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CURRICULUM VITAE
Dr Vassilis SPANOS
June 2015
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PERSONAL DETAILS
NAME Vassilis
SURNAME SPANOS
ADDRESS 3, Sokrates Street
Nea Pedeli 15362
Athens, Greece
Tel: (+30) 210 6390563, (+30) 6946 331718
e-mail : vspanos@mathetinkardiasou.gr
web site : www.mathetinkardiasou.gr
DATE OF BIRTH 19 March 1965
FAMILY STATUS Married, one daughter (8 years old)
Medical Education: 1982-88: University of Athens
Medical School, Greece
Qualifications: 1989: Medical School Diploma:
Ptychio Iatrikes
1998: Specialist in Cardiology
Awards: 2000: European Society of Cardiology
Training Fellowship (for the year 2001)
Languages: Greek, English, Italian, French
General Medical Council No 4079978
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POSTS HELD
2015 (April) – now (current post): Catheterization Laboratory Director, Iatriko
Hospital, Athens, Greece, Consultant of the Hellenic Heart Foundation (ELIKAR).
Iatriko is a private hospital dealing with the full range of adult and pediatric medicine.
The work in the Catheterization Laboratory involves all the range of interventional
cardiology.
Continuing participation in the activities of ELIKAR (Hellenic Heart Foundation)
.
2009 (September) – 2015(April): Consultant Interventional Cardiologist and
Assistant Director of the Cardiology Clinic, Athens Euroclinic Hospital, and
Consultant of the Hellenic Heart Foundation (ELIKAR).
Euroclinic is a private Hospital dealing with all range of clinical and interventional
cardiology. The majority of the coronary interventions in the Cath Lab are complex
(referrals from other hospitals/angioplasty failures).
Regular participation in the activities of ELIKAR (Hellenic Heart Foundation).
ELIKAR is a nonprofit organization aiming to information of lay people in life style
modification to achieve reduction of cardiovascular morbidity and mortality.
2004 (April) – 2009 (August): Consultant Interventional Cardiologist, Athens
Euroclinic Hospital and Consultant of the Hellenic Heart Foundation (ELIKAR).
Performance of interventional procedures (around 80-100 coronary interventions
/year), the vast majority being referrals from other centres (either angioplasty failures
or complex disease).
Regular participation in the activities of ELIKAR (Hellenic Heart Foundation,
described elsewhere).
2003 (September) – 2004 (March): Consultant Interventional Cardiologist, Athens
Euroclinic Hospital and Research Associate of Mediolanum Cardiovascular
Research (MCR).
Clinical duties and performance of diagnostic and interventional procedures in the
Cath Lab of a private Athens Hospital.
Continuation of the research coordination activities at the MCR (communication
through mails and regular 2-3 days’ trips to Milan).
2002 (December)- 2003 (August): Interventional Cardiology Registrar at EMO
Centro Cuore Columbus, Intravascular ultrasound (IVUS) Director in San
Raffaele Hospital and EMO Centro Cuore Columbus & IVUS Scientific Director
and Research Associate of Mediolanum Cardiovascular Research (MCR), Milan,
Italy (under Dr A. Colombo).
Clinical duties in the Catheterization Lab and the ward at EMO Centro Cuore
Columbus clinic.
Performance of IVUS sub-analysis for the studies organized by MCR, responsibility
of training and coordination of MCR staff in 3D-IVUS measurements and supervision
of the work of the MCR staff in: preparation and organization of multi-centre trials,
quantitative coronary angiography (QCA) measurements and final data evaluation and
presentation.
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Training of fellows in San Raffaele Hospital in the full range of IVUS analysis
(including 3D IVUS) and coordination of IVUS database for both centres (Centro
Cuore Columbus and San Raffaele)
2002 (September)-2002 (November): IVUS Scientific Director in Mediolanum
Cardiovascular Research (MCR) &
Interventional Cardiology Registrar, San Raffaele Hospital, Milan, Italy (under Dr
A. Colombo).
Responsibility for the co-ordination of the IVUS department in MCR: IVUS sub-
analysis in clinical trials, training and supervision of MCR staff in performing 3D-
IVUS.
At the same time I continued with my clinical responsibilities at San Raffaele hospital
(described in the next paragraph).
2001 (September)-2002 (August): Interventional Cardiology Registrar, San
Raffaele Hospital, Milan, Italy (under Dr A. Colombo).
This was a 1-year contract at San Raffaele Hospital involving clinical and research
activities, with active participation in the Catheterization Lab (performance of more
than 800 diagnostic catheterizations and around 250 coronary interventions).
The clinical work took place at San Raffaele Hospital and was divided between
responsibilities in the ward and in the Catheterization Lab on a monthly rotation basis.
Ward work was related to admission, discharge and follow-up of patients undergoing
coronary interventions.
Lab work involved diagnostic catheterizations and coronary as well as peripheral
vascular interventions.
2000 (November)-2001 (September): Research Fellow in San Raffaele Hospital &
Centro Cuore Columbus, Milan, Italy (under Dr A. Colombo)
This was a post that included research activities as well as clinical activities with
financial support from a Training Fellowship of the European Society of Cardiology
and a scholarship of San Raffaele Hospital.
The research work concerned data collection and analysis for both San Raffaele
Hospital and Centro Cuore Columbus: QCA measurements, IVUS performance and
evaluation, as well as data analysis, manuscript and abstract preparation and
presentation of the results at international meetings.
1999 (January)-2000 (October): Associate of the Department of Cardiology of
Athens Medical School, Catheterization Laboratory, Hippokration Hospital, Athens
(under Ass. Professor P. Toutouzas).
Work in the Catheterization Lab, performing full diagnostic adult catheterization and
a small number of coronary interventions as first operator; regular cardiology
consultations for inpatients at the General Medical and Surgical departments and
participation in outpatients’ clinics.
1995 (August)-1998 (August): Trainee in Cardiology, Department of Cardiology of
Athens Medical School, Hippokration Hospital, Athens (under Professor P.
Toutouzas).
This was a three-year rotation through the Cardiology & Cardiothoracic Wards,
Exercise Treadmill Testing Department, Echocardiography Department, Intensive
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Therapy Unit and the Catheterization Laboratory in the context of specialization in
Cardiology.
1995 (February)-1995 (July): Senior House Officer (S.H.O.) in General
Medicine/Cardiology, Tameside General Hospital, Aston under Lyne, Lancashire
(under Dr Husaini, consultant physician with a special interest in Cardiology).
Tameside was a busy district general hospital in the United Kingdom.
Responsibility of acute general medical admissions, day to day care of patients in the
ward and supervision of the House Officer; responsibility for one cardiology clinic
every week.
While working with Dr Husaini I had the opportunity to come closer to adult non-
invasive cardiology, although limited by the tools available to a non-tertiary
department.
1994 (August)-1995 (January): S.H.O. in General Medicine/Chest Diseases,
Tameside General Hospital, Aston under Lyne, Lancashire (under Dr Chopra,
Consultant Physician).
The usual S.H.O. activities (described in the previous paragraph) including one
general medical and two chest clinics every week. Exposure to all kinds of chest
diseases, both on an emergency basis and concerning the long-term management.
1994 (June 6th - July 31st): S.H.O. in General Medicine/Diabetes & Endocrinology,
Tameside General Hospital, Aston under Lyne, Lancashire (under Dr O’Mullane,
Consultant Physician).
During the above post (advertised as a locum post, but soon after my employment -
under mutual agreement- regarded as part of my rotation at Tameside) I was
responsible for admissions, day to day care of patients and I participated in two
general medical and two diabetic clinics every week. There was wide exposure to
medical problems, especially the ones arising during the long-term management of
diabetic patients.
1994 (April 18th -May 3rd) & 1994 (May 14th-29th): Locum S.H.O. in General
Medicine, Wrexham Maelor Hospital, Wrexham, Clwyd (under Dr Child & Dr
Baker).
Locum posts in this district general hospital, which gave me the opportunity to
become affiliated to the responsibilities of the S.H.O. in a British hospital.
1993 (January)-1994 (January): Trainee in Internal Medicine, 3rd Department of
Internal Medicine, Papademetriou Hospital of Athens, Greece (part of the training
leading to the exams for the «specialist in Cardiology» title).
A post that dealt with a wide variety of medical problems in this general hospital of
Athens.
1992 (January)-1992 (November): Physician in the Greek Army (obligatory military
service).
I served in the acute unit of a Recruitment Center at Kalamata (Southern Greece) on a
shift basis, dealing with acute medical/surgical problems of the military personnel.
1990 (June)-1991 (November): General Physician, Health Center of Meligala,
Messinia, Greece (obligatory rural service).
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Follow up of chronic problems in a primary care setting and management of
medical/surgical emergencies for a rural population of 20.000 people.
PROCEDURES
Basic techniques: In the course of my training I have gained confidence in
temporary cardiac pacemaker insertion, pericardial aspiration and Intra Aortic Balloon
Pump (IABP) insertion.
Diagnostic catheterization: During my training in the Catheterization Laboratory I
gained confidence and wide experience in performing right and left cardiac
catheterization, coronary angiography and peripheral vascular catheterization.
