The BBI Solutions Disease State Plasma Newsflash gives details about our current inventory of bulk disease state plasma and clinical patient samples. This month’s edition includes a sneak peek at our upcoming new product, Synthetic Rubella IgM serum.

1. Inventory
Newsflash
March 2014
Disease State Plasma
Capabilities
Current Inventory
Clinical Samples
Capabilities
Current Inventory
Specialty blood products
Capabilities
Inventory correct at time of publication
Quality Partnership ResultsInnovation

2.  Save time and optimise your success
rate by selecting from our highly
characterised disease state plasma units
 Have confidence in supply sustainability
by choosing a partner with global
collections directly from hospitals and
blood banks
 No longer struggle to collect a
representative set of samples – we
have rare materials from early disease
diagnosis available
 Never question quality or traceability by
choosing products collected with ethics
approval and donor consent when
relevant, stored at a HTA licenced facility
Why choose BBI ?
Quick Links
What’s New?
Disease State Plasma
Our Capabilities >
Current Inventory >
Clinical Samples
Our Capabilities >
Current Inventory >
Speciality Blood
Our Capabilities >
How to order >

3. What’s New This Month?
Synthetic Rubella IgM Serum
A synthetic alternative designed to
mimic a high titre native Rubella IgM
serum.
 Supply sustainability
 Batch to batch consistency
 Proven performance
 Demonstrated linearity
Autoimmune Disease State Plasma
 Anti-Nuclear Ab Negative
 A-RNP / A-SS-A
 A-dsDNA
Infectious Disease State Plasma
 HTLV-1 / HTLV-2
 Parvovirus B19
 Hepatitis E Virus
 Malaria
 Hep B Core Ab
Newly Sourced ProductsComing soon . . .
Request a sample today >

4. Infectious Disease Autoimmune Cardiac
 Chlamydia IgG / IgM  Anti-GBM  Cholesterol
 CMV IgG / IgM / Negative  Anti-RNP / Anti-SSA  HDL
 EBV IgG / IgM  ANCA (Anti-MPO / Anti-PR3)  Hypertension
 H. Pylori  Celiac Disease  LDL
 HAV IgG / IgM  Crohn’s Disease  Triglyceride
 HCV IgG  Gliadin Antibodies IgA / IgG
 HBsAg  HAMA Organ Failure / Impairment
 HBc IgM / Total Ab  Rheumatoid Factor  Renal Failure
 HBeAg / HBeAb  SLE  Kidney Transplant
 HIV 1  Tissue Transglutaminase Abs  Liver Transplant
 HIV 2  Anti-Nuclear Antibody Negative - NEW
 HIV O Diabetes
 HSV 2 IgG / IgM Autoimmune Thyroid Disease  Glucose
 HTLV-1 - NEW  Anti-Tg  HbA1c
 HTLV-2 - NEW  Anti-TPO  Diagnosis (Type I / II)
 HEV - NEW  Graves Disease
 Lyme IgG / IgM  Hashimoto’s Disease Pregnancy
 Malaria - NEW  Amniotic Fluid
 Parvovirus B19 Inflammation / Allergy  Pregnancy Serum
 Rubella IgG / Negative  CRP  Chronological Bulk Urine
 Rubella IgM – NEW  SAA
 Syphilis IgG / IgM  Specific IgE (Allergy) Other Biomaterials
 Toxoplasma IgG / IgM / Negative  CSF
Drugs of Abuse  Urine
Biochemistry  CDT  Saliva
 Vitamin D  Cord Serum
Our Capabilities | Disease State Plasma

5. Current Inventory | Disease State Plasma
Infectious Diseases
Disease
Type
Product Code
Quantitative
results & other
markers Tested
Volume available
in stock (ml)
Collection
Method
FDA Tested
Negative for
other virals
HAV SH265 HAV IgM >6,000 ml Apheresis Yes
HBV SH256
HBc IgM, HBc Total,
HBeAg, HBeAb
>24,000 ml Recovered Yes
HBc IgM SH258
HBc IgM, HBc Total,
HBeAg, HBeAb
~700ml Recovered Yes
HCV SH259
Viral load
Genotype
~2,400 ml Recovered Yes
HIV SH315
RNA+, Ab+, Viral
Load, Genotype
>15,000 ml Recovered Yes
Syphilis SH266
TPHA, VDRL, RPR,
IgM
>35,000 ml Recovered Yes
Toxoplasma SH275 Toxo IgM >1,000 ml Recovered Yes
CMV SH272 CMV IgM >3,000 ml Recovered Yes

