4. A cholinesterase or choline esterase (ChE) is an
esterase enzyme that lyses choline-based esters
Autonomic Nervous
System1.cholinesterases
2.Anticholinesterases
3.Therapeutic
Implications
7. Agents which inhibit ChE,
protect ACh from hydrolysis – persistence
of the action
produce cholinergic effects in vivo and
potentiate ACh both in vivo and in vitro
Autonomic Nervous
System1.cholinesterases
2.Anticholinesterases
3.Therapeutic
Implications
20. Autonomic Nervous
System1.cholinesterases
2.Anticholinesterases
3.Therapeutic
Implications
Physostigmine Neostigmine and
congeners
Organophosphates
Rapidly absorbed -
g.i.t. and parenteral sites
poorly absorbed orally Absorbed from all sites
including intact skin and
lungs
Crosses blood-brain
barrier & Cornea
do not effectively
penetrate cornea or cross
blood-brain barrier
Crosses all the barriers
Hydrolysis by ChE Partially hydrolysed and
partially excreted
unchanged in urine
hydrolyzed as well as
oxidized in the body and
little is excreted
unchanged.
26. - Senile dementia - deposition of amyloid plaques in
the hippocampus (Presence of neurofibrillary
tangles).
- Loss of cholinergic neurons in the brain
- Anticholinesterases that can cross the blood brain
barrier are the mainstay of treatment of this disease
1. Description
2. Mechanism
3. Management
Alzheimer's Disease
27. https://www.youtube.com/watch?v=zTd0-A5yDZI
1. Central Nervous System
1.Sedative–HypnoticDrugs
2.Parkinsonism
3.OtherNeurodegenerative
Disorders
4.AntiepilepticDrugs
5.AntipsychoticDrugs
6.AntidepressantDrugs
7.Antianxietydrugs
8.Alcohol
9.Opioids
a. Alzheimer's Disease
29. - Auto immune disorder
- Development of auto antibodies - nicotinic receptors
at the muscle endplate
- free Nm cholinoceptors to 1/3 of normal or less and
structural damage to the neuromuscular junction.
- weakness and easy fatigability on repeated activity,
with recovery after rest.
1. Description
2. Mechanism
3. Management
MYAESTHENIA GRAVIS
33. Autonomic Nervous
System
1.cholinesterases
2.Anticholinesterases
3.Therapeutic
Implications
4. Poisoning
OP POISONING
• Irritation of eye, lacrimation, salivation, sweating,
copious tracheo-bronchial secretions, miosis, blurring of
vision, bronchospasm, breathlessness, colic, involuntary
defecation and urination.
• Fall in BP, bradycardia or tachycardia, cardiac
arrhythmias, vascular collapse.
• Muscular fasciculations, weakness, respiratory paralysis
(central as well as peripheral).
• Irritability, disorientation, unsteadiness, tremor, ataxia,
convulsions, coma and death.
• Death is generally due to respiratory failure