Performance of a large number of diagnostic catheterizations, including use of radial
and brachial artery access. Conversion to radial artery as the preferred access site
since 2013.
Coronary interventions: Performance of more than 300 interventions, while
training in Milan and around 80-100 procedures/year since, for a variety of coronary
lesions including complex ones:
coronary bifurcations, with stenting of the main branch and balloon angioplasty
for the side branch or double stenting techniques: modified T stenting and crushing
technique
in-stent restenosis, with the use of conventional and cutting balloon angioplasty,
occasionally followed by beta intracoronary brachytherapy
calcified lesions, with the use of cutting balloon or FX Minirail balloon angioplasty
and rotablator use
diffuse disease & small vessel disease, with use of intravascular ultrasound and
intracoronary pressure measurements for definition of the appropriate treatment
strategy
unprotected left main stenosis, ostium, shaft and bifurcation, while working in
Milan and at my personal practice in Euroclinic Hospital after the results of SYNTAX
Trial.
Radial artery cannulation is the preferred access site for coronary interventions.
Working with Dr A. Colombo (2000-2003) I also had the opportunity to use a lot
of different devices, many used in our centre as initial evaluation in clinical trials:
the Galileo intracoronary beta-brachytherapy catheter,
different atherectomy devices as the “Fox-Hollow” catheter,
the rotablator catheter,
the cutting balloon coronary catheter,
the Angioguard and the Percuserge protection devices,
the “Rescue” thrombus aspiration coronary system,
the “Volcano” and the “Epiphany” thermography catheters,
laser catheters and
the “FrontRunner” device for chronic total coronary occlusions.
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Non Coronary interventions:
At Iatrikon Heart Center we have organized a Trans Catheter Aortic Valve
implantation team and we have successfully treated the first 3 patients.
I have also participated in a discrete number of peripheral vascular interventions
while working at San Raffaele hospital (carotid arteries, renal arteries, iliac and
femoral arteries).
Intravascular ultrasound: I also had the opportunity to gain wide experience in
performing and evaluating intravascular ultrasound (IVUS) examination
- either for diagnostic purposes:
Cases where the angiography is inconclusive as regards the significance of
stenosis, especially in left main coronary artery disease and ostial disease
- or as a tool to help determine the treatment strategy during coronary
interventions:
During implantation of bare and drug-eluting stents, in cases of in-stent restenosis
and in cases of diffuse or small vessel disease.
RESEARCH
Participation in research work organized by the department during my cardiology
training at Hippokration hospital, mainly work with intravascular ultrasound (IVUS).
Participation in clinical research in San Raffaele & Centro Cuore Columbus:
quantitative coronary angiography (QCA) and intravascular ultrasound (IVUS)
measurements, clinical and angiographic follow-up of patients, as well as data
analysis and presentation of the results at international meetings.
Participation in the conduction of multi-center trials since September 2002, due
to my duties in Mediolanum Cardiovascular Research (MCR) center. During this time
I gained experience with the design and performance of multicenter clinical trials, as
well as evaluation and presentation of the results. Amongst others:
Clinical Project Leader in CIRIUS Bifurcation Trial (the first study using the
CYPHERTM stent for coronary bifurcations) and co-ordination of IVUS subanalysis of
the study.
The study has been conducted in 5 centres (Centro Cuore Columbus in Milan, Lenox-
Hill Hospital in New York, ICPS centre in Massy, Paris, Mayo Clinic in Rochester,
Minessota and University of Erlangen, Germany) with Dr Antonio Colombo as
primary investigator.
Conceptualization and structure of the protocol of the CACTUS (Coronary
Bifurcations: Application of the Crushing Technique Using Sirolimus-Eluting
Stents) Trial organized by the MCR aiming to define best available technique for
coronary artery bifurcations treatment.
IVUS sub-analysis from the Rescut (REStenosis CUTting balloon evaluation)
study, a multicenter trial that compared cutting balloon to conventional balloon
angioplasty in the treatment of in-stent restenosis (the clinical results were presented
during the Transcatheter Cardiovascular Therapeutics 2002 - late breaking clinical
trial).
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RELATED EXPERIENCE
Participation in the Investigator’s Meetings in the course of the “Evaluation of the
sirolimus-eluting stent in the treatment of patients with bifurcation lesions” study
(organized by Cordis Corp. in New York, August 2002 and in Chicago, November
2002) presenting the IVUS analysis of the study.
Participation as faculty expert in the organization of JIM 2003 international
meeting of coronary and peripheral vascular interventions.
Participation as member of the organizing committee of Clinical Cardiology
Congress in 2003-2015 organized by the Hellenic Heart Foundation (ELIKAR).
Reviewer of research work submitted to the annual European Society of
Cardiology (ESC) Congress (2004-2015) as well as to the Hellenic Journal of
Cardiology (HJC).
PLANS
I wish to contribute to clinical research projects undertaken by the medical
industry. In this perspective I have applied for the Executive MSc Health Economics,
Outcomes and Management in Cardiovascular Science, a part time program that will
start in December 2015 at London School of Economics
OTHER INTERESTS
I am a cinema lover and I spend a lot of my free time trying not to miss any of the
films I consider interesting. I also enjoy theater, listening to music and reading
literature.
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PUBLISHED WORK
Peer review journals:
1. Ahmed W, Mendiz O, Thomas M, Taxus Olympia Participating Physicians: Usage
patterns and 1 year outcomes with the Taxus Liberte stent. Results of the TAXUS
OLYMPIA Registry. Catheter Cardiovasc Interv 2011 Jun 1;77(7):979-992.
2. Spanos V, Toutouzas P: The ever increasing role of percutaneous interventions in
coronary revascularization. Hellenic J Cardiol 2010 Nov-Dec;51(6):512-7.
3 Karabinos I, Spanos V: Percutaneous transluminal coronary angioplasty in a
patient with three small vessel disease: the role of intravascular ultrasound. Hellenic
J Cardiol 2008 Nov-Dec;49(6):432-3.
4. Spanos V, Toutouzas P. Multivessel coronary artery disease treated with drug-
eluting stents.Hellenic Journal of Cardiology. 2004:315-318.
5. Spanos V, Toutouzas P, Voridis E. Modified T stenting technique with crushing
using paclitaxel-eluting stents. Hellenic Journal of Cardiology. 2004:213-217.
6. Colombo A, Moses JW, Morice MC, Ludwig J, Holmes DR, Jr, Spanos V, Louvard
E, Desmedt B, Di Mario C, Leon M: Randomized study to evaluate sirolimus-eluting
stents implanted at coronary bifurcation lesions. Circulation 2004;109(10):1244-9.
7. Stankovic G, Orlic D, Corvaja N, Airoldi F, Chieffo A, Spanos V,
Motorfano M, Carlino M, Finci L, SanGiorgi M, Colombo A: Incidence,
predictors, in-hospital, and late outcomes of coronary artery perforations.
Am J Cardiol. 2004 Jan 15;93(2):213-6.
8. Spanos V., Vitrella G., Colombo A.: Using intravascular ultrasound with drug-
eluting stents. What have we learned so far? Minerva Cardioangiol. 2003
Oct;51(5):493-505, 505-11.
9. Orlic D, Reimers B, Stanckovic G, Corvaja N, Chieffo A, Airoldi F, Spanos V,
Favero L, Di Mario C, Colombo A: Initial experience with a new 8 French-
compatible directional atherectomy catheter: immediate and mid-term results.
Catheter Cardiovasc Interv. 2003 Oct;60(2):159-66.
10. Colombo A, Stankovic G, Orlic D, Corvaja N, Liistro F, Airoldi F, Chieffo A,
Spanos V, Montorfano M, Di Mario C: Modified “T” Stenting Technique with
“Crushing” for Bifurcation Lesions: Immediate Results and 30-day Outcome
Catheter Cardiovasc Interv. 2003 Oct;60(2):145-51.
11. Airoldi F., Di Mario C., Stankovic G., Briguori C., Carlino M., Chieffo A., Liistro
F., Montorfano M., Pagnotta P., Spanos V., Tavano D., Colombo A.: Clinical and
angiographic outcome of directional atherectomy followed by stent implantation in
de-novo coronary lesions located at the ostium of the left anterior descending artery
Heart. 2003 Sep;89(9):1050-4.
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12. Spanos V, Stankovic G, Colombo A: A tortuous distal carotid artery: How to
overcome the problem, maintaining the goal to guarantee distal protection
International J Invasive Cardiol 2003;5(2):77-80.
13. Colombo A, Orlic D, Stankovic G, Corvaja N, Spanos V, Motorfano M, Liistro F,
Carlino M, Airoldi F, Chieffo A, Di Mario C: Preliminary observations regarding
angiographic pattern of restenosis after rapamycin-eluting stents implantation
Circulation 2003 May 6;107(17):2178-80.
14. Briguori C, Sarais C, Pagnotta P, Airoldi F, Liistro F, Sgura F, Spanos V, Carlino
M, Montorfano M, Di Mario C, Colombo A: Elective versus provisional intra-aortic
balloon pumping in high-risk percutaneous transluminal coronary angioplasties Am
Heart J 2003 Apr;145(4):700-7.
