Pyoderma at Vets South, Exeter
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This document discusses strategies for controlling canine pyoderma, which is a common skin infection in dogs. It begins by explaining why dogs are predisposed to pyoderma, noting defects in their natural defense mechanisms. It then covers the classification of pyoderma, common clinical signs, diagnosis, and treatment approaches. Treatment involves both systemic and topical antibiotics, with discussions of specific antibiotic options and their advantages. The document also addresses issues with antibiotic resistance and strategies to prevent further development of resistance. It concludes by thanking the presenters and asking if the audience has any additional questions.
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Pyoderma at Vets South, Exeter
- 1. The Changing Face of Canine Pyoderma- New Strategies for Control Anthony Chadwick BVSc CertVD MRCVS The Webinar Vet
- 2. David Lloyd • Antibiotic stewardship CPD should be obligatory • FECAVA conference Dublin 2012 • Pre-congress 2015- free for BVA members • www.theinternationalwebinarvet.com/precongress
- 3. Ian Mason “The dog is a pyoderma waiting to happen”
- 4. What we are covering this afternoon • Why is the dog a pyoderma waiting to happen? • Classification of pyoderma • Clinical signs • Diagnosis of pyoderma- ddx • Treatment • Problems with resistance
- 5. Why?
- 6. Normal defence mechanisms defective • Physical • Chemical • Microbial
- 7. A Pathogenic Staphylococcus • S pseudintermedius • Bacteria produces a variety of substances including enterotoxins, toxic shock protein, protein A and haemolysins • Increase adhesion to keratinocytes • Act as superantigens and upregulate the immunological responses • Some strains produce slime which encapsulate the bacteria and inhibit phagocytosis whilst increasing its ability to adhere
- 8. Classification of pyoderma • Surface • Superficial • Deep
- 9. Surface pyodermas • Pyotraumatic dermatitis • Intertrigo(skin fold pyoderma) • Impetigo
- 10. Superficial pyodermas • Superficial bacterial folliculitis • Mucocutaneous pyoderma
- 11. Deep pyodermas • Deep folliculitis/furunculosis • Deep pyotraumatic furunculosis • Nasal folliculitis/furunculosis • Pedal furunculosis • GSD pyoderma • Acral lick dermatitis • Abscesses and granulomas
- 12. Clinical signs
- 13. Clinical signs
- 20. Diagnosis • Cytology • Culture and sensitivity • Biopsy
- 24. What is your most likely diagnosis? • Acute Pyoderma • Demodicosis • Chronic pyoderma • Mycosis fungoides • Pemphigus foliaceous
- 26. Differential Diagnosis Pyoderma is always a secondary disease
- 27. Differentials • Allergy • Ectoparasite • Endocrine
- 28. How long would you treat a pyoderma case? • 7 days • 7-14 days • 15-21 days • 22-30 days • Longer than 1 month
- 30. Systemic Treatments • Antibiotics • Staphage lysate • Autogenous vaccines
- 31. Topical Treatments • Shampoos • Creams • Ointments
- 32. Antibiotics • Potentiated sulphonamides 15-30mg/kg bid • Clindamycin 11mg/kg sid • Potentiated amoxicillin 12.5mg/kg bid • Cephalexin 15-30mg/kg bid • Cefovecin 8mg/kg ev 14 days • Enrofloxacin 5mg/kg sid • Marbofloxacin 2mg/kg sid
- 34. Cefovecin • Can increase compliance • But sub-optimal levels of antibiotic after the 2 weeks • Is a 3rd generation cephalosporin
- 35. Staphage lysate • Stimulates both humoral and cellular immunity • 1 study showed 77% of dogs had significant benefits
- 36. Autogenous vaccines • Prepared individually for each dog from a culture • Given with antibiotics and then weaned off antibiotics • Speak to RVC • Particularly useful in cases of recurrent idiopathic pyoderma
- 44. Shampoos • Ethyl Lactate • Chlorhexidine • Benzoyl peroxide
- 45. Creams • Fusidic acid • Mupirocin
- 46. Problems with Resistance Ollie 3yo
- 47. Ollie 3yo Bulldog • Pyoderma caused by MRSP • Sensitive to doxycycline • Treated with chlorhexidine shampoo
- 48. MRSA and MRSP How often have you seen a resistant case this year • 0 • 1-2 • 3-5 • 6-10 • More than 10
- 49. Methicillin resistance • First reported in 1960s • Due to a mecA gene encoding an altered PBP • S aureus human pathogen • S pseudintermedius companion animal pathogen • More of a problem in USA and Europe but coming
- 50. How can we prevent • Better hygiene in the practice. • Use less antibiotics where possible. • Higher doses and for longer times. • Use appropriate antibiotic for pyoderma. • Teach compliance. • Don’t use corticosteroids at the same time
- 51. Do you use something milky for your cat speys? • Yes • No
- 52. The Webinar Vet Vets South offer • 3 talks as recordings • Slides on slideshare • £1 trial • Pre-congress day free for BVA members
- 53. Thanks • David Lloyd • You for listening
- 54. Any Questions?