
Grand Challenges Explorations
Anyone can apply
 From any country and any discipline and at any level of experience
 From academia, government, non-profits or industry
 Review is “blind” and champion-based

Applying is easy
 Two page application
 No preliminary data required

Awards are frequent and rapid
 Two opportunities to apply each year
 Awards made in 4-6 months
 Phase I funding of US$100,000 can lead to Phase II funding of up to US$1M


GCE Selection Process


FAP GCE Partnership
1. Grants selected through regular GCE process
− Brazilian submissions will be processed by the GCE program’s standard review
mechanism
− Selected proposals will be funded by BMGF at US$100,000
− Direct grant agreement between grantee and BMGF
− FAPs will collaborate with foundation to deepen reach of GCE call into Brazil

1. For participating states, FAP will supplement funding for all grantees
based in the state in which it covers
− FAPs will formalize their endorsement of BMGF selection process or conduct
expedited diligence to formalize project selection
− Respective FAP will provide additional funding equivalent to US$50,000 or $100,000
in Brazilian Reals
− FAPs establish separate grant agreement directly with grantee

1. Successful projects can apply for Phase II grants
− Coordination with CNPq and others during selection process (TBD)


Open GCE RFP: Round 9

 Protect Crop Plants From Biotic Stresses From Field to Market

 New Approaches for the Interrogation of Anti-malarial Compounds

 Aid is Working. Tell the World.

 Design New Approaches to Optimize Immunization Systems

 Explore New Solutions for Global Health Priority Areas

Round 9 runs from February 29 to May 15, 2012; all applications
are welcome in one of these issue areas


Round 9 GCE Topics
Protect Crop Plants from Biotic Stresses from Field to Market
Challenge: Soliciting transformative solutions to pest and pathogen pressures faced by
smallholder farmers in developing countries; encouraging researchers and entrepreneurs to
generate ideas that will revolutionize current approaches to crop protection by focusing on
plants, pests, pathogens, weeds and/or their interactions.

New Approaches for the Interrogation of Anti-Malarial Compounds
Challenge: Supporting unconventional and radically new approaches, methods, and assays to
analyze, characterize, and prioritize anti-malarial compounds and to glean more information
required for the development of next generation malaria drugs.

Aid Is Working. Tell the World.
Challenge: Soliciting new approaches to communications that motivate the public in wealthy
countries of the world to change their minds about aid, and take actions to demonstrate
their support.


Round 9 GCE Topics

Design New Approaches to Optimize Immunization Systems
Challenge: Supporting novel approaches to optimizing the performance of immunization
logistics and supply systems in low-resource settings which address one or more of these
gap areas: vaccine product characteristics, supply system design, environmental impact,
information systems, human resources and vaccination acceptance.

Explore New Solutions for Global Health Priority Areas
Challenge: Soliciting new solutions for global health priority areas: malaria, HIV, tuberculosis,
pneumonia, enteric disease and diarrhea, polio, maternal and neonatal health, and/or
family planning; revolutionary new technologies or improvements upon current
technologies; low-cost solutions; and projects with clear and testable scientific plans.


“Open Topic”
February 2012 - Round 9 Topics: March 2010 - Round 5 Topics:
• New Approaches for the Interrogation of Anti-malarial Compounds • Create Low-Cost Cell Phone-Based Applications for Priority Global
• Aid is Working. Tell the World Health Conditions
• Protect Crop Plants from Biotic Stresses From Field to Market • Create New Technologies to Improve the Health of Mothers and
• Design New Approaches to Optimize Immunization Systems Newborns
• Explore New Solutions in Global Health Priority Areas • Create New Ways to Protect Against Infectious Disease
• Create New Technologies for Contraception
August 2011 - Round 8 Topics:
• Protect Crop Plants from Biotic Stresses From Field to Market September 2009 - Round 4 Topics:
• Design New Approaches to Optimize Immunization Systems • Create New Technologies for Contraception
• Explore New Solutions in Global Health Priority Areas • Create New Ways to Induce and Measure Mucosal Immunity
• Explore Nutrition for Healthy Growth of Infants and Children • Create Low-Cost Diagnostics for Priority Global Health Conditions
• Apply Synthetic Biology to Global Health Challenges • Create New Ways to Protect Against Infectious Disease