6. Current Inventory | Disease State Plasma
Autoimmune / Non-infectious Diseases
Disease Type Product Code
Quantitative
results
Volume available
in stock (ml)
Collection
Method
FDA Tested
Negative for
other virals
ANA Neg SH139 Yes >3,000 ml Apheresis Yes
A-GBM SH336 Yes >13,000 ml Apheresis Yes
dsDNA SH237 Yes >13,000 ml Apheresis Yes
p-ANCA (MPO) SH152 Yes >12,000 ml Apheresis Yes
SAA SH127 Yes >12,000 ml Apheresis Yes
Anti-RNP / Anti-SS-A SH293 Yes >5,500ml Apheresis Yes
Celiac Disease SH235 Yes >1,000 ml Apheresis Yes
Thyroid Disease SH245 / SH244 Yes >100,000 ml Apheresis CE marked
Allergy / Raised IgE SH166 / SH234 Yes >5,000 ml Apheresis Yes
Pregnancy
(1st / 2nd / 3rd trimester)
SH285 / SH283 /
SH284
Yes >10,000 ml Apheresis Yes
Renal Failure SH507 Yes >3,000 ml Apheresis Yes
Contraceptive Pill SH312 No >1,500 ml Apheresis Yes

7. Our Capabilities | Clinical Samples
Infectious Disease Autoimmune Thyroid Diabetes
 Chlamydia pneumoniae IgA/IgG  ASO  Free T3 (Triiodothyronine)  HbA1c
 Chlamydia trachomatis IgA/IgG  Anti-Cardiolipin  Free T4 (Thyroxine)  Diagnosis (Type I / II)
 CMV IgG / IgM / Negative  Anti-CCP  Parathyroid Hormone (PTH)
 EBV  Anti-dsDNA  TSH Organ Failure/Impairment
 HCV IgG  Anti-GBM  Renal Failure
 HBsAg / Anti-HBs  Anti-Nuclear Antibodies - Pregnancy  Hepatic Impairment
 HBc IgM / Total Ab SS-A/Ro, SS-B/La, Sm, RNP  hCG
 HBeAg / HBeAb Jo-1, PM-SCL, KU, Centromere,  Pre-eclampsia Oncology
 HEV - NEW AMA-M2, RIB-P, RO52  Pregnancy serum  AFP
 HIV 1 / 2 / O  Anti-Tg  CA 125
 HTLV-1 / HTLV-2  Anti-TPO Cardiac  CA 15-3
 Malaria  ANCA (Anti-MPO / Anti-PR3)  Cholesterol  CA 19-9
 Measles IgG  Celiac Disease  CK-MB  CEA
 Mycoplasma pneumoniae  Crohn’s Disease  D Dimer  CYFRA
 Parvovirus B19  Gliadin Antibodies IgA / IgG  HDL  PSA
 Rubella IgM / IgG / Negative  HAMA  Hypertension
 Sepsis  Histone Antibodies  LDL Endocrine
 Syphilis IgG / IgM  Rheumatoid Factor  Myoglobin  Cortisol
 Toxo IgG / IgM / Negative  SLE  NT proBNP  FSH
 Yersinia IgG / IgM  Tissue Transglutaminase Abs  Triglyceride  LH
 Troponin I  Oestradiol
Biochemistry Neurological  Progesterone
 Vitamin D  Alzheimer’s Disease Drugs of Abuse  Prolactin
 Bilirubin (Total)  NSE  Urine  SHBG
 Calcium  CDT  Testosterone
 Potassium Allergy
 CRP  Raised Specific IgE

8. Current Inventory
Code no. Description Type Characteristics
NEW HEV Plasma Panel Characterised
 Quantitative viral load result
 Genotyping results
NEW HTLV I/II Panel Characterised
 Serology by ChLIA and ELISA
 Line Immunoassay to differentiate HTLV I and HTLV II
NEW Malaria Panel Characterised  Serology by ELISA and Immunofluorescence
SHK510-4G HIV Plasma Panel Genotyped
 Genotypes B, C, F and K
 Testing results for multiple markers
 Quantitative viral load result
SHK510-4HC HIV Plasma Panel Highly Characterised
 Testing results for multiple markers
 Quantitative viral load result
SHK259-4HC
HCV Plasma
Panel
Highly Characterised
 Quantitative viral load result
 Genotyping results
 Semi-quantitative methods for serology / NAT
SHK266-4HC
Syphilis Plasma
Panel
Highly characterised
 Testing results for multiple markers
 Syphilis IgM status
SHK505-0
SH505-1
SHK505-2
Toxoplasma
Plasma Panel
Characterised
 Quantitative IgG & semi-quantitative IgM results
 IgM avidity testing data
Panel specifications
 Citrated plasma
 Extensive donor demographics
 Tested for HIV1 & 2 Abs, HBsAg, HCV Ab, HIV-
1/HBV/HCV PCR and Syphilis
 Individual donors (no duplicates)
 Donor consent
Infectious Disease Panels

