Tissue Rejection types & Prevention

1. Tissue Rejection
Types And Prevention
Syed Dawood Shah
Mirpur University Of
Science And Technology
Azaad Kashmir Pakistan

2. Introduction
• Transplant rejection
occurs when
transplanted tissue is
rejected by the
recipient's immune
system, which
destroys the
transplanted tissue.

3. There Are Three Types Of
Rejection
 Hyperacute Rejection:
 Acute Rejection:
 Chronic Rejection:

4. Hyperacute Rejection:
• Hyperacute rejection is seen when the
recipient has pre-existing antibodies that
are reactive with the donor tissue.
This may be because:
The individual has been sensitized to the donor
MHC.
The animal may have natural pre-existing
antibodies

5. Hyperacute Rejection:
Time Of reaction:
With in minutes
Consequences:
Cause inflammatory response, increasing
vascular leakage, but can also cause blood
coagulation.
The result is rapid destruction of graft.

6. Hyperacute Rejection:

7. Acute Rejection:
 Acute rejection is normally seen days to week
after transplantation.
 Donor dendritic cell play an important role in
triggering acute rejection

8. Acute Rejection:

9. Chronic Rejection
 In vascularized organ chronic rejection
present as occlusion of blood vessels.
 Smooth muscle cell proliferation is often
seen.
 This eventually leads to blockage of the
blood vessels and subsequent ischemia of
the organ.

10. Agents of Chronic Rejection
 A low-grade T cell response;
 Antibodies

11. Chronic Rejection

12. Prevention Methods For Tissue
Rejection

13. Methods of Prevention
The two major methods for preventing
rejection of allografts are:
To match donor and recipient to
minimize antigenic differences
To use immunosuppressive regiments
that Block the immune response
against the Tissue.

14. Methods of Prevention
• Blood grouping
• Human leukocyte antigen (HLA)
matching
• Tissue matching

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