Partnering on Innovative HealthResearch in BrazilMarch 7, 2012
Presentation Outline• Update on Partnership activities in Brazil• GCE Initiative Overview and FAP Collaboration• Next Step...
Brazil MOH-BMGF Strategic Alliance                 Broad Health MoU: Brazilian MoH (SCTIE) and Gates Foundation           ...
Grand Challenges BrazilThe foundation is engaged in conversations with the MOH on a possible GC Brazilfocused on:         ...
In December 2011, the Gates Foundation and the FAPs formed a partnership around Grand Challenges Explorations to invest in...
Overview:Grand Challenges Explorations Anyone can apply    From any country and any discipline and at any level of experi...
GCE Selection Process                        © 2011 Bill & Melinda Gates Foundation   |   7                        © 2011 ...
FAP GCE Partnership1. Grants selected through regular GCE process      − Brazilian submissions will be processed by the GC...
Open GCE RFP: Round 9 Protect Crop Plants From Biotic Stresses From Field to Market New Approaches for the Interrogation...
Round 9 GCE TopicsProtect Crop Plants from Biotic Stresses from Field to MarketChallenge: Soliciting transformative soluti...
Round 9 GCE TopicsDesign New Approaches to Optimize Immunization SystemsChallenge: Supporting novel approaches to optimizi...
“Open Topic”February 2012 - Round 9 Topics:                                           March 2010 - Round 5 Topics:    • Ne...
Brazilian Submissions by City:Rounds 1 – 8                                 © 2011 Bill & Melinda Gates Foundation   |   13...
GCE Phase I Grants to Brazil:Rounds 1 – 6Increasing Vaccination Efficacy with ACE InhibitorsJulio Scharfstein at Universid...
Proposals by City – Rounds 1-8                                 © 2011 Bill & Melinda Gates Foundation   |   15  March 7, 2...
Funded Projects by City – Rounds 1-8                                       © 2011 Bill & Melinda Gates Foundation   |   16...
Proposals by City – S. America Rounds 1-8                                            © 2011 Bill & Melinda Gates Foundatio...
Funded Projects by City – S. America Rounds 1-8                                                  © 2011 Bill & Melinda Gat...
Outreach to researchers makes a difference   www.grandchallenges.org/brp                                      © 2011 Bill ...
Next Steps Comments on the “Implementation Plan” Outreach and Marketing – March, April (May 15 deadline) • Email Outreac...
Thank You            © 2011 Bill & Melinda Gates Foundation   |   21            © 2011 Bill & Melinda Gates Foundation   |...
Proposals by City – Africa Rounds 1-8                                        © 2011 Bill & Melinda Gates Foundation   |   ...
Funded Projects by City – Africa Rounds 1-8                                              © 2011 Bill & Melinda Gates Found...
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Fundação Bill e Melina Gates

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  • ©2010 Bill & Melinda Gates Foundation
  • ©2010 Bill & Melinda Gates Foundation
  • © 2009 Bill & Melinda Gates Foundation
  • © 2010 Bill & Melinda Gates Foundation
  • © 2010 Bill & Melinda Gates Foundation
  • © 2010 Bill & Melinda Gates Foundation
  • © 2010 Bill & Melinda Gates Foundation
  • © 2010 Bill & Melinda Gates Foundation
  • © 2010 Bill & Melinda Gates Foundation
  • Palestra 6

    1. 1. Partnering on Innovative HealthResearch in BrazilMarch 7, 2012
    2. 2. Presentation Outline• Update on Partnership activities in Brazil• GCE Initiative Overview and FAP Collaboration• Next Steps © 2011 Bill & Melinda Gates Foundation | 2March 7, 2012 © 2011 Bill & Melinda Gates Foundation | 2
