This conclusion is based on a significant association among “non-Chinese,” versus a nonsignificant association among “Chinese.” Do you agree with the conclusion?
Yes, I agree
No, I do not agree
Assessing Study Conclusions Sergentanis TN, Economopoulos KP. Breast Cancer Res Treat 2010;12:195-202. This is part of a table from a meta-analysis of genetic factors that concludes: “polymorphisms of both GSTT1 and GSTP1 genes seem [to be] associated with elevated breast cancer risk in a race-specific manner.” CI = confidence interval; OR = odds ratio OR for GSTT1 null copy carriers (95% CI) Non-Chinese 1.13 (1.04, 1.22) Chinese 1.06 (0.88, 1.29)
Assessing Study Methods As described in the methods section of a paper, the authors opted to use random or fixed effects models according to whether a heterogeneity test was significant. Data on GSTP1 Sergentanis TN, Economopoulos KP. Breast Cancer Res Treat 2010;12:195-202. CI = confidence interval F = fixed effects model OR = odds ratio
This quiz was prepared by Joseph Lau, M.D., and Thomas Trikalinos, M.D., Ph.D., members of the Tufts Medical Center Evidence-based Practice Center.
The information in this module is based on Chapter 9 in Version 1.0 of the Methods Guide for Comparative Effectiveness Reviews (available at: http://www.effectivehealthcare.ahrq.gov/repFiles/2007_10DraftMethodsGuide.pdf).