15. Colombo A., Spanos V.: A new technique for coronary bifurcations?
Good news! (Editorial) J Invasive Cardiol 2003 Apr;15(4):184-5.
16. Spanos V, Stankovic G, Tobis J, Colombo A: The challenge of in-stent
restenosis; insights from intravascular ultrasound (review) Eur Heart J
2003; 24(2):138-150.
17. Stankovic G, Liistro F, Moshiri S, Briguori C, Corvaja N, Chieffo A, Montorfano
M, Finci L, Spanos V, Di Mario C, Colombo A: Carotid artery stenting in the first
100 consecutive patients: results and follow-up Heart 2002; 88: 381-386.
18. Takagi T, Stankovic G, Finci L, Toutouzas K, Chieffo A, Spanos V, Liistro F,
Briguori C, Corvaja N, Albiero R, Sivieri G, Paloschi R, Di Mario C, Colombo A:
Results and long-term predictors of adverse clinical events after elective
percutaneous interventions on unprotected left main coronary artery. Circulation
2002 Aug 6;106(6):698-702.
19. Toutouzas K, Stankovic G, Takagi T, Spanos V, Di Mario C, Albiero R,
Corvaja N, Gaglione A, Colombo A: Outcome of treatment of aorto-ostial
lesions involving the right coronary artery or a saphenous-vein graft with a
polytetrafluoroethylene-covered stent Am J Cardiol 2002; 90:63-66.
20. Sallam M, Spanos V, Briguori C, Di Mario C, Tzifos V, Dharmadhikari A,
Albiero R, Colombo A: Predictors of re-occlusion after successful recanalization of
chronic total occlusion J Invasive Cardiol 2001 Jul;13(7):511-15.
21. Vavuranakis M, Stefanadis C, Toutouzas K, Pitsavos C, Spanos V, Toutouzas P:
Impaired compensatory coronary artery enlargement to atherosclerosis contributes to
the development of coronary artery stenosis in diabetic patients. An in vivo
intravascular ultrasound study. Eur Heart J 1997; 18:1090-1094.
Books:
1. Spanos V: “Καρδιά: Έμαθες; Σώθηκες!”, Dioptra Publications, Athens
2002
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2. Spanos V, Di Mario C, Opizzi M: Treatment of Acute Myocardial
Infarction (AMI) with Embolus Aspiration. In: Rothman M, ed. Case
Studies in Interventional Cardiology. 6th ed: Martin Dunitz Ltd; 2003:86-
91.
Congresses:
Annual Congress of The American Heart Association (AHA, published in
Circulation):
1. V. Spanos, K. Toutouzas, A. Chieffo, J. Kostov, R. Albiero, A. Amato, C. Briguori,
G. Stankovic, C. Di Mario, A. Colombo: Six-month angiographic follow-up after
implantation of the sirolimus drug-eluting stent at coronary bifurcations; a three-
dimensional intravascular ultrasound study Circulation 2002;106(Sup II) 391:1945
2. V. Spanos, S. Moshiri, C. Sarrais, M. Montorfano, F. Airoldi, D. Maccagni, F.
Liistro, G. Tucci, M. Ferraro, R. Albiero: Diffuse In-stent Restenosis: Outcomes of
Balloon Angioplasty and Cutting Balloon Angioplasty Circulation 2002;106(Sup II)
391:1945.
3. G. Stankovic, M. Ferraro, J. Kostov, C. Milici, N. Corvaja, R. Albiero, A. Chieffo,
V. Spanos, F. Airoldi, F. Liistro, L. Finci: Coronary artery perforations: incidence,
predictors and clinical outcome Circulation 2002;106(Sup II) 444:2210
4. C. Briguori, C. Sarais, V. Spanos, P. Pagnotta, R. Albiero, G. Stankovic, M.
Carlino, A. Colombo: Impact of strut’s thickness on restenosis after stent implantation
in small coronary vessels Circulation 2001;104 (sup II) 665:3139
Annual Congress of The American College of Cardiology (ACC, published in JACC):
1. V. Spanos, G. Stankovic, F. Airoldi, M. Montorfano, N. Corvaja, F.
Liistro, A. Chieffo, M. Segura, D. Tavano, C. Di Mario, A. Colombo: Use
of the sirolimus drug-eluting stents for “real world” coronary lesions – The
Milan experience. Results of the first 400 lesions J Am Coll Cardiol
2003;41(Suppl A):12A
2. F. Airoldi, V. Spanos,G. Stankovic, et al. Bifurcational coronary artery
lesion treatment with rapamycin-eluting stents: results from a single center
experience. J Am Coll Cardiol. 2003;41(Suppl A):53A
3. K. Toutouzas, G. Stankovic, T. Takagi, V. Spanos, C. Di Mario, R.
Albiero, N. Corvaja, A. Chieffo, G. Sivieri, A. Colombo: Impact of stent
length on restenosis rate in small vessels. J Am Coll Cardiol 2002;
53A:1149-22
4. K. Toutouzas, G. Stankovic, T. Takagi, V. Spanos, C. Di Mario, R.
Albiero, N. Corvaja, G. Sivieri, D. Milici, A. Colombo: Failure of PTFE-
covered stents to lower restenosis rate in aorto-ostial lesions. J Am Coll
Cardiol 2002; 61A:1195-122
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5. M. Vavuranakis, C. Stefanadis, C. Pitsavos, E. Lazaki, K. Toutouzas, I.
Kallikazaros, V. Spanos, P. Toutouzas: Coronary artery distensibility determined by
simultaneous intracoronary pressure recordings and intracoronary ultrasound is
impaired in patients with diabetes mellitus. J Am Coll Cardiol 1997; 124A:942-133
Annual Trans Catheter Therapeutics Congress (TCT, published in the Am Journal
Cardiol):
1. G. Stankovic, D. Orlic, A. Chieffo, V. Spanos, N. Corvaja, G. Sangiorgi,
F. Airoldi, A. Colombo: Predictors of CK-MBelevation after Percutaneous
Coronary Intervention using Sirolimus-eluting stents Am J Cardiol 2003;
TCT-432.
2. D. Orlic, G. Stankovic, F. Airoldi, A. Chieffo, V. Spanos, D. Tavano, I.
Michev, N. Corvaja, A. Colombo: Changes in stenting technique by using
sirolimus-eluting stents in the real world Am J Cardiol 2003; TCT-443.
3. F. Airoldi, G. Stankovic, D. Orlic, C. Briguori, V. Spanos, M. Carlino,
M. Montorfano, I. Michev, R. Rogacka, D. Tavano, A. Chieffo, A.
Colombo: Immediate and midterm results of rapamycin-eluting stent
implantation in bifurcational coronary artery lesions Am J Cardiol 2003;
TCT-142.
4. F. Airoldi, G. Stankovic, D. Orlic, C. Briguori, V. Spanos, M. Carlino,
M. Montorfano, I. Michev, R. Rogacka, D. Tavano, A. Chieffo, C. Di
Mario, A. Colombo: The modified T stenting technique with crushing for
bifurcation lesions: immediate results and 6-month clinical outcomes Am J
Cardiol 2003; TCT-143.
5. D. Orlic, B. Reimers, G. Stankovic, N. Corvaja, V. Spanos, L. Favero, A.
Chieffo, F. Airoldi, M. Montorfano, L. Finci, A. Colombo: Initial
experience with a new concept 8Fr compatible Directional Atherectomy
catheter: 30-day and 6-month clinical outcome Am J Cardiol 2003; TCT-
526.
6. D. Orlic, C. Di Mario, G. Stankovic, G. Sangiorgi, N. Corvaja, V.
Spanos, F. Airoldi, A. Chieffo, M. Montorfano, M. Carlino, I. Michev, A.
Colombo: Balloon overdilatation in rapamycin-eluting stents: preliminary
report of 6-month angiographic outcome Am J Cardiol 2003; TCT-451.
7. D. Orlic, C. Di Mario, G. Stankovic, N. Corvaja, G. Sangiorgi, A.
Chieffo, F. Airoldi, V. Spanos, M. Montorfano, M. Ferraro, A. Colombo:
Multivessel coronary artery stenting with Sirolimus-eluting stent
implanatation: immediate and midterm results Am J Cardiol 2003; TCT-
211.
8. D. Orlic, G. Stankovic, L. Finci, G. Sangiorgi, N. Corvaja, E. Bonizzoni,
A. Chieffo, F. Airoldi, V. Spanos, G. Vitrela, A. Amato, A. Colombo:
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Clinical and angiographic parameters associated with restenosis in
Sirolimus-eluting stents Am J Cardiol 2003; TCT-440.
9. D. Orlic, G. Stankovic, C. Di Mario, N. Corvaja, F. Airoldi, A. Chieffo,
M. Montorfano, M. Carlino, V. Spanos, D. Tavano, G. Martini, L. Finci, A.
Colombo: Preliminary observations regarding angiographic pattern of
restenosis after rapamycin-eluting stents implanatation Am J Cardiol 2003;
TCT-123.