    3. 3. Brazil MOH-BMGF Strategic Alliance Broad Health MoU: Brazilian MoH (SCTIE) and Gates Foundation Broad Health MoU: Brazilian MoH (SCTIE) and Gates Foundation October 2011 October 2011Vaccine Development Discovery Research / Family Health Joint Global Health and Manufacturing Grand Challenges Research Initiatives Dengue: - Field testing of vector control strategy in partnership with MOH and Fiocruz researchers © 2011 Bill & Melinda Gates Foundation | 3 March 7, 2012 © 2011 Bill & Melinda Gates Foundation | 3
    4. 4. Grand Challenges BrazilThe foundation is engaged in conversations with the MOH on a possible GC Brazilfocused on:  Joint funding of projects in Brazil as part of international GC initiatives  Focus on global health and development priorities  Proposed first cooperation around Family Health GC  GC initiatives pursued and funded by Brazilian sources  Focus on national health priorities  Partnership between BMGF and FAPs to provide supplemental funding to Brazilian GCE Phase I grantees formalized in December 2011  Co-funding with CNPq for Phase II grants still under discussion Next steps:  Continue dialogue with MOH on Grand Challenges framework and potential Family Health GC partnership  Secure partnership with CNPq for Phase II grants  Continue to engage other research funders in Brazil around potential GC partnerships © 2011 Bill & Melinda Gates Foundation | 4March 7, 2012 © 2011 Bill & Melinda Gates Foundation | 4
    5. 5. In December 2011, the Gates Foundation and the FAPs formed a partnership around Grand Challenges Explorations to invest in high- risk health and development research. © 2011 Bill & Melinda Gates Foundation | 5March 7, 2012 © 2011 Bill & Melinda Gates Foundation | 5
    6. 6. Overview:Grand Challenges Explorations Anyone can apply  From any country and any discipline and at any level of experience  From academia, government, non-profits or industry  Review is “blind” and champion-based Applying is easy  Two page application  No preliminary data required Awards are frequent and rapid  Two opportunities to apply each year  Awards made in 4-6 months  Phase I funding of US$100,000 can lead to Phase II funding of up to US$1M © 2011 Bill & Melinda Gates Foundation | 6 March 7, 2012 © 2011 Bill & Melinda Gates Foundation | 6
    7. 7. GCE Selection Process © 2011 Bill & Melinda Gates Foundation | 7 © 2011 Bill & Melinda Gates Foundation | 7
    8. 8. FAP GCE Partnership1. Grants selected through regular GCE process − Brazilian submissions will be processed by the GCE program’s standard review mechanism − Selected proposals will be funded by BMGF at US$100,000 − Direct grant agreement between grantee and BMGF − FAPs will collaborate with foundation to deepen reach of GCE call into Brazil1. For participating states, FAP will supplement funding for all grantees based in the state in which it covers − FAPs will formalize their endorsement of BMGF selection process or conduct expedited diligence to formalize project selection − Respective FAP will provide additional funding equivalent to US$50,000 or $100,000 in Brazilian Reals − FAPs establish separate grant agreement directly with grantee1. Successful projects can apply for Phase II grants − Coordination with CNPq and others during selection process (TBD) © 2011 Bill & Melinda Gates Foundation | 8 March 7, 2012 © 2011 Bill & Melinda Gates Foundation | 8
    9. 9. Open GCE RFP: Round 9 Protect Crop Plants From Biotic Stresses From Field to Market New Approaches for the Interrogation of Anti-malarial Compounds Aid is Working. Tell the World. Design New Approaches to Optimize Immunization Systems Explore New Solutions for Global Health Priority Areas Round 9 runs from February 29 to May 15, 2012; all applications are welcome in one of these issue areas © 2011 Bill & Melinda Gates Foundation | 9March 7, 2012 © 2011 Bill & Melinda Gates Foundation | 9