9. Current Inventory | Clinical Samples
Code No. Marker Category Panel Type Matrix IRB
SG186-1 HbA1c Diabetes High Titre W/Blood Y
SG336-2 Type I Diabetes Diabetes Diagnosis Serum Y
SG187-2 Diabetes Type II Diabetes Diagnosis Serum Y
SG316-2 FSH Endocrine Mixed Titre * Serum Y
SG608-2 Procalcitonin Endocrine Mixed Titre Serum Y
SG369-2 Progesterone Endocrine High Titre Serum Y
SG490-2 SHBG Endocrine Mixed Titre * Serum Y
SG360-2 AFP Oncology Mixed Titre * Serum Y
SG355-2 CA125 Oncology High Titre Serum Y
SG362-2 CA15-3 Oncology High Titre Serum Y
SG321-2 CEA Oncology High Titre Serum Y
SG358-2 CA19-9 Oncology High Titre Serum Y
SG317-2 PSA Oncology Mixed Titre Serum Y
Non-Infectious Disease Panels (1)
* Many of the Mixed Titre samples fall within the clinically significant range

10. Current Inventory | Clinical Samples
Code No. Marker Category Panel Type Matrix IRB
SG323-2 cTnI Cardiac Mixed Titre * Serum Y
SG324-4 D Dimer Cardiac Low Titre Citrate Pl. Y
SG587-2 Triglyceride Cardiac Mixed Titre * Serum Y
SG312-2 Free T3 Thyroid Mixed Titre * Serum Y
SG313-2 Free T4 Thyroid Mixed Titre * Serum Y
SG314-2 TSH Thyroid High Titre Serum Y
SG505-2 Hepatic Impairment Organ Failure / Impairment High Titre Serum Y
SG507-2 Renal Failure Organ Failure / Impairment High Titre Serum Y
SG383-2 Pregnancy Pregnancy 1
st
Trimester Serum Y
SG384-2 Pregnancy Pregnancy 3
rd
Trimester Serum Y
SG521-2 Crohn’s Autoimmune Diagnosis Serum Y
Non-Infectious Disease Panels (2)
* Many of the Mixed Titre samples fall within the clinically significant range

11. Current Inventory | Clinical Samples
Code No. Marker Category Panel Type Matrix IRB
SG508-2 Allergy (Specific IgE+) Allergy Mixed Titre Serum Y
d1 House Dust Mite, European (Dermatophagoides pteronyssinus)
d2 House Dust Mite, American (Dermatophagoides farinae)
e1 Cat dander (Felis domesticus)
e3 Horse dander (Equus caballus)
e5 Dog dander (Canis familiaris)
e82 Rabbit epithelium (Oryctolagus cuniculus)
f1 Egg White (Gallus spp.)
f13 Peanut (Arachis hypogaea)
f2 Cow's Milk (Bos spp.)
f84 Kiwi (Actinidia deliciosa)
g6 Timothy grass pollen (Phleum pratense)
i3 Common wasp, Yellow jacket wasp venom (Vespula spp.)
t2 Grey alder pollen (Alnus incana)
t3 Common silver birch pollen (Betula verrucosa)
t4 Hazel pollen (Corylus avellana)
Non-Infectious Disease Panels

12. Current Inventory | Clinical Samples
Code
No.
Marker Category Panel Type Matrix IRB
SG609-2 Normal, Female Healthy Donors Serum
 Minimum volume of 2ml
 Collected and frozen
within 24 hours
 Age, Gender, Race,
Collection Date
 Non viral tested
N
SG610-2
Normal,
Male
Healthy Donors Serum N
SG609-6 Normal, Female Healthy Donors Lith Hep Plasma
 Drawn from hospitalised
non-cardiac patients
 Minimum volume of 2ml
 Collected and frozen
within 24 hours
 Age, Gender, Race,
Collection Date,
Confirmation of non-
cardiac status,
 Non viral tested
N
SG610-6
Normal,
Male
Healthy Donors Lith Hep Plasma N
Normal, Health Donor Panels

13. Our Capabilities | Specialty Blood Products
 Normal serum and plasma and
speciality products in a variety of
anticoagulants
 Range of volume from 1ml to full single
serum / plasma units
 Large scale collections possible
>1,000 L
 Custom control of the pre-analytical
phase available
Custom Plasma collection in
FDA licensed facilities
 Custom anticoagulant,
capabilities of >500L per
month
“Packed” red cells
 Available in bulk in K3-
EDTA

14. How to Order
Please get in touch to arrange a quote for
any of our products.
If you can’t find what you are looking for, take
a look at some of our customised services:
 Custom collections
 Defibrination service
 Heat inactivation
 Pooling service
 Custom testing / screening
 Custom specifications for products
requiring regular supply for production
info@bbisolutions.com
USA: 1-800-423-8199
Intl: +44 (0) 2920 747 232
On ordering quote – NF MAR