10. V. Spanos, G. Stankovic, F. Airoldi, R. Albiero, N. Corvaja, J. Kostof,
A. Chieffo, M. Segura, C. Di Mario, A. Colombo: Use of the Sirolimus
drug-eluting stents for “real world” coronary lesions Am J Cardiol 2002;
5H; TCT-12
11. V. Spanos, G. Stankovic, M. Montorfano, F. Airoldi, R. Albiero, C.
Sarais, F. Sgura, A. Chieffo, M. Ferraro, C. Briguori, C. Di Mario, A.
Colombo Mid-term results of intracoronary brachytherapy for the treatment
of ostial lesions Am J Cardiol 2002; 101H: TCT-253
12. F. Airoldi, C. Di Mario, G. Stankovic, V. Spanos, A. Chieffo, R. Albiero, M.
Ferraro, M. Carlino, C. Briguori, A. Colombo: Bifurcational coronary artery treatment
with Rapamicine-eluting stent: Results from a single center experience in the first 50
cases Am J Cardiol 2002; 5H; TCT-10
13. C. Sarais, C. Briguori, P. Pagnota, A. Chieffo, V. Spanos, F. Sgura, F.
Airoldi, F. Liistro, C. Di Mario, A. Colombo: Impact of vessel angulation
on early and late outcome after coronary stent implantation Am J Cardiol
2002; 95H; TCT-239
14. F. Airoldi, C. Di Mario, C. Briguori, G. Stankovic, M. Carlino, F.
Liistro, V. Spanos, J. Kostof, A. Chieffo, C. Sarais, M. Ferraro, A.
Colombo: Immediate and mid-term effects of debulking before stenting in
de-novo coronary artery lesions located in the left main Am J Cardiol
2002; 108H: TCT-271
15. F. Airoldi, C. Di Mario, A. Chieffo, C. Briguori, G. Stankovic, M.
Carlino, F. Liistro, V. Spanos, J. Kostof, C. Sarais, M. Ferraro, R. Rogacka,
A. Colombo: Clinical and angiographic effects of directional atherectomy
in de-novo coronary artery lesions located at the ostium of the left anterior
descending artery Am J Cardiol 2002; 108H: TCT-272
16. F. Liistro, A. Chieffo, G. Stankovic, V. Spanos, J. Kostof, F. Sgura, C.
Di Mario, M. Montorfano, C. Cesere, A. Colombo: Coronary intervention
in the elderly: Comparison on immediate and long-term outcome between
octagenarians and septuagenarians Am J Cardiol 2002; 176H: TCT-460
17. N. Corvaja, B. Reimers, C. Milici, J. Kostof, G. Stankovic, G. Martini,
V. Spanos, R. Albiero, C. Di Mario, A. Colombo: Carotid stenting in the
elderly: Is filter neuroprotection of any help? Am J Cardiol 2002; 59H:
TCT-139
14
18. C. Briguori, C. Sarrais, V. Spanos, G. Gimelli, P. Pagnotta, M. Carlino,
R. Albiero, C. Di Mario, A. Colombo: Influence of stent strut thikness on
restenosis rates in small coronary arteries Am J Cardiol 2001; 88(Supp 1
5A)
Annual European Society of Cardiology Congress (ESC, published in the EurHeartJ):
1. Spanos V., Moshiri S., Sarrais C., Montorfano M., Albiero R., Airoldi F., Briguori
C., Liistro F., Stankovic G., Di Mario C., Colombo A.: Cutting Balloon Angioplasty
vs. Balloon Angioplasty for treating diffuse In-stent Restenosis ESC 2002
2. C. Briguori, C. Sarais, V. Spanos, G. Gimelli, F. Sgura, M. Carlino, C. Di Mario, P.
Pagnotta, A. Colombo, F. Airoldi: Clinical and angiographic predictors of false small
coronary vessels Eur Heart J 2001 239 (1297)
3. S. Moshiri, C. Sarais, V. Spanos, A. Ferrari, C. Di Mario, A. Colombo, F. Liistro,
M. Montorfano, G. Gimelli: Carotid angioplasty and stent placement: a technique in
evolution for carotid artery stenosis; Italian experience Eur Heart J 2001 633 (3479)
4. M. Vavuranakis, V. Spanos, V. Vukcevic, K. Toutouzas, C. Chrisohou, D. Markou,
K. Tzioumis, C. Stefanadis, K. Aggeli, P. Toutouzas: Intracoronary ultrasound
findings of angiographically normal LMCA in patients with HTN and Left
Ventricular Hypertrophy. Is LMCA adequately sized? Eur Heart J 2000 269 (1538)
5. K. Toutouzas, M. Vavuranakis, L. Diamantopoulos, C. Stefanadis, C. Pitsavos, N.
Giatrakos, V. Spanos, P. Toutouzas: Acute effect of stenting in the elastic properties
of human coronary arteries: insights in the mechanics of stenting Eur Heart J 1997
381 (2184)
Other Congresses:
Congress of the Italian Society of Interventional Cardiology (GISE)
1. V. Spanos, F. Airoldi, A. Chieffo, R. Albiero, M. Montorfano, N.
Corvaja, M. Segura, F. Sgura, M. Murino, G. Stankovic, C. Di Mario, A.
Colombo: The use of the Sirolimus drug-eluting stent for “real world”
coronary lesions. Results of the first 200 cases Emodinamica 2002
(Lug/Set); 30 (sup):46
2. V. Spanos, G. Stankovic, M. Montorfano, F. Airoldi, R. Albiero, A.
Chieffo, D. Tavano, V. Romano, A. Colombo: Coronary intervention in the
elderly: comparison of immediate and long-term clinical outcome between
octogenarians and septuagenarians Emodinamica 2002 (Lug/Set); 30
(sup):27
3. F. Liistro, G. Stankovic, A. Chieffo, V. Spanos, J. Kostov, F. Sgura, C.
Di Mario, M. Montorfano, F. Airoldi, R. Albiero, C. Sarais, D. Tavano, M.
Ferraro, C. Rossi, C. Briguori, , A. Colombo: Mid term results after use of
15
intracoronary beta brachytherapy in ostial coronary lesions Emodinamica
2002 (Lug/Set); 30 (sup):27
4. F. Airoldi, C. Di Mario, G. Stankovic, D. Tavano, V. Spanos, R. Albiero,
M. Ferraro, M. Carlino, P. Pagnota, M. Montorfano, C. Briguori, , A.
Colombo: Bifurcational coronary artery treatment with rapamycine eluting
stents: results from a single center experience on the first 50 cases
Emodinamica 2002 (Lug/Set); 30 (sup):26
5. A. Chieffo, G. Stankovic, M. Montorfano, F. Airoldi, V. Spanos, M.
Ferraro, A. Ferrari, C. Cesere, R. Rogacka, A. Colombo Acute and late
outcome after DCA plus stenting versus stenting alone in true bifurcation
lesions Emodinamica 2002 (Lug/Set); 30 (sup):28
6. F. Airoldi, C. Di Mario, D. Tavano, C. Briguori,, G. Stankovic, M.
Carlino, F. Liistro, V. Spanos, M. Montorfano, A. Chieffo, C. Sarais, M.
Ferraro, R. Rogacka, A. Colombo: Clinical and angiographic effects of
directional atherectomy in de-novo coronary artery lesions located at the
ostium of the left anterior descending artery Emodinamica 2002 (Lug/Set);
30 (sup):25
7. F. Airoldi, C. Di Mario, C. Briguori,, D. Tavano, G. Stankovic, M.
Carlino, P. Pagnota, M. Montorfano, F. Liistro, V. Spanos, A. Chieffo, C.
Sarais, A. Castelli, A. Colombo: Immediate and mid-term effects of
debulking before stenting in de-novo coronary artery lesions located in the
left main Emodinamica 2002 (Lug/Set); 30 (sup):25
8. . V. Spanos, M. Ferraro, G. Stankovic, G. Sivieri, A. Chieffo, D.
Maccagni, F. Liistro, C. Briguori, C. Di Mario, A. Colombo: Predictors of
adverse vents following bail-out use of glycoprotein IIb/IIIa inhibitors
GISSE 2001
9. V. Spanos, S. Moshiri, C. Sarais, F. Liistro, A. Castelli, M. Montorfano,
C. Briguori, G. Stankovic, C. Di Mario, A. Colombo: Follow-up results
following cutting balloon treatment of aggressive versus non-aggressive in
stent restenosis GISSE 2001
16
REFEREES
1. Dr Antonio Colombo
Director of the Catheterization Laboratory, EMO Centro Cuore Columbus
& San Raffaele Hospital, Milan
Via Buonarroti 48, 20145 Milan, Italy
Tel: (+39) 02-4812920
Fax: (+39) 02-48193433
e-mail: info@emocolumbus.it
2. Dr Carlo Di Mario
Catheterization Laboratory,
Royal Brompton Hospital
Sydney Street
London SW3 6NP, UK
Tel: (+44) 207-352 8121
Fax: (+44) 207-351 8473
e-mail: c.dimario@rbh.nthames.nhs.uk
3. Professor P. Toutouzas
Director of Hellenic Heart Foundation (EL.I.KAR.)