    10. 10. Round 9 GCE TopicsProtect Crop Plants from Biotic Stresses from Field to MarketChallenge: Soliciting transformative solutions to pest and pathogen pressures faced by smallholder farmers in developing countries; encouraging researchers and entrepreneurs to generate ideas that will revolutionize current approaches to crop protection by focusing on plants, pests, pathogens, weeds and/or their interactions.New Approaches for the Interrogation of Anti-Malarial CompoundsChallenge: Supporting unconventional and radically new approaches, methods, and assays to analyze, characterize, and prioritize anti-malarial compounds and to glean more information required for the development of next generation malaria drugs.Aid Is Working. Tell the World.Challenge: Soliciting new approaches to communications that motivate the public in wealthy countries of the world to change their minds about aid, and take actions to demonstrate their support. © 2011 Bill & Melinda Gates Foundation | 10 March 7, 2012 © 2011 Bill & Melinda Gates Foundation | 10
    11. 11. Round 9 GCE TopicsDesign New Approaches to Optimize Immunization SystemsChallenge: Supporting novel approaches to optimizing the performance of immunization logistics and supply systems in low-resource settings which address one or more of these gap areas: vaccine product characteristics, supply system design, environmental impact, information systems, human resources and vaccination acceptance.Explore New Solutions for Global Health Priority AreasChallenge: Soliciting new solutions for global health priority areas: malaria, HIV, tuberculosis, pneumonia, enteric disease and diarrhea, polio, maternal and neonatal health, and/or family planning; revolutionary new technologies or improvements upon current technologies; low-cost solutions; and projects with clear and testable scientific plans. © 2011 Bill & Melinda Gates Foundation | 11 March 7, 2012 © 2011 Bill & Melinda Gates Foundation | 11
    12. 12. “Open Topic”February 2012 - Round 9 Topics: March 2010 - Round 5 Topics: • New Approaches for the Interrogation of Anti-malarial Compounds • Create Low-Cost Cell Phone-Based Applications for Priority Global • Aid is Working. Tell the World Health Conditions • Protect Crop Plants from Biotic Stresses From Field to Market • Create New Technologies to Improve the Health of Mothers and • Design New Approaches to Optimize Immunization Systems Newborns • Explore New Solutions in Global Health Priority Areas • Create New Ways to Protect Against Infectious Disease • Create New Technologies for ContraceptionAugust 2011 - Round 8 Topics: • Protect Crop Plants from Biotic Stresses From Field to Market September 2009 - Round 4 Topics: • Design New Approaches to Optimize Immunization Systems • Create New Technologies for Contraception • Explore New Solutions in Global Health Priority Areas • Create New Ways to Induce and Measure Mucosal Immunity • Explore Nutrition for Healthy Growth of Infants and Children • Create Low-Cost Diagnostics for Priority Global Health Conditions • Apply Synthetic Biology to Global Health Challenges • Create New Ways to Protect Against Infectious DiseaseMarch 2011 - Round 7 Topics: March 2009 - Round 3 Topics: • The Poliovirus Endgame: Create Ways to Accelerate, Sustain and • Create Low-Cost Diagnostics for Priority Global Health Conditions Monitor Eradication • Create New Ways to Induce Mucosal Immunity • Create the Next Generation of Sanitation Technologies • Create New Vaccines for Diarrhea, HIV, Malaria, Pneumonia, and TB • Create Low-Cost Cell Phone-Based Solutions for Improved Uptake and • Create New Tools to Accelerate the Eradication of Malaria Coverage of Childhood Vaccinations • Design New Approaches to Cure HIV Infection September 2008 - Round 2 Topics: • Explore Nutrition for Healthy Growth of Infants and Children • Explore the Basis For Latency in Tuberculosis • Apply Synthetic Biology to Global Health Challenges • Create New Ways to Protect Against Infectious Disease • Create New Vaccines for Diarrhea, HIV, Malaria, Pneumonia, and TBAugust 2010 - Round 