March 2011 - Round 7 Topics: March 2009 - Round 3 Topics:
• The Poliovirus Endgame: Create Ways to Accelerate, Sustain and • Create Low-Cost Diagnostics for Priority Global Health Conditions
Monitor Eradication • Create New Ways to Induce Mucosal Immunity
• Create the Next Generation of Sanitation Technologies • Create New Vaccines for Diarrhea, HIV, Malaria, Pneumonia, and TB
• Create Low-Cost Cell Phone-Based Solutions for Improved Uptake and • Create New Tools to Accelerate the Eradication of Malaria
Coverage of Childhood Vaccinations
• Design New Approaches to Cure HIV Infection September 2008 - Round 2 Topics:
• Explore Nutrition for Healthy Growth of Infants and Children • Explore the Basis For Latency in Tuberculosis
• Apply Synthetic Biology to Global Health Challenges • Create New Ways to Protect Against Infectious Disease
• Create New Vaccines for Diarrhea, HIV, Malaria, Pneumonia, and TB
August 2010 - Round 6 Topics: • Create New Tools to Accelerate the Eradication of Malaria
• Create New Ways to Protect Against Infectious Disease • Create Drugs and Delivery Systems to Limit Drug Resistance
• Create New Technologies for Contraception • Create New Ways to Prevent or Cure HIV Infection
• Design New Approaches to Cure HIV Infection
• Create the Next Generation of Sanitation Technologies March 2008 - Round 1 Topics:
• Create Low-Cost Cell Phone-Based Applications for Priority Global • Create Drugs and Delivery Systems to Limit Drug Resistance
Health Conditions • Create New Ways to Prevent or Cure HIV Infection
• The Poliovirus Endgame: Create Ways to Accelerate, Sustain and • Explore the Basis For Latency in Tuberculosis
Monitor Eradication Create New Ways to Protect Against Infectious Disease
• Create New Technologies to Improve the Health of Mothers and
Newborns


Brazilian Submissions by City:
Rounds 1 – 8


GCE Phase I Grants to Brazil:
Rounds 1 – 6
Increasing Vaccination Efficacy with ACE Inhibitors
Julio Scharfstein at Universidade Federal do Rio de Janeiro

Idea: Interfere with innate homeostasis at the onset of vaccination by re-purposing ACE
inhibitor (Captopril) to boost efficacy of vaccination

Large-scale MHC: Epitope Analysis for Vaccine Development
Gustavo Fioravanti Vieira at Universidade Federal do Rio Grande do Sul
Idea: Use bioinformatic approach to identify MHC and immune response features among viral
peptides through the comparison of immunogenic epitopes already in the literature

"Lego" like Sanitation System: Pit Latrines Made of Biocompost
Antonio Avila at Universidade Federal de Minas Gerais
Idea: Develop a biodegradable “Eco-blocks” assemblage system for pit latrines to replace
concrete slabs or conventional brick/cement materials


Proposals by City – Rounds 1-8


Funded Projects by City – Rounds 1-8


Proposals by City – S. America Rounds 1-8


Funded Projects by City – S. America Rounds 1-8


Outreach to researchers makes a difference

www.grandchallenges.org/brp


Next Steps
 Comments on the “Implementation Plan”
 Outreach and Marketing – March, April (May 15 deadline)
• Email Outreach to networks – Point of contacts?
• Potential for Announcement of Partnership Mid-April
 Information Exchanged – Gates <-> FAPS
• What information is desired
• Past & Present Applicants
 Proposal Development
 Preparing for grantmaking
• Speed
• Flexibility in grant terms
 Managing Expectations – Long-term investment in success


Thank You


Proposals by City – Africa Rounds 1-8


Funded Projects by City – Africa Rounds 1-8


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