Director of Cardiology Department
Athens Euroclinic Hospital
7, Athanasiadou Street
115 27, Athens, Greece
Tel: (+30) 210-6416790
Fax: (+30) 210-6416757
e-mail: elikar@elikar.gr

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SPANOS VASSILIS CURRICULUM VITAE June 2015

  • 1. CURRICULUM VITAE Dr Vassilis SPANOS June 2015
  • 2. 2 PERSONAL DETAILS NAME Vassilis SURNAME SPANOS ADDRESS 3, Sokrates Street Nea Pedeli 15362 Athens, Greece Tel: (+30) 210 6390563, (+30) 6946 331718 e-mail : vspanos@mathetinkardiasou.gr web site : www.mathetinkardiasou.gr DATE OF BIRTH 19 March 1965 FAMILY STATUS Married, one daughter (8 years old) Medical Education: 1982-88: University of Athens Medical School, Greece Qualifications: 1989: Medical School Diploma: Ptychio Iatrikes 1998: Specialist in Cardiology Awards: 2000: European Society of Cardiology Training Fellowship (for the year 2001) Languages: Greek, English, Italian, French General Medical Council No 4079978
  • 3. 3 POSTS HELD 2015 (April) – now (current post): Catheterization Laboratory Director, Iatriko Hospital, Athens, Greece, Consultant of the Hellenic Heart Foundation (ELIKAR). Iatriko is a private hospital dealing with the full range of adult and pediatric medicine. The work in the Catheterization Laboratory involves all the range of interventional cardiology. Continuing participation in the activities of ELIKAR (Hellenic Heart Foundation) . 2009 (September) – 2015(April): Consultant Interventional Cardiologist and Assistant Director of the Cardiology Clinic, Athens Euroclinic Hospital, and Consultant of the Hellenic Heart Foundation (ELIKAR). Euroclinic is a private Hospital dealing with all range of clinical and interventional cardiology. The majority of the coronary interventions in the Cath Lab are complex (referrals from other hospitals/angioplasty failures). Regular participation in the activities of ELIKAR (Hellenic Heart Foundation). ELIKAR is a nonprofit organization aiming to information of lay people in life style modification to achieve reduction of cardiovascular morbidity and mortality. 2004 (April) – 2009 (August): Consultant Interventional Cardiologist, Athens Euroclinic Hospital and Consultant of the Hellenic Heart Foundation (ELIKAR). Performance of interventional procedures (around 80-100 coronary interventions /year), the vast majority being referrals from other centres (either angioplasty failures or complex disease). Regular participation in the activities of ELIKAR (Hellenic Heart Foundation, described elsewhere). 2003 (September) – 2004 (March): Consultant Interventional Cardiologist, Athens Euroclinic Hospital and Research Associate of Mediolanum Cardiovascular Research (MCR). Clinical duties and performance of diagnostic and interventional procedures in the Cath Lab of a private Athens Hospital. Continuation of the research coordination activities at the MCR (communication through mails and regular 2-3 days’ trips to Milan). 2002 (December)- 2003 (August): Interventional Cardiology Registrar at EMO Centro Cuore Columbus, Intravascular ultrasound (IVUS) Director in San Raffaele Hospital and EMO Centro Cuore Columbus & IVUS Scientific Director and Research Associate of Mediolanum Cardiovascular Research (MCR), Milan, Italy (under Dr A. Colombo). Clinical duties in the Catheterization Lab and the ward at EMO Centro Cuore Columbus clinic. Performance of IVUS sub-analysis for the studies organized by MCR, responsibility of training and coordination of MCR staff in 3D-IVUS measurements and supervision of the work of the MCR staff in: preparation and organization of multi-centre trials, quantitative coronary angiography (QCA) measurements and final data evaluation and presentation.
  • 4. 4 Training of fellows in San Raffaele Hospital in the full range of IVUS analysis (including 3D IVUS) and coordination of IVUS database for both centres (Centro Cuore Columbus and San Raffaele) 2002 (September)-2002 (November): IVUS Scientific Director in Mediolanum Cardiovascular Research (MCR) & Interventional Cardiology Registrar, San Raffaele Hospital, Milan, Italy (under Dr A. Colombo). Responsibility for the co-ordination of the IVUS department in MCR: IVUS sub- analysis in clinical trials, training and supervision of MCR staff in performing 3D- IVUS. At the same time I continued with my clinical responsibilities at San Raffaele hospital (described in the next paragraph). 2001 (September)-2002 (August): Interventional Cardiology Registrar, San Raffaele Hospital, Milan, Italy (under Dr A. Colombo). This was a 1-year contract at San Raffaele Hospital involving clinical and research activities, with active participation in the Catheterization Lab (performance of more than 800 diagnostic catheterizations and around 250 coronary interventions). The clinical work took place at San Raffaele Hospital and was divided between responsibilities in the ward and in the Catheterization Lab on a monthly rotation basis. Ward work was related to admission, discharge and follow-up of patients undergoing coronary interventions. Lab work involved diagnostic catheterizations and coronary as well as peripheral vascular interventions. 2000 (November)-2001 (September): Research Fellow in San Raffaele Hospital & Centro Cuore Columbus, Milan, Italy (under Dr A. Colombo) This was a post that included research activities as well as clinical activities with financial support from a Training Fellowship of the European Society of Cardiology and a scholarship of San Raffaele Hospital. The research work concerned data collection and analysis for both San Raffaele Hospital and Centro Cuore Columbus: QCA measurements, IVUS performance and evaluation, as well as data analysis, manuscript and abstract preparation and presentation of the results at international meetings. 1999 (January)-2000 (October): Associate of the Department of Cardiology of Athens Medical School, Catheterization Laboratory, Hippokration Hospital, Athens (under Ass. Professor P. Toutouzas). Work in the Catheterization Lab, performing full diagnostic adult catheterization and a small number of coronary interventions as first operator; regular cardiology consultations for inpatients at the General Medical and Surgical departments and participation in outpatients’ clinics. 1995 (August)-1998 (August): Trainee in Cardiology, Department of Cardiology of Athens Medical School, Hippokration Hospital, Athens (under Professor P. Toutouzas). This was a three-year rotation through the Cardiology & Cardiothoracic Wards, Exercise Treadmill Testing Department, Echocardiography Department, Intensive
  • 5. 5 Therapy Unit and the Catheterization Laboratory in the context of specialization in Cardiology. 1995 (February)-1995 (July): Senior House Officer (S.H.O.) in General Medicine/Cardiology, Tameside General Hospital, Aston under Lyne, Lancashire (under Dr Husaini, consultant physician with a special interest in Cardiology). Tameside was a busy district general hospital in the United Kingdom. Responsibility of acute general medical admissions, day to day care of patients in the ward and supervision of the House Officer; responsibility for one cardiology clinic every week. While working with Dr Husaini I had the opportunity to come closer to adult non- invasive cardiology, although limited by the tools available to a non-tertiary department. 1994 (August)-1995 (January): S.H.O. in General Medicine/Chest Diseases, Tameside General Hospital, Aston under Lyne, Lancashire (under Dr Chopra, Consultant Physician). The usual S.H.O. activities (described in the previous paragraph) including one general medical and two chest clinics every week. Exposure to all kinds of chest diseases, both on an emergency basis and concerning the long-term management. 1994 (June 6th - July 31st): S.H.O. in General Medicine/Diabetes & Endocrinology, Tameside General Hospital, Aston under Lyne, Lancashire (under Dr O’Mullane, Consultant Physician). During the above post (advertised as a locum post, but soon after my employment - under mutual agreement- regarded as part of my rotation at Tameside) I was responsible for admissions, day to day care of patients and I participated in two general medical and two diabetic clinics every week. There was wide exposure to medical problems, especially the ones arising during the long-term management of diabetic patients. 1994 (April 18th -May 3rd) & 1994 (May 14th-29th): Locum S.H.O. in General Medicine, Wrexham Maelor Hospital, Wrexham, Clwyd (under Dr Child & Dr Baker). Locum posts in this district general hospital, which gave me the opportunity to become affiliated to the responsibilities of the S.H.O. in a British hospital. 1993 (January)-1994 (January): Trainee in Internal Medicine, 3rd Department of Internal Medicine, Papademetriou Hospital of Athens, Greece (part of the training leading to the exams for the «specialist in Cardiology» title). A post that dealt with a wide variety of medical problems in this general hospital of Athens. 1992 (January)-1992 (November): Physician in the Greek Army (obligatory military service). I served in the acute unit of a Recruitment Center at Kalamata (Southern Greece) on a shift basis, dealing with acute medical/surgical problems of the military personnel. 1990 (June)-1991 (November): General Physician, Health Center of Meligala, Messinia, Greece (obligatory rural service).