6 Topics: • Create New Tools to Accelerate the Eradication of Malaria • Create New Ways to Protect Against Infectious Disease • Create Drugs and Delivery Systems to Limit Drug Resistance • Create New Technologies for Contraception • Create New Ways to Prevent or Cure HIV Infection • Design New Approaches to Cure HIV Infection • Create the Next Generation of Sanitation Technologies March 2008 - Round 1 Topics: • Create Low-Cost Cell Phone-Based Applications for Priority Global • Create Drugs and Delivery Systems to Limit Drug Resistance Health Conditions • Create New Ways to Prevent or Cure HIV Infection • The Poliovirus Endgame: Create Ways to Accelerate, Sustain and • Explore the Basis For Latency in Tuberculosis Monitor Eradication Create New Ways to Protect Against Infectious Disease • Create New Technologies to Improve the Health of Mothers and Newborns © 2011 Bill & Melinda Gates Foundation | 12 © 2011 Bill & Melinda Gates Foundation | 12
    13. 13. Brazilian Submissions by City:Rounds 1 – 8 © 2011 Bill & Melinda Gates Foundation | 13 March 7, 2011 © 2011 Bill & Melinda Gates Foundation | 13
    14. 14. GCE Phase I Grants to Brazil:Rounds 1 – 6Increasing Vaccination Efficacy with ACE InhibitorsJulio Scharfstein at Universidade Federal do Rio de JaneiroIdea: Interfere with innate homeostasis at the onset of vaccination by re-purposing ACE inhibitor (Captopril) to boost efficacy of vaccinationLarge-scale MHC: Epitope Analysis for Vaccine DevelopmentGustavo Fioravanti Vieira at Universidade Federal do Rio Grande do SulIdea: Use bioinformatic approach to identify MHC and immune response features among viral peptides through the comparison of immunogenic epitopes already in the literature "Lego" like Sanitation System: Pit Latrines Made of Biocompost Antonio Avila at Universidade Federal de Minas Gerais Idea: Develop a biodegradable “Eco-blocks” assemblage system for pit latrines to replace concrete slabs or conventional brick/cement materials © 2011 Bill & Melinda Gates Foundation | 14 March 7, 2012 © 2011 Bill & Melinda Gates Foundation | 14
    15. 15. Proposals by City – Rounds 1-8 © 2011 Bill & Melinda Gates Foundation | 15 March 7, 2011 © 2011 Bill & Melinda Gates Foundation | 15
    16. 16. Funded Projects by City – Rounds 1-8 © 2011 Bill & Melinda Gates Foundation | 16 March 7, 2011 © 2011 Bill & Melinda Gates Foundation | 16
    17. 17. Proposals by City – S. America Rounds 1-8 © 2011 Bill & Melinda Gates Foundation | 17 March 7, 2011 © 2011 Bill & Melinda Gates Foundation | 17
    18. 18. Funded Projects by City – S. America Rounds 1-8 © 2011 Bill & Melinda Gates Foundation | 18 March 7, 2011 © 2011 Bill & Melinda Gates Foundation | 18
    19. 19. Outreach to researchers makes a difference www.grandchallenges.org/brp © 2011 Bill & Melinda Gates Foundation | 19 © 2011 Bill & Melinda Gates Foundation | 19
    20. 20. Next Steps Comments on the “Implementation Plan” Outreach and Marketing – March, April (May 15 deadline) • Email Outreach to networks – Point of contacts? • Potential for Announcement of Partnership Mid-April Information Exchanged – Gates <-> FAPS • What information is desired • Past & Present Applicants Proposal Development Preparing for grantmaking • Speed • Flexibility in grant terms Managing Expectations – Long-term investment in success © 2011 Bill & Melinda Gates Foundation | 20 © 2011 Bill & Melinda Gates Foundation | 20
    21. 21. Thank You © 2011 Bill & Melinda Gates Foundation | 21 © 2011 Bill & Melinda Gates Foundation | 21
    22. 22. Proposals by City – Africa Rounds 1-8 © 2011 Bill & Melinda Gates Foundation | 22 March 7, 2011 © 2011 Bill & Melinda Gates Foundation | 22
    23. 23. Funded Projects by City – Africa Rounds 1-8 © 2011 Bill & Melinda Gates Foundation | 23 March 7, 2011 © 2011 Bill & Melinda Gates Foundation | 23

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