  • 6. 6 Follow up of chronic problems in a primary care setting and management of medical/surgical emergencies for a rural population of 20.000 people. PROCEDURES Basic techniques: In the course of my training I have gained confidence in temporary cardiac pacemaker insertion, pericardial aspiration and Intra Aortic Balloon Pump (IABP) insertion. Diagnostic catheterization: During my training in the Catheterization Laboratory I gained confidence and wide experience in performing right and left cardiac catheterization, coronary angiography and peripheral vascular catheterization. Performance of a large number of diagnostic catheterizations, including use of radial and brachial artery access. Conversion to radial artery as the preferred access site since 2013. Coronary interventions: Performance of more than 300 interventions, while training in Milan and around 80-100 procedures/year since, for a variety of coronary lesions including complex ones: coronary bifurcations, with stenting of the main branch and balloon angioplasty for the side branch or double stenting techniques: modified T stenting and crushing technique in-stent restenosis, with the use of conventional and cutting balloon angioplasty, occasionally followed by beta intracoronary brachytherapy calcified lesions, with the use of cutting balloon or FX Minirail balloon angioplasty and rotablator use diffuse disease & small vessel disease, with use of intravascular ultrasound and intracoronary pressure measurements for definition of the appropriate treatment strategy unprotected left main stenosis, ostium, shaft and bifurcation, while working in Milan and at my personal practice in Euroclinic Hospital after the results of SYNTAX Trial. Radial artery cannulation is the preferred access site for coronary interventions. Working with Dr A. Colombo (2000-2003) I also had the opportunity to use a lot of different devices, many used in our centre as initial evaluation in clinical trials: the Galileo intracoronary beta-brachytherapy catheter, different atherectomy devices as the “Fox-Hollow” catheter, the rotablator catheter, the cutting balloon coronary catheter, the Angioguard and the Percuserge protection devices, the “Rescue” thrombus aspiration coronary system, the “Volcano” and the “Epiphany” thermography catheters, laser catheters and the “FrontRunner” device for chronic total coronary occlusions.
  • 7. 7 Non Coronary interventions: At Iatrikon Heart Center we have organized a Trans Catheter Aortic Valve implantation team and we have successfully treated the first 3 patients. I have also participated in a discrete number of peripheral vascular interventions while working at San Raffaele hospital (carotid arteries, renal arteries, iliac and femoral arteries). Intravascular ultrasound: I also had the opportunity to gain wide experience in performing and evaluating intravascular ultrasound (IVUS) examination - either for diagnostic purposes: Cases where the angiography is inconclusive as regards the significance of stenosis, especially in left main coronary artery disease and ostial disease - or as a tool to help determine the treatment strategy during coronary interventions: During implantation of bare and drug-eluting stents, in cases of in-stent restenosis and in cases of diffuse or small vessel disease. RESEARCH Participation in research work organized by the department during my cardiology training at Hippokration hospital, mainly work with intravascular ultrasound (IVUS). Participation in clinical research in San Raffaele & Centro Cuore Columbus: quantitative coronary angiography (QCA) and intravascular ultrasound (IVUS) measurements, clinical and angiographic follow-up of patients, as well as data analysis and presentation of the results at international meetings. Participation in the conduction of multi-center trials since September 2002, due to my duties in Mediolanum Cardiovascular Research (MCR) center. During this time I gained experience with the design and performance of multicenter clinical trials, as well as evaluation and presentation of the results. Amongst others: Clinical Project Leader in CIRIUS Bifurcation Trial (the first study using the CYPHERTM stent for coronary bifurcations) and co-ordination of IVUS subanalysis of the study. The study has been conducted in 5 centres (Centro Cuore Columbus in Milan, Lenox- Hill Hospital in New York, ICPS centre in Massy, Paris, Mayo Clinic in Rochester, Minessota and University of Erlangen, Germany) with Dr Antonio Colombo as primary investigator. Conceptualization and structure of the protocol of the CACTUS (Coronary Bifurcations: Application of the Crushing Technique Using Sirolimus-Eluting Stents) Trial organized by the MCR aiming to define best available technique for coronary artery bifurcations treatment. IVUS sub-analysis from the Rescut (REStenosis CUTting balloon evaluation) study, a multicenter trial that compared cutting balloon to conventional balloon angioplasty in the treatment of in-stent restenosis (the clinical results were presented during the Transcatheter Cardiovascular Therapeutics 2002 - late breaking clinical trial).
  • 8. 8 RELATED EXPERIENCE Participation in the Investigator’s Meetings in the course of the “Evaluation of the sirolimus-eluting stent in the treatment of patients with bifurcation lesions” study (organized by Cordis Corp. in New York, August 2002 and in Chicago, November 2002) presenting the IVUS analysis of the study. Participation as faculty expert in the organization of JIM 2003 international meeting of coronary and peripheral vascular interventions. Participation as member of the organizing committee of Clinical Cardiology Congress in 2003-2015 organized by the Hellenic Heart Foundation (ELIKAR). Reviewer of research work submitted to the annual European Society of Cardiology (ESC) Congress (2004-2015) as well as to the Hellenic Journal of Cardiology (HJC). PLANS I wish to contribute to clinical research projects undertaken by the medical industry. In this perspective I have applied for the Executive MSc Health Economics, Outcomes and Management in Cardiovascular Science, a part time program that will start in December 2015 at London School of Economics OTHER INTERESTS I am a cinema lover and I spend a lot of my free time trying not to miss any of the films I consider interesting. I also enjoy theater, listening to music and reading literature.
  • 9. 9 PUBLISHED WORK Peer review journals: 1. Ahmed W, Mendiz O, Thomas M, Taxus Olympia Participating Physicians: Usage patterns and 1 year outcomes with the Taxus Liberte stent. Results of the TAXUS OLYMPIA Registry. Catheter Cardiovasc Interv 2011 Jun 1;77(7):979-992. 2. Spanos V, Toutouzas P: The ever increasing role of percutaneous interventions in coronary revascularization. Hellenic J Cardiol 2010 Nov-Dec;51(6):512-7. 3 Karabinos I, Spanos V: Percutaneous transluminal coronary angioplasty in a patient with three small vessel disease: the role of intravascular ultrasound. Hellenic J Cardiol 2008 Nov-Dec;49(6):432-3. 4. Spanos V, Toutouzas P. Multivessel coronary artery disease treated with drug- eluting stents.Hellenic Journal of Cardiology. 2004:315-318. 5. Spanos V, Toutouzas P, Voridis E. Modified T stenting technique with crushing using paclitaxel-eluting stents. Hellenic Journal of Cardiology. 2004:213-217. 6. Colombo A, Moses JW, Morice MC, Ludwig J, Holmes DR, Jr, Spanos V, Louvard E, Desmedt B, Di Mario C, Leon M: Randomized study to evaluate sirolimus-eluting stents implanted at coronary bifurcation lesions. Circulation 2004;109(10):1244-9. 7. Stankovic G, Orlic D, Corvaja N, Airoldi F, Chieffo A, Spanos V, Motorfano M, Carlino M, Finci L, SanGiorgi M, Colombo A: Incidence, predictors, in-hospital, and late outcomes of coronary artery perforations. Am J Cardiol. 2004 Jan 15;93(2):213-6. 8. Spanos V., Vitrella G., Colombo A.: Using intravascular ultrasound with drug- eluting stents. What have we learned so far? Minerva Cardioangiol. 2003 Oct;51(5):493-505, 505-11. 9. Orlic D, Reimers B, Stanckovic G, Corvaja N, Chieffo A, Airoldi F, Spanos V, Favero L, Di Mario C, Colombo A: Initial experience with a new 8 French- compatible directional atherectomy catheter: immediate and mid-term results. Catheter Cardiovasc Interv. 2003 Oct;60(2):159-66. 10. Colombo A, Stankovic G, Orlic D, Corvaja N, Liistro F, Airoldi F, Chieffo A, Spanos V, Montorfano M, Di Mario C: Modified “T” Stenting Technique with “Crushing” for Bifurcation Lesions: Immediate Results and 30-day Outcome Catheter Cardiovasc Interv. 2003 Oct;60(2):145-51. 11. Airoldi F., Di Mario C., Stankovic G., Briguori C., Carlino M., Chieffo A., Liistro F., Montorfano M., Pagnotta P., Spanos V., Tavano D., Colombo A.: Clinical and angiographic outcome of directional atherectomy followed by stent implantation in de-novo coronary lesions located at the ostium of the left anterior descending artery Heart. 2003 Sep;89(9):1050-4.
  • 10. 10 12. Spanos V, Stankovic G, Colombo A: A tortuous distal carotid artery: How to overcome the problem, maintaining the goal to guarantee distal protection International J Invasive Cardiol 2003;5(2):77-80. 13. Colombo A, Orlic D, Stankovic G, Corvaja N, Spanos V, Motorfano M, Liistro F, Carlino M, Airoldi F, Chieffo A, Di Mario C: Preliminary observations regarding angiographic pattern of restenosis after rapamycin-eluting stents implantation Circulation 2003 May 6;107(17):2178-80. 14. Briguori C, Sarais C, Pagnotta P, Airoldi F, Liistro F, Sgura F, Spanos V, Carlino M, Montorfano M, Di Mario C, Colombo A: Elective versus provisional intra-aortic balloon pumping in high-risk percutaneous transluminal coronary angioplasties Am Heart J 2003 Apr;145(4):700-7. 15. Colombo A., Spanos V.: A new technique for coronary bifurcations? Good news! (Editorial) J Invasive Cardiol 2003 Apr;15(4):184-5. 16. Spanos V, Stankovic G, Tobis J, Colombo A: The challenge of in-stent restenosis; insights from intravascular ultrasound (review) Eur Heart J 2003; 24(2):138-150. 17. Stankovic G, Liistro F, Moshiri S, Briguori C, Corvaja N, Chieffo A, Montorfano M, Finci L, Spanos V, Di Mario C, Colombo A: Carotid artery stenting in the first 100 consecutive patients: results and follow-up Heart 2002; 88: 381-386. 18. Takagi T, Stankovic G, Finci L, Toutouzas K, Chieffo A, Spanos V, Liistro F, Briguori C, Corvaja N, Albiero R, Sivieri G, Paloschi R, Di Mario C, Colombo A: Results and long-term predictors of adverse clinical events after elective percutaneous interventions on unprotected left main coronary artery. Circulation 2002 Aug 6;106(6):698-702. 19. Toutouzas K, Stankovic G, Takagi T, Spanos V, Di Mario C, Albiero R, Corvaja N, Gaglione A, Colombo A: Outcome of treatment of aorto-ostial lesions involving the right coronary artery or a saphenous-vein graft with a polytetrafluoroethylene-covered stent Am J Cardiol 2002; 90:63-66. 20. Sallam M, Spanos V, Briguori C, Di Mario C, Tzifos V, Dharmadhikari A, Albiero R, Colombo A: Predictors of re-occlusion after successful recanalization of chronic total occlusion J Invasive Cardiol 2001 Jul;13(7):511-15. 21. Vavuranakis M, Stefanadis C, Toutouzas K, Pitsavos C, Spanos V, Toutouzas P: Impaired compensatory coronary artery enlargement to atherosclerosis contributes to the development of coronary artery stenosis in diabetic patients. An in vivo intravascular ultrasound study. Eur Heart J 1997; 18:1090-1094. Books: 1. Spanos V: “Καρδιά: Έμαθες; Σώθηκες!”, Dioptra Publications, Athens 2002
  • 11. 11 2. Spanos V, Di Mario C, Opizzi M: Treatment of Acute Myocardial Infarction (AMI) with Embolus Aspiration. In: Rothman M, ed. Case Studies in Interventional Cardiology. 6th ed: Martin Dunitz Ltd; 2003:86- 91. Congresses: Annual Congress of The American Heart Association (AHA, published in Circulation): 1. V. Spanos, K. Toutouzas, A. Chieffo, J. Kostov, R. Albiero, A. Amato, C. Briguori, G. Stankovic, C. Di Mario, A. Colombo: Six-month angiographic follow-up after implantation of the sirolimus drug-eluting stent at coronary bifurcations; a three- dimensional intravascular ultrasound study Circulation 2002;106(Sup II) 391:1945 2. V. Spanos, S. Moshiri, C. Sarrais, M. Montorfano, F. Airoldi, D. Maccagni, F. Liistro, G. Tucci, M. Ferraro, R. Albiero: Diffuse In-stent Restenosis: Outcomes of Balloon Angioplasty and Cutting Balloon Angioplasty Circulation 2002;106(Sup II) 391:1945. 3. G. Stankovic, M. Ferraro, J. Kostov, C. Milici, N. Corvaja, R. Albiero, A. Chieffo, V. Spanos, F. Airoldi, F. Liistro, L. Finci: Coronary artery perforations: incidence, predictors and clinical outcome Circulation 2002;106(Sup II) 444:2210 4. C. Briguori, C. Sarais, V. Spanos, P. Pagnotta, R. Albiero, G. Stankovic, M. Carlino, A. Colombo: Impact of strut’s thickness on restenosis after stent implantation in small coronary vessels Circulation 2001;104 (sup II) 665:3139 Annual Congress of The American College of Cardiology (ACC, published in JACC): 1. V. Spanos, G. Stankovic, F. Airoldi, M. Montorfano, N. Corvaja, F. Liistro, A. Chieffo, M. Segura, D. Tavano, C. Di Mario, A. Colombo: Use of the sirolimus drug-eluting stents for “real world” coronary lesions – The Milan experience. Results of the first 400 lesions J Am Coll Cardiol 2003;41(Suppl A):12A 2. F. Airoldi, V. Spanos,G. Stankovic, et al. Bifurcational coronary artery lesion treatment with rapamycin-eluting stents: results from a single center experience. J Am Coll Cardiol. 2003;41(Suppl A):53A 3. K. Toutouzas, G. Stankovic, T. Takagi, V. Spanos, C. Di Mario, R. Albiero, N. Corvaja, A. Chieffo, G. Sivieri, A. Colombo: Impact of stent length on restenosis rate in small vessels. J Am Coll Cardiol 2002; 53A:1149-22 4. K. Toutouzas, G. Stankovic, T. Takagi, V. Spanos, C. Di Mario, R. Albiero, N. Corvaja, G. Sivieri, D. Milici, A. Colombo: Failure of PTFE- covered stents to lower restenosis rate in aorto-ostial lesions. J Am Coll Cardiol 2002; 61A:1195-122
  • 12. 12 5. M. Vavuranakis, C. Stefanadis, C. Pitsavos, E. Lazaki, K. Toutouzas, I. Kallikazaros, V. Spanos, P. Toutouzas: Coronary artery distensibility determined by simultaneous intracoronary pressure recordings and intracoronary ultrasound is impaired in patients with diabetes mellitus. J Am Coll Cardiol 1997; 124A:942-133 Annual Trans Catheter Therapeutics Congress (TCT, published in the Am Journal Cardiol): 1. G. Stankovic, D. Orlic, A. Chieffo, V. Spanos, N. Corvaja, G. Sangiorgi, F. Airoldi, A. Colombo: Predictors of CK-MBelevation after Percutaneous Coronary Intervention using Sirolimus-eluting stents Am J Cardiol 2003; TCT-432. 2. D. Orlic, G. Stankovic, F. Airoldi, A. Chieffo, V. Spanos, D. Tavano, I. Michev, N. Corvaja, A. Colombo: Changes in stenting technique by using sirolimus-eluting stents in the real world Am J Cardiol 2003; TCT-443. 3. F. Airoldi, G. Stankovic, D. Orlic, C. Briguori, V. Spanos, M. Carlino, M. Montorfano, I. Michev, R. Rogacka, D. Tavano, A. Chieffo, A. Colombo: Immediate and midterm results of rapamycin-eluting stent implantation in bifurcational coronary artery lesions Am J Cardiol 2003; TCT-142. 4. F. Airoldi, G. Stankovic, D. Orlic, C. Briguori, V. Spanos, M. Carlino, M. Montorfano, I. Michev, R. Rogacka, D. Tavano, A. Chieffo, C. Di Mario, A. Colombo: The modified T stenting technique with crushing for bifurcation lesions: immediate results and 6-month clinical outcomes Am J Cardiol 2003; TCT-143. 5. D. Orlic, B. Reimers, G. Stankovic, N. Corvaja, V. Spanos, L. Favero, A. Chieffo, F. Airoldi, M. Montorfano, L. Finci, A. Colombo: Initial experience with a new concept 8Fr compatible Directional Atherectomy catheter: 30-day and 6-month clinical outcome Am J Cardiol 2003; TCT- 526. 6. D. Orlic, C. Di Mario, G. Stankovic, G. Sangiorgi, N. Corvaja, V. Spanos, F. Airoldi, A. Chieffo, M. Montorfano, M. Carlino, I. Michev, A. Colombo: Balloon overdilatation in rapamycin-eluting stents: preliminary report of 6-month angiographic outcome Am J Cardiol 2003; TCT-451. 7. D. Orlic, C. Di Mario, G. Stankovic, N. Corvaja, G. Sangiorgi, A. Chieffo, F. Airoldi, V. Spanos, M. Montorfano, M. Ferraro, A. Colombo: Multivessel coronary artery stenting with Sirolimus-eluting stent implanatation: immediate and midterm results Am J Cardiol 2003; TCT- 211. 8. D. Orlic, G. Stankovic, L. Finci, G. Sangiorgi, N. Corvaja, E. Bonizzoni, A. Chieffo, F. Airoldi, V. Spanos, G. Vitrela, A. Amato, A. Colombo:
  • 13. 13 Clinical and angiographic parameters associated with restenosis in Sirolimus-eluting stents Am J Cardiol 2003; TCT-440. 9. D. Orlic, G. Stankovic, C. Di Mario, N. Corvaja, F. Airoldi, A. Chieffo, M. Montorfano, M. Carlino, V. Spanos, D. Tavano, G. Martini, L. Finci, A. Colombo: Preliminary observations regarding angiographic pattern of restenosis after rapamycin-eluting stents implanatation Am J Cardiol 2003; TCT-123. 10. V. Spanos, G. Stankovic, F. Airoldi, R. Albiero, N. Corvaja, J. Kostof, A. Chieffo, M. Segura, C. Di Mario, A. Colombo: Use of the Sirolimus drug-eluting stents for “real world” coronary lesions Am J Cardiol 2002; 5H; TCT-12 11. V. Spanos, G. Stankovic, M. Montorfano, F. Airoldi, R. Albiero, C. Sarais, F. Sgura, A. Chieffo, M. Ferraro, C. Briguori, C. Di Mario, A. Colombo Mid-term results of intracoronary brachytherapy for the treatment of ostial lesions Am J Cardiol 2002; 101H: TCT-253 12. F. Airoldi, C. Di Mario, G. Stankovic, V. Spanos, A. Chieffo, R. Albiero, M. Ferraro, M. Carlino, C. Briguori, A. Colombo: Bifurcational coronary artery treatment with Rapamicine-eluting stent: Results from a single center experience in the first 50 cases Am J Cardiol 2002; 5H; TCT-10 13. C. Sarais, C. Briguori, P. Pagnota, A. Chieffo, V. Spanos, F. Sgura, F. Airoldi, F. Liistro, C. Di Mario, A. Colombo: Impact of vessel angulation on early and late outcome after coronary stent implantation Am J Cardiol 2002; 95H; TCT-239 14. F. Airoldi, C. Di Mario, C. Briguori, G. Stankovic, M. Carlino, F. Liistro, V. Spanos, J. Kostof, A. Chieffo, C. Sarais, M. Ferraro, A. Colombo: Immediate and mid-term effects of debulking before stenting in de-novo coronary artery lesions located in the left main Am J Cardiol 2002; 108H: TCT-271 15. F. Airoldi, C. Di Mario, A. Chieffo, C. Briguori, G. Stankovic, M. Carlino, F. Liistro, V. Spanos, J. Kostof, C. Sarais, M. Ferraro, R. Rogacka, A. Colombo: Clinical and angiographic effects of directional atherectomy in de-novo coronary artery lesions located at the ostium of the left anterior descending artery Am J Cardiol 2002; 108H: TCT-272 16. F. Liistro, A. Chieffo, G. Stankovic, V. Spanos, J. Kostof, F. Sgura, C. Di Mario, M. Montorfano, C. Cesere, A. Colombo: Coronary intervention in the elderly: Comparison on immediate and long-term outcome between octagenarians and septuagenarians Am J Cardiol 2002; 176H: TCT-460 17. N. Corvaja, B. Reimers, C. Milici, J. Kostof, G. Stankovic, G. Martini, V. Spanos, R. Albiero, C. Di Mario, A. Colombo: Carotid stenting in the elderly: Is filter neuroprotection of any help? Am J Cardiol 2002; 59H: TCT-139
  • 14. 14 18. C. Briguori, C. Sarrais, V. Spanos, G. Gimelli, P. Pagnotta, M. Carlino, R. Albiero, C. Di Mario, A. Colombo: Influence of stent strut thikness on restenosis rates in small coronary arteries Am J Cardiol 2001; 88(Supp 1 5A) Annual European Society of Cardiology Congress (ESC, published in the EurHeartJ): 1. Spanos V., Moshiri S., Sarrais C., Montorfano M., Albiero R., Airoldi F., Briguori C., Liistro F., Stankovic G., Di Mario C., Colombo A.: Cutting Balloon Angioplasty vs. Balloon Angioplasty for treating diffuse In-stent Restenosis ESC 2002 2. C. Briguori, C. Sarais, V. Spanos, G. Gimelli, F. Sgura, M. Carlino, C. Di Mario, P. Pagnotta, A. Colombo, F. Airoldi: Clinical and angiographic predictors of false small coronary vessels Eur Heart J 2001 239 (1297) 3. S. Moshiri, C. Sarais, V. Spanos, A. Ferrari, C. Di Mario, A. Colombo, F. Liistro, M. Montorfano, G. Gimelli: Carotid angioplasty and stent placement: a technique in evolution for carotid artery stenosis; Italian experience Eur Heart J 2001 633 (3479) 4. M. Vavuranakis, V. Spanos, V. Vukcevic, K. Toutouzas, C. Chrisohou, D. Markou, K. Tzioumis, C. Stefanadis, K. Aggeli, P. Toutouzas: Intracoronary ultrasound findings of angiographically normal LMCA in patients with HTN and Left Ventricular Hypertrophy. Is LMCA adequately sized? Eur Heart J 2000 269 (1538) 5. K. Toutouzas, M. Vavuranakis, L. Diamantopoulos, C. Stefanadis, C. Pitsavos, N. Giatrakos, V. Spanos, P. Toutouzas: Acute effect of stenting in the elastic properties of human coronary arteries: insights in the mechanics of stenting Eur Heart J 1997 381 (2184) Other Congresses: Congress of the Italian Society of Interventional Cardiology (GISE) 1. V. Spanos, F. Airoldi, A. Chieffo, R. Albiero, M. Montorfano, N. Corvaja, M. Segura, F. Sgura, M. Murino, G. Stankovic, C. Di Mario, A. Colombo: The use of the Sirolimus drug-eluting stent for “real world” coronary lesions. Results of the first 200 cases Emodinamica 2002 (Lug/Set); 30 (sup):46 2. V. Spanos, G. Stankovic, M. Montorfano, F. Airoldi, R. Albiero, A. Chieffo, D. Tavano, V. Romano, A. Colombo: Coronary intervention in the elderly: comparison of immediate and long-term clinical outcome between octogenarians and septuagenarians Emodinamica 2002 (Lug/Set); 30 (sup):27 3. F. Liistro, G. Stankovic, A. Chieffo, V. Spanos, J. Kostov, F. Sgura, C. Di Mario, M. Montorfano, F. Airoldi, R. Albiero, C. Sarais, D. Tavano, M. Ferraro, C. Rossi, C. Briguori, , A. Colombo: Mid term results after use of
  • 15. 15 intracoronary beta brachytherapy in ostial coronary lesions Emodinamica 2002 (Lug/Set); 30 (sup):27 4. F. Airoldi, C. Di Mario, G. Stankovic, D. Tavano, V. Spanos, R. Albiero, M. Ferraro, M. Carlino, P. Pagnota, M. Montorfano, C. Briguori, , A. Colombo: Bifurcational coronary artery treatment with rapamycine eluting stents: results from a single center experience on the first 50 cases Emodinamica 2002 (Lug/Set); 30 (sup):26 5. A. Chieffo, G. Stankovic, M. Montorfano, F. Airoldi, V. Spanos, M. Ferraro, A. Ferrari, C. Cesere, R. Rogacka, A. Colombo Acute and late outcome after DCA plus stenting versus stenting alone in true bifurcation lesions Emodinamica 2002 (Lug/Set); 30 (sup):28 6. F. Airoldi, C. Di Mario, D. Tavano, C. Briguori,, G. Stankovic, M. Carlino, F. Liistro, V. Spanos, M. Montorfano, A. Chieffo, C. Sarais, M. Ferraro, R. Rogacka, A. Colombo: Clinical and angiographic effects of directional atherectomy in de-novo coronary artery lesions located at the ostium of the left anterior descending artery Emodinamica 2002 (Lug/Set); 30 (sup):25 7. F. Airoldi, C. Di Mario, C. Briguori,, D. Tavano, G. Stankovic, M. Carlino, P. Pagnota, M. Montorfano, F. Liistro, V. Spanos, A. Chieffo, C. Sarais, A. Castelli, A. Colombo: Immediate and mid-term effects of debulking before stenting in de-novo coronary artery lesions located in the left main Emodinamica 2002 (Lug/Set); 30 (sup):25 8. . V. Spanos, M. Ferraro, G. Stankovic, G. Sivieri, A. Chieffo, D. Maccagni, F. Liistro, C. Briguori, C. Di Mario, A. Colombo: Predictors of adverse vents following bail-out use of glycoprotein IIb/IIIa inhibitors GISSE 2001 9. V. Spanos, S. Moshiri, C. Sarais, F. Liistro, A. Castelli, M. Montorfano, C. Briguori, G. Stankovic, C. Di Mario, A. Colombo: Follow-up results following cutting balloon treatment of aggressive versus non-aggressive in stent restenosis GISSE 2001
  • 16. 16 REFEREES 1. Dr Antonio Colombo Director of the Catheterization Laboratory, EMO Centro Cuore Columbus & San Raffaele Hospital, Milan Via Buonarroti 48, 20145 Milan, Italy Tel: (+39) 02-4812920 Fax: (+39) 02-48193433 e-mail: info@emocolumbus.it 2. Dr Carlo Di Mario Catheterization Laboratory, Royal Brompton Hospital Sydney Street London SW3 6NP, UK Tel: (+44) 207-352 8121 Fax: (+44) 207-351 8473 e-mail: c.dimario@rbh.nthames.nhs.uk 3. Professor P. Toutouzas Director of Hellenic Heart Foundation (EL.I.KAR.) Director of Cardiology Department Athens Euroclinic Hospital 7, Athanasiadou Street 115 27, Athens, Greece Tel: (+30) 210-6416790 Fax: (+30) 210-6416757 e-mail: elikar@elikar.gr